Solid-phase synthesis of stereoregular oligodeoxyribonucleoside phosphorothioates using bicyclic oxazaphospholidine derivatives as monomer units

Journal of the American Chemical Society

Volumn 130, Issue 47, 2008, Pages 16031-16037

  Oka, Natsuhisa ^a   Yamamoto, Mika ^a   Sato, Terutoshi ^a   Wada, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; MOLECULAR ORBITALS; MONOMERS; PHOSPHORUS COMPOUNDS;

AB INITIO MOLECULAR ORBITAL CALCULATIONS; ACIDIC ACTIVATORS; CONFIGURATIONAL STABILITIES; CONFIGURATIONALLY; DIASTEREO SELECTIVITIES; EPIMERIZATION; INVERSION PROCESSES; MONOMER UNITS; ORGANOPHOSPHORUS COMPOUNDS; PHASE SYNTHESES; PHOSPHOROTHIOATE; PHOSPHOROTHIOATES; RING STRUCTURES; SOLID SUPPORTS; STEREOREGULAR;

ISOMERS;

3' O BICYCLIC OXAZAPHOSPHOLIDINE; MONOMER; NUCLEOTIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME INVERSION; DIASTEREOISOMER; DNA SYNTHESIS; EPIMERIZATION; HUMAN; HUMAN CELL; NUCLEOTIDE METABOLISM; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON TRANSPORT; SOLID PHASE SYNTHESIS; STEREOCHEMISTRY; TRANS ISOMER;

BICYCLO COMPOUNDS, HETEROCYCLIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGODEOXYRIBONUCLEOTIDES; OXAZOLES; PHOSPHORUS; STEREOISOMERISM; SULFHYDRYL COMPOUNDS;

EID: 56749161695     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja805780u     Document Type: Article

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