Cholinergic protection via α7 nicotinic acetylcholine receptors and PI3K-Akt pathway in LPS-induced neuroinflammation

Neurochemistry International

Volumn 56, Issue 1, 2010, Pages 135-142

  Tyagi, Ethika ^a   Agrawal, Rahul ^a   Nath, Chandishwar ^a   Shukla, Rakesh ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

7 nicotinic acetylcholine receptors; COX 2; iNOS; Lipopolysaccharide; Proinflammatory cytokines

Indexed keywords

ACETYLCHOLINESTERASE; CYCLOOXYGENASE 2; DIHYDRO BETA ERYTHROIDINE; DONEPEZIL; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MALONALDEHYDE; METHYLLYCACONITINE; NEOSTIGMINE; NICOTINIC RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCOPOLAMINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACETYLCHOLINESTERASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CHOLINESTERASE INHIBITORS; CYCLOOXYGENASE 2; ENCEPHALITIS; GLUTATHIONE; INDANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 73449105029     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.09.011     Document Type: Article

References (44)

1. Agrawal R., Tyagi E., Shukla R., and Nath C. A study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia. Neuropharmacology 56 (2009) 779-787
2. Borovikova L.V., Ivanova S., Zhang M., Yang H., Botchkina G.I., Watkins L.R., Wang H., Abumrad N., Eaton J.W., and Tracey K.J. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405 (2000) 458-462
3. Brufani M., and Filocamo L. Rational design of cholinesterase inhibitors. In: Giacobini E. (Ed). Cholinesterases and Cholinesterase Inhibitors: Basic, Preclinical and Clinical Aspects (2000), Informa Health Care 27-46
4. Colado M.I., O'Shea E., Granados R., Misra A., Murray T.K., and Green A.R. A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurons in the brains of mothers and neonates following administration of the drug during pregnancy. Br. J. Pharmacol. 121 (1997) 827-833
5. Das A., Dikshit M., and Nath C. Profile of acetylcholinesterase in brain areas of male and female rats of adult and old age. Life Sci. 68 (2001) 1545-1555
6. Davidge S.T., Baker P.N., McLaughlin M.K., and Roberts J.M. Nitric oxide produced by endothelial cells increases production of eicosanoids through activation of prostaglandin H synthase. Circ. Res. 77 (1995) 274-283
7. Deak T., Bellamy C., and D'Agostino L.G. Exposure to forced swim stress does not alter central production of IL-1. Brain Res. 972 (2003) 53-63
8. Eklind S., Hagberg H., Wang X., Sävman K., Leverin A.L., Hedtjärn M., and Mallard C. Effect of lipopolysaccharide on global gene expression in the immature rat brain. Pediatr. Res. 60 (2006) 161-168
9. Evron T., Greenberg D., Mor T.S., and Soreq H. Adaptive changes in acetylcholinesterase gene expression as mediators of recovery from chemical and biological insults. Toxicology 233 (2007) 97-107
10. Feng L., Sun W., Xia Y., Tang W.W., Chanmugam P., Soyoola E., Wilson C.B., and Hwang D. Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch. Biochem. Biophys. 307 (1993) 361-368
11. Gahtan E., and Overmier J.B. Inflammatory pathogenesis in Alzheimer's disease: biological mechanisms and cognitive sequeli. Neurosci. Biobehav. Rev. 23 (1999) 615-637
12. 3H] dopa in various regions of the brain. J. Neurochem. 13 (1966) 655-670
13. Harris S.G., Padilla J., Koumas L., Ray D., and Phipps R.P. Prostaglandins as modulators of immunity. Trends Immunol. 23 (2002) 144-150
14. Hoozemans J.J., Veerhuis R., Rozemuller A.J., Arendt T., and Eikelenboom P. Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex. Neurobiol. Dis. 15 (2004) 492-499
15. Kristof A.S., Fielhaber J., Triantafillopoulos A., Nemoto S., and Moss J. Phosphatidylinositol 3-kinase-dependent suppression of the human inducible nitric-oxide synthase promoter is mediated by FKHRL1. J. Biol. Chem. 281 (2006) 23958-23968
16. Laduzek K., Kowalski J., Gabryel B., and Herman Z.S. Chlorpromazine and loxapine reduce interleukin 1β and interleukin-2 release by rat mixed glial and microglial cell culture. Eur. Neuropsychopharmacol. 15 (2005) 23-30
17. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
18. Lüth H.J., Holzer M., Gärtner U., Staufenbiel M., and Arendt T. Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. Brain Res. 913 (2001) 57-67
19. 2 and by cyclooxygenase inhibitors. Glia 19 (1997) 152-160
20. Minghetti L., Polazzi E., Nicolini A., Créminon C., and Levi G. Interferon-γ and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression. J. Neurochem. 66 (1996) 1963-1970
21. Minghetti L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J. Neuropathol. Exp. Neurol. 63 (2004) 901-910
22. Nathan C. Points of control in inflammation. Nature 420 (2002) 846-852
23. Nizri E., Amitay Y.H., Sicsic C., Lavon I., and Brenner T. Antiinflammatory properties of cholinergic up-regulation: a new role for acetylcholinesterase inhibitors. Neuropharmacology 50 (2006) 540-547
24. Quan N., Sundar S.K., and Weiss J.M. Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide. J. Neuroimmunol. 49 (1994) 125-134
25. Reale M., Iarlori C., Gambi F., Feliciani C., Salone A., Toma L., DeLuca G., Salvatore M., Conti P., Gambi, and Domenico. Treatment with an acetylcholinesterase inhibitor in Alzheimer patient modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. J. Neuroimmunol. 148 (2004) 162-171
26. Rich J.B., Rasmusson D.X., Folstein M.F., Carson K.A., Kawas C., and Brandt J. Nonsteroidal anti-inflammatory drugs in Alzheimer's disease. Neurology 45 (1995) 1441-1445
27. Sharma M., and Gupta Y.K. Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment. Life Sci. 68 (2001) 1021-1029
28. Shytle R.D., Mori T., Townsend K., Vendrame M., Sun M., Zeng J., Ehrhart J., Silver A.A., Sanberg P.R., and Tan J. Cholinergic modulation of microglia activation by α 7 nicotinic receptors. J. Neurochem. 89 (2004) 337-343
29. Simone R.D., Ajmone-Cat M.A., and Minghetti L. Atypical anti-inflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Mol. Neurobiol. 29 (2004) 197-212
30. Stuchbury G., and Munch G. Alzheimer's associated inflammation, potential drug targets and future therapies. J. Neural Transm. 112 (2005) 429-453
31. Sugino K., Dhi K., Yamada K., and Kawasaki T. The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants. Surgery 101 (1987) 746-752
32. Swierkosz T.A., Michell J.A., Warner T.D., Botting R.M., and Vane J.R. Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids. Br. J. Pharmacol. 114 (1995) 1335-1342
33. Takada Y., Yonezawa A., Kume T., Katsuki H., Kaneko S., Sugimoto H., and Akaike A. Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. J. Pharmacol. Exp. Ther. 306 (2003) 772-777
34. Takatori Y.T., Kume T., Sugimoto M., Katsuki H., Sugimoto H., and Akaike A. Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Neuropharmacology 51 (2006) 474-486
35. Tanaka S., Ide M., Shibutani T., Ohtaki H., Numazawa S., Shioda S., and Yoshida T. Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats. J. Neurosci. Res. 83 (2006) 557-566
36. Thomas J.A. Oxidative stress, oxidant defense and dietary constituents. In: Maurice E., Shils M.E., Olson J.A., and Shike M. (Eds). Modern Nutrition in Health and Disease (1994), Awaverly, Philadelphia 501-512
37. Tyagi E., Agrawal R., Nath C., and Shukla R. Effect of anti dementia drugs on LPS induced neuroinflammation in mice. Life Sci. 80 (2007) 1977-1983
38. Tyagi E., Agrawal R., Nath C., and Shukla R. Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain. J. Neuroimmunol. 205 (2008) 51-56
39. Tyagi, E., Agrawal, R., Nath, C., Shukla, R., in press. Inhibitory role of cholinergic system mediated via α7 nicotinic acetylcholine receptor in LPS induced neuroinflammation. Innate Immun. July 8, doi:10.1177/1753425909104680.
40. Wang C.H., and Smith R.L. Lowry determination of protein in the presence of triton X-100. Anal. Biochem. 63 (1975) 414-417
41. Wang H., Yu M., Ochani M., Amella C.A., Tanovic M., and Susarla S. Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation. Nature 421 (2003) 384-388
42. Williard L.B., Hauss-Wegrzyniak B., and Wenk G.L. Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats. Neuroscience 88 (1999) 193-200
43. Yamada K., Komori Y., Tanaka T., Senzaki K., Nikai T., Sugihara H., Kameyama T., and Nabeshima T. Brain dysfunction associated with an induction of nitric oxide synthase following an intracerebral injection of lipopolysaccharide in rats. Neuroscience 88 (1999) 281-294
44. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., and Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11 (1993) 371-386