Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups

Journal of Medicinal Chemistry

Volumn 57, Issue 21, 2014, Pages 9152-9167

  Bozdag, Murat ^a   Ferraroni, Marta ^a   Carta, Fabrizio ^a   Vullo, Daniela ^a   Lucarini, Laura ^a   Orlandini, Elisabetta ^b   Rossello, Armando ^b   Nuti, Elisa ^b   Scozzafava, Andrea ^a   Masini, Emanuela ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N (4 METHYL 2 OXO 2H CHROMEN 7 YLCARBAMOYL)BENZENESULFONAMIDE; 2 CHLORO N (4 SULFAMOYLPHENETHYLCARBAMOYL)BENZENESULFONAMIDE; 2 METHYL N (4 METHYL 2 OXO 2H CHROMEN 7 YLCARBAMOYL)BENZENESULFONAMIDE; 2 METHYL N (4 SULFAMOYLPHENETHYLCARBAMOYL)BENZENESULFONAMIDE; 4 CHLORO N (4 METHYL 2 OXO 2H CHROMEN 7 YLCARBAMOYL)BENZENESULFONAMIDE; 4 CHLORO N (4 SULFAMOYLPHENETHYLCARBAMOYL)BENZENESULFONAMIDE; 4 FLUORO N (4 METHYL 2 OXO 2H CHROMEN 7 YLCARBAMOYL)BENZENESULFONAMIDE; 4 FLUORO N (4 SULFAMOYLPHENETHYLCARBAMOYL)BENZENESULFONAMIDE; 4 METHYL N (4 METHYL 2 OXO 2H CHROMEN 7 YLCARBAMOYL)BENZENESULFONAMIDE; 4 METHYL N (4 SULFAMOYLPHENETHYLCARBAMOYL)BENZENESULFONAMIDE; 5 (3 TOSYLUREIDO)PYRIDINE 2 SULFONAMIDE; 5 [3 (2 CHLOROPHENYLSULFONYL)UREIDO]PYRIDINE 2 SULFONAMIDE; 5 [3 (2 TOLYLSULFONYL)UREIDO]PYRIDINE 2 SULFONAMIDE; 5 [3 (4 CHLOROPHENYLSULFONYL)UREIDO]PYRIDINE 2 SULFONAMIDE; 5 [3 (4 FLUOROPHENYLSULFONYL)UREIDO]PYRIDINE 2 SULFONAMIDE; 5 [3 (PHENYLSULFONYL)UREIDO]PYRIDINE 2 SULFONAMIDE; ACETAZOLAMIDE; BENZENE DERIVATIVE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; COUMARIN DERIVATIVE; DORZOLAMIDE; N (4 METHYL 2 OXO 2H CHROMEN 7 YLCARBAMOYL)BENZENESULFONAMIDE; N (4 SULFAMOYLPHENETHYLCARBAMOYL)BENZENESULFONAMIDE; SULFONAMIDE; UNCLASSIFIED DRUG; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II;

ALBINO RABBIT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; MALE; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; TONOMETER; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; METABOLISM; RABBIT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; COUMARINS; CRYSTALLOGRAPHY, X-RAY; GLAUCOMA; INTRAOCULAR PRESSURE; MALE; MODELS, MOLECULAR; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84923780190     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501314c     Document Type: Article

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