HSPA12B inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells

Journal of Cellular and Molecular Medicine

Volumn 19, Issue 3, 2015, Pages 544-554

  Wu, Jun ^a   Li, Xuehan ^a   Huang, Lei ^a   Jiang, Surong ^a   Tu, Fei ^b   Zhang, Xiaojin ^a   Ma, He ^a   Li, Rongrong ^a   Li, Chuanfu ^c   Li, Yuehua ^d   Ding, Zhengnian ^a   Liu, Li ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING NORMAL UNIVERSITY   (China)

^c East Tennessee State University   (United States)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Heat shock protein A12B; HUVECs; Inflammation; Lipopolysaccharide; PI3K Akt signalling

Indexed keywords

ANDROSTANE DERIVATIVE; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 70; HSPA12B PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; WORTMANNIN;

ADENOVIRIDAE; ANTAGONISTS AND INHIBITORS; CELL ADHESION; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL MOTION; CELL SURVIVAL; DRUG EFFECTS; ENZYME ACTIVATION; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; NEUTROPHIL; RNA INTERFERENCE; SECRETION (PROCESS); UMBILICAL VEIN ENDOTHELIAL CELL;

ADENOVIRIDAE; ANDROSTADIENES; CELL ADHESION; CELL MEMBRANE PERMEABILITY; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; ENZYME ACTIVATION; GREEN FLUORESCENT PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; NEUTROPHILS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84923288972     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12464     Document Type: Article

References (36)

1. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008; 454: 428-35.
2. Meigs JB, Hu FB, Rifai N, et al. Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA. 2004; 291: 1978-86.
3. Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 1998; 91: 3527-61.
4. Peters K, Unger RE, Brunner J, et al. Molecular basis of endothelial dysfunction in sepsis. Cardiovasc Res. 2003; 60: 49-57.
5. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. 2000; 406: 782-7.
6. Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signalling. 2001; 13: 85-94.
7. Yang X, Zhang G, Tang X, et al. Toll-like receptor 4/nuclear factor-κB signaling pathway is involved in ACTG-toxin H-mediated anti-inflammatory effect. Mol Cell Biochem. 2013; 374: 29-36.
8. Ploppa A, Schmidt V, Hientz A, et al. Mechanisms of leukocyte distribution during sepsis: an experimental study on the interdependence of cell activation, shear stress and endothelial injury. Crit Care. 2010; 14: R201.
9. Jiang YR, Chen KJ, Xu YG, et al. Effects of propyl gallate on adhesion of polymorphonuclear leukocytes to human endothelial cells induced by tumor necrosis factor alpha. Chin J Integr Med. 2009; 15: 47-53.
10. Han Z, Truong QA, Park S, et al. Two Hsp70 family members expressed in atherosclerotic lesions. Proc Natl Acad Sci USA. 2003; 100: 1256-61.
11. Steagall RJ, Rusiñol AE, Truong QA, et al. HSPA12B is predominantly expressed in endothelial cells and required for angiogenesis. Arterioscler Thromb Vasc Biol. 2006; 26: 2012-8.
12. Hu G, Tang J, Zhang B, et al. A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. J Cell Sci. 2006; 119: 4117-26.
13. Zhang WJ, Wei H, Hagen T, et al. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci USA. 2007; 104: 4077-82.
14. Fukao T, Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 2003; 24: 358-63.
15. Williams DL, Li C, Ha T, et al. Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis. J Immunol. 2004; 172: 449-56.
16. Zhou H, Qian J, Li C, et al. Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism. Cardiovasc Res. 2011; 89: 109-18.
17. Jaffe EA, Nachman RL, Becker CG, et al. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest. 1973; 52: 2745-56.
18. Hordijk PL, Anthony E, Mul FP, et al. Vascular endothelial cadherin modulates endothelial monolayer permeability. J Cell Sci. 1999; 112: 1915-23.
19. Hu Y. Isolation of human and mouse neutrophils ex vivo and in vitro. Methods Mol Biol. 2012; 844: 101-13.
20. Granger DN, Kubes P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol. 1994; 55: 662-75.
21. Wang X, Zhang X, Cheng Y, et al. Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism. Neurotoxicology. 2010; 31: 101-12.
22. Tinsley JH, Ustinova EE, Xu W, et al. Src-dependent, neutrophil-mediated vascular hyperpermeability and β-catenin modification. Am J Physiol Cell Physiol. 2002; 283: C1745-51.
23. Shen J, DiCorleto PE. ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-acti-vated protein kinase pathways. Circ Res. 2008; 102: 448-56.
24. Xu YQ, Long L, Yan JQ, et al. Simvastatin induces neuroprotection in 6-OHDA-lesioned PC12 via the PI3K/AKT/caspase 3 pathway and anti-inflammatory responses. CNS Neurosci Ther. 2013; 19: 170-7.
25. Xu CQ, Liu BJ, Wu JF, et al. Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway. Eur J Pharmacol. 2010; 642: 146-53.
26. You W, Min X, Zhang X, et al. Cardiac-specific expression of heat shock protein 27 attenuated endotoxin-induced cardiac dysfunction and mortality in mice through a PI3K/Akt-dependent mechanism. Shock. 2009; 32: 108-17.
27. Sanlorenzo L, Zhao B, Spight D, et al. Heat shock inhibition of lipopolysaccharide-mediated tumor necrosis factor expression is associated with nuclear induction of MKP-1 and inhibition of mitogen-activated protein kinase activation. Crit Care Med. 2004; 32: 2284-92.
28. Wong HR, Mannix RJ, Rusnak JM, et al. The heat-shock response attenuates lipopolysaccharide-mediated apoptosis in cultured sheep pulmonary artery endothelial cells. Am J Respir Cell Mol Biol. 1996; 15: 745-51.
29. Sun DI, Nizamutdinova IT, Kim YM, et al. Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression. Int Immunopharmacol. 2008; 8: 1272-81.
30. Raeburn CD, Calkins CM, Zimmerman MA, et al. ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutro-phil accumulation. Am J Physiol Regul Integr Comp Physiol. 2002; 283: 477-86.
31. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J. 1994; 8: 504-12.
32. Liu XH, Pan LL, Yang HB, et al. Leonurine attenuates lipopolysaccharide induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways. Eur J Pharmacol. 2012; 680: 108-14.
33. Tyagi E, Agrawal R, Nath C, et al. Cholinergic protection via alpha7 nicotinic acetylcholine receptors and PI3K-Akt pathway in LPS-induced neuroin-flammation. Neurochem Int. 2010; 56: 135-42.
34. Li XQ, Cao W, Li T, et al. Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysac-charide involving PI3K/Akt pathway. Int Immunopharmacol. 2009; 9: 1032-41.
35. Hyam SR, Lee IA, Gu W, et al. Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages. Eur J Pharmacol. 2013; 708: 21-9.
36. Jung JS, Shin KO, Lee YM, et al. Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia. Biochim Biophys Acta. 2013; 1831: 1016-26.