메뉴 건너뛰기




Volumn 29, Issue 3, 2015, Pages 323-331

Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models

Author keywords

allergy; antioxidant; flavonoid; hesperetin; inflammation

Indexed keywords

7,3' DIMETHOXY HESPERITIN; AGLYCONE; ALPHA GLUCOSYL HESPERIDIN; BIOFLAVONOID; CYCLOOXYGENASE 2; DRUG METABOLITE; FLAVONE DERIVATIVE; FLAVONOID; HESPERETIN; HESPERIDIN; HESPERIDIN DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIOXIDANT;

EID: 84924298691     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5256     Document Type: Review
Times cited : (717)

References (76)
  • 1
    • 82055165424 scopus 로고    scopus 로고
    • Hesperidin alleviates acetaminophen induced toxicity in wistar rats by abrogation of oxidative stress, apoptosis and inflammation
    • Ahmad ST, Arjumand W, Nafees S, et al,. 2012. Hesperidin alleviates acetaminophen induced toxicity in wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicol Lett 208: 149-161.
    • (2012) Toxicol Lett , vol.208 , pp. 149-161
    • Ahmad, S.T.1    Arjumand, W.2    Nafees, S.3
  • 2
    • 68949125047 scopus 로고    scopus 로고
    • Hesperidin attenuates benzo[α] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance
    • Arafa HMM, Aly HAA, Abd-Ellah MF, El-Refaey HM,. 2009. Hesperidin attenuates benzo[α] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance. Toxicol Ind Health 25: 417-427.
    • (2009) Toxicol Ind Health , vol.25 , pp. 417-427
    • Arafa, H.M.M.1    Aly, H.A.A.2    Abd-Ellah, M.F.3    El-Refaey, H.M.4
  • 4
    • 34250709440 scopus 로고    scopus 로고
    • Effect of hesperidin on nicotine toxicity and histopathological studies
    • Balakrishnan A, Menon VP,. 2007a. Effect of hesperidin on nicotine toxicity and histopathological studies. Toxicol Mech Meth 17: 233-239.
    • (2007) Toxicol Mech Meth , vol.17 , pp. 233-239
    • Balakrishnan, A.1    Menon, V.P.2
  • 5
    • 34047261247 scopus 로고    scopus 로고
    • Protective effect of hesperidin on nicotine induced toxicity in rats
    • Balakrishnan A, Menon VP,. 2007b. Protective effect of hesperidin on nicotine induced toxicity in rats. Indian J Exp Biol 45: 194-202.
    • (2007) Indian J Exp Biol , vol.45 , pp. 194-202
    • Balakrishnan, A.1    Menon, V.P.2
  • 6
    • 33745127751 scopus 로고    scopus 로고
    • Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells
    • Chen TH, Kao YC, Chen BC, Chen CH, Chan P, Lee HM,. 2006. Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells. Eur J Pharmacol 541: 138-146.
    • (2006) Eur J Pharmacol , vol.541 , pp. 138-146
    • Chen, T.H.1    Kao, Y.C.2    Chen, B.C.3    Chen, C.H.4    Chan, P.5    Lee, H.M.6
  • 7
    • 77956339120 scopus 로고    scopus 로고
    • Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes
    • Chen M, Gu H, Ye Y, et al,. 2010a. Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes. Food Chem Toxicol 48: 2980-2987.
    • (2010) Food Chem Toxicol , vol.48 , pp. 2980-2987
    • Chen, M.1    Gu, H.2    Ye, Y.3
  • 8
    • 77956339120 scopus 로고    scopus 로고
    • Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes
    • Chen MC, Gu HG, Ye YY, et al,. 2010b. Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes. Food Chem Toxicol 48: 2980-2987.
    • (2010) Food Chem Toxicol , vol.48 , pp. 2980-2987
    • Chen, M.C.1    Gu, H.G.2    Ye, Y.Y.3
  • 9
    • 77949807509 scopus 로고    scopus 로고
    • Hesperidin Upregulates Heme Oxygenase-1 to Attenuate Hydrogen Peroxide-Induced Cell Damage in Hepatic L02 Cells
    • Chen MC, Ye YY, Ji G, Liu JW,. 2010c. Hesperidin Upregulates Heme Oxygenase-1 To Attenuate Hydrogen Peroxide-Induced Cell Damage in Hepatic L02 Cells. J Agric Food Chem 58: 3330-3335.
    • (2010) J Agric Food Chem , vol.58 , pp. 3330-3335
    • Chen, M.C.1    Ye, Y.Y.2    Ji, G.3    Liu, J.W.4
  • 10
    • 84893746750 scopus 로고    scopus 로고
    • Hesperidin prevents androgen deficiency-induced none loss in male mice
    • Chiba H, Kim H, Matsumoto A, et al,. 2014. Hesperidin prevents androgen deficiency-induced none loss in male mice. Phytother Res 28: 289-295.
    • (2014) Phytother Res , vol.28 , pp. 289-295
    • Chiba, H.1    Kim, H.2    Matsumoto, A.3
  • 11
    • 34948879632 scopus 로고    scopus 로고
    • Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells
    • Choi IY, Kim SJ, Jeong HJ, et al,. 2007. Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells. Mol Cell Biochem 305: 153-161.
    • (2007) Mol Cell Biochem , vol.305 , pp. 153-161
    • Choi, I.Y.1    Kim, S.J.2    Jeong, H.J.3
  • 12
    • 50049130554 scopus 로고    scopus 로고
    • Oxidative stress, inflammation and cardiovascular disease in chronic renal failure
    • Cottone S, Lorito MC, Riccobene R, et al,. 2008. Oxidative stress, inflammation and cardiovascular disease in chronic renal failure. J Nephrol 21: 175-179.
    • (2008) J Nephrol , vol.21 , pp. 175-179
    • Cottone, S.1    Lorito, M.C.2    Riccobene, R.3
  • 13
    • 84898954223 scopus 로고    scopus 로고
    • Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l-arginine-NO-cGMP pathway and BDNF levels
    • Donato F, de Gomes MG, Goes AT, et al,. 2014a. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l-arginine-NO-cGMP pathway and BDNF levels. Brain Res Bull 104: 19-26.
    • (2014) Brain Res Bull , vol.104 , pp. 19-26
    • Donato, F.1    De Gomes, M.G.2    Goes, A.T.3
  • 14
    • 84898954223 scopus 로고    scopus 로고
    • Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l-arginine-NO-cGMP pathway and BDNF levels
    • Donato F, de Gomes MG, Goes ATR, et al,. 2014b. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l-arginine-NO-cGMP pathway and BDNF levels. Brain Res Bull 104: 19-26.
    • (2014) Brain Res Bull , vol.104 , pp. 19-26
    • Donato, F.1    De Gomes, M.G.2    Goes, A.T.R.3
  • 15
    • 84870585864 scopus 로고    scopus 로고
    • The inhibitory effect of polyphenols on human gut microbiota
    • Duda-Chodak A,. 2012. The inhibitory effect of polyphenols on human gut microbiota. J Physiol Pharmacol 63: 497-503.
    • (2012) J Physiol Pharmacol , vol.63 , pp. 497-503
    • Duda-Chodak, A.1
  • 17
    • 50949129577 scopus 로고    scopus 로고
    • Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain
    • El-Sayed EM, Abo-Salem OM, Abd-Ellah MF, Abd-Alla GM,. 2008. Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain. J Biochem Mol Toxic 22: 268-273.
    • (2008) J Biochem Mol Toxic , vol.22 , pp. 268-273
    • El-Sayed, E.M.1    Abo-Salem, O.M.2    Abd-Ellah, M.F.3    Abd-Alla, G.M.4
  • 18
    • 0035367819 scopus 로고    scopus 로고
    • Signaling by Type i and II cytokine receptors: Ten years after
    • Gadina M, Hilton D, Johnston JA, et al,. 2001. Signaling by Type I and II cytokine receptors: Ten years after. Curr Opin Immunol 13: 363-373.
    • (2001) Curr Opin Immunol , vol.13 , pp. 363-373
    • Gadina, M.1    Hilton, D.2    Johnston, J.A.3
  • 19
    • 0035667114 scopus 로고    scopus 로고
    • Chemistry and pharmacology of the Citrus bioflavonoid hesperidin
    • Garg A, Garg S, Zaneveld LJD, Singla AK,. 2001. Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res 15: 655-669.
    • (2001) Phytother Res , vol.15 , pp. 655-669
    • Garg, A.1    Garg, S.2    Zaneveld, L.J.D.3    Singla, A.K.4
  • 20
    • 79953222936 scopus 로고    scopus 로고
    • Effects of flavonoids and other polyphenols on inflammation
    • González R, Ballester I, Lõpez-Posadas R, et al,. 2011. Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci 51: 331-362.
    • (2011) Crit Rev Food Sci , vol.51 , pp. 331-362
    • González, R.1    Ballester, I.2    Lõpez-Posadas, R.3
  • 21
    • 0035415723 scopus 로고    scopus 로고
    • Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat
    • Guardia T, Rotelli AE, Juarez AO, Pelzer LE,. 2001. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 56: 683-687.
    • (2001) Farmaco , vol.56 , pp. 683-687
    • Guardia, T.1    Rotelli, A.E.2    Juarez, A.O.3    Pelzer, L.E.4
  • 22
    • 18144406539 scopus 로고    scopus 로고
    • Oxidative stress and inflammation in Parkinson's disease: Is there a causal link?
    • Hald A, Lotharius J,. 2005. Oxidative stress and inflammation in Parkinson's disease: Is there a causal link? Exp Neurol 193: 279-290.
    • (2005) Exp Neurol , vol.193 , pp. 279-290
    • Hald, A.1    Lotharius, J.2
  • 23
    • 33846331650 scopus 로고    scopus 로고
    • Oxidative stress and cancer: Have we moved forward?
    • Halliwell B,. 2007. Oxidative stress and cancer: Have we moved forward? Biochem J 401: 1-11.
    • (2007) Biochem J , vol.401 , pp. 1-11
    • Halliwell, B.1
  • 24
    • 0034736046 scopus 로고    scopus 로고
    • Advances in flavonoid research since 1992
    • Harborne JB, Williams CA,. 2000. Advances in flavonoid research since 1992. Phytochemistry 55: 481-504.
    • (2000) Phytochemistry , vol.55 , pp. 481-504
    • Harborne, J.B.1    Williams, C.A.2
  • 25
    • 0035943597 scopus 로고    scopus 로고
    • Nuclear Factor κb is a Molecular Target for Sulforaphane-mediated Anti-inflammatory Mechanisms
    • Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhäuser C,. 2001. Nuclear Factor κB Is a Molecular Target for Sulforaphane-mediated Anti-inflammatory Mechanisms. J Biol Chem 276: 32008-32015.
    • (2001) J Biol Chem , vol.276 , pp. 32008-32015
    • Heiss, E.1    Herhaus, C.2    Klimo, K.3    Bartsch, H.4    Gerhäuser, C.5
  • 26
    • 23344436043 scopus 로고    scopus 로고
    • Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression
    • Hirata A, Murakami Y, Shoji M, Kadoma Y, Fujisawa S,. 2005. Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression. Anticancer Res 25: 3367-3374.
    • (2005) Anticancer Res , vol.25 , pp. 3367-3374
    • Hirata, A.1    Murakami, Y.2    Shoji, M.3    Kadoma, Y.4    Fujisawa, S.5
  • 27
    • 69249214023 scopus 로고    scopus 로고
    • Protective effects of hesperidin against genotoxicity induced by 99mTc-MIBI in human cultured lymphocyte cells
    • Hosseinimehr SJ, Ahmadi A, Beiki D, Habibi E, Mahmoudzadeh A,. 2009. Protective effects of hesperidin against genotoxicity induced by 99mTc-MIBI in human cultured lymphocyte cells. Nucl Med Biol 36: 863-867.
    • (2009) Nucl Med Biol , vol.36 , pp. 863-867
    • Hosseinimehr, S.J.1    Ahmadi, A.2    Beiki, D.3    Habibi, E.4    Mahmoudzadeh, A.5
  • 28
    • 70449127048 scopus 로고    scopus 로고
    • Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel
    • Huang YS, Ho SC,. 2010. Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel. Food Chem 119: 868-873.
    • (2010) Food Chem , vol.119 , pp. 868-873
    • Huang, Y.S.1    Ho, S.C.2
  • 29
    • 79955931722 scopus 로고    scopus 로고
    • Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation
    • Jain M, Parmar HS,. 2011. Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. Inflamm Res 60: 483-491.
    • (2011) Inflamm Res , vol.60 , pp. 483-491
    • Jain, M.1    Parmar, H.S.2
  • 30
    • 84918797244 scopus 로고    scopus 로고
    • Gelidium elegans, an edible red seaweed, and hesperidin inhibit lipid accumulation and production of reactive oxygen species and reactive nitrogen species in 3 T3-L1 and RAW264.7 cells
    • DOI: 10.1002/ptr.5186.
    • Jeon HJ, Seo MJ, Choi HS, Lee OH, Lee BY,. 2014. Gelidium elegans, an edible red seaweed, and hesperidin inhibit lipid accumulation and production of reactive oxygen species and reactive nitrogen species in 3 T3-L1 and RAW264.7 cells. Phytother Res. DOI: 10.1002/ptr.5186.
    • (2014) Phytother Res
    • Jeon, H.J.1    Seo, M.J.2    Choi, H.S.3    Lee, O.H.4    Lee, B.Y.5
  • 31
    • 59949102624 scopus 로고    scopus 로고
    • Evaluation of antioxidant activity of hesperidin and its protective effect on H 2O 2 induced oxidative damage on pBR322 DNA and RBC cellular membrane
    • Kalpana KB, Srinivasan M, Menon VP,. 2009. Evaluation of antioxidant activity of hesperidin and its protective effect on H 2O 2 induced oxidative damage on pBR322 DNA and RBC cellular membrane. Mol Cell Biochem 323: 21-29.
    • (2009) Mol Cell Biochem , vol.323 , pp. 21-29
    • Kalpana, K.B.1    Srinivasan, M.2    Menon, V.P.3
  • 32
    • 78049296495 scopus 로고    scopus 로고
    • Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9
    • Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T,. 2010. Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. Eur J Pharmacol 649: 320-327.
    • (2010) Eur J Pharmacol , vol.649 , pp. 320-327
    • Kamaraj, S.1    Anandakumar, P.2    Jagan, S.3    Ramakrishnan, G.4    Devaki, T.5
  • 33
    • 78650929774 scopus 로고    scopus 로고
    • Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice
    • Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T,. 2011. Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice. Fund Clin Pharmacol 25: 91-98.
    • (2011) Fund Clin Pharmacol , vol.25 , pp. 91-98
    • Kamaraj, S.1    Anandakumar, P.2    Jagan, S.3    Ramakrishnan, G.4    Devaki, T.5
  • 34
    • 80051785668 scopus 로고    scopus 로고
    • Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways
    • Kang SR, Park KI, Park HS, et al,. 2011. Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways. Food Chem 129: 1721-1728.
    • (2011) Food Chem , vol.129 , pp. 1721-1728
    • Kang, S.R.1    Park, K.I.2    Park, H.S.3
  • 36
    • 76749145986 scopus 로고    scopus 로고
    • Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata
    • Kazłowska K, Hsu T, Hou CC, Yang WC, Tsai GJ,. 2010. Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata. J Ethnopharmacol 128: 123-130.
    • (2010) J Ethnopharmacol , vol.128 , pp. 123-130
    • Kazłowska, K.1    Hsu, T.2    Hou, C.C.3    Yang, W.C.4    Tsai, G.J.5
  • 37
    • 3042625013 scopus 로고    scopus 로고
    • Hesperetin: A potent antioxidant against peroxynitrite
    • Kim JY, Jung KJ, Choi JS, Chung HY,. 2004. Hesperetin: A potent antioxidant against peroxynitrite. Free Radic Res 38: 761-769.
    • (2004) Free Radic Res , vol.38 , pp. 761-769
    • Kim, J.Y.1    Jung, K.J.2    Choi, J.S.3    Chung, H.Y.4
  • 38
    • 79959226608 scopus 로고    scopus 로고
    • Antiasthmatic Effects of Hesperidin, a Potential Th2 Cytokine Antagonist, in a Mouse Model of Allergic Asthma
    • Kim SH, Kim BK, Lee YC,. 2011. Antiasthmatic Effects of Hesperidin, a Potential Th2 Cytokine Antagonist, in a Mouse Model of Allergic Asthma. Mediat Inflamm 2011: 485402.
    • (2011) Mediat Inflamm , vol.2011 , pp. 485402
    • Kim, S.H.1    Kim, B.K.2    Lee, Y.C.3
  • 39
    • 39749153768 scopus 로고    scopus 로고
    • Effects of α-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans
    • Kometani T, Fukuda T, Kakuma T, et al,. 2008. Effects of α-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans. Immunopharmacol Immunotoxicol 30: 117-134.
    • (2008) Immunopharmacol Immunotoxicol , vol.30 , pp. 117-134
    • Kometani, T.1    Fukuda, T.2    Kakuma, T.3
  • 41
    • 77957143970 scopus 로고    scopus 로고
    • Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis
    • Lee JH, Kim GH,. 2010. Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis. J Food Sci 75: H212-H217.
    • (2010) J Food Sci , vol.75 , pp. H212-H217
    • Lee, J.H.1    Kim, G.H.2
  • 42
    • 4043153467 scopus 로고    scopus 로고
    • Antiallergic activity of hesperidin is activated by intestinal microflora
    • Lee NK, Choi SH, Park SH, Park EK, Kim DH,. 2004. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 71: 174-180.
    • (2004) Pharmacology , vol.71 , pp. 174-180
    • Lee, N.K.1    Choi, S.H.2    Park, S.H.3    Park, E.K.4    Kim, D.H.5
  • 43
    • 38949143942 scopus 로고    scopus 로고
    • Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms
    • Li R, Li J, Cai L, Hu CM, Zhang L,. 2008a. Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms. J Pharm Pharmacol 60: 221-228.
    • (2008) J Pharm Pharmacol , vol.60 , pp. 221-228
    • Li, R.1    Li, J.2    Cai, L.3    Hu, C.M.4    Zhang, L.5
  • 44
    • 45349104773 scopus 로고    scopus 로고
    • Therapeutic effect of hesperidin on adjuvant arthritis in rats and its mechanisms
    • Li R, Li J, Hu CM, Zhang L, Jiang H,. 2008b. Therapeutic effect of hesperidin on adjuvant arthritis in rats and its mechanisms. Chin Pharmacol Bull 24: 494-498.
    • (2008) Chin Pharmacol Bull , vol.24 , pp. 494-498
    • Li, R.1    Li, J.2    Hu, C.M.3    Zhang, L.4    Jiang, H.5
  • 45
    • 77951573898 scopus 로고    scopus 로고
    • Hesperidin suppresses adjuvant arthritis in rats by inhi biting synoviocyte activity (Phytotherapy Research (2010) 24, Suppl. 1, (S71-76))
    • Li R, Cai L, Xie XF, Yang F, Li J,. 2010a. Hesperidin suppresses adjuvant arthritis in rats by inhi biting synoviocyte activity (Phytotherapy Research (2010) 24, Suppl. 1, (S71-76)). Phytotherapy Research 24: 632.
    • (2010) Phytotherapy Research , vol.24 , pp. 632
    • Li, R.1    Cai, L.2    Xie, X.F.3    Yang, F.4    Li, J.5
  • 46
    • 75749156173 scopus 로고    scopus 로고
    • Hesperidin suppresses adjuvant arthritis in rats by inhibiting synoviocyte activity
    • Li R, Cai L, Xie XF, Yang F, Li J,. 2010b. Hesperidin suppresses adjuvant arthritis in rats by inhibiting synoviocyte activity. Phytother Res 24: S71-S76.
    • (2010) Phytother Res , vol.24 , pp. S71-S76
    • Li, R.1    Cai, L.2    Xie, X.F.3    Yang, F.4    Li, J.5
  • 47
    • 84869460448 scopus 로고    scopus 로고
    • Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation
    • Li D, Mitsuhashi S, Ubukata M,. 2012a. Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation. Pharm Biol 50: 1531-1535.
    • (2012) Pharm Biol , vol.50 , pp. 1531-1535
    • Li, D.1    Mitsuhashi, S.2    Ubukata, M.3
  • 48
    • 84864150240 scopus 로고    scopus 로고
    • Therapeutic effect of 7, 3-Dimethoxy hesperetin on adjuvant arthritis in rats through inhibiting JAK2-STAT3 signal pathway
    • Li R, Cai L, Ren DY, Xie XF, Hu CM, Li J,. 2012b. Therapeutic effect of 7, 3-Dimethoxy hesperetin on adjuvant arthritis in rats through inhibiting JAK2-STAT3 signal pathway. Int Immunopharmacol 14: 157-163.
    • (2012) Int Immunopharmacol , vol.14 , pp. 157-163
    • Li, R.1    Cai, L.2    Ren, D.Y.3    Xie, X.F.4    Hu, C.M.5    Li, J.6
  • 49
    • 84869195059 scopus 로고    scopus 로고
    • 7,3-Dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis
    • Li R, Cai L, Xie XF, Peng L, Wu TN, Li J,. 2013. 7,3-Dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis. Immunopharmacol Immunotoxicol 35: 139-146.
    • (2013) Immunopharmacol Immunotoxicol , vol.35 , pp. 139-146
    • Li, R.1    Cai, L.2    Xie, X.F.3    Peng, L.4    Wu, T.N.5    Li, J.6
  • 50
    • 59749100749 scopus 로고    scopus 로고
    • Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
    • Martinez MC, Fernandez SP, Loscalzo LM, et al,. 2009. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacol Biochem Behav 92: 291-296.
    • (2009) Pharmacol Biochem Behav , vol.92 , pp. 291-296
    • Martinez, M.C.1    Fernandez, S.P.2    Loscalzo, L.M.3
  • 51
    • 24744455436 scopus 로고    scopus 로고
    • Endothelial cell gene regulation
    • Minami T, Aird WC,. 2005. Endothelial cell gene regulation. Trends Cardiovas Med 15:.e1-174.e11.
    • (2005) Trends Cardiovas Med , vol.15 , pp. e1-174e11
    • Minami, T.1    Aird, W.C.2
  • 52
    • 41149119816 scopus 로고    scopus 로고
    • Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells
    • Nizamutdinova IT, Jeong JJ, Xu GH, et al,. 2008. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells. Int Immunopharmacol 8: 670-678.
    • (2008) Int Immunopharmacol , vol.8 , pp. 670-678
    • Nizamutdinova, I.T.1    Jeong, J.J.2    Xu, G.H.3
  • 53
    • 0032212793 scopus 로고    scopus 로고
    • Inhibition of Th1 development mediated by GATA-3 through an IL-4- independent mechanism
    • Ouyang W, Ranganath SH, Weindel K, et al,. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4- independent mechanism. Immunity 9: 745-755.
    • (1998) Immunity , vol.9 , pp. 745-755
    • Ouyang, W.1    Ranganath, S.H.2    Weindel, K.3
  • 54
    • 84908357224 scopus 로고    scopus 로고
    • Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model
    • DOI: 10.1007/s10072-014-1725-5.
    • Oztanir MN, Ciftci O, Cetin A, Aladag MA,. 2014. Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model. Neurol Sci. DOI: 10.1007/s10072-014-1725-5.
    • (2014) Neurol Sci
    • Oztanir, M.N.1    Ciftci, O.2    Cetin, A.3    Aladag, M.A.4
  • 55
    • 84892548573 scopus 로고    scopus 로고
    • Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans
    • Perche O, Vergnaud-Gauduchon J, Morand C, Dubray C, Mazur A, Vasson MP,. 2013. Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans. Clin Nutr 1: 130-135.
    • (2013) Clin Nutr , vol.1 , pp. 130-135
    • Perche, O.1    Vergnaud-Gauduchon, J.2    Morand, C.3    Dubray, C.4    Mazur, A.5    Vasson, M.P.6
  • 56
    • 0033859612 scopus 로고    scopus 로고
    • Flavonoids as antioxidants
    • Pietta PG,. 2000. Flavonoids as antioxidants. J Nat Prod 63: 1035-1042.
    • (2000) J Nat Prod , vol.63 , pp. 1035-1042
    • Pietta, P.G.1
  • 57
    • 84860546997 scopus 로고    scopus 로고
    • Protective Effect of Hesperidin, a Citrus Flavanoglycone, Against gamma-Radiation-Induced Tissue Damage in Sprague-Dawley Rats
    • Pradeep K, Ko KC, Choi MH, Kang JA, Chung YJ, Park SH,. 2012. Protective Effect of Hesperidin, a Citrus Flavanoglycone, Against gamma-Radiation-Induced Tissue Damage in Sprague-Dawley Rats. J Med Food 15: 419-427.
    • (2012) J Med Food , vol.15 , pp. 419-427
    • Pradeep, K.1    Ko, K.C.2    Choi, M.H.3    Kang, J.A.4    Chung, Y.J.5    Park, S.H.6
  • 58
    • 0034883342 scopus 로고    scopus 로고
    • Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency
    • Ramelet AA,. 2001. Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency. Angiology 52: S49-S56.
    • (2001) Angiology , vol.52 , pp. S49-S56
    • Ramelet, A.A.1
  • 62
    • 84875231744 scopus 로고    scopus 로고
    • Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage
    • Sahu BD, Kuncha M, Sindhura GJ, Sistla R,. 2013. Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage. Phytomedicine 20: 453-460.
    • (2013) Phytomedicine , vol.20 , pp. 453-460
    • Sahu, B.D.1    Kuncha, M.2    Sindhura, G.J.3    Sistla, R.4
  • 64
    • 0142060124 scopus 로고    scopus 로고
    • Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line
    • Sakata K, Hirose Y, Qiao Z, Tanaka T, Mori H,. 2003. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett 199: 139-145.
    • (2003) Cancer Lett , vol.199 , pp. 139-145
    • Sakata, K.1    Hirose, Y.2    Qiao, Z.3    Tanaka, T.4    Mori, H.5
  • 65
    • 84870215821 scopus 로고    scopus 로고
    • Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats
    • Shi X, Liao S, Mi H, et al,. 2012. Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats. Molecules 17: 12868-12881.
    • (2012) Molecules , vol.17 , pp. 12868-12881
    • Shi, X.1    Liao, S.2    Mi, H.3
  • 66
    • 84888806341 scopus 로고    scopus 로고
    • Cyclophosphamide altered the myocardial marker enzymes: Protection provoked by Hesperidin in Rats
    • Shrivastava M, Kar V, Shrivastava S,. 2013. Cyclophosphamide altered the myocardial marker enzymes: Protection provoked by Hesperidin in Rats. Int J Phytomed 5: 141-145.
    • (2013) Int J Phytomed , vol.5 , pp. 141-145
    • Shrivastava, M.1    Kar, V.2    Shrivastava, S.3
  • 68
    • 84883743308 scopus 로고    scopus 로고
    • Pharmacokinetics of hesperetin and naringenin in the Zhi Zhu Wan, a traditional chinese medicinal formulae, and its pharmacodynamics study
    • Sun H, Dong T, Zhang A, et al,. 2013. Pharmacokinetics of hesperetin and naringenin in the Zhi Zhu Wan, a traditional chinese medicinal formulae, and its pharmacodynamics study. Phytother Res 27: 1345-1351.
    • (2013) Phytother Res , vol.27 , pp. 1345-1351
    • Sun, H.1    Dong, T.2    Zhang, A.3
  • 69
    • 20444484556 scopus 로고    scopus 로고
    • Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice
    • Verbeek R, Van Tol EAF, Van Noort JM,. 2005. Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice. Biochem Pharmacol 70: 220-228.
    • (2005) Biochem Pharmacol , vol.70 , pp. 220-228
    • Verbeek, R.1    Van Tol, E.A.F.2    Van Noort, J.M.3
  • 70
    • 0038544209 scopus 로고    scopus 로고
    • Mast cells and oral inflammation
    • Walsh LJ,. 2003. Mast cells and oral inflammation. Crit Rev Oral Biol Med 14: 188-198.
    • (2003) Crit Rev Oral Biol Med , vol.14 , pp. 188-198
    • Walsh, L.J.1
  • 71
    • 84859419789 scopus 로고    scopus 로고
    • Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model
    • Wei D, Ci X, Chu X, Wei M, Hua S, Deng X,. 2012. Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model. Inflammation 35: 114-121.
    • (2012) Inflammation , vol.35 , pp. 114-121
    • Wei, D.1    Ci, X.2    Chu, X.3    Wei, M.4    Hua, S.5    Deng, X.6
  • 72
    • 21644479440 scopus 로고    scopus 로고
    • Antioxidant activity of the flavonoid hesperidin in chemical and biological systems
    • Wilmsen PK, Spada DS, Salvador M,. 2005. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J Agric Food Chem 53: 4757-4761.
    • (2005) J Agric Food Chem , vol.53 , pp. 4757-4761
    • Wilmsen, P.K.1    Spada, D.S.2    Salvador, M.3
  • 73
    • 69849110523 scopus 로고    scopus 로고
    • Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium
    • Xu L, Yang ZL, Li P, Zhou YQ,. 2009. Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium. Phytomedicine 16: 989-995.
    • (2009) Phytomedicine , vol.16 , pp. 989-995
    • Xu, L.1    Yang, Z.L.2    Li, P.3    Zhou, Y.Q.4
  • 74
    • 84883010397 scopus 로고    scopus 로고
    • Hesperidin metabolite hesperetin 7-O-glucuronide, but not hesperetin 3'-O-glucuronide, exerts hypotensive, vasodiatory, and anti-inflammatory activities
    • Yamamoto M, Jokura H, Hashizume K, et al,. 2013. Hesperidin metabolite hesperetin 7-O-glucuronide, but not hesperetin 3'-O-glucuronide, exerts hypotensive, vasodiatory, and anti-inflammatory activities. Food Funct 4: 1346-1351.
    • (2013) Food Funct , vol.4 , pp. 1346-1351
    • Yamamoto, M.1    Jokura, H.2    Hashizume, K.3
  • 75
    • 84862960597 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: An ex vivo approach
    • Yang HL, Chen SC, Senthil Kumar KJ, et al,. 2012. Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: An ex vivo approach. J Agric Food Chem 60: 522-532.
    • (2012) J Agric Food Chem , vol.60 , pp. 522-532
    • Yang, H.L.1    Chen, S.C.2    Senthil Kumar, K.J.3
  • 76
    • 34147177149 scopus 로고    scopus 로고
    • The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro
    • Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST,. 2007. The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro. Life Sci 80: 1821-1831.
    • (2007) Life Sci , vol.80 , pp. 1821-1831
    • Yeh, C.C.1    Kao, S.J.2    Lin, C.C.3    Wang, S.D.4    Liu, C.J.5    Kao, S.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.