Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice

Fundamental and Clinical Pharmacology

Volumn 25, Issue 1, 2011, Pages 91-98

  Kamaraj, Sattu ^a   Anandakumar, Pandi ^a   Jagan, Sundaram ^a   Ramakrishnan, Gopalakrishnan ^a   Devaki, Thiruvengadam ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

ETC complexes; Hesperidin; Lipid peroxidation; Lung cancer; Mitochondria; TCA cycle enzymes

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BENZO[A]PYRENE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HESPERIDIN; ISOCITRATE DEHYDROGENASE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PREVENTION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; LUNG CANCER; LUNG CARCINOGENESIS; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY CHAIN;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; BENZO(A)PYRENE; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; HESPERIDIN; LIPID PEROXIDATION; LUNG NEOPLASMS; MALE; MICE; MITOCHONDRIA; NEOPLASMS, EXPERIMENTAL;

EID: 78650929774     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2010.00812.x     Document Type: Article

References (47)

1. Parkin D.M., Bray F., Ferlay J., Pisani P. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer (2001) 94 153-156.
2. Wynder E.L., Hoffmann D. A study of tobacco carcinogenesis. VII. The role of higher polycyclic hydrocarbons. Cancer (1959) 12 1079-1086.
3. Van Duuren B.L., Goldschmidt B.M. Cocarcinogenic and tumor-promoting agents in tobacco carcinogenesis. J. Natl Cancer Inst. (1976) 56 1237-1242.
4. Hecht S.S. Tobacco smoke carcinogens and lung cancer. J. Natl Cancer Inst. (1999) 91 1194-1210.
5. Osborn M.R., Beland F.A., Harvey R.G., Brookes P. The reaction of BaPDE with DNA. Int. J. Cancer (1976) 18 362-368.
6. Hecht S.S. Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke. Environ. Health Perspect. (1997) 105 955-963.
7. Montanari A., Chen J., Widmer W. Citrus flavonoids: a review of past biological activity against disease. Discovery of new flavonoids from Dancy tangerine cold pressed peel oil solids and leaves. Adv. Exp. Med. Biol. (1998) 439 103-116.
8. Tian Q., Miller E.G., Ahmad H., Tang L., Patil B.S. Differential inhibition of human cancer cell proliferation by citrus limonoids. Nutr. Cancer (2001) 40 180-184.
9. Winawer S., Fletcher R., Rex D. et al. Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence. Gastroenterology (2003) 124 544-560.
10. Galati E.M., Monforte M.T., Kirjavainen S., Forestieri A.M., Trovato A., Tripodo M.M. Biological effects of hesperidin, a citrus flavonoid. (Note I): antiinflammatory and analgesic activity. Farmaco (1994) 40 709-712.
11. Ratty A.K., Das N.P. Effects of flavonoids on nonenzymatic lipid peroxidation: structure-activity relationship. Biochem. Med. Metab. Biol. (1988) 39 69-79.
12. Fujiki H., Horiuchi T., Yamashita K. et al. Inhibition of tumor promotion by flavonoids. Prog. Clin. Biol. Res. (1986) 213 429-440.
13. Huang M.T., Wood A.W., Newmark H.L. et al. Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids. Carcinogenesis (1983) 4 1631-1637.
14. Tanaka T. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination. Cancer Res. (1997) 57 246-252.
15. Kamaraj S., Ramakrishnan G., Anandakumar P., Jagan S., Devaki T. Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest. New Drugs (2009) 27 214-222.
16. Garcia-Ruiz C., Colell A., Morales A., Kaplowitz N., Fernandez-Checa J.C. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol. Pharmacol. (1995) 48 825-834.
17. Kamaraj S., Vinodhkumar R., Anandakumar P., Jagan S., Ramakrishnan G., Devaki T. The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol. Pharm. Bull. (2007) 30 2268-2273.
18. Johnson D., Lardy H. Isolation of liver and kidney mitochondria. Methods Enzymol. (1967) 10 94-96.
19. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. (1951) 193 265-275.
20. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. (1979) 95 351-358.
21. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. (1974) 47 469-474.
22. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase, 1973 by the American Association for the Advancement of Science, 1973, pp. 588-590.
23. Staal G.E., Visser J., Veeger C. Purification and properties of glutathione reductase of human erythrocytes. Biochim. Biophys. Acta (1969) 185 39-48.
24. Moron M.S., Depierre J.W., Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim. Biophys. Acta (1979) 582 67-78.
25. Desai I.D. Vitamin E analysis methods for animal tissues. Methods Enzymol. (1984) 105 138-147.
26. Omaye S.T., Turnbull J.D., Sauberlich H.E. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol. (1979) 62 3-11.
27. Sinha A.K. Colorimetric assay of catalase. Anal. Biochem. (1972) 47 389-394.
28. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. (1974) 249 7130-7139.
29. King J. The dehydrogenases or oxidoreductases-lactate dehydrogenase. Practical clinical enzymology. Nostrand Company Limited, London, 1965, 83-93.
30. Reed L.J., Mukherjee B.B. a-Ketoglutarate dehydrogenase complex from Escherichia coli. Methods Enzymol. (1969) 13 55-61.
31. Slater E.C., Borner W.D. Jr. The effect of fluoride on the succinic oxidase system. Biochem. J. (1952) 52 185-196.
32. Mehler A.H., Kornberg A., Grisolia S., Ochoa S. The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate. J. Biol. Chem. (1948) 174 961-977.
33. Birch-Machin M.A., Briggs H.L., Saborido A.A., Bindoff L.A., Turnbull D.M. An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria. Biochem Med Metab Biol (1994) 51 35-42.
34. Krahenbuhl S., Talos C., Wiesmann U., Hoppel C.L. Development and evaluation of a spectrophotometric assay for complex III in isolated mitochondria, tissues and fibroblasts from rats and humans. Clin. Chim. Acta (1994) 230 177-187.
35. Capaldi R.A., Marusich M.F., Taanman J.W. Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells. Methods Enzymol. (1995) 260 117-132.
36. Smith L. Spectrophotometric assay of cytochrome c oxidase. Methods Biochem. Anal. (1955) 2 427-434.
37. Williamson J.R., Corkey B.E. Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods. Methods Enzymol. (1969) 13 434-513.
38. Thiberville L., Payne P., Vielkinds J. et al. Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus. Cancer Res. (1995) 55 5133-5139.
39. Virmani A.K., Fong K.M., Kodagoda D. et al. Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types. Genes Chromosomes Cancer (1998) 21 308-319.
40. Hu G., Cassano P.A. Antioxidant nutrients and pulmonary function: the Third National Health and Nutrition Examination Survey (NHANES III). Am. J. Epidemiol. (2000) 151 975-981.
41. Senthilnathan P., Padmavathi R., Magesh V., Sakthisekaran D. Chemotherapeutic efficacy of paclitaxel in combination with Withania somnifera on benzo(a)pyrene induced experimental lung cancer. Cancer Sci. (2006) 97 658-664.
42. Veena C.K., Josephine A., Preetha S.P., Rajesh N.G., Varalakshmi P. Mitochondrial dysfunction in an animal model of hyperoxaluria: a prophylactic approach with fucoidan. Eur. J. Pharmacol. (2008) 579 330-336.
43. Anandakumar P., Kamaraj S., Jagan S., Ramakrishnan G., Vinodhkumar R., Devaki T. Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice. Phytother Res (2008) 22 529-533.
44. Selvendiran K., Senthilnathan P., Magesh V., Sakthisekaran D. Modulatory effect of Piperine on mitochondrial antioxidant system in Benzo(a)pyrene-induced experimental lung carcinogenesis. Phytomedicine (2004) 11 85-89.
45. Pedersen P.L. Tumor mitochondria and the bioenergetics of cancer cells. Prog. Exp. Tumor Res. (1978) 22 190-274.
46. Thirunavukkarasu C., Singh J.P.V., Selvendiran K., Sakthisekaran D. Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats. Cell Biochem. Funct. (2001) 19 265-271.
47. Senthilnathan P., Padmavathi R., Magesh V., Sakthisekaran D. Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer. Life Sci. (2006) 78 1010-1014.