The CCN family: A new class of inflammation modulators?

Biochimie

Volumn 93, Issue 3, 2011, Pages 377-388

  Kular, L ^a,b   Pakradouni, J ^a,b,c   Kitabgi, P ^a,b   Laurent, M ^a,b   Martinerie, C ^a,b  

^a HÔPITAL SAINT ANTOINE   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c Paris Santé Cochin Incubator   (France)

Author keywords

Chemokines; CYR61 CTGF NOV family; Cytokines; Inflammation; Inflammatory diseases

Indexed keywords

CHEMOKINE; CONNECTIVE TISSUE GROWTH FACTOR; CYSTEINE RICH PROTEIN 61; HISTAMINE; INTERLEUKIN 1BETA; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; NITRIC OXIDE; PROSTAGLANDIN DERIVATIVE; PROTEIN CCN; PROTEIN CCN4; SCLEROPROTEIN; SEROTONIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ATHEROSCLEROSIS; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; EXTRACELLULAR MATRIX; IN VITRO STUDY; INFLAMMATION; KIDNEY DISEASE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SECRETION; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

ANIMALS; CCN INTERCELLULAR SIGNALING PROTEINS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS;

EID: 79951517589     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2010.11.010     Document Type: Review

References (166)

1. R.O. Hynes The extracellular matrix: not just pretty fibrils Science 326 2009 1216 1219
2. P. Bornstein, and E.H. Sage Matricellular proteins: extracellular modulators of cell function Curr. Opin. Cell Biol. 14 2002 608 616 (Pubitemid 35247745)
3. A.S. Llera, M.R. Girotti, L.G. Benedetti, and O.L. Podhajcer Matricellular proteins and inflammatory cells: a task force to promote or defeat cancer? Cytokine Growth Factor Rev. 21 2010 67 76
4. C. Chiodoni, M.P. Colombo, and S. Sangaletti Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis Cancer Metastasis Rev. 29 2010 295 307
5. P. Bork The modular architecture of a new family of growth regulators related to connective tissue growth factor FEBS Lett. 327 1993 125 130 (Pubitemid 23211174)
6. T. O'Brien, G. Yang, L. Sanders, and L. Lau Expression of cyr61, a growth factor-inducible immediate-early gene Mol. Cell Biol. 10 1990 3569 3577 (Pubitemid 20198182)
7. D.M. Bradham, A. Igarashi, R.L. Potter, and G.R. Grotendorst Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10 J. Cell Biol. 114 1991 1285 1294 (Pubitemid 21909886)
8. V. Joliot, C. Martinerie, G. Dambrine, G. Plassiart, M. Brisac, J. Crochet, and B. Perbal Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas Mol. Cell Biol. 12 1992 10 21
9. D. Pennica, T.A. Swanson, J.W. Welsh, M.A. Roy, D.A. Lawrence, J. Lee, J. Brush, L.A. Taneyhill, B. Deuel, M. Lew, C. Watanabe, R.L. Cohen, M.F. Melhem, G.G. Finley, P. Quirke, A.D. Goddard, K.J. Hillan, A.L. Gurney, D. Botstein, and A.J. Levine WISP genes are members of the connective tissue growth factor family that are up-regulated in human colon tumors Proc. Natl. Acad. Sci. 95 1998 14717 14722 (Pubitemid 29003696)
10. D.R. Brigstock, R. Goldschmeding, K.I. Katsube, S.C. Lam, L.F. Lau, K. Lyons, C. Naus, B. Perbal, B. Riser, M. Takigawa, and H. Yeger Proposal for a unified CCN nomenclature Mol. Pathol. 56 2003 127 128 (Pubitemid 36461474)
11. B. Perbal, and M. Takigawa CCN Proteins: a New Family of Cell Growth and Differentiation Regulators 2005 Imperial College Press London
12. C.C. Chen, and L.F. Lau Functions and mechanisms of action of CCN matricellular proteins Int. J. Biochem. Cell Biol. 41 2009 771 783
13. C.T. Fu, J.F. Bechberger, M.A. Ozog, B. Perbal, and C.C. Naus CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression J. Biol. Chem. 279 2004 36943 36950 (Pubitemid 39129044)
14. C.L. Li, V. Martinez, B. He, A. Lombet, and B. Perbal A role for CCN3 (NOV) in calcium signalling Mol. Pathol. 55 2002 250 261
15. H. Thibout, C. Martinerie, C. Creminon, F. Godeau, P. Boudou, Y. Le Bouc, and M. Laurent Characterization of human NOV in biological fluids: an enzyme immunoassay for the quantification of human NOV in sera from patients with diseases of the adrenal gland and of the nervous system J. Clin. Endocrinol. Metab. 88 2003 327 336 (Pubitemid 36115185)
16. N.A. Wahab, H. Brinkman, and R.M. Mason Uptake and intracellular transport of the connective tissue growth factor: a potential mode of action Biochem. J. 359 2001 89 97 (Pubitemid 32939210)
17. N. Planque, C. Long Li, S. Saule, A.M. Bleau, and B. Perbal Nuclear addressing provides a clue for the transforming activity of amino-truncated CCN3 proteins J. Cell Biochem. 99 2006 105 116 (Pubitemid 44297954)
18. V. Vallacchi, M. Daniotti, F. Ratti, D. Di Stasi, P. Deho, A. De Filippo, G. Tragni, A. Balsari, A. Carbone, L. Rivoltini, G. Parmiani, N. Lazar, B. Perbal, and M. Rodolfo CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma Cancer Res. 68 2008 715 723 (Pubitemid 351206747)
19. K.C. Wiesman, L. Wei, C. Baughman, J. Russo, M.R. Gray, and J.J. Castellot CCN5, a secreted protein, localizes to the nucleus J. Cell Commun. Signal 4 2010 91 98
20. A.W. Rachfal, and D.R. Brigstock Structural and functional properties of CCN proteins Vitam. Horm. 70 2005 69 103 (Pubitemid 43589023)
21. J.M. Schober, N. Chen, T.M. Grzeszkiewicz, I. Jovanovic, E.E. Emeson, T.P. Ugarova, R.D. Ye, L.F. Lau, and S.C. Lam Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions Blood 99 2002 4457 4465 (Pubitemid 34627215)
22. T. Bai, C.C. Chen, and L.F. Lau Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages J. Immunol. 184 2010 3223 3232
23. I. Cicha, A. Yilmaz, M. Klein, D. Raithel, D.R. Brigstock, W.G. Daniel, M. Goppelt-Struebe, and C.D. Garlichs Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro Arterioscler. Thromb. Vasc. Biol. 25 2005 1008 1013 (Pubitemid 40627847)
24. E. Sanchez-Lopez, S. Rayego, R. Rodrigues-Diez, J.S. Rodriguez, R. Rodrigues-Diez, J. Rodriguez-Vita, G. Carvajal, L.S. Aroeira, R. Selgas, S.A. Mezzano, A. Ortiz, J. Egido, and M. Ruiz-Ortega CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB J. Am. Soc. Nephrol. 20 2009 1513 1526
25. A.M. Babic, C.C. Chen, and L.F. Lau Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo Mol. Cell Biol. 19 1999 2958 2966 (Pubitemid 29144541)
26. C.C. Chen, N. Chen, and L.F. Lau The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts J. Biol. Chem. 276 2001 10443 10452
27. S.J. Leu, S.C. Lam, and L.F. Lau Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells J. Biol. Chem. 277 2002 46248 46255 (Pubitemid 35417617)
28. C. Lin, S.J. Leu, N. Chen, C.M. Tebeau, S.X. Lin, C.Y. Yeung, and L.F. Lau CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family J. Biol. Chem. 278 2003 24200 24208 (Pubitemid 36830256)
29. A. Jedsadayanmata, C.C. Chen, M.L. Kireeva, L.F. Lau, and S.C. Lam Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3) J. Biol. Chem. 274 1999 24321 24327
30. M. Gawaz, F.J. Neumann, T. Dickfeld, A. Reininger, H. Adelsberger, A. Gebhardt, and A. Schomig Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction Circulation 96 1997 1809 1818 (Pubitemid 27400738)
31. S. Kubota, and M. Takigawa CCN family proteins and angiogenesis: from embryo to adulthood Angiogenesis 10 2007 1 11 (Pubitemid 46356220)
32. D.R. Brigstock Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61) Angiogenesis 5 2002 153 165 (Pubitemid 36687518)
33. K. Grote, G. Salguero, M. Ballmaier, M. Dangers, H. Drexler, and B. Schieffer The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration Blood 110 2007 877 885 (Pubitemid 47267424)
34. H.Y. Lee, J.W. Chung, S.W. Youn, J.Y. Kim, K.W. Park, B.K. Koo, B.H. Oh, Y.B. Park, B. Chaqour, K. Walsh, and H.S. Kim Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia Circ. Res. 100 2007 372 380
35. L.M. Delmolino, N.A. Stearns, and J.J. Castellot Jr. COP-1, a member of the CCN family, is a heparin-induced growth arrest specific gene in vascular smooth muscle cells J. Cell Physiol. 188 2001 45 55 (Pubitemid 32476495)
36. T. Shimoyama, S. Hiraoka, M. Takemoto, M. Koshizaka, H. Tokuyama, T. Tokuyama, A. Watanabe, M. Fujimoto, H. Kawamura, S. Sato, Y. Tsurutani, Y. Saito, B. Perbal, H. Koseki, and K. Yokote CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration Arterioscler. Thromb. Vasc. Biol. 30 2010 675 682
37. W.H. Fan, M. Pech, and M.J. Karnovsky Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro Eur. J. Cell Biol. 79 2000 915 923 (Pubitemid 32000725)
38. K. Hishikawa, T. Nakaki, and T. Fujii Transforming growth factor-beta(1) induces apoptosis via connective tissue growth factor in human aortic smooth muscle cells Eur. J. Pharmacol. 385 1999 287 290
39. K. Hishikawa, T. Nakaki, and T. Fujii Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells Eur. J. Pharmacol. 392 2000 19 22 (Pubitemid 30169027)
40. S.M. Kim, J.H. Park, S.K. Chung, J.Y. Kim, H.Y. Hwang, K.C. Chung, I. Jo, S.I. Park, and J.H. Nam Coxsackievirus B3 infection induces cyr61 activation via JNK to mediate cell death J. Virol. 78 2004 13479 13488 (Pubitemid 39612748)
41. K. Kurozumi, J. Hardcastle, R. Thakur, J. Shroll, M. Nowicki, A. Otsuki, E.A. Chiocca, and B. Kaur Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61 Mol. Ther. 16 2008 1382 1391
42. N. Wiedmaier, S. Muller, M. Koberle, B. Manncke, J. Krejci, I.B. Autenrieth, and E. Bohn Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner Int. J. Med. Microbiol. 298 2008 231 243 (Pubitemid 351318367)
43. S. Muehlich, N. Schneider, F. Hinkmann, C.D. Garlichs, and M. Goppelt-Struebe Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets Atherosclerosis 175 2004 261 268 (Pubitemid 38942906)
44. S. Sakamoto, M. Yokoyama, X. Zhang, K. Prakash, K. Nagao, T. Hatanaka, R.H. Getzenberg, and Y. Kakehi Increased expression of CYR61, an extracellular matrix signaling protein, in human benign prostatic hyperplasia and its regulation by lysophosphatidic acid Endocrinology 145 2004 2929 2940 (Pubitemid 38686242)
45. A. Hahn, J. Heusinger-Ribeiro, T. Lanz, S. Zenkel, and M. Goppelt-Struebe Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by Rho proteins and the actin cytoskeleton J. Biol. Chem. 275 2000 37429 37435 (Pubitemid 32004847)
46. S. Sanjabi, L.A. Zenewicz, M. Kamanaka, and R.A. Flavell Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity Curr. Opin. Pharmacol. 9 2009 447 453
47. N.H. Moritani, S. Kubota, T. Sugahara, and M. Takigawa Comparable response of ccn1 with ccn2 genes upon arthritis: an in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines Cell Commun. Signal. 3 2005 6
48. S.H. Kok, K.L. Hou, C.Y. Hong, J.S. Wang, P.C. Liang, C.C. Chang, M. Hsiao, H. Yang, E.H. Lai, and S.K. Lin Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis Arthritis Rheum. 2010
49. Q. Zhang, J. Wu, Q. Cao, L. Xiao, L. Wang, D. He, G. Ouyang, J. Lin, B. Shen, Y. Shi, Y. Zhang, D. Li, and N. Li A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis Arthritis Rheum. 60 2009 3602 3612
50. K. Nozawa, M. Fujishiro, M. Kawasaki, H. Kaneko, K. Iwabuchi, M. Yanagida, F. Suzuki, K. Miyazawa, Y. Takasaki, H. Ogawa, K. Takamori, and I. Sekigawa Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis Arthritis Res. Ther. 11 2009 R174
51. J. Lin, B. Liliensiek, M. Kanitz, U. Schimanski, H. Bohrer, R. Waldherr, E. Martin, G. Kauffmann, R. Ziegler, and P.P. Nawroth Molecular cloning of genes differentially regulated by TNF-alpha in bovine aortic endothelial cells, fibroblasts and smooth muscle cells Cardiovasc. Res. 38 1998 802 813 (Pubitemid 28319890)
52. D.J. Abraham, X. Shiwen, C.M. Black, S. Sa, Y. Xu, and A. Leask Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts J. Biol. Chem. 275 2000 15220 15225 (Pubitemid 30337246)
53. J. Dammeier, H.D. Beer, M. Brauchle, and S. Werner Dexamethasone is a novel potent inducer of connective tissue growth factor expression. Implications for glucocorticoid therapy J. Biol. Chem. 273 1998 18185 18190 (Pubitemid 28334738)
54. S. Kunzmann, C. Schmidt-Weber, J.M. Zingg, A. Azzi, B.W. Kramer, K. Blaser, C.A. Akdis, and C.P. Speer Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling J. Allergy Clin. Immunol. 119 2007 1398 1407 (Pubitemid 46855848)
55. A. Karger, B. Fitzner, P. Brock, G. Sparmann, J. Emmrich, S. Liebe, and R. Jaster Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells Cell Signal 20 2008 1865 1872
56. L.A. Cooker, D. Peterson, J. Rambow, M.L. Riser, R.E. Riser, F. Najmabadi, D. Brigstock, and B.L. Riser TNF-alpha, but not IFN-gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis Am. J. Physiol. Ren. Physiol. 293 2007 F157 F165
57. A. Keil, I.E. Blom, R. Goldschmeding, and H.D. Rupprecht Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells Kidney Int. 62 2002 401 411 (Pubitemid 34779751)
58. K. Masuko, M. Murata, K. Yudoh, H. Shimizu, M. Beppu, H. Nakamura, and T. Kato Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor BMC Res. Notes 3 2010 5
59. E. Sanchez-Lopez, J. Rodriguez-Vita, C. Cartier, M. Ruperez, V. Esteban, G. Carvajal, R. Rodrigues-Diez, J.J. Plaza, J. Egido, and M. Ruiz-Ortega Inhibitory effect of interleukin-1beta on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells Am. J. Physiol. Ren. Physiol. 294 2008 F149 F160
60. S. Xie, M.B. Sukkar, R. Issa, U. Oltmanns, A.G. Nicholson, and K.F. Chung Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells Am. J. Physiol. Lung Cell Mol. Physiol. 288 2005 L68 L76
61. M. Fukunaga-Kalabis, G. Martinez, Z.J. Liu, J. Kalabis, P. Mrass, W. Weninger, S.M. Firth, N. Planque, B. Perbal, and M. Herlyn CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1 J. Cell Biol. 175 2006 563 569 (Pubitemid 44790610)
62. J.T. Colston, S.D. de la Rosa, M. Koehler, K. Gonzales, R. Mestril, G.L. Freeman, S.R. Bailey, and B. Chandrasekar Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor Am. J. Physiol. Heart Circ. Physiol. 293 2007 H1839 H1846
63. K. Venkatachalam, B. Venkatesan, A.J. Valente, P.C. Melby, S. Nandish, J.E. Reusch, R.A. Clark, and B. Chandrasekar WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death J. Biol. Chem. 284 2009 14414 14427
64. H. Cheon, D.L. Boyle, and G.S. Firestein Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis J. Rheumatol. 31 2004 2106 2114 (Pubitemid 39453227)
65. M.S. Parisi, E. Gazzerro, S. Rydziel, and E. Canalis Expression and regulation of CCN genes in murine osteoblasts Bone 38 2006 671 677
66. J. Lafont, C. Jacques, G. Le Dreau, F. Calhabeu, H. Thibout, C. Dubois, F. Berenbaum, M. Laurent, and C. Martinerie New target genes for NOV/CCN3 in chondrocytes: TGF-beta2 and type X collagen J. Bone Miner. Res. 20 2005 2213 2223 (Pubitemid 41698784)
67. B.L. Riser, F. Najmabadi, B. Perbal, D.R. Peterson, J.A. Rambow, M.L. Riser, E. Sukowski, H. Yeger, and S.C. Riser CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease Am. J. Pathol. 174 2009 1725 1734
68. G. Grotendorst A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene Cell Growth Differ. 7 1996 469 480 (Pubitemid 26362091)
69. G. Grotendorst Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts Cytokine Growth Factor Rev. 8 1997 171 179 (Pubitemid 28077925)
70. R.P. Ryseck, H. Macdonald-Bravo, M.G. Mattei, and R. Bravo Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein Cell Growth Differ. 2 1991 225 233
71. B. Perbal Contribution of MAV-1-induced nephroblastoma to the study of genes involved in human Wilms' tumor development Crit. Rev. Oncog. 5 1994 589 613
72. G. Scholz, C. Martinerie, B. Perbal, and H. Hanafusa Transcriptional down-regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src Mol. Cell Biol. 16 1996 481 486
73. H. Kawaki, S. Kubota, A. Suzuki, N. Lazar, T. Yamada, T. Matsumura, T. Ohgawara, T. Maeda, B. Perbal, K.M. Lyons, and M. Takigawa Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage J. Bone Miner. Res. 23 2008 1751 1764
74. G.W. Zuo, C.D. Kohls, B.C. He, L. Chen, W. Zhang, Q. Shi, B.Q. Zhang, Q. Kang, J. Luo, X. Luo, E.R. Wagner, S.H. Kim, F. Restegar, R.C. Haydon, Z.L. Deng, H.H. Luu, T.C. He, and Q. Luo The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis Histol. Histopathol. 25 2010 795 806
75. B. Perbal NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues Mol. Pathol. 54 2001 57 79 (Pubitemid 32269998)
76. M. Jutel, M. Akdis, and C.A. Akdis Histamine, histamine receptors and their role in immune pathology Clin. Exp. Allergy 39 2009 1786 1800
77. I. Cloez-Tayarani, and J.P. Changeux Nicotine and serotonin in immune regulation and inflammatory processes: a perspective J. Leukoc. Biol. 81 2007 599 606 (Pubitemid 46393537)
78. T. Muller, T. Durk, B. Blumenthal, M. Grimm, S. Cicko, E. Panther, S. Sorichter, Y. Herouy, F. Di Virgilio, D. Ferrari, J. Norgauer, and M. Idzko 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo PLoS One 4 2009 e6453
79. N. Takuwa, M. Ganz, Y. Takuwa, R.B. Sterzel, and H. Rasmussen Studies of the mitogenic effect of serotonin in rat renal mesangial cells Am. J. Physiol. 257 1989 F431 F439
80. M. Kasho, M. Sakai, T. Sasahara, Y. Anami, T. Matsumura, T. Takemura, H. Matsuda, S. Kobori, and M. Shichiri Serotonin enhances the production of type IV collagen by human mesangial cells Kidney Int. 54 1998 1083 1092 (Pubitemid 28449895)
81. J.S. Grewal, Y.V. Mukhin, M.N. Garnovskaya, J.R. Raymond, and E.L. Greene Serotonin 5-HT2A receptor induces TGF-beta1 expression in mesangial cells via ERK: proliferative and fibrotic signals Am. J. Physiol. 276 1999 F922 F930
82. S. Gupta, M.R. Clarkson, J. Duggan, and H.R. Brady Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis Kidney Int. 58 2000 1389 1399
83. M.K. Phanish, S.K. Winn, and M.E. Dockrell Connective tissue growth factor-(CTGF, CCN2)-a marker, mediator and therapeutic target for renal fibrosis Nephron Exp. Nephrol. 114 2010 e83 92
84. J. Xu, B. Yao, X. Fan, M.M. Langworthy, M.Z. Zhang, and R.C. Harris Characterization of a putative intrarenal serotonergic system Am. J. Physiol. Ren. Physiol. 293 2007 F1468 F1475
85. L. Li, A. Hsu, and P.K. Moore Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation-a tale of three gases! Pharmacol. Ther. 123 2009 386 400
86. J. Wani, M. Carl, A. Henger, P.J. Nelson, and H. Rupprecht Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells Biol. Chem. 388 2007 497 506 (Pubitemid 46800261)
87. H. Wang, R. Zhang, S. Wen, D.M. McCafferty, P.L. Beck, and W.K. MacNaughton Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis J. Mol. Med. 87 2009 435 445
88. S. Narumiya Prostanoids and inflammation: a new concept arising from receptor knockout mice J. Mol. Med. 87 2009 1015 1022
89. D.A. Ricupero, D.C. Rishikof, P.P. Kuang, C.F. Poliks, and R.H. Goldstein Regulation of connective tissue growth factor expression by prostaglandin E(2) Am. J. Physiol. 277 1999 L1165 L1171
90. J. Yu, G.N. Prado, B. Schreiber, P. Polgar, P. Polgar, and L. Taylor Role of prostaglandin E(2) EP receptors and cAMP in the expression of connective tissue growth factor Arch. Biochem. Biophys. 404 2002 302 308 (Pubitemid 34913562)
91. S.A. Black Jr., A.H. Palamakumbura, M. Stan, and P.C. Trackman Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase J. Biol. Chem. 282 2007 15416 15429 (Pubitemid 47093284)
92. J.K. Burgess, Q. Ge, M.H. Poniris, S. Boustany, S.M. Twigg, J.L. Black, and P.R. Johnson Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix Am. J. Physiol. Lung Cell Mol. Physiol. 290 2006 L153 L161
93. C.Q. Feitoza, G.M. Goncalves, P. Semedo, M.A. Cenedeze, H.S. Pinheiro, F.C. Beraldo, O.F. dos Santos, P. Teixeira Vde, M.A. dos Reis, M. Mazzali, A. Pacheco-Silva, and N.O. Camara Inhibition of COX 1 and 2 prior to renal ischemia/reperfusion injury decreases the development of fibrosis Mol. Med. 14 2008 724 730
94. I. Gashaw, S. Stiller, C. Boing, R. Kimmig, and E. Winterhager Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium Endocrinology 149 2008 2261 2269 (Pubitemid 351574533)
95. R. Meyuhas, E. Pikarsky, E. Tavor, A. Klar, R. Abramovitch, J. Hochman, T.G. Lago, and A. Honigman A key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells Mol. Cancer Res. 6 2008 1397 1409
96. Y. Liang, C. Li, V.M. Guzman, A.J. Evinger 3rd, C.E. Protzman, A.H. Krauss, and D.F. Woodward Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression J. Biol. Chem. 278 2003 27267 27277 (Pubitemid 36876884)
97. W. Xu, C.L. Chou, D.D. Israel, A.J. Hutchinson, and J.W. Regan PGF(2alpha) stimulates FP prostanoid receptor mediated crosstalk between Ras/Raf signaling and Tcf transcriptional activation Biochem. Biophys. Res. Commun. 381 2009 625 629
98. G. Hashimoto, I. Inoki, Y. Fujii, T. Aoki, E. Ikeda, and Y. Okada Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165 J. Biol. Chem. 277 2002 36288 36295
99. R.A. Dean, G.S. Butler, Y. Hamma-Kourbali, J. Delbe, D.R. Brigstock, J. Courty, and C.M. Overall Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis Mol. Cell Biol. 27 2007 8454 8465
100. T. Eguchi, S. Kubota, K. Kawata, Y. Mukudai, J. Uehara, T. Ohgawara, S. Ibaragi, A. Sasaki, T. Kuboki, and M. Takigawa Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene Mol. Cell Biol. 28 2008 2391 2413 (Pubitemid 351429984)
101. M.T. Lin, C.Y. Zuon, C.C. Chang, S.T. Chen, C.P. Chen, B.R. Lin, M.Y. Wang, Y.M. Jeng, K.J. Chang, P.H. Lee, W.J. Chen, and M.L. Kuo Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway Clin. Cancer Res. 11 2005 5809 5820
102. B.R. Lin, C.C. Chang, L.R. Chen, M.H. Wu, M.Y. Wang, I.H. Kuo, C.Y. Chu, K.J. Chang, P.H. Lee, W.J. Chen, M.L. Kuo, and M.T. Lin Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2 Mol. Cancer Res. 5 2007 1111 1123
103. X. Wang, S.V. McLennan, T.J. Allen, and S.M. Twigg Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes J. Cell Commun. Signal 4 2010 15 23
104. S.H. Wu, X.H. Wu, C. Lu, L. Dong, G.P. Zhou, and Z.Q. Chen Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells Kidney Int. 69 2006 248 256 (Pubitemid 43323074)
105. S.H. Wu, C. Lu, L. Dong, and Z.Q. Chen Signal transduction involved in CTGF-induced production of chemokines in mesangial cells Growth Factor. 26 2008 192 200
106. G. Le Dreau, L. Kular, A.B. Nicot, C. Calmel, S. Melik-Parsadaniantz, P. Kitabgi, M. Laurent, and C. Martinerie NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins Glia 58 2010 1510 1521
107. N. Nguyen, A. Kuliopulos, R.A. Graham, and L. Covic Tumor-derived Cyr61(CCN1) promotes stromal matrix metalloproteinase-1 production and protease-activated receptor 1-dependent migration of breast cancer cells Cancer Res. 66 2006 2658 2665
108. T.W. Tan, W.H. Yang, Y.T. Lin, S.F. Hsu, T.M. Li, S.T. Kao, W.C. Chen, Y.C. Fong, and C.H. Tang Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells Carcinogenesis 30 2009 258 268
109. T.W. Tan, C.H. Lai, C.Y. Huang, W.H. Yang, H.T. Chen, H.C. Hsu, Y.C. Fong, and C.H. Tang CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells J. Cell Biochem. 107 2009 345 356
110. E.N. Blaney Davidson, E.L. Vitters, F.M. Mooren, N. Oliver, W.B. Berg, and P.M. van der Kraan Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage Arthritis Rheum. 54 2006 1653 1661
111. W.H. Fan, and M.J. Karnovsky Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells J. Biol. Chem. 277 2002 9800 9805 (Pubitemid 34968083)
112. C.G. Lin, C.C. Chen, S.J. Leu, T.M. Grzeszkiewicz, and L.F. Lau Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing J. Biol. Chem. 280 2005 8229 8237 (Pubitemid 40349724)
113. M. Laurent, C. Martinerie, H. Thibout, M. Hoffman, F. Verrecchia, Y. Le Bouc, A. Mauviel, and H. Kleinman NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism FASEB J. 17 2003 1919 1921
114. L.L. Soon, T.A. Yie, A. Shvarts, A.J. Levine, F. Su, and K.M. Tchou-Wong Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation J. Biol. Chem. 278 2003 11465 11470 (Pubitemid 36792706)
115. A.C. Lake, and J.J. Castellot Jr. CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells Cell Commun. Signal. 1 2003 5
116. J.G. Abreu, N.I. Ketpura, B. Reversade, and E.M. De Robertis Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta Nat. Cell Biol. 4 2002 599 604
117. T. Mori, S. Kawara, M. Shinozaki, N. Hayashi, T. Kakinuma, A. Igarashi, T. Takigawa, T. Nakanishi, and K. Takehara Role and interaction of connective tissue growth factor with transforming growth factor-b in a persistent mouse fibrosis model J. Cell Physiol. 181 1999 153 159 (Pubitemid 29400382)
118. R. Lemaire, G. Farina, J. Bayle, M. Dimarzio, S.A. Pendergrass, A. Milano, M.L. Whitfield, and R. Lafyatis Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome J. Invest. Dermatol. 130 2010 1514 1523
119. C.C. Chen, and L.F. Lau Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines J. Cell Commun. Signal 4 2010 63 69
120. C.C. Chen, J.L. Young, R.I. Monzon, N. Chen, V. Todorovic, and L.F. Lau Cytotoxicity of TNF alpha is regulated by integrin-mediated matrix signaling Embo J. 26 2007 1257 1267 (Pubitemid 46398716)
121. V. Juric, C.C. Chen, and L.F. Lau Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo Mol. Cell Biol. 29 2009 3266 3279
122. C.A. Franzen, C.C. Chen, V. Todorovic, V. Juric, R.I. Monzon, and L.F. Lau Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis Mol. Cancer Res. 7 2009 1045 1055
123. F.E. Mo, A.G. Muntean, C.C. Chen, D.B. Stolz, S.C. Watkins, and L.F. Lau CYR61 (CCN1) is essential for placental development and vascular integrity Mol. Cell Biol. 22 2002 8709 8720 (Pubitemid 35397184)
124. S. Ivkovic, B.S. Yoon, S.N. Popoff, F.F. Safadi, D.E. Libuda, R.C. Stephenson, A. Daluiski, and K.M. Lyons Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development Development 130 2003 2779 2791 (Pubitemid 37069592)
125. R. Ross Atherosclerosis-an inflammatory disease N. Engl. J. Med. 340 1999 115 126
126. A. Hilfiker, D. Hilfiker-Kleiner, M. Fuchs, K. Kaminski, A. Lichtenberg, H.J. Rothkotter, B. Schieffer, and H. Drexler Expression of CYR61, an angiogenic immediate early gene, in arteriosclerosis and its regulation by angiotensin II Circulation 106 2002 254 260 (Pubitemid 34761308)
127. F. Sigala, S. Georgopoulos, E. Papalambros, D. Chasiotis, G. Vourliotakis, A. Niforou, A. Kotsinas, N. Kavantzas, E. Patsouris, V.G. Gorgoulis, and E. Bastounis Heregulin, cysteine rich-61 and matrix metalloproteinase 9 expression in human carotid atherosclerotic plaques: relationship with clinical data Eur. J. Vasc. Endovasc. Surg. 32 2006 238 245 (Pubitemid 44204108)
128. B.S. Oemar, A. Werner, J.M. Garnier, D.D. Do, N. Godoy, M. Nauck, W. Marz, J. Rupp, M. Pech, and T.F. Luscher Human connective tissue growth factor is expressed in advanced atherosclerotic lesions Circulation 95 1997 831 839 (Pubitemid 27091522)
129. T.M. Grzeszkiewicz, V. Lindner, N. Chen, S.C. Lam, and L.F. Lau The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans Endocrinology 143 2002 1441 1450 (Pubitemid 34274374)
130. H. Matsumae, Y. Yoshida, K. Ono, K. Togi, K. Inoue, Y. Furukawa, Y. Nakashima, Y. Kojima, M. Nobuyoshi, T. Kita, and M. Tanaka CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model
131. P.D. Ellis, Q. Chen, P.J. Barker, J.C. Metcalfe, and P.R. Kemp Nov gene encodes adhesion factor for vascular smooth muscle cells and is dynamically regulated in response to vascular injury Arterioscler. Thromb. Vasc. Biol. 20 2000 1912 1919 (Pubitemid 30644640)
132. P. Zimmet, D. Magliano, Y. Matsuzawa, G. Alberti, and J. Shaw The metabolic syndrome: a global public health problem and a new definition J. Atheroscler. Thromb. 12 2005 295 300
133. L. Bouchard, A. Tchernof, Y. Deshaies, S. Lebel, F.S. Hould, P. Marceau, and M.C. Vohl CYR61 polymorphisms are associated with plasma HDL-cholesterol levels in obese individuals Clin. Genet. 72 2007 224 229 (Pubitemid 47300025)
134. J.T. Tan, S.V. McLennan, W.W. Song, L.W. Lo, J.G. Bonner, P.F. Williams, and S.M. Twigg Connective tissue growth factor inhibits adipocyte differentiation Am. J. Physiol. Cell Physiol. 295 2008 C740 C751
135. E. Canalis, S. Zanotti, W.G. Beamer, A.N. Economides, and A. Smerdel-Ramoya Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice Endocrinology 2010
136. T. Nakanishi, T. Yamaai, M. Asano, K. Nawachi, M. Suzuki, T. Sugimoto, and M. Takigawa Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism Biochem. Biophys. Res. Commun. 281 2001 678 681 (Pubitemid 32917854)
137. A. Smerdel-Ramoya, S. Zanotti, L. Stadmeyer, D. Durant, and E. Canalis Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia Endocrinology 149 2008 4374 4381
138. J.M. Manns, A.B. Uknis, M.C. Rico, A. Agelan, J. Castaneda, I. Arango, M.F. Barbe, F.F. Safadi, S.N. Popoff, and R.A. DeLa Cadena A peptide from thrombospondin 1 modulates experimental erosive arthritis by regulating connective tissue growth factor Arthritis Rheum. 54 2006 2415 2422 (Pubitemid 44205001)
139. S. Omoto, K. Nishida, Y. Yamaai, M. Shibahara, T. Nishida, T. Doi, H. Asahara, T. Nakanishi, H. Inoue, and M. Takigawa Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage Osteoarthr. Cartil. 12 2004 771 778 (Pubitemid 39272839)
140. T. Nishida, S. Kubota, S. Kojima, T. Kuboki, K. Nakao, T. Kushibiki, Y. Tabata, and M. Takigawa Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor) J. Bone Miner. Res. 19 2004 1308 1319 (Pubitemid 41094373)
141. K. Nakao, S. Kubota, H. Doi, T. Eguchi, M. Oka, T. Fujisawa, T. Nishida, and M. Takigawa Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: possible regenerative roles in articular cartilage metabolism Bone 36 2005 884 892 (Pubitemid 40616023)
142. C.S. Haas, C.J. Creighton, X. Pi, I. Maine, A.E. Koch, G.K. Haines, S. Ling, A.M. Chinnaiyan, and J. Holoshitz Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins Arthritis Rheum. 54 2006 2047 2060 (Pubitemid 44051060)
143. A.B. Blom, S.M. Brockbank, P.L. van Lent, H.M. van Beuningen, J. Geurts, N. Takahashi, P.M. van der Kraan, F.A. van de Loo, B.W. Schreurs, K. Clements, P. Newham, and W.B. van den Berg Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1 Arthritis Rheum. 60 2009 501 512
144. J. Meng, X. Ma, D. Ma, and C. Xu Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis Osteoarthr. Cartil. 13 2005 1115 1125 (Pubitemid 41672509)
145. C.K. Glass, K. Saijo, B. Winner, M.C. Marchetto, and F.H. Gage Mechanisms underlying inflammation in neurodegeneration Cell 140 2010 918 934
146. C. Albrecht, H. von Der Kammer, M. Mayhaus, J. Klaudiny, M. Schweizer, and R.M. Nitsch Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61 J. Biol. Chem. 275 2000 28929 28936
147. C. Liu, X.J. Liu, P.D. Crowe, G.S. Kelner, J. Fan, G. Barry, F. Manu, N. Ling, E.B. De Souza, and R.A. Maki Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation Gene 238 1999 471 478 (Pubitemid 29446181)
148. G. Le Dreau, A. Nicot, M. Benard, H. Thibout, D. Vaudry, C. Martinerie, and M. Laurent NOV/CCN3 promotes maturation of cerebellar granule neuron precursors Mol. Cell Neurosci. 2009
149. U. Ueberham, E. Ueberham, H. Gruschka, and T. Arendt Connective tissue growth factor in Alzheimer's disease Neuroscience 116 2003 1 6 (Pubitemid 36110424)
150. Z. Zhao, L. Ho, J. Wang, W. Qin, E.D. Festa, C. Mobbs, P. Hof, A. Rocher, S. Masur, V. Haroutunian, and G.M. Pasinetti Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance-associated promotion of Alzheimer's disease beta-amyloid neuropathology FASEB J. 19 2005 2081 2082 (Pubitemid 41759772)
151. M. Hertel, Y. Tretter, C. Alzheimer, and S. Werner Connective tissue growth factor: a novel player in tissue reorganization after brain injury? Eur. J. Neurosci. 12 2000 376 380 (Pubitemid 30068443)
152. J.M. Schwab, E. Postler, T.D. Nguyen, M. Mittelbronn, R. Meyermann, and H.J. Schluesener Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction Neuropathol. Appl. Neurobiol. 26 2000 434 440
153. J.M. Schwab, R. Beschorner, T.D. Nguyen, R. Meyermann, and H.J. Schluesener Differential cellular accumulation of connective tissue growth factor defines a subset of reactive astrocytes, invading fibroblasts, and endothelial cells following central nervous system injury in rats and humans J. Neurotrauma 18 2001 377 388 (Pubitemid 32336544)
154. S. Conrad, H.J. Schluesener, M. Adibzahdeh, and J.M. Schwab Spinal cord injury induction of lesional expression of profibrotic and angiogenic connective tissue growth factor confined to reactive astrocytes, invading fibroblasts and endothelial cells J. Neurosurg. Spine 2 2005 319 326
155. J.P. Morrison, T.V. Ton, J.B. Collins, R.C. Switzer, P.B. Little, D.L. Morgan, and R.C. Sills Gene expression studies reveal that DNA damage, vascular perturbation, and inflammation contribute to the pathogenesis of carbonyl sulfide neurotoxicity Toxicol. Pathol. 37 2009 502 511
156. J.A. McClain, L.L. Phillips, and H.L. Fillmore Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration Neurosci. Lett. 460 2009 27 31
157. W.G. Spliet, E. Aronica, M. Ramkema, J. Aten, and D. Troost Increased expression of connective tissue growth factor in amyotrophic lateral sclerosis human spinal cord Acta Neuropathol. 106 2003 449 457 (Pubitemid 37265849)
158. L. Wen-Xin, C. Martinerie, W. Zumkeller, M. Westphal, and B. Perbal Differential expression of novH and CTGF in human glioma cell lines J. Clin. Pathol. Mol. Pathol. 49 1996 M91 M97
159. D. Xie, D. Yin, H.J. Wang, G.T. Liu, R. Elashoff, K. Black, and H.P. Koeffler Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas Clin. Cancer Res. 10 2004 2072 2081 (Pubitemid 38375569)
160. N. Gupta, H. Wang, T.L. McLeod, C.C. Naus, S. Kyurkchiev, S. Advani, J. Yu, B. Perbal, and R.R. Weichselbaum Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV) Mol. Pathol. 54 2001 293 299 (Pubitemid 32928254)
161. S. Sangaletti, and M.P. Colombo Matricellular proteins at the crossroad of inflammation and cancer Cancer Lett. 267 2008 245 253
162. M. Khatami 'Yin and Yang' in inflammation: duality in innate immune cell function and tumorigenesis Expert Opin. Biol. Ther. 8 2008 1461 1472
163. F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability Carcinogenesis 30 2009 1073 1081
164. A. Dhar, and A. Ray The CCN family proteins in carcinogenesis Exp. Oncol. 32 2010 2 9
165. A. Leask Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2 J. Cell Commun. Signal 3 2009 161 162
166. D.R. Brigstock Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): from pharmacological inhibition in vitro to targeted siRNA therapy in vivo J. Cell Commun. Signal 3 2009 5 18