Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1

Nucleic Acids Research

Volumn 37, Issue 20, 2009, Pages 6927-6941

  Vickers, Timothy A ^a   Lima, Walt F ^a   Wu, Hongjiang ^a   Nichols, Josh G ^a   Linsley, Peter S ^b   Crooke, Stanley T ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b REGULUS THERAPEUTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE 1 PROTEIN; ARGONAUTE 2 PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; EIF2C1 PROTEIN, HUMAN; EIF2C2 PROTEIN, MOUSE; INITIATION FACTOR; INITIATION FACTOR 2; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CB PROTEIN, HUMAN; RIBONUCLEASE III;

ARTICLE; CELL LEVEL; CHEMICAL MODIFICATION; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; KNOCKOUT GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN FUNCTION; REDUCTION; RNA DEGRADATION; RNA INTERFERENCE; ANIMAL; CELL CULTURE; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MOUSE MUTANT; RNA STABILITY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; EUKARYOTIC INITIATION FACTOR-2; EUKARYOTIC INITIATION FACTORS; GENE EXPRESSION PROFILING; HUMANS; MICE; MICE, KNOCKOUT; RIBONUCLEASE III; RNA INTERFERENCE; RNA STABILITY; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 73349086270     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp735     Document Type: Article

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