The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis

Molecular Pharmacology

Volumn 71, Issue 1, 2007, Pages 73-82

  Lima, Walt F ^a,b   Rose, John B ^a   Nichols, Josh G ^a   Wu, Hongjiang ^a   Migawa, Michael T ^a   Wyrzykiewicz, Tadeusz K ^a   Vasquez, Guillermo ^a   Swayze, Eric E ^a   Crooke, Stanley T ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' ARA FLUOROTHYMIDINE; 2' METHOXYETHYL NUCLEOTIDE; 5' METHOXYETHYL NUCLEOTIDE; HETERODUPLEX; INDOLE DERIVATIVE; OLIGONUCLEOTIDE; RIBONUCLEASE H; TETRAFLUOROINDOLE; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; ENZYME ACTIVITY; GEOMETRY; HETERODUPLEX ANALYSIS; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; RNA STRUCTURE;

BASE SEQUENCE; CATALYSIS; HUMANS; KINETICS; NUCLEIC ACID HETERODUPLEXES; OLIGONUCLEOTIDES, ANTISENSE; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RIBONUCLEASE H, CALF THYMUS;

EID: 33845878530     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.025429     Document Type: Article

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