Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model

Neurological Sciences

Volumn 35, Issue 9, 2014, Pages 1393-1399

  Oztanir, M Namik ^a   Ciftci, Osman ^a   Cetin, Asli ^a   Aladag, M Arif ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

C57BL J6 mice; Global cerebral I R; Hesperidin; Neuronal damage; Oxidative stress

Indexed keywords

HESPERIDIN; SCAVENGER; CASPASE 3; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HESPERADIN; INDOLE DERIVATIVE; NEUROPROTECTIVE AGENT; SULFONAMIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN TISSUE; C57BL 6 MOUSE; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MOUSE; NERVE INJURY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; REPERFUSION INJURY; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN ISCHEMIA; CASPASE 3; CATALASE; DISEASE MODELS, ANIMAL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INDOLES; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; REPERFUSION INJURY; SULFONAMIDES; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84908357224     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-014-1725-5     Document Type: Article

References (22)

1. Zhang S, Qi Y, Xu Y, Han X, Peng J, Liu K, Sun CK (2013) Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. Neurochem Int 63(5):522-532. doi:10.1016/j.neuint.2013.08.008 (Epub 2013 Sep 4)
2. Wang B, Wu N, Liang F, Zhang S, Ni W, Cao Y, Xia D, Xi H (2013) 7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats. J Mol Histol (Epub ahead of print)
3. Zhai X, Chen X, Shi J, Shi D, Ye Z, Liu W, Li M, Wang Q, Kang Z, Bi H, Sun X (2013) Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. Free Radic Biol Med 65:731-741
4. Heo JH, Han SW, Lee SK (2005) Free radicals as triggers of brain edema formation after stroke. Free Radic Biol Med 39:51-70
5. Margaill I, Plotkine M, Lerouet D (2005) Antioxidant strategies in the treatment of stroke. Free Radic Biol Med 39:429-443 (Pubitemid 41021642)
6. Oztanir MN, Ciftci O, Cetin A, Durak MA, Basak N, Akyuva Y (2014) The beneficial effects of 18β-glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model. Neurol Sci. doi:10.1007/s10072-014-1685-9
7. Aras M, Altaş M, Meydan S, Nacar E, Karcioǧlu M, Ulutaş KT, Serarslan Y. (2014) Effects of ebselen on ischemia/reperfusion injury in rat brain. Int J Neurosci (Epub ahead of print)
8. Ciftci O, Ozdemir I, Aydin M, Beytur A (2012) Beneficial effects of chrysin on the reproductive system of adult male rats. Andrologia 44(3):181-186. doi:10.1111/j.1439-0272.2010.01127.x (Epub 2011 Mar 7)
9. Kamisli S, Ciftci O, Kaya K, Cetin A, Kamisli O, Ozcan C (2013) Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats. Toxicol Ind Health (Epub ahead of print)
10. Gaur V, Kumar A (2010) Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction. Pharmacol Rep 62(4):635-648
11. Shagirtha K, Pari L (2011) Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats. Ecotoxicol Environ Saf 74(7):2105-2111 (Epub 2011 Jun 29)
12. Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ, Rice-Evans C (2003) Interaction between flavonoids and the blood-brain barrier: in vitro studies. J Neurochem 85(1):180-192. doi:10.1046/j.1471-4159.2003.01652.x. PMID12641740 (Pubitemid 36389708)
13. Hwang SL, Shih PH, Yen GC (2012) Neuroprotective effects of citrus flavonoids. J Agric Food Chem 60(4):877-885 (Epub 2012 Jan 23)
14. Yonekura I, Kawahara N, Nakatomi H, Furuya K, Kirino T (2004) A model of global cerebral ischemia in C57 BL/6 mice. J Cereb Blood Flow Metab 24:151-158 (Pubitemid 38199108)
15. Ciftci O, Ozdemir I, Vardi N, Beytur A, Oguz F (2012) Ameliorating effects of quercetin and chrysin on 2,3,7,8-tetrachlo-rodibenzo- p-dioxin-induced nephrotoxicity in rats. Toxicol Ind Health 28:947-954
16. Oguzturk H, Ciftci O, Aydin M, Timurkaan N, Beytur A, Yilmaz F (2012) Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats. Andrologia 44:243-249
17. Chen XH, Lin ZZ, Liu AM, Ye JT, Luo Y, Luo YY, Mao XX, Liu PQ, Pi RB (2010) The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischaemia in C57 BL/6 J mice. J Pharm Pharmacol 62:915-923
18. Zhan C, Yang J (2006) Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Pharmacol Res 53:303-309 (Pubitemid 43247544)
19. Guo Y, Chen ZW (2008) Protective effects of total flavones of Rhododendra on cerebral ischemia reperfusion injury. Am J Chin Med 36:343-354 (Pubitemid 351712440)
20. Gandhi C, Upaganalawar A, Balaraman R (2009) Protection against invivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin. Free Radic Res 43(9):817-827. doi:10.1080/10715760903071656 (Epub 2009 Jul 3)
21. Sunil AG, Kesavanarayanan KS, Kalaivani P, Sathiya S, Ranju V, Priya RJ, Pramila B, Paul FD, Venkhatesh J, Babu CS (2011) Total oligomeric flavonoids of Cyperus rotundus ameliorates neurological deficits, excitotoxicity and behavioral alterations induced by cerebral ischemic-reperfusion injury in rats. Brain Res Bull 84:394-405
22. Wang JJ, Cui P (2013) Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway. J Asian Nat Prod Res 15:1023-1037