Hesperidin attenuates benzo[α] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance

Toxicology and Industrial Health

Volumn 25, Issue 6, 2009, Pages 417-427

  Arafa, Hmm ^a   Aly, Haa ^a   Abd Ellah, Mf ^a   El Refaey, Hm ^a  

^a Al Azhar University   (Egypt)

Author keywords

antioxidant; benzo pyrene; epididymal function; hesperidin; testicular toxicity

Indexed keywords

BENZO[A]PYRENE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HESPERIDIN; LACTATE DEHYDROGENASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDIDYMIS; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NECROBIOTIC DISORDER; NONHUMAN; RAT; SEMINIFEROUS TUBULE; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS FUNCTION; TESTIS INJURY; TESTIS WEIGHT;

ANIMALS; ANTIOXIDANTS; BENZO(A)PYRENE; CARCINOGENS; DISEASE MODELS, ANIMAL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HESPERIDIN; L-LACTATE DEHYDROGENASE; MALE; MALONDIALDEHYDE; NECROSIS; ORGAN SIZE; RATS; SEMINIFEROUS TUBULES; SPERM COUNT; SPERMATOCYTES; SUPEROXIDE DISMUTASE; TESTICULAR DISEASES; TESTIS;

ANIMALIA; CITRUS; RATTUS;

EID: 68949125047     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233709106624     Document Type: Article

References (55)

1. Abd-Allah AR, Aly HA, Moustafa AM, Abdel-Aziz AA, Hamada FM (2000) Adverse testicular effects of some quinolone members in rats. Pharmacol Res 41: 211–219.
2. Abdel-Wahab MH (2003) Testicular toxicity of dibromoacetonitrile and possible protection by tertiary butylhydroquinone. Pharmacol Res 47: 509–515.
3. Akpan V, Huang S, Lodovici M, Dolara P (2006) High levels of carcinogenic polycyclic aromatic hydrocarbons (PAH) in 20 brands of Chinese cigarettes. J Appl Toxicol 26: 480–483.
4. Amann RP, Johnson L, Thompson DL, Pickett BW (1976) Daily spermatozoal production, epididymal spermatozoal reserves and transit time of spermatozoa through the epididymis of the rhesus monkey. Biol Reprod 15: 586–592.
5. Amann RP, Kavanaugh JF, Griel LC, Voglmayr JK (1974) Sperm production of Holstein bulls determined from testicular spermatid reserves, after cannulation of rete testis or vas deferens, and by daily ejaculation. J Dairy Sci 57: 93–99.
6. Anderson RA, Oswald C, Willis BR, Zaneveld LJ (1983) Relationship between semen characteristics and fertility in electroejaculated mice. J Reprod Fertil 68: 1–7.
7. Archibong AE, Inyang F, Ramesh A, Greenwood M, Nayyar T, Kopsombut P (2002) Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene. Reprod Toxicol 16: 801–808.
8. Archibong AE, Ramesh A, Niaz MS, Brooks CM, Roberson SI, Lunstra DD (2008) Effects of benzo(a)pyrene on intra-testicular function in F-344 rats. Int J Environ Res Public Health 5: 32–40.
9. Balakrishnan A, Menon VP (2007) Antioxidant properties of hesperidin in nicotine-induced lung toxicity. Fundam Clin Pharmacol 21: 535–546.
10. Banchroft JD, Stevens A, Turner DR (1996) Theory and Practice of Histological Techniques, Fourth ed. New York: Churchil Livingstone, pp. 1–88.
11. Casini ML, Gerli S, Unfer V (2006) An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study. Gynecol Endocrinol 22: 399–401.
12. Cheever KL, Weigel WW, Rechards DE, Lal JB, Plotnick HB (1989) Testicular effect of bis (2-methoxyethyl) ether in the adult male rat. Toxicol Ind Health 5: 1099–1109.
13. Choi EJ (2008) Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice. Life Sci 82: 1059–1064.
14. de Lamirande E, Gagnon C (1992) Reactive oxygen species and human spermatozoa. II. Depletion of adenosine triphosphate plays an important role in the inhibition of sperm motility. J Androl 13: 379–386.
15. Dhawan K, Kumar S, Sharma A (2002) Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats. J Med Food 5: 43–48.
16. Doostdar H, Burke MD, Mayer RT (2000) Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1. Toxicology 144: 31–38.
17. Friesen MC, Demers PA, Spinelli JJ, Le ND (2008) Adequacy of benzo(a)pyrene and benzene soluble materials as indicators of exposure to polycyclic aromatic hydrocarbons in a Söderberg aluminum smelter. J Occup Environ Hyg 5: 6–14.
18. Garg A, Garg S, Zaneveld LJ, Singla AK (2001) Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res 15: 655–669.
19. Goel HC, Samanta N, Kannan K, Kumar IP, Bala M (2006) Protection of spermatogenesis in mice against gamma ray induced damage by Hippophae rhamnoides. Andrologia 38: 199–207.
20. Habig WH, Pabst MJ, Jacob WB (1974) Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130–7139.
21. Hecht SS (2003) Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 3: 733–744.
22. Hollman PCH, Batan MB (1997) Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 51: 305–310.
23. Inyang F, Ramesh A, Kopsombut P, Niaz MS, Hood DB, Nyanda AM (2003) Disruption of testicular steroidogenesis and epididymal function by inhaled benzo-(a)pyrene. Reprod Toxicol 17: 527–537.
24. Irwin RJ, Van Mouwerik M, Stevens L, Seese MD, Basham W (1997) Environmental Contaminants Encyclopedia: Benzo[a]pyrene (BaP) Entry. National Park Service, Water Resources Divisions, Water Operations Branch, Colorado, USA.
25. Izawa H, Kohara M, Aizawa K, Suganuma H, Inakuma T, Watanabe G (2008) Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles. Biosci Biotechnol Biochem 72: 1235–1241.
26. Izawa H, Kohara M, Watanabe G, Taya K, Sagai M (2007) Effects of diesel exhaust particles on the male reproductive system in strains of mice with different aryl hydrocarbon receptor responsiveness. J Reprod Dev 53: 1191–1197.
27. Jeng HA; Yu L; (2008) Alteration of sperm quality and hormone levels by polycyclic aromatic hydrocarbons on airborne particulate particles. J Environ Sci Health A Tox Hazard Subst Environ Eng 43: 675–681.
28. Jung UJ, Lee MK, Park YB, Kang MA, Choi MS (2006) Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 38: 1134–1145.
29. Kamaraj S, Ramakrishnan G, Anandakumar P, Jagan S, Devaki T (2009) Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs 27: 214–222.
30. Kim HS, Kwack SJ, Lee BM (2008) Lipid peroxidation, antioxidant enzymes, and benzo[a]pyrene-quinones in the blood of rats treated with benzo[a]pyrene. Chem Biol Interact 127: 139–150.
31. Knuckles ME, Inyang F, Ramesh A (2008) Acute and subchronic oral toxicities of benzo[a]pyrene in F-344 rats. Toxicol Sci 61: 382–388.
32. Lee BM, Shim GA (2007) Dietary exposure estimation of benzo[a]pyrene and cancer risk assessment. J Toxicol Environ Health A 70: 1391–1394.
33. Li R, Li J, Cai L, Hu CM, Zhang L (2008) Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms. J Pharm Pharmacol 60: 221–228.
34. Lowry OH, Rosenbrough NJ, Farr AI, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275.
35. MacKenzie KM, Angevine DM (1981) Infertility in mice exposed in utero to benzo(a)pyrene. Biol Reprod 24: 183–191.
36. Manna P, Sinha M, Sil PC (2008) Protection of arsenic-induced testicular oxidative stress by arjunolic acid. Redox Rep 13: 67–77.
37. Marklund SL (1985) Superoxide dismutase isoenzymes in tissues and plasma from New Zealand Black mice. Mutat Res 148: 129–134.
38. Mi Y, Zhang C, Taya K (2007) Quercetin protects spermatogonial cells from 2,4-d-induced oxidative damage in embryonic chickens. J Reprod Dev 53: 749–754.
39. Mori K, Kaido M, Fujishiro K, Inoue N, Ide Y, Koide O (1991) Preventive effects of methylcobalamin on the testicular damage induced by ethylene oxide. Arch Toxicol 65: 396–401.
40. Narayana K (2008) An aminoglycoside antibiotic gentamycin induces oxidative stress, reduces antioxidant reserve and impairs spermatogenesis in rats. J Toxicol Sci 33: 85–96.
41. Nebert DW, Roe AL, Dieter MZ, Solis WA, Yang Y, Dalton TP (2000) Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem Pharmacol 59: 65–85.
42. Pradeep K, Park SH, Ko KC (2008) Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats. Eur J Pharmacol 587: 273–280.
43. Ramadan LA, Abd-Allah AR, Aly HA, Saad-el-Din AA (2002) Testicular toxicity effects of magnetic field exposure and prophylactic role of coenzyme Q10 and L-carnitine in mice. Pharmacol Res 46: 363–370.
44. Ramesh A, Inyang E, Hood DB, Archibong AE, Knuckles ME, Nyanda AM (2001) Metabolism, bioavailability and toxicokinetics of benzo(alpha)pyrene in F-344 rats following oral administration. Exp Toxicol Pathol 53: 275–290.
45. Ramesh A, Inyang F, Lunstra DD, Niaz MS, Kopsombut P, Jones KM (2008) Alteration of fertility endpoints in adult male F-344 rats by subchronic exposure to inhaled benzo(a)pyrene. Exp Toxicol Pathol 60: 269–280.
46. Raychoudhury SS, Kubinski D (2003) Polycyclic aromatic hydrocarbon-induced cytotoxicity in cultured rat Sertoli cells involves differential apoptotic response. Environ Health Perspect 111: 33–38.
47. Regoli F, Winston GW, Gorbi S, Frenzilli G, Nigro M, Corsi I (2003) Integrating enzymatic responses to organic chemical exposure with total oxyradical absorbing capacity and DNA damage in the European eel Anguilla anguilla. Environ Toxicol Chem 22: 2120–2129.
48. Romero DL, Mounho BJ, Lauer FT, Born JL, Burchiel SW (1997) Depletion of glutathione by benzo(a)pyrene metabolites, ionomycin, thapsigargin, and phorbol myristate in human peripheral blood mononuclear cells. Toxicol Appl Pharmacol 144: 62–69.
49. Roseff SJ (2002) Improvement in sperm quality and function with French maritime pine tree bark extract. J Reprod Med 47: 821–824.
50. Ross JA, Kasum CM (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22: 19–34.
51. Sedlak J, Lindsay RH (1968) Estimation of total protein sulfhydryl groups in tissues With Ellman, s reagent. Anal Biochem 25: 192–205.
52. Uchiyama M, Mihara M (1978) Determination of malonyldialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86: 271–278.
53. Wang C, Zhao Y, Zheng R, Ding X, Wei W, Zuo Z (2006) Effects of tributyltin, benzo[a]pyrene, and their mixture on antioxidant defense systems in Sebastiscus marmoratus. Ecotoxicol Environ Saf 65: 381–387.
54. Yeh YC, Lai HC, Ting CT, Lee WL, Wang LC, Wang KY (2007) Protection by doxycycline against doxorubicin-induced oxidative stress and apoptosis in mouse testes. Biochem Pharmacol 74: 969–980.
55. Yoshino I, Kometani T, Shoji F, Osoegawa A, Ohba T, Kouso H (2007) Induction of epithelial-mesenchymal transition-related genes by benzo[a]pyrene in lung cancer cells. Cancer 110: 369–374.