Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: Implications for arthritis gene therapy

Gene Therapy

Volumn 4, Issue 9, 1997, Pages 977-982

  Ghivizzani, S C ^a   Lechman, E R ^a   Tio, C ^a   Mule, K M ^a   Chada, S ^b   McCormack, J E ^b   Evans, C H ^a   Robbins, P D ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

In vivo gene delivery; Retroviral vectors; Rheumatoid arthritis; Synovium

Indexed keywords

BETA GALACTOSIDASE; HUMAN GROWTH HORMONE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTHRITIS; ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; HUMAN; KNEE; MARKER GENE; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPORTER GENE; RETROVIRUS; SYNOVIOCYTE; SYNOVIUM; TRANSGENE;

EID: 0030847418     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300486     Document Type: Article

References (26)

1. Arend W, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arth Rheum 1995; 38: 151-160.
2. Elliot M et al. Randomized, double blind comparison of a chimeric, monoclonal antibody to tumor-necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 1994; 344: 1105-1110.
3. Campion G et al Dose-range and dose-frequency of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arth Rheum 1996; 39: 1092-1101.
4. Drevlow B et al. Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis. Arth Rheum 1996; 39: 257-265.
5. Evans C, Robbins PD Gene therapy as a treatment for arthritis. Exp Opin Invest Drugs 1995; 4: 843-852.
6. Evans C, Robbins PD Pathways to gene therapy in rheumatoid arthritis Curr Opin Rheum 1996; 8: 230-234
7. Bandara G et al Intraarticular expression of biologically active interleukin-1-receptor antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci USA 1993; 90: 10764-10768.
8. Ota K et al. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol 1996; 156: 3558-3362.
9. Makarov S et al. Suppression of experimental arthritis by gene transfer of interleukin-1 receptor antagonist cDNA. Proc Natl Acad Sci USA 1996; 93: 402-406.
10. Evans CH et al. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially antiarthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther 1996; 7: 1261-1280.
11. Stratford-Perricaudet L, Perricaudet M. Gene therapy: the advent of adenovirus. In: Wolff JA (ed). Gene Therapeutics: Methods and Applications of Direct Gene Transfer. Birkhauser: Boston, 1994, pp 344-362.
12. Roessler B et al. Adenoviral-mediated gene transfer to rabbit synovium in vivo. J Clin Invest 1993; 92: 1085-1092.
13. Nita I et al. Direct gene delivery to synovium: an evaluation of potential vectors in vitro and in vivo. Arth Rheum 1996; 39: 820-828.
14. Yang Y et al. Cellular immunity to viral antigen limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-4411.
15. Mulligan R. The basic science of gene therapy. Science 1993; 260: 926-932.
16. Robbins P. Retro viral vectors. In: T Blankenstein, JA Barranger (eds). Gene Therapy: Principles and Application. Chapman and Hall. Germany, 1997 (in press).
17. Ghivizzani S et al. Constitutive intraarticular expression of human IL-1β following gene transfer to rabbit synovium produces all major pathologies of human arthritis. J Immunol (in press).
18. Chada S et al. Cross-reactive lysis of human targets infected with prototypic and clinical human immunodeficiency virus type 1 (HIV-1) strains by murine anti-HIV IIIB env-specific cytotoxic T lymphocytes. J Virol 1993; 67: 3409-3417.
19. Georgescu H, Mendelow D, Evans CH. HIG-82: an established cell line from rabbit periarticular soft tissue which retains the 'activatable' phenotype. In Vitro 1988; 24: 1015-1022.
20. Makarov S et al. Retrovirus-mediated in vivo transfer to synovium in bacterial cell wall-induced arthritis in rats. Gene Therapy 1995; 2: 424-428.
21. Firestein G, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid synovium. Clin Invest 1995; 96: 1631-1638.
22. Irwin M et al. Direct injection of a recombinant retroviral vector induces human immunodeficiency virus-specific immune responses in mice and nonhuman primates. J Virol 1994; 68: 5036-5044.
23. Martial J, Hallwell RA, Baxter JD, Goodman HM Human growth hormone: complementary DNA cloning and expression in bacteria. Science 1979; 205: 602-607.
24. Burns J et al. Vesicular stomatitis virus G glycoprotein pseudo-typed retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc Natl Acad Sci USA 1993; 90: 8033-6037.
25. Lander M, Chattopadhyay SK: A Mus dunni cell line that lacks sequences closely related to endogenous murine leukemia viruses and can be infected by ecotropic, amphotropic, xenotropic and mink cell focus-forming viruses. J Virol 1984; 52: 695-698.
26. Sanes J, Rubenstein JL, Nicolas JF. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J 1986; 5: 3133-3142.