5-Substituted 2-bromoindolo[3,2-b]quinoxalines. A class of potential antitumor agents with cdc25 phosphatase inhibitory properties

Archiv der Pharmazie

Volumn 331, Issue 11, 1998, Pages 352-358

  Abadi, Ashraf H ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antitumor testing; cdc kinase and phosphatase; Indolo 3.2 b quinoxaline

Indexed keywords

2 (2 BROMOINDOLO[3,2 B]QUINOXALIN 5 YL) N [[(CYCLOHEXYLAMINO)THIOXOMETHYL]AMINO]ETHANAMIDE; CYTOSTATIC AGENT; MELPHALAN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LC 50; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; FEMALE; HUMANS; MALE; PHOSPHORIC MONOESTER HYDROLASES; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0032444828     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4184(199811)331:11<352::AID-ARDP352>3.0.CO;2-2     Document Type: Article

References (7)

1. E.M. Acton, V.L. Narayanan, P.A. Risbood, R.H. Shoemaker, D.T. Vistica, M.R. Boyd, J. Med. Chem. 1994, 37, 2185.
2. J. Jurai, R.D. Haugwitz, R.K. Varma, K.D. Paul, J.F. Barrette, M. Cushman, J. Med. Chem. 1994, 37, 2190.
3. C. Auclair, A. Pierre, E. Voisin, O. Pepin, S. Cros, C. Colas, J.M. Saucier, B. Verschuere, P. Gros, C. Paloetti, Cancer Res. 1987, 47, 6254.
4. P. Juret, A. Tanguy , A. Girard, J.Y. Le Talaer, J.S. Abbatucci, Eur. J. Cancer 1978, 14, 205.
5. J. Harmenberg, A. Akesson-Johansson, A. Graslund, T. Malmfors, J. Bergman, B. Wahren, S. Akerfeldt, L. Lundblad, S. Cox, Antiviral Res. 1991, 75, 193.
6. I. Zegar, A. Graslund, J. Bergman, M. Ericksson, B. Norden, Chem. Biol. interact. 1989, 72, 277.
7. V.K. Kansal, P. Potier, Tetrahedron 1986, 42, 2389.