Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

Journal of Controlled Release

Volumn 76, Issue 1-2, 2001, Pages 129-138

  Nielsen, Carsten Uhd ^a   Andersen, Rikke ^a   Brodin, Birger ^a   Frokjaer, Sven ^a   Taub, Mitchell E ^a   Steffansen, Bente ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Affinity; Dipeptide model prodrugs; hPepT1; QSAR; Transport

Indexed keywords

BENZYL ALCOHOL; CARRIER PROTEIN; CEFALEXIN; DEXTRO ASPARTYL(BENZYL ALCOHOL)ALANINE; DEXTRO ASPARTYLALANINE; DEXTRO GLUTAMYL(BENZYL ALCOHOL)ALANINE; DEXTRO GLUTAMYLALANINE; HUMAN INTESTINAL PEPTIDE TRANSPORTER 1; PARAOXON; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG HYDROLYSIS; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSPORT; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTESTINE ABSORPTION; PH; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS;

CACO-2 CELLS; CARRIER PROTEINS; DIPEPTIDES; HUMANS; HYDROGEN-ION CONCENTRATION; PRODRUGS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 0035845726     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00427-8     Document Type: Article

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