Synthesis and evaluation of nitric oxide-releasing DDB derivatives as potential Pgp-mediated MDR reversal agents in MCF-7/Adr cells

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 801-805

  Tang, Xiaobo ^a   Gu, Xiaoke ^a   Ai, Hua ^a   Wang, Guangji ^a   Peng, Hui ^b   Lai, Yisheng ^a   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

DDB; MDR reversal agents; Multidrug resistance (MDR); NO releasing derivatives; Pgp inhibitor

Indexed keywords

DICARBOXYLIC ACID; DIMETHYL 4,4' DIMETHOXY 5,6,5',6' DIMETHYLENEDIOXYBIPHEN YL 2,2' DICARBOXYLATE; DOXORUBICIN; FLUOROURACIL; GLYCOPROTEIN P; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CHEMOSENSITIZATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ACCUMULATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; IC 50; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; DICARBOXYLIC ACIDS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; NITRIC OXIDE; P-GLYCOPROTEIN;

EID: 84855706085     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.065     Document Type: Article

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