Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer

Journal of Medicinal Chemistry

Volumn 58, Issue 5, 2015, Pages 2452-2464

  Ai, Yong ^a   Kang, Fenghua ^a   Huang, Zhangjian ^a   Xue, Xiaowen ^a   Lai, Yisheng ^a   Peng, Sixun ^a   Tian, Jide ^b   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; BARDOXOLONE AMINO ACID NITRIC OXIDE DONOR TRIHYBRID; BARDOXOLONE METHYL; BREAST CANCER RESISTANCE PROTEIN; FLUOROURACIL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; NITRIC OXIDE DONOR; PROTEIN KINASE B; STAT3 PROTEIN; UNCLASSIFIED DRUG; 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; OLEANOLIC ACID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLON CANCER; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; EPITHELIOID CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MALE; MOUSE; MTT ASSAY; NITRATION; NONHUMAN; PROTEIN FOLDING; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; COLONIC NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; INSTITUTE FOR CANCER RESEARCH MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

AMINO ACIDS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; MOLECULAR STRUCTURE; NITRIC OXIDE DONORS; OLEANOLIC ACID; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84924666732     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5019302     Document Type: Article

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