Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses

Pharmacology and Therapeutics

Volumn 148, Issue , 2015, Pages 34-46

  Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Butyrylcholinesterase; Clinical use; Cocaine; Genetic variants; Nerve agent

Indexed keywords

ACETYLCHOLINE; CHOLINESTERASE; COCAINE; ESTERASE; ORGANOPHOSPHATE; SCAVENGER; TETRAMER; NERVE GAS;

AMINO ACID SEQUENCE; ARTICLE; COCAINE DEPENDENCE; COCAINE INTOXICATION; CRYSTAL STRUCTURE; DETOXIFICATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG INTOXICATION; DRUG PURIFICATION; DRUG STABILITY; DRUG STRUCTURE; DRUG TISSUE LEVEL; DRUG USE; ENZYME BLOOD LEVEL; ENZYME PURIFICATION; ENZYME STABILITY; ENZYME STRUCTURE; GENE THERAPY; GENETIC VARIABILITY; HUMAN; HYDROLYSIS; LIPID METABOLISM; NEUROTOXICITY; NUCLEOTIDE SEQUENCE; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; CHEMISTRY; COCAINE-RELATED DISORDERS; GENETICS; METABOLISM; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BUTYRYLCHOLINESTERASE; COCAINE-RELATED DISORDERS; GENETIC VARIATION; HUMANS; NERVE AGENTS; PROTEIN CONFORMATION;

EID: 84923273015     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2014.11.011     Document Type: Review

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