Human rheumatoid synoviocytes express functional P2X7 receptors

Journal of Molecular Medicine

Volumn 86, Issue 8, 2008, Pages 937-949

  Caporali, Francesca ^a   Capecchi, Pier Leopoldo ^a   Gamberucci, Alessandra ^b   Lazzerini, Pietro Enea ^a   Pompella, Gerarda ^a   Natale, Mariarita ^a   Lorenzini, Sauro ^b   Selvi, Enrico ^b   Galeazzi, Mauro ^b   Laghi Pasini, Franco ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

IL 6; P2X7 receptors; Rheumatoid arthritis; Synoviocytes

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2X7 RECEPTOR ANTAGONIST; PURINERGIC RECEPTOR BLOCKING AGENT;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATIC DISEASE; SYNOVIOCYTE; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ARTHRITIS, RHEUMATOID; CALCIUM SIGNALING; CELL MEMBRANE; GENE EXPRESSION; HUMANS; INTERLEUKIN-6; RECEPTORS, PURINERGIC P2; RNA, MESSENGER; SYNOVIAL MEMBRANE;

EID: 48149089802     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0365-8     Document Type: Article

References (35)

1. T Pap U Muller-Ladner RE Gay S Gay 2000 Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis Arthritis Res 2 361 367
2. PA Guerne BL Zuraw JH Vaughan DA Carson M Lotz 1989 Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis J Clin Invest 83 585 592
3. K Hayashida T Nanki H Girschick S Yavuz T Ochi PE Lipsky 2001 Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8 Arthritis Res 3 118 126
4. A Hirth A Shapenko RW Kinne F Emmrich H Shultze-Koops U Sack 2002 Cytokine mRNA and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis Arthritis Res 4 117 125
5. LM Ryan JW Rachow DJ McCarty 1991 Synovial fluid ATP: a potential substrate for the production of inorganic pyrophosphate J Rheumatol 18 716 720
6. F Di Virgilio P Chiozzi D Ferrari S Falzoni JM Sanz A Morelli M Torboli G Bolognesi OR Baricordi 2001 Nucleotide receptors: an emerging family of regulatory molecules in blood cells Blood 97 587 600
7. A La Sala D Ferrari F Di Virgilio M Idzko J Norgauer G Girolomoni 2003 Alerting and tuning the immune response by extracellular nucleotides J Leukoc Biol 73 339 343
8. S Apasov M Koshiba F Redegeld MV Sitkovsky 1995 Role of extracellular ATP and P1 and P2 classes of purinergic receptors in T-cell development and cytotoxic T lymphocyte effector functions Immunol Rev 146 5 19
9. I Hide M Tanaka A Inoue K Nakajima S Kohsaka K Inoue Y Nakata 2000 Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia J Neurochem 75 965 972
10. V Ralevic G Burnstock 1998 Receptors for purines and pyrimidines Pharmacol Rev 50 413 492
11. MP Abbracchio G Burnstock JM Boeynaems EA Barnard JL Boyer C Kennedy GE Knight M Fumagalli C Gachet KA Jacobson GA Weisman 2006 International union of pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Pharmacol Rev 58 281 341
12. GR Dubyak C el-Moatassim 1993 Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides Am J Physiol 265 C577 C606
13. S Valera N Hussy RJ Evans N Adami RA North A Surprenant G Buell 1994 A new class of ligand-gated ion channels defined by P2x receptor for extracellular ATP Nature 371 516 519
14. D Ferrari P Chiozzi S Falzoni S Hanau F Di Virgilio 1987 Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin J Exp Med 185 579 582
15. 7 nucleotide receptor function in human monocytes by extracellular ions and receptor density Am J Physiol Cell Physiol 280 C943 C953
16. R Sluyter JA Barden JS Wiley 2001 Detection of P2X purinergic receptors on human B lymphocytes Cell Tissue Res 304 231 236
17. C Mutini S Falzoni D Ferrari P Chiozzi A Morelli OR Baricordi G Collo P Ricciardi-Castagnoli F Di Virgilio 1999 Mouse dendritic cells express the P2X7 purinergic receptor: characterization and possible participation in antigen presentation J Immunol 163 1958 1965
18. A Solini P Chiozzi A Morelli R Fellin F Di Virgilio 1999 Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release J Cell Sci 112 297 305
19. T Zimmermann E Kunisch R Pfeiffer A Hirth HD Stahl U Sack A Laube E Liesaus A Roth E Palombo-Kinne F Emmrich RW Kinne 2001 Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture-primary culture cells markedly differ from fourth-passage cells Arthritis Res 3 72 76
20. A Saalbach U Aneregg M Bruns E Schnabel K Herrmann UF Haustein 1996 Novel fibroblast-specific monoclonal antibodies: properties and specificities J Invest Dermatol 106 1314 1319
21. D Mulherin O Fitzgerald B Bresnihan 1996 Synovial tissue macrophage populations and articular damage in rheumatoid arthritis Arthritis Rheum 39 115 124
22. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254
23. F Di Virgilio C Fasolato TH Steinberg 1988 Inhibitors of membrane transport system for organic anions block fura2 excretion from PC12 and N2A cells Biochem J 256 959 963
24. G Grynkiewicz M Poenie RY Tsien 1985 A new generation of Ca2+ indicators with greatly improved fluorescence properties J Biol Chem 260 3440 3450
25. Z Walther LT May PB Sehgal 1988 Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines J Immunol 140 974 977
26. C Virginio D Church RA North A Surprenant 1997 Effect of divalent cations, protons and calmidazolium at the rat P2X7 receptor Neuropharmacology 36 1285 1294
27. Z Pfeiffer M Aga U Prabhu JJ Watters DJ Hall PJ Bertics 2004 The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho J Leukoc Biol 75 1173 1182
28. BS Khakh G Burnstock C Kennedy BF King RA North P Seguela M Voigt PP Humphrey 2001 International union of pharmacology: XXIV, current status of the nomenclature and properties of P2X receptors and their subunits Pharmacol Rev 53 107 118
29. M Murgia S Hanau P Pizzo M Rippa F Di Virgilio 1993 Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor J Biol Chem 268 8199 8203
30. M Feldmann FM Brennan RN Maini 1996 Rheumatoid arthritis Cell 85 307 310
31. GA Loredo HP Benton 1998 ATP and UTP activate calcium-mobilizing P2U-like receptors and act synergistically with interleukin-1 to stimulate prostaglandin E2 release from human rheumatoid synovial cells Arthritis Rheum 41 246 255
32. KA Jacobson MF Jarvis M Williams 2002 Perspective: purine and pyrimidine. (P2) receptors as drug targets J Med Chem 45 4057 4093
33. E Schulze-Lohoff C Hugo S Rost S Arnold A Gruber B Brune RB Sterzel 1998 Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z/P2X7 receptors Am J Physiol 275 F962 F971
34. F Rassendren GN Buell C Virginio G Collo RA North A Surprenant 1997 The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA J Biol Chem 272 5482 5486
35. M Slater S Danieletto A Gidley-Baird LC Teh JA Barden 2004 Early prostate cancer detected using expression of non-functional cytolytic P2X7 receptors Histopathology 44 206 215