Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 10, 2003, Pages 5658-5663

  Chen, Lan ^a   Walker, Deborah ^a   Sun, Binyuan ^a   Hu, Yanan ^a   Walker, Suzanne ^a   Kahne, Daniel ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAMBERMYCIN; CHLOROBIPHENYL VANCOMYCIN; DAMAGED CHLOROBIPHENYL VANCOMYCIN; DAMAGED TEICOPLANIN; DAMAGED VANCOMYCIN; DELIPIDATED MOENOMYCIN; GLYCOPEPTIDE; GLYCOSYLTRANSFERASE; PENICILLIN BINDING PROTEIN; TEICOPLANIN; UNCLASSIFIED DRUG; VANCOMYCIN DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG TARGETING; ENTEROCOCCUS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; ESCHERICHIA COLI; IC 50; INHIBITION KINETICS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE;

BACTERIAL PROTEINS; CARRIER PROTEINS; CLONING, MOLECULAR; CODON; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HEXOSYLTRANSFERASES; KINETICS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; MUTAGENESIS, INSERTIONAL; PENICILLIN-BINDING PROTEINS; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; PEPTIDYL TRANSFERASES; SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE; VANCOMYCIN; VANCOMYCIN RESISTANCE;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS; ESCHERICHIA COLI; POSIBACTERIA;

EID: 0038274041     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0931492100     Document Type: Article

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