Cyr61 participates in the pathogenesis of rheumatoid arthritis by promoting proIL-1β production by fibroblast-like synoviocytes through an AKT-dependent NF-κB signaling pathway

Clinical Immunology

Volumn 157, Issue 2, 2015, Pages 187-197

  Zhu, Xianjin ^a,b   Song, Yanfang ^c   Huo, Rongfen ^a   Zhang, Jie ^a   Sun, Songtao ^d   He, Yong ^d   Gao, Huali ^d   Zhang, Miaojia ^e   Sun, Xiaoxuan ^e   Zhai, Tianhang ^a   Li, Huidan ^a   Sun, Yue ^a   Zhou, Zhou ^a   Shen, Baihua ^a   Xiao, Lianbo ^d   Li, Ningli ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d Institute of Arthritis Research Shanghai Academy of Chinese Medical Sciences   (China)

^e THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cyr61; Fibroblast like synoviocyte; IL 1 ; Rheumatoid arthritis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYSTEINE RICH PROTEIN 61; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; OLIGONUCLEOTIDE; PROTEIN KINASE B; SMALL INTERFERING RNA; CYR61 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; INTERLEUKIN 1BETA CONVERTING ENZYME;

ADULT; AGED; ARTICLE; BIOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST LIKE SYNOVIOCYTE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE SYSTEM; INFLAMMATION; MALE; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; SYNOVIUM; WESTERN BLOTTING; CYTOLOGY; FIBROBLAST; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PROMOTER REGION; SYNOVIAL FLUID; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; CASPASE 1; CYSTEINE-RICH PROTEIN 61; FEMALE; FIBROBLASTS; HUMANS; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; NF-KAPPA B; OSTEOARTHRITIS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; SYNOVIAL MEMBRANE;

EID: 84924602816     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2015.02.010     Document Type: Article

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