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Volumn 16, Issue 1, 2015, Pages

Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

Author keywords

Aging; Amino acids; C. elegans; Histidine; Lifespan; Mitochondrial; Proline; Serine; Tryptophan

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE; ALPHA SYNUCLEIN; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; CYSTEINE; CYTOCHROME C OXIDASE; DEXTRO ASPARTIC ACID; DEXTRO GLUTAMIC ACID; DEXTRO SERINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; HYPOXIA INDUCIBLE FACTOR; INITIATION FACTOR; LEUCINE; LYSINE; METHIONINE; PHENYLALANINE; POLYGLUTAMINE; PROLINE; SERINE; THREONINE; TRICARBOXYLIC ACID; TRYPTOPHAN; TYROSINE; VALINE; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; HIF-1 PROTEIN, C ELEGANS; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SKN-1 PROTEIN, C ELEGANS; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR;

EID: 84924145639     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/s12863-015-0167-2     Document Type: Article
Times cited : (153)

References (83)
  • 1
    • 67650927732 scopus 로고    scopus 로고
    • The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans
    • Swire J, Fuchs S, Bundy JG, Leroi AM. The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans. Proc Biol Sci. 2009;276(1668):2747-54.
    • (2009) Proc Biol Sci , vol.276 , Issue.1668 , pp. 2747-2754
    • Swire, J.1    Fuchs, S.2    Bundy, J.G.3    Leroi, A.M.4
  • 3
    • 79851507742 scopus 로고    scopus 로고
    • Plasma amino acid imbalance: dangerous in chronic diseases?
    • Roth E, Druml W. Plasma amino acid imbalance: dangerous in chronic diseases? Curr Opin Clin Nutr Metab Care. 2011;14(1):67-74.
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , Issue.1 , pp. 67-74
    • Roth, E.1    Druml, W.2
  • 5
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996;273(5271):59-63.
    • (1996) Science , vol.273 , Issue.5271 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 6
    • 33745597874 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection
    • Pamplona R, Barja G. Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. Biochim Biophys Acta. 2006;1757(5-6):496-508.
    • (2006) Biochim Biophys Acta , vol.1757 , Issue.5-6 , pp. 496-508
    • Pamplona, R.1    Barja, G.2
  • 7
    • 23844464540 scopus 로고    scopus 로고
    • Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
    • Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell. 2005;4(3):119-25.
    • (2005) Aging Cell , vol.4 , Issue.3 , pp. 119-125
    • Miller, R.A.1    Buehner, G.2    Chang, Y.3    Harper, J.M.4    Sigler, R.5    Smith-Wheelock, M.6
  • 8
  • 9
    • 0023839144 scopus 로고
    • Histology and survival in age-delayed low-tryptophan-fed rats
    • Ooka H, Segall PE, Timiras PS. Histology and survival in age-delayed low-tryptophan-fed rats. Mech Ageing Dev. 1988;43(1):79-98.
    • (1988) Mech Ageing Dev , vol.43 , Issue.1 , pp. 79-98
    • Ooka, H.1    Segall, P.E.2    Timiras, P.S.3
  • 10
    • 0017111106 scopus 로고
    • Patho-physiologic findings after chronic tryptophan deficiency in rats: a model for delayed growth and aging
    • Segall PE, Timiras PS. Patho-physiologic findings after chronic tryptophan deficiency in rats: a model for delayed growth and aging. Mech Ageing Dev. 1976;5(2):109-24.
    • (1976) Mech Ageing Dev , vol.5 , Issue.2 , pp. 109-124
    • Segall, P.E.1    Timiras, P.S.2
  • 11
    • 67651162109 scopus 로고    scopus 로고
    • Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae
    • Alvers AL, Fishwick LK, Wood MS, Hu D, Chung HS, Dunn Jr WA, et al. Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell. 2009;8(4):353-69.
    • (2009) Aging Cell , vol.8 , Issue.4 , pp. 353-369
    • Alvers, A.L.1    Fishwick, L.K.2    Wood, M.S.3    Hu, D.4    Chung, H.S.5    Dunn, W.A.6
  • 12
    • 84892572891 scopus 로고    scopus 로고
    • Independent and additive effects of glutamic acid and methionine on yeast longevity
    • Wu Z, Song L, Liu SQ, Huang D. Independent and additive effects of glutamic acid and methionine on yeast longevity. PLoS One. 2013;8(11):e79319.
    • (2013) PLoS One , vol.8 , Issue.11
    • Wu, Z.1    Song, L.2    Liu, S.Q.3    Huang, D.4
  • 13
    • 79953162275 scopus 로고    scopus 로고
    • GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae
    • Kamei Y, Tamura T, Yoshida R, Ohta S, Fukusaki E, Mukai Y. GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2011;407(1):185-90.
    • (2011) Biochem Biophys Res Commun , vol.407 , Issue.1 , pp. 185-190
    • Kamei, Y.1    Tamura, T.2    Yoshida, R.3    Ohta, S.4    Fukusaki, E.5    Mukai, Y.6
  • 14
    • 84901743802 scopus 로고    scopus 로고
    • Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
    • Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD. Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging. PLoS Genet. 2014;10(2):e1004113.
    • (2014) PLoS Genet , vol.10 , Issue.2
    • Mirisola, M.G.1    Taormina, G.2    Fabrizio, P.3    Wei, M.4    Hu, J.5    Longo, V.D.6
  • 15
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • Powers 3rd RW, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006;20(2):174-84.
    • (2006) Genes Dev , vol.20 , Issue.2 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 16
    • 85047689281 scopus 로고    scopus 로고
    • Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants
    • Yoshida R, Tamura T, Takaoka C, Harada K, Kobayashi A, Mukai Y, et al. Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants. Aging Cell. 2010;9(4):616-25.
    • (2010) Aging Cell , vol.9 , Issue.4 , pp. 616-625
    • Yoshida, R.1    Tamura, T.2    Takaoka, C.3    Harada, K.4    Kobayashi, A.5    Mukai, Y.6
  • 17
    • 33646748876 scopus 로고    scopus 로고
    • Restriction of amino acids extends lifespan in Drosophila melanogaster
    • Min KJ, Tatar M. Restriction of amino acids extends lifespan in Drosophila melanogaster. Mech Ageing Dev. 2006;127(7):643-6.
    • (2006) Mech Ageing Dev , vol.127 , Issue.7 , pp. 643-646
    • Min, K.J.1    Tatar, M.2
  • 18
    • 72949117234 scopus 로고    scopus 로고
    • Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
    • Grandison RC, Piper MD, Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature. 2009;462(7276):1061-4.
    • (2009) Nature , vol.462 , Issue.7276 , pp. 1061-1064
    • Grandison, R.C.1    Piper, M.D.2    Partridge, L.3
  • 19
    • 80053641483 scopus 로고    scopus 로고
    • Increased transsulfuration mediates longevity and dietary restriction in Drosophila
    • Kabil H, Kabil O, Banerjee R, Harshman LG, Pletcher SD. Increased transsulfuration mediates longevity and dietary restriction in Drosophila. Proc Natl Acad Sci U S A. 2011;108(40):16831-6.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.40 , pp. 16831-16836
    • Kabil, H.1    Kabil, O.2    Banerjee, R.3    Harshman, L.G.4    Pletcher, S.D.5
  • 20
    • 2542462110 scopus 로고    scopus 로고
    • Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells
    • Ban H, Shigemitsu K, Yamatsuji T, Haisa M, Nakajo T, Takaoka M, et al. Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells. Int J Mol Med. 2004;13(4):537-43.
    • (2004) Int J Mol Med , vol.13 , Issue.4 , pp. 537-543
    • Ban, H.1    Shigemitsu, K.2    Yamatsuji, T.3    Haisa, M.4    Nakajo, T.5    Takaoka, M.6
  • 21
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem. 1998;273(23):14484-94.
    • (1998) J Biol Chem , vol.273 , Issue.23 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 22
    • 77952380764 scopus 로고    scopus 로고
    • Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster
    • Moskalev AA, Shaposhnikov MV. Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster. Rejuvenation Res. 2010;13(2-3):246-7.
    • (2010) Rejuvenation Res , vol.13 , Issue.2-3 , pp. 246-247
    • Moskalev, A.A.1    Shaposhnikov, M.V.2
  • 23
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004;14(10):885-90.
    • (2004) Curr Biol , vol.14 , Issue.10 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 24
    • 0022377027 scopus 로고
    • Effect of sulfur-containing compounds on the life span of Drosophila
    • Massie H, Williams T. Effect of sulfur-containing compounds on the life span of Drosophila. Age. 1985;8(4):128-35.
    • (1985) Age , vol.8 , Issue.4 , pp. 128-135
    • Massie, H.1    Williams, T.2
  • 25
    • 84891696893 scopus 로고    scopus 로고
    • Interactive effects of sex, social environment, dietary restriction, and methionine on survival and reproduction in fruit flies
    • Zajitschek F, Zajitschek SR, Friberg U, Maklakov AA. Interactive effects of sex, social environment, dietary restriction, and methionine on survival and reproduction in fruit flies. Age (Dordr). 2013;35(4):1193-204.
    • (2013) Age (Dordr) , vol.35 , Issue.4 , pp. 1193-1204
    • Zajitschek, F.1    Zajitschek, S.R.2    Friberg, U.3    Maklakov, A.A.4
  • 26
    • 84859475161 scopus 로고    scopus 로고
    • Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
    • Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, et al. Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab. 2012;15(4):451-65.
    • (2012) Cell Metab , vol.15 , Issue.4 , pp. 451-465
    • Zarse, K.1    Schmeisser, S.2    Groth, M.3    Priebe, S.4    Beuster, G.5    Kuhlow, D.6
  • 27
    • 84866297918 scopus 로고    scopus 로고
    • Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
    • van der Goot AT, Zhu W, Vazquez-Manrique RP, Seinstra RI, Dettmer K, Michels H, et al. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proc Natl Acad Sci U S A. 2012;109(37):14912-7.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.37 , pp. 14912-14917
    • Goot, A.T.1    Zhu, W.2    Vazquez-Manrique, R.P.3    Seinstra, R.I.4    Dettmer, K.5    Michels, H.6
  • 28
    • 84919608398 scopus 로고    scopus 로고
    • Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import
    • He C, Tsuchiyama SK, Nguyen QT, Plyusnina EN, Terrill SR, Sahibzada S, et al. Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import. PLoS Genet. 2014;10(12):e1004860.
    • (2014) PLoS Genet , vol.10 , Issue.12
    • He, C.1    Tsuchiyama, S.K.2    Nguyen, Q.T.3    Plyusnina, E.N.4    Terrill, S.R.5    Sahibzada, S.6
  • 29
    • 84892753640 scopus 로고    scopus 로고
    • TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans
    • Ferguson AA, Roy S, Kormanik KN, Kim Y, Dumas KJ, Ritov VB, et al. TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans. PLoS Genet. 2013;9(12):e1004020.
    • (2013) PLoS Genet , vol.9 , Issue.12
    • Ferguson, A.A.1    Roy, S.2    Kormanik, K.N.3    Kim, Y.4    Dumas, K.J.5    Ritov, V.B.6
  • 30
    • 77957661352 scopus 로고    scopus 로고
    • Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice
    • D'Antona G, Ragni M, Cardile A, Tedesco L, Dossena M, Bruttini F, et al. Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metab. 2010;12(4):362-72.
    • (2010) Cell Metab , vol.12 , Issue.4 , pp. 362-372
    • D'Antona, G.1    Ragni, M.2    Cardile, A.3    Tedesco, L.4    Dossena, M.5    Bruttini, F.6
  • 32
    • 84860439210 scopus 로고    scopus 로고
    • Interplay between lipids and branched-chain amino acids in development of insulin resistance
    • Newgard CB. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 2012;15(5):606-14.
    • (2012) Cell Metab , vol.15 , Issue.5 , pp. 606-614
    • Newgard, C.B.1
  • 33
    • 84864065342 scopus 로고    scopus 로고
    • Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2
    • Baker BM, Nargund AM, Sun T, Haynes CM. Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2. PLoS Genet. 2012;8(6):e1002760.
    • (2012) PLoS Genet , vol.8 , Issue.6
    • Baker, B.M.1    Nargund, A.M.2    Sun, T.3    Haynes, C.M.4
  • 34
    • 84883817838 scopus 로고    scopus 로고
    • The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans
    • Rousakis A, Vlassis A, Vlanti A, Patera S, Thireos G, Syntichaki P. The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Aging Cell. 2013;12(5):742-51.
    • (2013) Aging Cell , vol.12 , Issue.5 , pp. 742-751
    • Rousakis, A.1    Vlassis, A.2    Vlanti, A.3    Patera, S.4    Thireos, G.5    Syntichaki, P.6
  • 35
    • 69949094944 scopus 로고    scopus 로고
    • A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan
    • Shibamura A, Ikeda T, Nishikawa Y. A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech Ageing Dev. 2009;130(9):652-5.
    • (2009) Mech Ageing Dev , vol.130 , Issue.9 , pp. 652-655
    • Shibamura, A.1    Ikeda, T.2    Nishikawa, Y.3
  • 36
    • 84861388555 scopus 로고    scopus 로고
    • Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans
    • Saitoh Y, Katane M, Kawata T, Maeda K, Sekine M, Furuchi T, et al. Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans. Mol Cell Biol. 2012;32(10):1967-83.
    • (2012) Mol Cell Biol , vol.32 , Issue.10 , pp. 1967-1983
    • Saitoh, Y.1    Katane, M.2    Kawata, T.3    Maeda, K.4    Sekine, M.5    Furuchi, T.6
  • 37
    • 24944504370 scopus 로고    scopus 로고
    • Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts
    • Hamase K, Konno R, Morikawa A, Zaitsu K. Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts. Biol Pharm Bull. 2005;28(9):1578-84.
    • (2005) Biol Pharm Bull , vol.28 , Issue.9 , pp. 1578-1584
    • Hamase, K.1    Konno, R.2    Morikawa, A.3    Zaitsu, K.4
  • 38
    • 84916203269 scopus 로고    scopus 로고
    • Insulin/insulin-like growth factor signaling in C. elegans
    • Murphy CT, Hu PJ. Insulin/insulin-like growth factor signaling in C. elegans. WormBook 2013:1-43.
    • (2013) WormBook , pp. 1-43
    • Murphy, C.T.1    Hu, P.J.2
  • 39
    • 68149149835 scopus 로고    scopus 로고
    • The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans
    • Zhang Y, Shao Z, Zhai Z, Shen C, Powell-Coffman JA. The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One. 2009;4(7):e6348.
    • (2009) PLoS One , vol.4 , Issue.7
    • Zhang, Y.1    Shao, Z.2    Zhai, Z.3    Shen, C.4    Powell-Coffman, J.A.5
  • 40
    • 84855182851 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
    • Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev. 2012;11(2):230-41.
    • (2012) Ageing Res Rev , vol.11 , Issue.2 , pp. 230-241
    • Salminen, A.1    Kaarniranta, K.2
  • 41
    • 35848937781 scopus 로고    scopus 로고
    • Autophagy is required for dietary restriction-mediated life span extension in C. elegans
    • Jia K, Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007;3(6):597-9.
    • (2007) Autophagy , vol.3 , Issue.6 , pp. 597-599
    • Jia, K.1    Levine, B.2
  • 42
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    • Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 2008;4(2):e24.
    • (2008) PLoS Genet , vol.4 , Issue.2
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 43
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature. 2007;447(7144):550-5.
    • (2007) Nature , vol.447 , Issue.7144 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 44
    • 77649225979 scopus 로고    scopus 로고
    • Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response
    • Zhong M, Niu W, Lu ZJ, Sarov M, Murray JI, Janette J, et al. Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response. PLoS Genet. 2010;6(2):e1000848.
    • (2010) PLoS Genet , vol.6 , Issue.2
    • Zhong, M.1    Niu, W.2    Lu, Z.J.3    Sarov, M.4    Murray, J.I.5    Janette, J.6
  • 45
    • 84894486696 scopus 로고    scopus 로고
    • Nutrient regulation of the mTOR complex 1 signaling pathway
    • Kim SG, Buel GR, Blenis J. Nutrient regulation of the mTOR complex 1 signaling pathway. Mol Cells. 2013;35(6):463-73.
    • (2013) Mol Cells , vol.35 , Issue.6 , pp. 463-473
    • Kim, S.G.1    Buel, G.R.2    Blenis, J.3
  • 48
    • 84903139148 scopus 로고    scopus 로고
    • The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
    • Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G et al.. The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 2014.
    • (2014) Nature
    • Chin, R.M.1    Fu, X.2    Pai, M.Y.3    Vergnes, L.4    Hwang, H.5    Deng, G.6
  • 49
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 2007;6(1):95-110.
    • (2007) Aging Cell , vol.6 , Issue.1 , pp. 95-110
    • Hansen, M.1    Taubert, S.2    Crawford, D.3    Libina, N.4    Lee, S.J.5    Kenyon, C.6
  • 50
    • 33847199335 scopus 로고    scopus 로고
    • eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
    • Syntichaki P, Troulinaki K, Tavernarakis N. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature. 2007;445(7130):922-6.
    • (2007) Nature , vol.445 , Issue.7130 , pp. 922-926
    • Syntichaki, P.1    Troulinaki, K.2    Tavernarakis, N.3
  • 51
    • 78651276219 scopus 로고    scopus 로고
    • Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans
    • Mouchiroud L, Molin L, Kasturi P, Triba MN, Dumas ME, Wilson MC, et al. Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell. 2011;10(1):39-54.
    • (2011) Aging Cell , vol.10 , Issue.1 , pp. 39-54
    • Mouchiroud, L.1    Molin, L.2    Kasturi, P.3    Triba, M.N.4    Dumas, M.E.5    Wilson, M.C.6
  • 52
  • 54
    • 74049134984 scopus 로고    scopus 로고
    • Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway
    • Williams DS, Cash A, Hamadani L, Diemer T. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009;8(6):765-8.
    • (2009) Aging Cell , vol.8 , Issue.6 , pp. 765-768
    • Williams, D.S.1    Cash, A.2    Hamadani, L.3    Diemer, T.4
  • 55
    • 77949801832 scopus 로고    scopus 로고
    • A low cost and quick assay system using the free-living nematode Caenorhabditis elegans to determine the effects of Kampo medicines on life span
    • Yamaguchi T, Onodera A, Yasuda K, Nishio Y, Arai M, Tsuda M, et al. A low cost and quick assay system using the free-living nematode Caenorhabditis elegans to determine the effects of Kampo medicines on life span. AATEX. 2008;13:1-10.
    • (2008) AATEX , vol.13 , pp. 1-10
    • Yamaguchi, T.1    Onodera, A.2    Yasuda, K.3    Nishio, Y.4    Arai, M.5    Tsuda, M.6
  • 56
    • 11244344049 scopus 로고    scopus 로고
    • The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans
    • Hajdu-Cronin YM, Chen WJ, Sternberg PW. The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans. Genetics. 2004;168(4):1937-49.
    • (2004) Genetics , vol.168 , Issue.4 , pp. 1937-1949
    • Hajdu-Cronin, Y.M.1    Chen, W.J.2    Sternberg, P.W.3
  • 57
    • 20444406124 scopus 로고    scopus 로고
    • Compensatory regulation among ER chaperones in C. elegans
    • Kapulkin WJ, Hiester BG, Link CD. Compensatory regulation among ER chaperones in C. elegans. FEBS Lett. 2005;579(14):3063-8.
    • (2005) FEBS Lett , vol.579 , Issue.14 , pp. 3063-3068
    • Kapulkin, W.J.1    Hiester, B.G.2    Link, C.D.3
  • 58
    • 84901838039 scopus 로고    scopus 로고
    • The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?
    • Bennett CF, Kaeberlein M. The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation? Exp Gerontol. 2014;56:142-6.
    • (2014) Exp Gerontol , vol.56 , pp. 142-146
    • Bennett, C.F.1    Kaeberlein, M.2
  • 59
    • 79956371387 scopus 로고    scopus 로고
    • The physiological action of picolinic acid in the human brain
    • Grant RS, Coggan SE, Smythe GA. The physiological action of picolinic acid in the human brain. Int J Tryptophan Res. 2009;2:71-9.
    • (2009) Int J Tryptophan Res , vol.2 , pp. 71-79
    • Grant, R.S.1    Coggan, S.E.2    Smythe, G.A.3
  • 61
    • 84880517634 scopus 로고    scopus 로고
    • The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
    • Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Canto C, et al. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 2013;154(2):430-41.
    • (2013) Cell , vol.154 , Issue.2 , pp. 430-441
    • Mouchiroud, L.1    Houtkooper, R.H.2    Moullan, N.3    Katsyuba, E.4    Ryu, D.5    Canto, C.6
  • 63
    • 80055117409 scopus 로고    scopus 로고
    • Assaying beta-amyloid toxicity using a transgenic C. elegans model
    • Dostal V, Link CD. Assaying beta-amyloid toxicity using a transgenic C. elegans model. J Vis Exp. 2010;44:e2252.
    • (2010) J Vis Exp , vol.44
    • Dostal, V.1    Link, C.D.2
  • 64
    • 0036678146 scopus 로고    scopus 로고
    • The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    • Morley JF, Brignull HR, Weyers JJ, Morimoto RI. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2002;99(16):10417-22.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.16 , pp. 10417-10422
    • Morley, J.F.1    Brignull, H.R.2    Weyers, J.J.3    Morimoto, R.I.4
  • 65
    • 84904883028 scopus 로고    scopus 로고
    • Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model
    • Ari C, Poff AM, Held HE, Landon CS, Goldhagen CR, Mavromates N, et al. Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. PLoS One. 2014;9(7):e103526.
    • (2014) PLoS One , vol.9 , Issue.7
    • Ari, C.1    Poff, A.M.2    Held, H.E.3    Landon, C.S.4    Goldhagen, C.R.5    Mavromates, N.6
  • 66
    • 70350365110 scopus 로고    scopus 로고
    • Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression
    • Lee S-J, Murphy CT, Kenyon C. Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression. Cell Metab. 2009;10(5):379-91.
    • (2009) Cell Metab , vol.10 , Issue.5 , pp. 379-391
    • Lee, S.-J.1    Murphy, C.T.2    Kenyon, C.3
  • 67
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007;6(4):280-93.
    • (2007) Cell Metab , vol.6 , Issue.4 , pp. 280-293
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5    Ristow, M.6
  • 69
    • 0021691035 scopus 로고
    • The effect of dietary methionine on the copper content of tissues and survival of young and old mice
    • Massie HR, Aiello VR. The effect of dietary methionine on the copper content of tissues and survival of young and old mice. Exp Gerontol. 1984;19(6):393-9.
    • (1984) Exp Gerontol , vol.19 , Issue.6 , pp. 393-399
    • Massie, H.R.1    Aiello, V.R.2
  • 70
    • 84890592528 scopus 로고    scopus 로고
    • Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans
    • Depuydt G, Xie F, Petyuk VA, Shanmugam N, Smolders A, Dhondt I, et al. Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans. Mol Cell Proteomics. 2013;12(12):3624-39.
    • (2013) Mol Cell Proteomics , vol.12 , Issue.12 , pp. 3624-3639
    • Depuydt, G.1    Xie, F.2    Petyuk, V.A.3    Shanmugam, N.4    Smolders, A.5    Dhondt, I.6
  • 71
  • 73
    • 84893442805 scopus 로고    scopus 로고
    • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
    • Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624-38.
    • (2013) Cell , vol.155 , Issue.7 , pp. 1624-1638
    • Gomes, A.P.1    Price, N.L.2    Ling, A.J.3    Moslehi, J.J.4    Montgomery, M.K.5    Rajman, L.6
  • 74
    • 84905059746 scopus 로고    scopus 로고
    • Opinion controversy to chromium picolinate therapy's safety and efficacy: ignoring 'anecdotes' of case reports or recognising individual risks and new guidelines urgency to introduce innovation by predictive diagnostics?
    • Golubnitschaja O, Yeghiazaryan K. Opinion controversy to chromium picolinate therapy's safety and efficacy: ignoring 'anecdotes' of case reports or recognising individual risks and new guidelines urgency to introduce innovation by predictive diagnostics? Epma J. 2012;3(1):11.
    • (2012) Epma J , vol.3 , Issue.1 , pp. 11
    • Golubnitschaja, O.1    Yeghiazaryan, K.2
  • 75
    • 40849118472 scopus 로고    scopus 로고
    • Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    • Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell. 2008;132(6):1025-38.
    • (2008) Cell , vol.132 , Issue.6 , pp. 1025-1038
    • Tullet, J.M.1    Hertweck, M.2    An, J.H.3    Baker, J.4    Hwang, J.Y.5    Liu, S.6
  • 76
    • 84855321183 scopus 로고    scopus 로고
    • Histone methylation makes its mark on longevity
    • Han S, Brunet A. Histone methylation makes its mark on longevity. Trends Cell Biol. 2012;22(1):42-9.
    • (2012) Trends Cell Biol , vol.22 , Issue.1 , pp. 42-49
    • Han, S.1    Brunet, A.2
  • 77
    • 22344443522 scopus 로고    scopus 로고
    • A systematic RNAi screen for longevity genes in C. elegans
    • Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, et al. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005;19(13):1544-55.
    • (2005) Genes Dev , vol.19 , Issue.13 , pp. 1544-1555
    • Hamilton, B.1    Dong, Y.2    Shindo, M.3    Liu, W.4    Odell, I.5    Ruvkun, G.6
  • 78
    • 73449114300 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16
    • Hashimoto T, Horikawa M, Nomura T, Sakamoto K. Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. Biogerontology. 2010;11(1):31-43.
    • (2010) Biogerontology , vol.11 , Issue.1 , pp. 31-43
    • Hashimoto, T.1    Horikawa, M.2    Nomura, T.3    Sakamoto, K.4
  • 80
    • 84855987831 scopus 로고    scopus 로고
    • Reductive carboxylation supports growth in tumour cells with defective mitochondria
    • Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2012;481(7381):385-8.
    • (2012) Nature , vol.481 , Issue.7381 , pp. 385-388
    • Mullen, A.R.1    Wheaton, W.W.2    Jin, E.S.3    Chen, P.H.4    Sullivan, L.B.5    Cheng, T.6
  • 81
    • 38449085292 scopus 로고    scopus 로고
    • Maintenance of C. elegans
    • Stiernagle T. Maintenance of C. elegans. WormBook. 2006;11:1-11.
    • (2006) WormBook , vol.11 , pp. 1-11
    • Stiernagle, T.1
  • 82
    • 77953152484 scopus 로고    scopus 로고
    • A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans
    • Fitzgerald VK, Mensack MM, Wolfe P, Thompson HJ. A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans. Biotechniques. 2009;47(4 Suppl):ix-xv.
    • (2009) Biotechniques , vol.47 , Issue.4 , pp. 9-15
    • Fitzgerald, V.K.1    Mensack, M.M.2    Wolfe, P.3    Thompson, H.J.4
  • 83
    • 84875041132 scopus 로고    scopus 로고
    • Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces alpha synuclein aggregation in Caenorhabditis elegans
    • Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, et al. Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces alpha synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets. 2012;11(8):984-92.
    • (2012) CNS Neurol Disord Drug Targets , vol.11 , Issue.8 , pp. 984-992
    • Shukla, V.1    Phulara, S.C.2    Yadav, D.3    Tiwari, S.4    Kaur, S.5    Gupta, M.M.6


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