PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

PLoS Genetics

Volumn 11, Issue 1, 2015, Pages

  Baker, Christopher L ^a   Kajita, Shimpei ^a,b   Walker, Michael ^a   Saxl, Ruth L ^a   Raghupathy, Narayanan ^a   Choi, Kwangbom ^a   Petkov, Petko M ^a   Paigen, Kenneth ^a  

^a JACKSON LABORATORY   (United States)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; HISTONE METHYLTRANSFERASE; PROTEIN PRDM9; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HISTONE LYSINE METHYLTRANSFERASE; PRDM9 PROTEIN, MOUSE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN MODIFICATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SEQUENCE; EVOLUTIONARY HOTSPOT EROSION; GENE; GENE CONVERSION; GENETIC ENGINEERING AND GENE TECHNOLOGY; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; HIGH THROUGHPUT SEQUENCING; HISTONE MODIFICATION; HYBRID MOUSE STRAIN; IN VITRO STUDY; IN VIVO STUDY; MALE; MEIOTIC RECOMBINATION; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MOUSE; MUS MUSCULUS CASTANEUS; MUS MUSCULUS DOMESTICUS; MUS SPRETUS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRDM9 GENE; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN DIFFERENCE; TRANSCRIPTION INITIATION SITE; ANIMAL; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENETICS; HOMOLOGOUS RECOMBINATION; MEIOSIS; NUCLEOTIDE MOTIF;

MUS MUSCULUS; MUS SPRETUS;

ANIMALS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; GENE CONVERSION; HAPLOTYPES; HISTONE-LYSINE N-METHYLTRANSFERASE; HOMOLOGOUS RECOMBINATION; MEIOSIS; MICE; NUCLEOTIDE MOTIFS;

EID: 84924388025     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004916     Document Type: Article

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