-
1
-
-
67650927732
-
The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans
-
Swire J, Fuchs S, Bundy JG, Leroi AM. The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans. Proc Biol Sci. 2009;276(1668):2747-54.
-
(2009)
Proc Biol Sci
, vol.276
, Issue.1668
, pp. 2747-2754
-
-
Swire, J.1
Fuchs, S.2
Bundy, J.G.3
Leroi, A.M.4
-
2
-
-
77149171951
-
A metabolic signature of long life in Caenorhabditis elegans
-
Fuchs S, Bundy JG, Davies SK, Viney JM, Swire JS, Leroi AM. A metabolic signature of long life in Caenorhabditis elegans. BMC Biol. 2010;8:14.
-
(2010)
BMC Biol
, vol.8
, pp. 14
-
-
Fuchs, S.1
Bundy, J.G.2
Davies, S.K.3
Viney, J.M.4
Swire, J.S.5
Leroi, A.M.6
-
3
-
-
79851507742
-
Plasma amino acid imbalance: dangerous in chronic diseases?
-
Roth E, Druml W. Plasma amino acid imbalance: dangerous in chronic diseases? Curr Opin Clin Nutr Metab Care. 2011;14(1):67-74.
-
(2011)
Curr Opin Clin Nutr Metab Care
, vol.14
, Issue.1
, pp. 67-74
-
-
Roth, E.1
Druml, W.2
-
5
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996;273(5271):59-63.
-
(1996)
Science
, vol.273
, Issue.5271
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
6
-
-
33745597874
-
Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection
-
Pamplona R, Barja G. Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. Biochim Biophys Acta. 2006;1757(5-6):496-508.
-
(2006)
Biochim Biophys Acta
, vol.1757
, Issue.5-6
, pp. 496-508
-
-
Pamplona, R.1
Barja, G.2
-
7
-
-
23844464540
-
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
-
Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell. 2005;4(3):119-25.
-
(2005)
Aging Cell
, vol.4
, Issue.3
, pp. 119-125
-
-
Miller, R.A.1
Buehner, G.2
Chang, Y.3
Harper, J.M.4
Sigler, R.5
Smith-Wheelock, M.6
-
8
-
-
0027512877
-
Low methionine ingestion by rats extends life span
-
Orentreich N, Matias JR, DeFelice A, Zimmerman JA. Low methionine ingestion by rats extends life span. J Nutr. 1993;123(2):269-74.
-
(1993)
J Nutr
, vol.123
, Issue.2
, pp. 269-274
-
-
Orentreich, N.1
Matias, J.R.2
DeFelice, A.3
Zimmerman, J.A.4
-
9
-
-
0023839144
-
Histology and survival in age-delayed low-tryptophan-fed rats
-
Ooka H, Segall PE, Timiras PS. Histology and survival in age-delayed low-tryptophan-fed rats. Mech Ageing Dev. 1988;43(1):79-98.
-
(1988)
Mech Ageing Dev
, vol.43
, Issue.1
, pp. 79-98
-
-
Ooka, H.1
Segall, P.E.2
Timiras, P.S.3
-
10
-
-
0017111106
-
Patho-physiologic findings after chronic tryptophan deficiency in rats: a model for delayed growth and aging
-
Segall PE, Timiras PS. Patho-physiologic findings after chronic tryptophan deficiency in rats: a model for delayed growth and aging. Mech Ageing Dev. 1976;5(2):109-24.
-
(1976)
Mech Ageing Dev
, vol.5
, Issue.2
, pp. 109-124
-
-
Segall, P.E.1
Timiras, P.S.2
-
11
-
-
67651162109
-
Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae
-
Alvers AL, Fishwick LK, Wood MS, Hu D, Chung HS, Dunn Jr WA, et al. Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell. 2009;8(4):353-69.
-
(2009)
Aging Cell
, vol.8
, Issue.4
, pp. 353-369
-
-
Alvers, A.L.1
Fishwick, L.K.2
Wood, M.S.3
Hu, D.4
Chung, H.S.5
Dunn, W.A.6
-
12
-
-
84892572891
-
Independent and additive effects of glutamic acid and methionine on yeast longevity
-
Wu Z, Song L, Liu SQ, Huang D. Independent and additive effects of glutamic acid and methionine on yeast longevity. PLoS One. 2013;8(11):e79319.
-
(2013)
PLoS One
, vol.8
, Issue.11
-
-
Wu, Z.1
Song, L.2
Liu, S.Q.3
Huang, D.4
-
13
-
-
79953162275
-
GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae
-
Kamei Y, Tamura T, Yoshida R, Ohta S, Fukusaki E, Mukai Y. GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2011;407(1):185-90.
-
(2011)
Biochem Biophys Res Commun
, vol.407
, Issue.1
, pp. 185-190
-
-
Kamei, Y.1
Tamura, T.2
Yoshida, R.3
Ohta, S.4
Fukusaki, E.5
Mukai, Y.6
-
14
-
-
84901743802
-
Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
-
Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD. Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging. PLoS Genet. 2014;10(2):e1004113.
-
(2014)
PLoS Genet
, vol.10
, Issue.2
-
-
Mirisola, M.G.1
Taormina, G.2
Fabrizio, P.3
Wei, M.4
Hu, J.5
Longo, V.D.6
-
15
-
-
30944458446
-
Extension of chronological life span in yeast by decreased TOR pathway signaling
-
Powers 3rd RW, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006;20(2):174-84.
-
(2006)
Genes Dev
, vol.20
, Issue.2
, pp. 174-184
-
-
Powers, R.W.1
Kaeberlein, M.2
Caldwell, S.D.3
Kennedy, B.K.4
Fields, S.5
-
16
-
-
85047689281
-
Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants
-
Yoshida R, Tamura T, Takaoka C, Harada K, Kobayashi A, Mukai Y, et al. Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants. Aging Cell. 2010;9(4):616-25.
-
(2010)
Aging Cell
, vol.9
, Issue.4
, pp. 616-625
-
-
Yoshida, R.1
Tamura, T.2
Takaoka, C.3
Harada, K.4
Kobayashi, A.5
Mukai, Y.6
-
17
-
-
33646748876
-
Restriction of amino acids extends lifespan in Drosophila melanogaster
-
Min KJ, Tatar M. Restriction of amino acids extends lifespan in Drosophila melanogaster. Mech Ageing Dev. 2006;127(7):643-6.
-
(2006)
Mech Ageing Dev
, vol.127
, Issue.7
, pp. 643-646
-
-
Min, K.J.1
Tatar, M.2
-
18
-
-
72949117234
-
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
-
Grandison RC, Piper MD, Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature. 2009;462(7276):1061-4.
-
(2009)
Nature
, vol.462
, Issue.7276
, pp. 1061-1064
-
-
Grandison, R.C.1
Piper, M.D.2
Partridge, L.3
-
19
-
-
80053641483
-
Increased transsulfuration mediates longevity and dietary restriction in Drosophila
-
Kabil H, Kabil O, Banerjee R, Harshman LG, Pletcher SD. Increased transsulfuration mediates longevity and dietary restriction in Drosophila. Proc Natl Acad Sci U S A. 2011;108(40):16831-6.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.40
, pp. 16831-16836
-
-
Kabil, H.1
Kabil, O.2
Banerjee, R.3
Harshman, L.G.4
Pletcher, S.D.5
-
20
-
-
2542462110
-
Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells
-
Ban H, Shigemitsu K, Yamatsuji T, Haisa M, Nakajo T, Takaoka M, et al. Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells. Int J Mol Med. 2004;13(4):537-43.
-
(2004)
Int J Mol Med
, vol.13
, Issue.4
, pp. 537-543
-
-
Ban, H.1
Shigemitsu, K.2
Yamatsuji, T.3
Haisa, M.4
Nakajo, T.5
Takaoka, M.6
-
21
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem. 1998;273(23):14484-94.
-
(1998)
J Biol Chem
, vol.273
, Issue.23
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.P.3
Kozlowski, M.T.4
Belham, C.5
Avruch, J.6
-
22
-
-
77952380764
-
Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster
-
Moskalev AA, Shaposhnikov MV. Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster. Rejuvenation Res. 2010;13(2-3):246-7.
-
(2010)
Rejuvenation Res
, vol.13
, Issue.2-3
, pp. 246-247
-
-
Moskalev, A.A.1
Shaposhnikov, M.V.2
-
23
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004;14(10):885-90.
-
(2004)
Curr Biol
, vol.14
, Issue.10
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
24
-
-
0022377027
-
Effect of sulfur-containing compounds on the life span of Drosophila
-
Massie H, Williams T. Effect of sulfur-containing compounds on the life span of Drosophila. Age. 1985;8(4):128-35.
-
(1985)
Age
, vol.8
, Issue.4
, pp. 128-135
-
-
Massie, H.1
Williams, T.2
-
25
-
-
84891696893
-
Interactive effects of sex, social environment, dietary restriction, and methionine on survival and reproduction in fruit flies
-
Zajitschek F, Zajitschek SR, Friberg U, Maklakov AA. Interactive effects of sex, social environment, dietary restriction, and methionine on survival and reproduction in fruit flies. Age (Dordr). 2013;35(4):1193-204.
-
(2013)
Age (Dordr)
, vol.35
, Issue.4
, pp. 1193-1204
-
-
Zajitschek, F.1
Zajitschek, S.R.2
Friberg, U.3
Maklakov, A.A.4
-
26
-
-
84859475161
-
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
-
Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, et al. Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab. 2012;15(4):451-65.
-
(2012)
Cell Metab
, vol.15
, Issue.4
, pp. 451-465
-
-
Zarse, K.1
Schmeisser, S.2
Groth, M.3
Priebe, S.4
Beuster, G.5
Kuhlow, D.6
-
27
-
-
84866297918
-
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
-
van der Goot AT, Zhu W, Vazquez-Manrique RP, Seinstra RI, Dettmer K, Michels H, et al. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proc Natl Acad Sci U S A. 2012;109(37):14912-7.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.37
, pp. 14912-14917
-
-
Goot, A.T.1
Zhu, W.2
Vazquez-Manrique, R.P.3
Seinstra, R.I.4
Dettmer, K.5
Michels, H.6
-
28
-
-
84919608398
-
Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import
-
He C, Tsuchiyama SK, Nguyen QT, Plyusnina EN, Terrill SR, Sahibzada S, et al. Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import. PLoS Genet. 2014;10(12):e1004860.
-
(2014)
PLoS Genet
, vol.10
, Issue.12
-
-
He, C.1
Tsuchiyama, S.K.2
Nguyen, Q.T.3
Plyusnina, E.N.4
Terrill, S.R.5
Sahibzada, S.6
-
29
-
-
84892753640
-
TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans
-
Ferguson AA, Roy S, Kormanik KN, Kim Y, Dumas KJ, Ritov VB, et al. TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans. PLoS Genet. 2013;9(12):e1004020.
-
(2013)
PLoS Genet
, vol.9
, Issue.12
-
-
Ferguson, A.A.1
Roy, S.2
Kormanik, K.N.3
Kim, Y.4
Dumas, K.J.5
Ritov, V.B.6
-
30
-
-
77957661352
-
Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice
-
D'Antona G, Ragni M, Cardile A, Tedesco L, Dossena M, Bruttini F, et al. Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metab. 2010;12(4):362-72.
-
(2010)
Cell Metab
, vol.12
, Issue.4
, pp. 362-372
-
-
D'Antona, G.1
Ragni, M.2
Cardile, A.3
Tedesco, L.4
Dossena, M.5
Bruttini, F.6
-
31
-
-
84902603273
-
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
-
De Haes W, Frooninckx L, Van Assche R, Smolders A, Depuydt G, Billen J, et al. Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci U S A. 2014;111(24):E2501-2509.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.24
, pp. e2501-2509
-
-
Haes, W.1
Frooninckx, L.2
Assche, R.3
Smolders, A.4
Depuydt, G.5
Billen, J.6
-
32
-
-
84860439210
-
Interplay between lipids and branched-chain amino acids in development of insulin resistance
-
Newgard CB. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 2012;15(5):606-14.
-
(2012)
Cell Metab
, vol.15
, Issue.5
, pp. 606-614
-
-
Newgard, C.B.1
-
33
-
-
84864065342
-
Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2
-
Baker BM, Nargund AM, Sun T, Haynes CM. Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2. PLoS Genet. 2012;8(6):e1002760.
-
(2012)
PLoS Genet
, vol.8
, Issue.6
-
-
Baker, B.M.1
Nargund, A.M.2
Sun, T.3
Haynes, C.M.4
-
34
-
-
84883817838
-
The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans
-
Rousakis A, Vlassis A, Vlanti A, Patera S, Thireos G, Syntichaki P. The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans. Aging Cell. 2013;12(5):742-51.
-
(2013)
Aging Cell
, vol.12
, Issue.5
, pp. 742-751
-
-
Rousakis, A.1
Vlassis, A.2
Vlanti, A.3
Patera, S.4
Thireos, G.5
Syntichaki, P.6
-
35
-
-
69949094944
-
A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan
-
Shibamura A, Ikeda T, Nishikawa Y. A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech Ageing Dev. 2009;130(9):652-5.
-
(2009)
Mech Ageing Dev
, vol.130
, Issue.9
, pp. 652-655
-
-
Shibamura, A.1
Ikeda, T.2
Nishikawa, Y.3
-
36
-
-
84861388555
-
Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans
-
Saitoh Y, Katane M, Kawata T, Maeda K, Sekine M, Furuchi T, et al. Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans. Mol Cell Biol. 2012;32(10):1967-83.
-
(2012)
Mol Cell Biol
, vol.32
, Issue.10
, pp. 1967-1983
-
-
Saitoh, Y.1
Katane, M.2
Kawata, T.3
Maeda, K.4
Sekine, M.5
Furuchi, T.6
-
37
-
-
24944504370
-
Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts
-
Hamase K, Konno R, Morikawa A, Zaitsu K. Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts. Biol Pharm Bull. 2005;28(9):1578-84.
-
(2005)
Biol Pharm Bull
, vol.28
, Issue.9
, pp. 1578-1584
-
-
Hamase, K.1
Konno, R.2
Morikawa, A.3
Zaitsu, K.4
-
38
-
-
84916203269
-
Insulin/insulin-like growth factor signaling in C. elegans
-
Murphy CT, Hu PJ. Insulin/insulin-like growth factor signaling in C. elegans. WormBook 2013:1-43.
-
(2013)
WormBook
, pp. 1-43
-
-
Murphy, C.T.1
Hu, P.J.2
-
39
-
-
68149149835
-
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans
-
Zhang Y, Shao Z, Zhai Z, Shen C, Powell-Coffman JA. The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One. 2009;4(7):e6348.
-
(2009)
PLoS One
, vol.4
, Issue.7
-
-
Zhang, Y.1
Shao, Z.2
Zhai, Z.3
Shen, C.4
Powell-Coffman, J.A.5
-
40
-
-
84855182851
-
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
-
Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev. 2012;11(2):230-41.
-
(2012)
Ageing Res Rev
, vol.11
, Issue.2
, pp. 230-241
-
-
Salminen, A.1
Kaarniranta, K.2
-
41
-
-
35848937781
-
Autophagy is required for dietary restriction-mediated life span extension in C. elegans
-
Jia K, Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007;3(6):597-9.
-
(2007)
Autophagy
, vol.3
, Issue.6
, pp. 597-599
-
-
Jia, K.1
Levine, B.2
-
42
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
-
Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 2008;4(2):e24.
-
(2008)
PLoS Genet
, vol.4
, Issue.2
-
-
Hansen, M.1
Chandra, A.2
Mitic, L.L.3
Onken, B.4
Driscoll, M.5
Kenyon, C.6
-
43
-
-
34249888736
-
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
-
Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature. 2007;447(7144):550-5.
-
(2007)
Nature
, vol.447
, Issue.7144
, pp. 550-555
-
-
Panowski, S.H.1
Wolff, S.2
Aguilaniu, H.3
Durieux, J.4
Dillin, A.5
-
44
-
-
77649225979
-
Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response
-
Zhong M, Niu W, Lu ZJ, Sarov M, Murray JI, Janette J, et al. Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response. PLoS Genet. 2010;6(2):e1000848.
-
(2010)
PLoS Genet
, vol.6
, Issue.2
-
-
Zhong, M.1
Niu, W.2
Lu, Z.J.3
Sarov, M.4
Murray, J.I.5
Janette, J.6
-
45
-
-
84894486696
-
Nutrient regulation of the mTOR complex 1 signaling pathway
-
Kim SG, Buel GR, Blenis J. Nutrient regulation of the mTOR complex 1 signaling pathway. Mol Cells. 2013;35(6):463-73.
-
(2013)
Mol Cells
, vol.35
, Issue.6
, pp. 463-473
-
-
Kim, S.G.1
Buel, G.R.2
Blenis, J.3
-
46
-
-
84860461929
-
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
-
Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, et al. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 2012;15(5):713-24.
-
(2012)
Cell Metab
, vol.15
, Issue.5
, pp. 713-724
-
-
Robida-Stubbs, S.1
Glover-Cutter, K.2
Lamming, D.W.3
Mizunuma, M.4
Narasimhan, S.D.5
Neumann-Haefelin, E.6
-
47
-
-
0642367846
-
Genetics: influence of TOR kinase on lifespan in C. elegans
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature. 2003;426(6967):620.
-
(2003)
Nature
, vol.426
, Issue.6967
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
48
-
-
84903139148
-
The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
-
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G et al.. The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 2014.
-
(2014)
Nature
-
-
Chin, R.M.1
Fu, X.2
Pai, M.Y.3
Vergnes, L.4
Hwang, H.5
Deng, G.6
-
49
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 2007;6(1):95-110.
-
(2007)
Aging Cell
, vol.6
, Issue.1
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.J.5
Kenyon, C.6
-
50
-
-
33847199335
-
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
-
Syntichaki P, Troulinaki K, Tavernarakis N. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature. 2007;445(7130):922-6.
-
(2007)
Nature
, vol.445
, Issue.7130
, pp. 922-926
-
-
Syntichaki, P.1
Troulinaki, K.2
Tavernarakis, N.3
-
51
-
-
78651276219
-
Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans
-
Mouchiroud L, Molin L, Kasturi P, Triba MN, Dumas ME, Wilson MC, et al. Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell. 2011;10(1):39-54.
-
(2011)
Aging Cell
, vol.10
, Issue.1
, pp. 39-54
-
-
Mouchiroud, L.1
Molin, L.2
Kasturi, P.3
Triba, M.N.4
Dumas, M.E.5
Wilson, M.C.6
-
52
-
-
71749087303
-
The lifespan-promoting effect of acetic acid and Reishi polysaccharide
-
Chuang M-H, Chiou S-H, Huang C-H, Yang W-B, Wong C-H. The lifespan-promoting effect of acetic acid and Reishi polysaccharide. Bioorg Med Chem. 2009;17(22):7831-40.
-
(2009)
Bioorg Med Chem
, vol.17
, Issue.22
, pp. 7831-7840
-
-
Chuang, M.-H.1
Chiou, S.-H.2
Huang, C.-H.3
Yang, W.-B.4
Wong, C.-H.5
-
53
-
-
84874619540
-
Malate and fumarate extend lifespan in Caenorhabditis elegans
-
Edwards CB, Copes N, Brito AG, Canfield J, Bradshaw PC. Malate and fumarate extend lifespan in Caenorhabditis elegans. PLoS One. 2013;8(3):e58345.
-
(2013)
PLoS One
, vol.8
, Issue.3
-
-
Edwards, C.B.1
Copes, N.2
Brito, A.G.3
Canfield, J.4
Bradshaw, P.C.5
-
54
-
-
74049134984
-
Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway
-
Williams DS, Cash A, Hamadani L, Diemer T. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009;8(6):765-8.
-
(2009)
Aging Cell
, vol.8
, Issue.6
, pp. 765-768
-
-
Williams, D.S.1
Cash, A.2
Hamadani, L.3
Diemer, T.4
-
55
-
-
77949801832
-
A low cost and quick assay system using the free-living nematode Caenorhabditis elegans to determine the effects of Kampo medicines on life span
-
Yamaguchi T, Onodera A, Yasuda K, Nishio Y, Arai M, Tsuda M, et al. A low cost and quick assay system using the free-living nematode Caenorhabditis elegans to determine the effects of Kampo medicines on life span. AATEX. 2008;13:1-10.
-
(2008)
AATEX
, vol.13
, pp. 1-10
-
-
Yamaguchi, T.1
Onodera, A.2
Yasuda, K.3
Nishio, Y.4
Arai, M.5
Tsuda, M.6
-
56
-
-
11244344049
-
The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans
-
Hajdu-Cronin YM, Chen WJ, Sternberg PW. The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans. Genetics. 2004;168(4):1937-49.
-
(2004)
Genetics
, vol.168
, Issue.4
, pp. 1937-1949
-
-
Hajdu-Cronin, Y.M.1
Chen, W.J.2
Sternberg, P.W.3
-
57
-
-
20444406124
-
Compensatory regulation among ER chaperones in C. elegans
-
Kapulkin WJ, Hiester BG, Link CD. Compensatory regulation among ER chaperones in C. elegans. FEBS Lett. 2005;579(14):3063-8.
-
(2005)
FEBS Lett
, vol.579
, Issue.14
, pp. 3063-3068
-
-
Kapulkin, W.J.1
Hiester, B.G.2
Link, C.D.3
-
58
-
-
84901838039
-
The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?
-
Bennett CF, Kaeberlein M. The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation? Exp Gerontol. 2014;56:142-6.
-
(2014)
Exp Gerontol
, vol.56
, pp. 142-146
-
-
Bennett, C.F.1
Kaeberlein, M.2
-
59
-
-
79956371387
-
The physiological action of picolinic acid in the human brain
-
Grant RS, Coggan SE, Smythe GA. The physiological action of picolinic acid in the human brain. Int J Tryptophan Res. 2009;2:71-9.
-
(2009)
Int J Tryptophan Res
, vol.2
, pp. 71-79
-
-
Grant, R.S.1
Coggan, S.E.2
Smythe, G.A.3
-
60
-
-
84884856782
-
Quinolinic acid: an endogenous neurotoxin with multiple targets
-
Lugo-Huitron R, Ugalde Muniz P, Pineda B, Pedraza-Chaverri J, Rios C, Perez-de la Cruz V. Quinolinic acid: an endogenous neurotoxin with multiple targets. Oxid Med Cell Longev. 2013;2013:104024.
-
(2013)
Oxid Med Cell Longev
, vol.2013
, pp. 104024
-
-
Lugo-Huitron, R.1
Ugalde Muniz, P.2
Pineda, B.3
Pedraza-Chaverri, J.4
Rios, C.5
Perez-de la Cruz, V.6
-
61
-
-
84880517634
-
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
-
Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Canto C, et al. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 2013;154(2):430-41.
-
(2013)
Cell
, vol.154
, Issue.2
, pp. 430-441
-
-
Mouchiroud, L.1
Houtkooper, R.H.2
Moullan, N.3
Katsyuba, E.4
Ryu, D.5
Canto, C.6
-
62
-
-
84868587924
-
Role of proline under changing environments: a review
-
Hayat S, Hayat Q, Alyemeni MN, Wani AS, Pichtel J, Ahmad A. Role of proline under changing environments: a review. Plant Signal Behav. 2012;7(11):1456-66.
-
(2012)
Plant Signal Behav
, vol.7
, Issue.11
, pp. 1456-1466
-
-
Hayat, S.1
Hayat, Q.2
Alyemeni, M.N.3
Wani, A.S.4
Pichtel, J.5
Ahmad, A.6
-
63
-
-
80055117409
-
Assaying beta-amyloid toxicity using a transgenic C. elegans model
-
Dostal V, Link CD. Assaying beta-amyloid toxicity using a transgenic C. elegans model. J Vis Exp. 2010;44:e2252.
-
(2010)
J Vis Exp
, vol.44
-
-
Dostal, V.1
Link, C.D.2
-
64
-
-
0036678146
-
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
-
Morley JF, Brignull HR, Weyers JJ, Morimoto RI. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2002;99(16):10417-22.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.16
, pp. 10417-10422
-
-
Morley, J.F.1
Brignull, H.R.2
Weyers, J.J.3
Morimoto, R.I.4
-
65
-
-
84904883028
-
Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model
-
Ari C, Poff AM, Held HE, Landon CS, Goldhagen CR, Mavromates N, et al. Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. PLoS One. 2014;9(7):e103526.
-
(2014)
PLoS One
, vol.9
, Issue.7
-
-
Ari, C.1
Poff, A.M.2
Held, H.E.3
Landon, C.S.4
Goldhagen, C.R.5
Mavromates, N.6
-
66
-
-
70350365110
-
Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression
-
Lee S-J, Murphy CT, Kenyon C. Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression. Cell Metab. 2009;10(5):379-91.
-
(2009)
Cell Metab
, vol.10
, Issue.5
, pp. 379-391
-
-
Lee, S.-J.1
Murphy, C.T.2
Kenyon, C.3
-
67
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007;6(4):280-93.
-
(2007)
Cell Metab
, vol.6
, Issue.4
, pp. 280-293
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
Urban, N.4
Birringer, M.5
Ristow, M.6
-
68
-
-
79955659470
-
Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome
-
Plaisance EP, Greenway FL, Boudreau A, Hill KL, Johnson WD, Krajcik RA, et al. Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. J Clin Endocrinol Metab. 2011;96(5):E836-40.
-
(2011)
J Clin Endocrinol Metab
, vol.96
, Issue.5
, pp. e836-e840
-
-
Plaisance, E.P.1
Greenway, F.L.2
Boudreau, A.3
Hill, K.L.4
Johnson, W.D.5
Krajcik, R.A.6
-
69
-
-
0021691035
-
The effect of dietary methionine on the copper content of tissues and survival of young and old mice
-
Massie HR, Aiello VR. The effect of dietary methionine on the copper content of tissues and survival of young and old mice. Exp Gerontol. 1984;19(6):393-9.
-
(1984)
Exp Gerontol
, vol.19
, Issue.6
, pp. 393-399
-
-
Massie, H.R.1
Aiello, V.R.2
-
70
-
-
84890592528
-
Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans
-
Depuydt G, Xie F, Petyuk VA, Shanmugam N, Smolders A, Dhondt I, et al. Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans. Mol Cell Proteomics. 2013;12(12):3624-39.
-
(2013)
Mol Cell Proteomics
, vol.12
, Issue.12
, pp. 3624-3639
-
-
Depuydt, G.1
Xie, F.2
Petyuk, V.A.3
Shanmugam, N.4
Smolders, A.5
Dhondt, I.6
-
71
-
-
84878138385
-
Mitonuclear protein imbalance as a conserved longevity mechanism
-
Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, et al. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature. 2013;497(7450):451-7.
-
(2013)
Nature
, vol.497
, Issue.7450
, pp. 451-457
-
-
Houtkooper, R.H.1
Mouchiroud, L.2
Ryu, D.3
Moullan, N.4
Katsyuba, E.5
Knott, G.6
-
72
-
-
84859599453
-
Metabotyping of long-lived mice using 1H NMR spectroscopy
-
Wijeyesekera A, Selman C, Barton RH, Holmes E, Nicholson JK, Withers DJ. Metabotyping of long-lived mice using 1H NMR spectroscopy. J Proteome Res. 2012;11(4):2224-35.
-
(2012)
J Proteome Res
, vol.11
, Issue.4
, pp. 2224-2235
-
-
Wijeyesekera, A.1
Selman, C.2
Barton, R.H.3
Holmes, E.4
Nicholson, J.K.5
Withers, D.J.6
-
73
-
-
84893442805
-
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624-38.
-
(2013)
Cell
, vol.155
, Issue.7
, pp. 1624-1638
-
-
Gomes, A.P.1
Price, N.L.2
Ling, A.J.3
Moslehi, J.J.4
Montgomery, M.K.5
Rajman, L.6
-
74
-
-
84905059746
-
Opinion controversy to chromium picolinate therapy's safety and efficacy: ignoring 'anecdotes' of case reports or recognising individual risks and new guidelines urgency to introduce innovation by predictive diagnostics?
-
Golubnitschaja O, Yeghiazaryan K. Opinion controversy to chromium picolinate therapy's safety and efficacy: ignoring 'anecdotes' of case reports or recognising individual risks and new guidelines urgency to introduce innovation by predictive diagnostics? Epma J. 2012;3(1):11.
-
(2012)
Epma J
, vol.3
, Issue.1
, pp. 11
-
-
Golubnitschaja, O.1
Yeghiazaryan, K.2
-
75
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
-
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, et al. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell. 2008;132(6):1025-38.
-
(2008)
Cell
, vol.132
, Issue.6
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
-
76
-
-
84855321183
-
Histone methylation makes its mark on longevity
-
Han S, Brunet A. Histone methylation makes its mark on longevity. Trends Cell Biol. 2012;22(1):42-9.
-
(2012)
Trends Cell Biol
, vol.22
, Issue.1
, pp. 42-49
-
-
Han, S.1
Brunet, A.2
-
77
-
-
22344443522
-
A systematic RNAi screen for longevity genes in C. elegans
-
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, et al. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005;19(13):1544-55.
-
(2005)
Genes Dev
, vol.19
, Issue.13
, pp. 1544-1555
-
-
Hamilton, B.1
Dong, Y.2
Shindo, M.3
Liu, W.4
Odell, I.5
Ruvkun, G.6
-
78
-
-
73449114300
-
Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16
-
Hashimoto T, Horikawa M, Nomura T, Sakamoto K. Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. Biogerontology. 2010;11(1):31-43.
-
(2010)
Biogerontology
, vol.11
, Issue.1
, pp. 31-43
-
-
Hashimoto, T.1
Horikawa, M.2
Nomura, T.3
Sakamoto, K.4
-
79
-
-
84896713080
-
Regulation of autophagy by cytosolic acetyl-coenzyme a
-
Marino G, Pietrocola F, Eisenberg T, Kong Y, Malik SA, Andryushkova A, et al. Regulation of autophagy by cytosolic acetyl-coenzyme a. Mol Cell. 2014;53(5):710-25.
-
(2014)
Mol Cell
, vol.53
, Issue.5
, pp. 710-725
-
-
Marino, G.1
Pietrocola, F.2
Eisenberg, T.3
Kong, Y.4
Malik, S.A.5
Andryushkova, A.6
-
80
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2012;481(7381):385-8.
-
(2012)
Nature
, vol.481
, Issue.7381
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
-
81
-
-
38449085292
-
Maintenance of C. elegans
-
Stiernagle T. Maintenance of C. elegans. WormBook. 2006;11:1-11.
-
(2006)
WormBook
, vol.11
, pp. 1-11
-
-
Stiernagle, T.1
-
82
-
-
77953152484
-
A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans
-
Fitzgerald VK, Mensack MM, Wolfe P, Thompson HJ. A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans. Biotechniques. 2009;47(4 Suppl):ix-xv.
-
(2009)
Biotechniques
, vol.47
, Issue.4
, pp. 9-15
-
-
Fitzgerald, V.K.1
Mensack, M.M.2
Wolfe, P.3
Thompson, H.J.4
-
83
-
-
84875041132
-
Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces alpha synuclein aggregation in Caenorhabditis elegans
-
Shukla V, Phulara SC, Yadav D, Tiwari S, Kaur S, Gupta MM, et al. Iridoid compound 10-O-trans-p-coumaroylcatalpol extends longevity and reduces alpha synuclein aggregation in Caenorhabditis elegans. CNS Neurol Disord Drug Targets. 2012;11(8):984-92.
-
(2012)
CNS Neurol Disord Drug Targets
, vol.11
, Issue.8
, pp. 984-992
-
-
Shukla, V.1
Phulara, S.C.2
Yadav, D.3
Tiwari, S.4
Kaur, S.5
Gupta, M.M.6
|