Mutation in insulin receptor attenuates oxidative stress and apoptosis in pancreatic beta-cells induced by nutrition excess: Reduced insulin signaling and ROS

Hormone and Metabolic Research

Volumn 47, Issue 3, 2015, Pages 176-183

  Tachibana, K ^a   Sakurai, K ^a   Yokoh, H ^a   Ishibashi, T ^a   Ishikawa, K ^a   Shirasawa, T ^b,c   Yokote, K ^a  

^a CHIBA UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

endoplasmic reticulum stress; insulin resistance; manganese superoxide dismutase

Indexed keywords

CHAPERONE; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HUMAN INSULIN; INSULIN; INSULIN RECEPTOR; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CALORIC INTAKE; CELL AGING; CELL DAMAGE; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE MUTATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIPID DIET; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OVERNUTRITION; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SIGNAL TRANSDUCTION; WILD TYPE; ADVERSE EFFECTS; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; MUTATION; PATHOPHYSIOLOGY;

MUS;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MUTATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 84924254589     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0034-1389990     Document Type: Article

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