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Volumn 19, Issue 3, 2000, Pages 533-543

Influence of diastereomeric ratios of deoxyribonucleoside phosphoramidites on the synthesis of phosphorothioate oligonucleotides

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

EID: 0033999899     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1080/15257770008035005     Document Type: Article
Times cited : (12)

References (36)
  • 1
    • 0001675653 scopus 로고
    • (Ed.: Wolff, M.E.), Wiley, and references cited therein
    • Crooke, S.T. (1995) in Burger's Medicinal Chemistry and Drug Discovery, Vol. 1 (Ed.: Wolff, M.E.), Wiley, pp. 863-900 and references cited therein.
    • (1995) Burger's Medicinal Chemistry and Drug Discovery , vol.1 , pp. 863-900
    • Crooke, S.T.1
  • 9
    • 0003787433 scopus 로고    scopus 로고
    • Comprehensive natural products chemistry
    • (Eds.: Barton, D.H.R.; Nakanishi, K.) (Ed. Kool, E.T.) Pergamon Press, in press
    • Sanghvi, Y.S. in Comprehensive Natural Products Chemistry, (1997), (Eds.: Barton, D.H.R.; Nakanishi, K.) in Volume 7: DNA and Aspects of Molecular Biology, (Ed. Kool, E.T.) Pergamon Press, in press.
    • (1997) DNA and Aspects of Molecular Biology , vol.7
    • Sanghvi, Y.S.1
  • 11
    • 85038048405 scopus 로고    scopus 로고
    • note
    • Several oligodeoxyribonucleotide phosphorothioates are in clinical trials e.g. ISIS 2922 has completed Phase III trials, an NDA was submitted and got approval for marketing from FDA in 1998, ISIS 2302, ISIS 3521, ISIS 5132 and ISIS 2503 are in Phase II stages, and several are in Phase I trials. In all about 20 drugs are being evaluated against various disease targets.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.