Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 6123-6136

  Foss Jr , Frank W ^a   Mathews, Thomas P ^a   Kharel, Yugesh ^b   Kennedy, Perry C ^b   Snyder, Ashley H ^b   Davis, Michael D ^b   Lynch, Kevin R ^b   Macdonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

FTY 720; Heterocycles; Lymphopenia; Pro drugs; Sphingosine 1 phosphate; Structure activity relationship

Indexed keywords

2 AMINO 2 [5 (4 OCTYLPHENYL) 1H IMIDAZOL 2 YL]PROPAN 1 OL; FINGOLIMOD; OXADIAZOLE DERIVATIVE; OXAZOLE DERIVATIVE; PRODRUG; PROPANOL; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; UNCLASSIFIED DRUG; VPC 44217; VPC 44218; VPC 44239; VPC 45070; VPC 46023; VPC 92249;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME SUBSTRATE; ENZYME SYNTHESIS; IN VIVO STUDY; LIGAND BINDING; LYMPHOCYTOPENIA; NONHUMAN; PROTEIN PHOSPHORYLATION; STEREOCHEMISTRY;

ANIMALS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOPENIA; MICE; PRODRUGS; PROPANOLS; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 68149087632     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.015     Document Type: Article

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