MnSOD mimic compounds can counteract mechanical stress and islet β cell apoptosis, although at appropriate concentration ranges

Journal of Cellular Physiology

Volumn 212, Issue 2, 2007, Pages 432-438

  Pedullà, Marcella ^a   D'Aquino, Riccardo ^a   Desiderio, Vincenzo ^a   De Francesco, Francesco ^a   Puca, Andrew ^b   Papaccio, Gianpaolo ^a,b  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Temple University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; MANGANESE SUPEROXIDE DISMUTASE; RECOMBINANT INTERLEUKIN 1BETA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ISOLATION; CHEMICAL STRESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; MECHANICAL STRESS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASES; CELL CULTURE TECHNIQUES; CELL SEPARATION; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FAS LIGAND PROTEIN; INSULIN; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; ISLETS OF LANGERHANS; METALLOPORPHYRINS; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN BIOSYNTHESIS; RATS; RATS, WISTAR; RNA, MESSENGER; STRESS, MECHANICAL; SUPEROXIDE DISMUTASE; TRANSCRIPTION, GENETIC;

EID: 34347394553     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21034     Document Type: Article

References (27)

1. Asayama K, Kooy NW, Burr IM. 1986. Effect of vitamin E deficiency and selenium deficiency on insulin secretory reserve and free radical scavenging systems in islets: Decrease of islet manganosuperoxide dismutase. J Lab Clin Med 107:459-464.
2. Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M. 2003. Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells. Diabetes 52:93-101.
3. Bendtzen K, Mandrup-Poulsen T, Nerup J, Nielsen JH, Dinarello CA, Svenson M. 1986. Cytotoxicity of human p17 interleukin-1 for pancreatic islets of Langerhans. Science 232:1545-1547.
4. Bernard D, Monte D, Vandenbunder B, Abbadie C. 2002. The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD. Oncogene 21:4392-4402.
5. Bertera S, Crawford ML, Alexander AM, Papworth GD, Watkins SC, Robbins PD, Trucco M. 2003. Gene transfer of MnSOD extends islet graft function in a mouse model of autoimmune diabetes. Diabetes 52:387-393.
6. Borg LAH, Cagliero E, Sandler S, Welsh N, Eizirik DL. 1992. Interleukin-1β increases the activity of superoxide dismutase in rat pancreatic islets. Endocrinology 130:2851-2857.
7. Bottino R, Fernandez LA, Ricordi C, Lehmann R, Tsan MF, Oliver R, Inverardi L. 1998. Transplantation of allogeneic islets of Langerhans in the rat liver: Effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 41:316-323.
8. Bottino R, Balamurugan AN, Bertera S, Pietropaolo M, Trucco M, Piganelli JD. 2002. Preservation of human islet cell functional mass by antioxidative action of a novel SOD mimic compound. Diabetes S1:2561-2567.
9. Chen H, Xiaoyan LiEpstein PN. 2005. MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity. Diabetes 54:1437-1445.
10. Gandy SE, Buse MG, Crouch RK. 1982. Protective role of superoxide dismutase against diabetogenic drugs. J Clin Invest 70:650-658.
11. Grankvist K, Marklund SL, Taljedal IB. 1981. Cu-Zn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J 199:393-398.
12. Kim H-P, Roe J-H, Chock PB, Yim MB. 1999. Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate. J Biol Chem 274:37455-37460.
13. Ling Z, de Castelee MV, Eizirik DL, Pipeleers DG. 2000. IL-1β-induced alteration in a β cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis. Diabetes 49:340-3345.
14. Malaisse WJ, Malaisse-Lagae F, Sener A, Pipeleers DG. 1982. Determinants of the selective toxicity of alloxan to the pancreatic β cell. Proc Natl Acad Sci USA 79:927-930.
15. Papaccio G. 1991. Prevention of low dose streptozocin-induced diabetes by acetyl-homocysteine-thiolactone. Diabetes Res Clin Pr 13:95-102.
16. Papaccio G, Pisanti FA, Frascatore S. 1986. Acetyl-homocysteine- thiolactone-induced increase of superoxide dismutase counteracts the effect of subdiabetogenic doses of streptozocin. Diabetes 35:470-474.
17. Papaccio G, Latronico MVG, Frascatore S, Pisanti FA. 1991. Superoxide dismutase in low-dose streptozocin-treated mice. A dynamic time-course study. Int J Pancreatol 10: 253-260.
18. Papaccio G, Frascatore S, Pisanti FA, Latronico MVG, Linn T. 1995. Superoxide dismutase in the nonobese diabetic (NOD) mouse: A dynamic time-course study. Life Sci 56:2223-2228.
19. Papaccio G, Latronico MGV, Pisanti FA, Federlin K, Linn T. 1998. Adhesion molecules and microvascular changes in the nonobese diabetic (NOD) mouse pancreas. An NO-inhibitor (L-NAME) is unable to block adhesion inflammation-induced activation. Autoimmunity 27:65-77.
20. Papaccio G, Nicoletti F, Pisanti FA, Galdieri M, Bendtzen K. 2002. An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells. Mol Med 8:536-545.
21. Papaccio G, Graziano A, d'Aquino R, Valiante S, Naro F. 2005a. A biphasic role of nuclear transcription factor (NF)-kB in the islet β-cell apoptosis induced by Interleukin (IL)-1β. J Cell Physiol 204:124-130.
22. Papaccio G, Graziano A, Valiante S, d'Aquino R, Travail A, Nicoletti F. 2005b. Interleukin (IL)-1β toxicity to islet p cells: Efaroxan exerts a complete protection. J Cell Physiol 203: 94-102.
23. Paraskevas S, Maysinger D, Wang R, Duguid TP, Rosenberg L. 2000. Cell loss in isolated human islets occurs by apoptosis. Pancreas 20:270-276.
24. Pileggi A, Molano RD, Berney T, Cattan P, Vizzardelli C, Oliver R, Franker C, Ricordi C, Pastori RL, Bach FH, Inverardi L. 2001. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 50:1983-1991.
25. Pisanti FA, Frascatore S, Papaccio G. 1988. Superoxide dismutase activity in the BB rat: A dynamic time-course study. Life Sci 43:1625-1632.
26. Stevens RB, Ansite JD, Mills CD, Lokeh A, Rossini TJ, Saxena M, Brown RR, Sutherland DE. 1996. Nitric oxide mediates early dysfunction of rat and mouse islets after transplantation. Transplantation 61:1740-1749.
27. Todaro M, Di Gaudio F, Lavitrano M, Stassi G, Papaccio G. 2003. Islet β-cell apoptosis triggered in vivo by interleukin-1β is not related to the inducible nitric oxide synthase pathway: Evidence for mitochondrial function impairment and lipoperoxidation. Endocrinology 144:4264-4271.