Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors

Journal of Medicinal Chemistry

Volumn 53, Issue 7, 2010, Pages 2766-2778

  Mathews, Thomas P ^a   Kennedy, Andrew J ^a   Kharel, Yugesh ^b   Kennedy, Perry C ^b   Nicoara, Oana ^b   Sunkara, Manjula ^c   Morris, Andrew J ^c   Wamhoff, Brian R ^b   Lynch, Kevin R ^b   MacDonald, Timothy L ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 CARBAMIMIDOYL N (4 DODECYLPHENYL)CYCLOPROPANECARBOXAMIDE; 1 CARBAMIMIDOYL N (4 HEXADECYLPHENYL)CYCLOPROPANECARBOXAMIDE; 1 CARBAMIMIDOYL N (4 TETRADECYLPHENYL)CYCLOPROPANECARBOXAMIDE; 2 (4 OCTYLBENZAMIDO)PROPANOIC ACID; AMIDINE; N (1 AMINO 1 IMINOPROPAN 2 YL) 4 OCTYLBENZAMIDE; N (1 AMINO 1 OXOPROPAN 2 YL) 4 OCTYLBENZAMIDE; N (1 CARBAMIMIDOYLCYCLOPROPYL) 4 DECYLBENZAMIDE; N (1 CARBAMIMIDOYLCYCLOPROPYL) 4 DODECYLBENZAMIDE; N (1 CARBAMIMIDOYLCYCLOPROPYL) 4 HEXADECYLBENZAMIDE; N (1 CARBAMIMIDOYLCYCLOPROPYL) 4 OCTYLBENZAMIDE; N (1 CARBAMIMIDOYLCYCLOPROPYL) 4 TETRADECYLBENZAMIDE; N (2 AMINO 2 IMINOETHYL) 4 OCTYLBENZAMIDE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; MUSCLE CELL; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; STRUCTURE ACTIVITY RELATION; VASCULAR SMOOTH MUSCLE;

AMIDINES; ANIMALS; CELL PROLIFERATION; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MICE; MYOCYTES, SMOOTH MUSCLE; OXADIAZOLES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STRUCTURE, TERTIARY; RATS; SPHINGOSINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 77950557394     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901860h     Document Type: Article

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