-
1
-
-
0001675653
-
-
(Ed.: Wolff, M.E.), Wiley, and references cited therein
-
Crooke, S.T. (1995) in Burger's Medicinal Chemistry and Drug Discovery, Vol. 1 (Ed.: Wolff, M.E.), Wiley, pp. 863-900 and references cited therein.
-
(1995)
Burger's Medicinal Chemistry and Drug Discovery
, vol.1
, pp. 863-900
-
-
Crooke, S.T.1
-
2
-
-
85038043178
-
Progress in oligonucleotide therapeutics
-
April 24-28, Anaheim, CA, USA
-
Crooke, S.T. (1994) in Progress in Oligonucleotide Therapeutics, American Society for Pharmacology and Experimental Therapeutics, Spring Meeting, April 24-28, Anaheim, CA, USA.
-
(1994)
American Society for Pharmacology and Experimental Therapeutics, Spring Meeting
-
-
Crooke, S.T.1
-
4
-
-
0003609792
-
-
(Eds.: Knorre, G. K.; Vlassov, V. V.; Zarytova, V. F.; Lebedev, A. V.; Federova, O. S.), CRC Press: Boca Raton, FL, USA
-
Knorre, G. K.; Vlassov, V. V.; Zarytova, V. F.; Lebedev, A. V.; Federova, O. S. (1994) in Design and Targeted Reactions of Oligonucleotide Derivatives; (Eds.: Knorre, G. K.; Vlassov, V. V.; Zarytova, V. F.; Lebedev, A. V.; Federova, O. S.), CRC Press: Boca Raton, FL, USA.
-
(1994)
Design and Targeted Reactions of Oligonucleotide Derivatives
-
-
Knorre, G.K.1
Vlassov, V.V.2
Zarytova, V.F.3
Lebedev, A.V.4
Federova, O.S.5
-
5
-
-
0011829478
-
-
September 19, La Jolla, CA, USA
-
Kisner, D. L. 12th International Roundtable on Nucleosides and Nucleotides, September 19, 1996, La Jolla, CA, USA.
-
(1996)
12th International Roundtable on Nucleosides and Nucleotides
-
-
Kisner, D.L.1
-
6
-
-
0028568244
-
-
Crooke, S. T.; Grillone, L. R.; Tendolkar, A.; Garrett, A.; Fraktin, M. J.; Leeds, J.; Barr, W. H. (1994) Biochem. Pharmacol., 56, 641-646.
-
(1994)
Biochem. Pharmacol.
, vol.56
, pp. 641-646
-
-
Crooke, S.T.1
Grillone, L.R.2
Tendolkar, A.3
Garrett, A.4
Fraktin, M.J.5
Leeds, J.6
Barr, W.H.7
-
7
-
-
0029100397
-
-
Agrawal, S.; Zhang, X.; Lu, Z.; Zhao, H.; Tamburin, J. M.; Yan, J.; Cai, H.; Diasio, R. B.; Habus, I.; Jiang, Z.; Iyer, R. P.; Yu, D.; Zhang, R. (1995) Biochem. Pharmacol., 50, 571-576.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 571-576
-
-
Agrawal, S.1
Zhang, X.2
Lu, Z.3
Zhao, H.4
Tamburin, J.M.5
Yan, J.6
Cai, H.7
Diasio, R.B.8
Habus, I.9
Jiang, Z.10
Iyer, R.P.11
Yu, D.12
Zhang, R.13
-
9
-
-
0003787433
-
Comprehensive natural products chemistry
-
(Eds.: Barton, D.H.R.; Nakanishi, K.) (Ed. Kool, E.T.) Pergamon Press, in press
-
Sanghvi, Y.S. in Comprehensive Natural Products Chemistry, (1997), (Eds.: Barton, D.H.R.; Nakanishi, K.) in Volume 7: DNA and Aspects of Molecular Biology, (Ed. Kool, E.T.) Pergamon Press, in press.
-
(1997)
DNA and Aspects of Molecular Biology
, vol.7
-
-
Sanghvi, Y.S.1
-
11
-
-
85038048405
-
-
note
-
Several oligodeoxyribonucleotide phosphorothioates are in clinical trials e.g. ISIS 2922 has completed Phase III trials, an NDA was submitted and got approval for marketing from FDA in 1998, ISIS 2302, ISIS 3521, ISIS 5132 and ISIS 2503 are in Phase II stages, and several are in Phase I trials. In all about 20 drugs are being evaluated against various disease targets.
-
-
-
-
17
-
-
0025250111
-
-
Iyer, R.P., Egan, W., Regan, J.B., Beaucage, S.L. (1990) J. Am. Chem. Soc., 112, 1253-1254.
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 1253-1254
-
-
Iyer, R.P.1
Egan, W.2
Regan, J.B.3
Beaucage, S.L.4
-
18
-
-
0025161168
-
-
Iyer, R.P., Philips, L.R., Egan, W., Regan, J.B., Beaucage, S.L. (1990) J. Org. Chem., 55, 4693-4699.
-
(1990)
J. Org. Chem.
, vol.55
, pp. 4693-4699
-
-
Iyer, R.P.1
Philips, L.R.2
Egan, W.3
Regan, J.B.4
Beaucage, S.L.5
-
19
-
-
0001687673
-
-
Sinha, N. D.; Biernat, J.; Köster, H. (1983) Tetrahedron Lett., 24, 5843-5846.
-
(1983)
Tetrahedron Lett.
, vol.24
, pp. 5843-5846
-
-
Sinha, N.D.1
Biernat, J.2
Köster, H.3
-
20
-
-
0000237826
-
-
Lyttle, M. H.; Wright, P. B.; Sinha, N. D.; Bain, J. D.; Chamberlin, A. R. (1991) J. Org. Chem., 56, 4608-4615.
-
(1991)
J. Org. Chem.
, vol.56
, pp. 4608-4615
-
-
Lyttle, M.H.1
Wright, P.B.2
Sinha, N.D.3
Bain, J.D.4
Chamberlin, A.R.5
-
21
-
-
85038042100
-
-
October 28-29, San Diego, CA, USA
-
Scozzari, A.N. Large Scale Oligonucleotide Synthesis : Production, Purification and Analysis, October 28-29, 1997, San Diego, CA, USA.
-
(1997)
Large Scale Oligonucleotide Synthesis : Production, Purification and Analysis
-
-
Scozzari, A.N.1
-
22
-
-
0026093795
-
-
Stec, W.J., Grajkowski, A., Koziolkiewicz, M., Uznanski, B. (1991) Nucleic Acids Res., 19, 5883-5888.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 5883-5888
-
-
Stec, W.J.1
Grajkowski, A.2
Koziolkiewicz, M.3
Uznanski, B.4
-
25
-
-
0029609588
-
-
Stec, W.J., Grajkowski, A., Kobylanska, A., Karwowski, B., Koziolkiewicz, M., Misiura, K., Okruszek, A., Wilk, A., Guga, P., Boczkowska, M. (1995) J. Am. Chem. Soc., 117, 12019.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 12019
-
-
Stec, W.J.1
Grajkowski, A.2
Kobylanska, A.3
Karwowski, B.4
Koziolkiewicz, M.5
Misiura, K.6
Okruszek, A.7
Wilk, A.8
Guga, P.9
Boczkowska, M.10
-
28
-
-
0029075417
-
-
Iyer, R.P., Yu, D., Ho, N., Tan, W., Agrawal, S. (1995) Tetrahedron: Asymmetry, 6, 1051-1054.
-
(1995)
Tetrahedron: Asymmetry
, vol.6
, pp. 1051-1054
-
-
Iyer, R.P.1
Yu, D.2
Ho, N.3
Tan, W.4
Agrawal, S.5
-
29
-
-
0011833665
-
-
Charubala, R., Stengele, K.P., Pfleiderer, W. (1989) Nucleosides Nucleotides, 8, 1007-1010.
-
(1989)
Nucleosides Nucleotides
, vol.8
, pp. 1007-1010
-
-
Charubala, R.1
Stengele, K.P.2
Pfleiderer, W.3
-
31
-
-
0011912896
-
-
Stec, W.J., Zon, G., Gallo, K.A., Byrd, R.A. (1985) Tetrahedron Lett., 26, 2191-2194.
-
(1985)
Tetrahedron Lett.
, vol.26
, pp. 2191-2194
-
-
Stec, W.J.1
Zon, G.2
Gallo, K.A.3
Byrd, R.A.4
-
33
-
-
0026275553
-
-
Wilk, A., Uznanski, B., Stec, W.J. (1991) Nucleic Acids Symp. Ser., 24, 63-66.
-
(1991)
Nucleic Acids Symp. Ser.
, vol.24
, pp. 63-66
-
-
Wilk, A.1
Uznanski, B.2
Stec, W.J.3
-
34
-
-
0024506335
-
-
Berner, S., Mühlegger, K., Seliger, H. (1989) Nucleic Acids Res., 17, 853-864.
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 853-864
-
-
Berner, S.1
Mühlegger, K.2
Seliger, H.3
-
35
-
-
0011889842
-
-
Dahl, B.H., Nielsen, J., Dahl, O. (1987) Nucleic Acids Res., 15, 1730-1743.
-
(1987)
Nucleic Acids Res.
, vol.15
, pp. 1730-1743
-
-
Dahl, B.H.1
Nielsen, J.2
Dahl, O.3
-
36
-
-
0026876215
-
-
Ghosh, M., Ghosh, K., Cohen, J.S. (1992) Antisense Res. Dev. 2, 11.
-
(1992)
Antisense Res. Dev.
, vol.2
, pp. 11
-
-
Ghosh, M.1
Ghosh, K.2
Cohen, J.S.3
|