Oleanolic acid enhances the radiosensitivity of tumor cells under mimetic hypoxia through the reduction in intracellular GSH content and HIF-1α expression

Oncology Reports

Volumn 31, Issue 5, 2014, Pages 2399-2406

  Qi, Rongxin ^a   Jin, Wenwen ^a   Wang, Juan ^a   Yi, Qiyi ^a   Yu, Maohu ^a   Xu, Shiguo ^a   Jin, Wensen ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Glutathione; Hypoxia; Oleanolic acid; Radiosensitivity

Indexed keywords

5,5' DITHIOBIS(2 NITROBENZOIC ACID); GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OLEANOLIC ACID; RADIOSENSITIZING AGENT;

ANIMAL CELL; ARTICLE; CANCER CELL; CLONOGENIC ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; ENZYME ACTIVITY; GLIOMA; HUMAN; HUMAN CELL; HYPOXIA; HYPOXIC CELL; LUNG CANCER; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RADIATION INJURY; RADIOSENSITIVITY; RAT; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL HYPOXIA; CELL SURVIVAL; DRUG EFFECTS; LUNG NEOPLASMS; METABOLISM; RADIATION DOSE; RADIATION RESPONSE; TUMOR CELL LINE;

ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; GLIOMA; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE SYNTHASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; MICRONUCLEUS TESTS; OLEANOLIC ACID; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RATS;

EID: 84898670977     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3064     Document Type: Article

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