Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis

Journal of Immunology

Volumn 188, Issue 11, 2012, Pages 5776-5784

  Lin, Jinpiao ^a   Zhou, Zhou ^a   Huo, Rongfen ^a   Xiao, Lianbo ^b   Ouyang, Guilin ^b   Wang, Li ^a   Sun, Yue ^a   Shen, Baihua ^a   Li, Dangsheng ^c   Li, Ningli ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Guanghua Rheumatology Hospital   (China)

^c Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAVBETA5 INTEGRIN; CYSTEINE RICH PROTEIN 61; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PROTEIN KINASE B;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; FIBROBLAST LIKE SYNOVIOCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SYNOVIOCYTE; TH17 CELL; UPREGULATION;

ADULT; AGED; ANIMALS; ARTHRITIS, RHEUMATOID; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYSTEINE-RICH PROTEIN 61; FEMALE; FIBROBLASTS; HUMANS; INTERLEUKIN-6; MALE; MICE; MICE, INBRED DBA; MIDDLE AGED; RECEPTORS, VITRONECTIN; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TH17 CELLS;

EID: 84862095866     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103201     Document Type: Article

References (49)

1. Firestein, G. S. 2003. Evolving concepts of rheumatoid arthritis. Nature 423: 356-361. (Pubitemid 40852711)
2. Gaffen, S. L. 2009. The role of interleukin-17 in the pathogenesis of rheumatoid arthritis. Curr. Rheumatol. Rep. 11: 365-370.
3. Sarkar, S., and D. A. Fox. 2010. Targeting IL-17 and Th17 cells in rheumatoid arthritis. Rheum. Dis. Clin. North Am. 36: 345-366.
4. Egan, P. J., A. van Nieuwenhuijze, I. K. Campbell, and I. P. Wicks. 2008. Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis. Arthritis Rheum. 58: 3720-3729.
5. Chabaud, M., J. M. Durand, N. Buchs, F. Fossiez, G. Page, L. Frappart, and P. Miossec. 1999. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 42: 963-970. (Pubitemid 29215007)
6. Stamp, L. K., M. J. James, and L. G. Cleland. 2004. Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis? Immunol. Cell Biol. 82: 1-9. (Pubitemid 38388713)
7. Koenders, M. I., L. A. Joosten, and W. B. van den Berg. 2006. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann. Rheum. Dis. 65(Suppl 3): iii29-iii33. (Pubitemid 44629098)
8. Lubberts, E., L. A. Joosten, B. Oppers, L. van den Bersselaar, C. J. Coenen-de Roo, J. K. Kolls, P. Schwarzenberger, F. A. van de Loo, and W. B. van den Berg. 2001. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J. Immunol. 167: 1004-1013. (Pubitemid 32660858)
9. Nakae, S., A. Nambu, K. Sudo, and Y. Iwakura. 2003. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171: 6173-6177. (Pubitemid 37467240)
10. Lubberts, E., M. I. Koenders, B. Oppers-Walgreen, L. van den Bersselaar, C. J. Coenen-de Roo, L. A. Joosten, and W. B. van den Berg. 2004. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum. 50: 650-659. (Pubitemid 38198849)
11. Feldmann, M., F. M. Brennan, and R. N. Maini. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14: 397-440. (Pubitemid 26130190)
12. Dayer, J. M., and E. Choy. 2010. Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor. Rheumatology (Oxford) 49: 15-24.
13. Stockinger, B., and M. Veldhoen. 2007. Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 19: 281-286. (Pubitemid 46687011)
14. Zhu, J., and W. E. Paul. 2010. Heterogeneity and plasticity of T helper cells. Cell Res. 20: 4-12.
15. Laurence, A., and J. J. O'Shea. 2007. T(H)-17 differentiation: of mice and men. Nat. Immunol. 8: 903-905.
16. Antonelli, A., C. Ferri, S. M. Ferrari, C. Mancusi, M. Colaci, M. Sebastiani, and P. Fallahi. 2011. IFN-γ and TNF-α induce a different modulation of interleukin- 6 in systemic sclerosis fibroblasts compared to healthy controls. Scand. J. Rheumatol. 40: 453-456.
17. Eda, H., B. L. Burnette, H. Shimada, H. R. Hope, and J. B. Monahan. 2011. Interleukin-1β-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase- 4. Cell Biol. Int. 35: 355-358.
18. Zhang, Q., J. Wu, Q. Cao, L. Xiao, L. Wang, D. He, G. Ouyang, J. Lin, B. Shen, Y. Shi, et al. 2009. A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum. 60: 3602-3612.
19. Kireeva, M. L., F. E. Mo, G. P. Yang, and L. F. Lau. 1996. Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Mol. Cell. Biol. 16: 1326-1334. (Pubitemid 26095602)
20. Menéndez, J. A., I. Mehmi, D. W. Griggs, and R. Lupu. 2003. The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives. Endocr. Relat. Cancer 10: 141-152. (Pubitemid 36758643)
21. Chen, C. C., and L. F. Lau. 2009. Functions and mechanisms of action of CCN matricellular proteins. Int. J. Biochem. Cell Biol. 41: 771-783.
22. Leu, S. J., S. C. Lam, and L. F. Lau. 2002. Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J. Biol. Chem. 277: 46248-46255.
23. Schober, J. M., N. Chen, T. M. Grzeszkiewicz, I. Jovanovic, E. E. Emeson, T. P. Ugarova, R. D. Ye, L. F. Lau, and S. C. Lam. 2002. Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediateearly gene products expressed in atherosclerotic lesions. Blood 99: 4457-4465. (Pubitemid 34627215)
24. Menendez, J. A., L. Vellon, I. Mehmi, P. K. Teng, D. W. Griggs, and R. Lupu. 2005. A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ ERK2 MAPK signaling pathway. Oncogene 24: 761-779. (Pubitemid 40216085)
25. Aletaha, D., T. Neogi, A. J. Silman, J. Funovits, D. T. Felson, C. O. Bingham, III, N. S. Birnbaum, G. R. Burmester, V. P. Bykerk, M. D. Cohen, et al. 2010. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62: 2569-2581.
26. Altman, R., E. Asch, D. Bloch, G. Bole, D. Borenstein, K. Brandt, W. Christy, T. D. Cooke, R. Greenwald, M. Hochberg, et al Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. 1986. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Arthritis Rheum. 29: 1039-1049.
27. Acosta-Rodriguez, E. V., G. Napolitani, A. Lanzavecchia, and F. Sallusto. 2007. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8: 942-949. (Pubitemid 47300008)
28. Kim, J. M., S. H. Ho, E. J. Park, W. Hahn, H. Cho, J. G. Jeong, Y. W. Lee, and S. Kim. 2002. Angiostatin gene transfer as an effective treatment strategy in murine collagen-induced arthritis. Arthritis Rheum. 46: 793-801. (Pubitemid 34214262)
29. Mauri, C., L. T. Mars, and M. Londei. 2000. Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process. Nat. Med. 6: 673-679. (Pubitemid 30398791)
30. Kim, J. S., H. An, W. J. Rieter, D. Esserman, K. M. Taylor-Pashow, R. B. Sartor, W. Lin, W. Lin, and T. K. Tarrant. 2009. Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis. Clin. Exp. Rheumatol. 27: 580-586.
31. Sheng, H., Y. Wang, Y. Jin, Q. Zhang, Y. Zhang, L. Wang, B. Shen, S. Yin, W. Liu, L. Cui, and N. Li. 2008. A critical role of IFN gamma in priming MSCmediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res. 18: 846-857.
32. Kato, H., and D. A. Fox. 2010. Are Th17 cells an appropriate new target in the treatment of rheumatoid arthritis? Clin. Transl. Sci. 3: 319-326.
33. Adams, L. S., S. Phung, N. Yee, N. P. Seeram, L. Li, and S. Chen. 2010. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res. 70: 3594-3605.
34. Zenewicz, L. A., and R. A. Flavell. 2011. Recent advances in IL-22 biology. Int. Immunol. 23: 159-163.
35. Lin, J., R. Huo, L. Wang, Z. Zhou, Y. Sun, B. Shen, R. Wang, and N. Li. 2011. A novel anti-Cyr61 antibody inhibits breast cancer growth and metastasis in vivo. Cancer Immunol. Immunother. In press.
36. Shuai, K., and B. Liu. 2003. Regulation of JAK-STAT signalling in the immune system. Nat. Rev. Immunol. 3: 900-911. (Pubitemid 37411719)
37. Murray, P. J. 2007. The JAK-STAT signaling pathway: input and output integration. J. Immunol. 178: 2623-2629. (Pubitemid 46333135)
38. Chen, N., C. C. Chen, and L. F. Lau. 2000. Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans. J. Biol. Chem. 275: 24953-24961. (Pubitemid 30626603)
39. Chen, C. C., N. Chen, and L. F. Lau. 2001. The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J. Biol. Chem. 276: 10443-10452.
40. Chen, Z., and J. J. O'Shea. 2008. Th17 cells: a new fate for differentiating helper T cells. Immunol. Res. 41: 87-102.
41. Zhou, L., I. I. Ivanov, R. Spolski, R. Min, K. Shenderov, T. Egawa, D. E. Levy, W. J. Leonard, and D. R. Littman. 2007. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8: 967-974. (Pubitemid 47300011)
42. Li, Q., and I. M. Verma. 2002. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2: 725-734.
43. Hayden, M. S., and S. Ghosh. 2011. NF-κB in immunobiology. Cell Res. 21: 223-244.
44. McLoughlin, R. M., B. J. Jenkins, D. Grail, A. S. Williams, C. A. Fielding, C. R. Parker, M. Ernst, N. Topley, and S. A. Jones. 2005. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc. Natl. Acad. Sci. USA 102: 9589-9594. (Pubitemid 40981725)
45. Genovese, M. C., J. D. McKay, E. L. Nasonov, E. F. Mysler, N. A. da Silva, E. Alecock, T. Woodworth, and J. J. Gomez-Reino. 2008. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 58: 2968-2980.
46. Bai, T., C. C. Chen, and L. F. Lau. 2010. Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages. J. Immunol. 184: 3223-3232.
47. Kular, L., J. Pakradouni, P. Kitabgi, M. Laurent, and C. Martinerie. 2011. The CCN family: a new class of inflammation modulators? Biochimie 93: 377-388.
48. Jun, J. I., and L. F. Lau. 2011. Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat. Rev. Drug Discov. 10: 945-963.
49. Lau, L. F. 2011. CCN1/CYR61: the very model of a modern matricellular protein. Cell. Mol. Life Sci. 68: 3149-3163.