Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

Nucleic Acids Research

Volumn 42, Issue 22, 2014, Pages 13456-13468

  Wan, W Brad ^a   Migawa, Michael T ^a   Vasquez, Guillermo ^a   Murray, Heather M ^a   Nichols, Josh G ^a   Gaus, Hans ^a   Berdeja, Andres ^a   Lee, Sam ^a   Hart, Christopher E ^a   Lima, Walt F ^a   Swayze, Eric E ^a   Seth, Punit P ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE 1; ANTISENSE OLIGONUCLEOTIDE 10; ANTISENSE OLIGONUCLEOTIDE 11; ANTISENSE OLIGONUCLEOTIDE 12; ANTISENSE OLIGONUCLEOTIDE 13; ANTISENSE OLIGONUCLEOTIDE 14; ANTISENSE OLIGONUCLEOTIDE 15; ANTISENSE OLIGONUCLEOTIDE 16; ANTISENSE OLIGONUCLEOTIDE 2; ANTISENSE OLIGONUCLEOTIDE 3; ANTISENSE OLIGONUCLEOTIDE 4; ANTISENSE OLIGONUCLEOTIDE 5; ANTISENSE OLIGONUCLEOTIDE 6; ANTISENSE OLIGONUCLEOTIDE 7; ANTISENSE OLIGONUCLEOTIDE 8; ANTISENSE OLIGONUCLEOTIDE 9; PHOSPHOROTHIOIC ACID; RIBONUCLEASE H; UNCLASSIFIED DRUG; ENDONUCLEASE S1, ASPERGILLUS; FUNGAL PROTEIN; NUCLEASE S1; OLIGONUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CATALYSIS; CHIRALITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME STABILITY; ESCHERICHIA COLI; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN MODIFICATION; STEREOCHEMISTRY; ANIMAL; CELL CULTURE; CHEMISTRY; METABOLISM; STEREOISOMERISM; SYNTHESIS; TEMPERATURE;

ANIMALS; CELLS, CULTURED; FUNGAL PROTEINS; MICE; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RIBONUCLEASE H; SINGLE-STRAND SPECIFIC DNA AND RNA ENDONUCLEASES; STEREOISOMERISM; TEMPERATURE;

EID: 84924538557     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku1115     Document Type: Article

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