Pretreatment with human serum butyrylcholinesterase alone prevents cardiac abnormalities, seizures, and death in Göttingen minipigs exposed to sarin vapor

Biochemical Pharmacology

Volumn 82, Issue 12, 2011, Pages 1984-1993

  Saxena, Ashima ^a   Sun, Wei ^a   Dabisch, Paul A ^b   Hulet, Stanley W ^b   Hastings, Nicholas B ^a,c   Jakubowski, Edward M ^b   Mioduszewski, Robert J ^b   Doctor, Bhupendra P ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b EDGEWOOD CHEMICAL BIOLOGICAL CENTER   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cardiac abnormality; Human serum butyrylcholinesterase; Minipig; Neuronal toxicity; Sarin vapor

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; ELECTROLYTE; HUMAN SERUM BUTYRYLCHOLINESTERASE; SARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS ANALYSIS; BLOOD SAMPLING; BREATHING RATE; CARDIOTOXICITY; CONTROLLED STUDY; DEATH; DISORDERS OF ACID BASE BALANCE; DOSE RESPONSE; DRUG EFFICACY; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; EXPOSURE; GRAND MAL SEIZURE; HEART PROTECTION; HEART RATE; HEART RHYTHM; LETHAL DOSE; MALE; METABOLITE; MINIPIG; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PULSE RATE; PUPIL; QT INTERVAL; RESPIRATORY FAILURE; VAPOR;

ACETYLCHOLINESTERASE; ANIMALS; ARRHYTHMIAS, CARDIAC; BUTYRYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; RESPIRATORY INSUFFICIENCY; SARIN; SEIZURES; SWINE; SWINE, MINIATURE;

EID: 80555122870     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.09.019     Document Type: Article

References (49)

1. G.B. Koelle Cholinesterases and anticholinesterases O. Ekhler, A. Farah, Handbuch der Experimentallen Pharmakologie 1963 Springer-Verlag Berlin
2. P. Taylor Anticholinesterase agents A.G. Gilman, T.W. Rall, A.S. Nies, P. Taylor, The pharmacological basis of therapeutics 1990 Macmillan New York 131
3. P.F. Heffron, and F. Hobbiger Relationship between inhibition of acetylcholinesterase and response of the rat phrenic nerve-diaphragm preparation to indirect stimulation at higher frequencies Br J Pharmacol 66 1979 323 329 (Pubitemid 9215620)
4. W.C. Stewart, and E.A. Anderson Effect of a cholinesterase inhibitor when injected into the medulla of the rabbit J Pharmacol Exp Ther 162 1968 309 318
5. W.C. Stewart The effects of sarin and atropine on the respiratory center and neuromuscular junctions of the rat Can J Biochem Physiol 37 1959 651 660
6. C.A. de Candole, W.W. Douglas, C.L. Evans, R. Holmes, K.E. Spencer, and R.W. Torrance The failure of respiration in death by anticholinesterase poisoning Br J Pharmacol Chemother 8 1953 466 475
7. B.P. Doctor, D.M. Maxwell, Y. Ashani, A. Saxena, and R.K. Gordon New approaches to medical protection against chemical warfare nerve agents S.M. Somani, J.A. Romano Jr. Chemical warfare nerve agents: toxicity at low levels 2001 CRC Press Washington, D.C. 191 214
8. Y. Ashani Prospective of human butyrylcholinesterase as a detoxifying antidote and potential regulator of controlled-release drugs Drug Dev Res 50 2000 298 308
9. Y. Ashani, and S. Pistinner Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model Toxicol Sci 77 2004 358 367 (Pubitemid 38262609)
10. Y. Ashani, S. Shapira, D. Levy, A.D. Wolfe, B.P. Doctor, and L. Raveh Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice Biochem Pharmacol 41 1991 37 41
11. L. Raveh, J. Grunwald, D. Marcus, Y. Papier, E. Cohen, and Y. Ashani Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization Biochem Pharmacol 45 1993 2465 2474 (Pubitemid 23189540)
12. R. Brandeis, L. Raveh, J. Grunwald, E. Cohen, and Y. Ashani Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats Pharmacol Biochem Behav 46 1993 889 896
13. L. Raveh, E. Grauer, J. Grunwald, E. Cohen, and Y. Ashani The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase Toxicol Appl Pharmacol 145 1997 43 53 (Pubitemid 27294768)
14. A. Saxena, W. Sun, J.M. Fedorko, I. Koplovitz, and B.P. Doctor Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX Biochem Pharmacol 81 2011 164 169
15. D.E. Lenz, D.M. Maxwell, I. Koplovitz, C.R. Clark, B.R. Capacio, and D.M. Cerasoli Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys Chem Biol Interact 157-158 2005 205 210 (Pubitemid 41757652)
16. W. Sun, B.P. Doctor, D.E. Lenz, and A. Saxena Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys Chem Biol Interact 175 2008 428 430
17. N. Allon, L. Raveh, E. Gilat, E. Cohen, J. Grunwald, and Y. Ashani Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase Toxicol Sci 43 1998 121 128 (Pubitemid 28363385)
18. E.C. Lee Clinical manifestations of sarin nerve gas exposure J Am Med Assoc 290 2003 659 662 (Pubitemid 37430488)
19. A. Saxena, W. Sun, P.A. Dabisch, S.W. Hulet, N.B. Hastings, and E.M. Jakubowski Efficacy of human serum butyrylcholinesterase against sarin vapor Chem Biol Interact 175 2008 267 272
20. A. Saxena, P. Tipparaju, C. Luo, and B.P. Doctor Pilot-scale production of human serum butyrylcholinesterase suitable for use as a bioscavenger against nerve agent toxicity Process Biochem 45 2010 1313 1318
21. Hulet SW, Sommerville DR, Jakubowski EM, Benton BJ, Forster JS, Dabisch PA, et al. Aberdeen Proving Ground: U.S. Army Edgewood Chemical Biological Center, 2005.
22. G.L. Ellman, K.D. Courtney, V. Andres Jr., and R.M. Feather-Stone A new and rapid colorimetric determination of acetylcholinesterase activity Biochem Pharmacol 7 1961 88 95
23. F. Worek, U. Mast, D. Kiderlen, C. Diepold, and P. Eyer Improved determination of acetylcholinesterase activity in human whole blood Clin Chim Acta 288 1999 73 90 (Pubitemid 29472417)
24. E.M. Jakubowski, J.M. McGuire, R.A. Evans, J.L. Edwards, S.W. Hulet, and B.J. Benton Quantitation of fluoride ion released sarin in red blood cell samples by gas chromatography-chemical ionization mass spectrometry using isotope dilution and large-volume injection J Anal Toxicol 28 2004 357 363 (Pubitemid 38944114)
25. F.H. Duffy, and J.L. Burchfiel Long term effects of the organophosphate sarin on EEG in monkeys and humans Neurotoxicology 1 1980 667 689 (Pubitemid 10134686)
26. R.P. Chilcott, C.H. Dalton, I. Hill, C.M. Davidson, K.L. Blohm, and M.G. Hamilton Clinical manifestations of VX poisoning following percutaneous exposure in the domestic white pig Hum Exp Toxicol 22 2003 255 261 (Pubitemid 36626423)
27. A. Saxena, C. Luo, N. Chilukuri, D.M. Maxwell, and B.P. Doctor Novel approaches to medical protection against chemical warfare nerve agents J.A.J. Romano, B.J. Lukey, H. Salem, Chemical warfare agents chemistry, pharmacology, and therapeutics 2007 CRC Press Boca Raton, FL 145 173
28. S.N. Dube, P. Kumar, D. Kumar, and S. Das Gupta Route-specific cardiorespiratory and neuromuscular changes following organophosphorous poisoning in rats Arch Int Pharmacodyn Ther 321 1993 112 122 (Pubitemid 23174974)
29. T. Fredriksson, C-H. Hansson, and B. Holmstedt Effects of sarin in the anesthetized and unanesthetized dog following inhalation, percutaneous absorption, and intravenous infusion Arch Int Pharmacodyn 126 1960 288 302
30. J.T. James, J.H. Manthei, B.S. Goodwin, D. Heitkamp, and S.P. Liebenberg Clinical chemistry reference values in two breeds of swine and their changes during percutaneous exposure to soman Am J Vet Res 48 1987 284 288
31. A. Ludomirsky, H.O. Klein, P. Sarelli, B. Becker, S. Hoffman, and U. Taitelman Q-T prolongation and polymorphous (torsade de pointes) ventricular arrhythmias associated with organophosphorus insecticide poisoning Am J Cardiol 49 1982 1654 1658 (Pubitemid 12003476)
32. D.M. Brill, A.S. Maisel, and R. Prabhu Polymorphic ventricular tachycardia and other complex arrhythmias in organophosphate insecticide poisoning J Electrocardiol 17 1984 97 102 (Pubitemid 14154401)
33. C. Wren, P.H. Carson, and J.M. Sanderson Organophosphate poisoning and complete heart block J R Soc Med 74 1981 688 689 (Pubitemid 12227114)
34. A. Anzueto, G.G. Berdine, G.T. Moore, C. Gleiser, D. Johnson, and C.D. White Pathophysiology of soman intoxication in primates Toxicol Appl Pharmacol 86 1986 56 68 (Pubitemid 17170474)
35. N. Allon, I. Rabinovitz, E. Manistersky, B.A. Weissman, and E. Grauer Acute and long-lasting cardiac changes following a single whole-body exposure to sarin vapor in rats Toxicol Sci 87 2005 385 390 (Pubitemid 41300685)
36. R. Ben Abraham, V. Rudick, and A.A. Weinbroum Practical guidelines for acute care of victims of bioterrorism: conventional injuries and concomitant nerve agent intoxication Anesthesiology 97 2002 989 1004
37. A.M. Saadeh, N.A. Farsakh, and M.K. al-Ali Cardiac manifestations of acute carbamate and organophosphate poisoning Heart 77 1997 461 464 (Pubitemid 27278426)
38. P. Karki, J.A. Ansari, S. Bhandary, and S. Koirala Cardiac and electrocardiographical manifestations of acute organophosphate poisoning Singapore Med J 45 2004 385 389 (Pubitemid 39093688)
39. D.J. Weidler Myocardial damage and cardiac arrhythmias after intracranial hemorrhage. A critical review Stroke 5 1974 759 764
40. N.M. Bakry, A.H. el-Rashidy, A.T. Eldefrawi, and M.E. Eldefrawi Direct actions of organophosphate anticholinesterases on nicotinic and muscarinic acetylcholine receptors J Biochem Toxicol 3 1988 235 259
41. A.T. Eldefrawi, and M.E. Eldefrawi Direct actions of organophosphorus anticholinesterases on muscarinic receptors J.E. Chambers, P.E. Levi, Organophosphates, chemistry, fate and effects 1992 Academic Press San Diego, CA 268 323
42. L. Raveh, S. Chapman, G. Cohen, D. Alkalay, E. Gilat, and I. Rabinovitz The involvement of the NMDA receptor complex in the protective effect of anticholinergic drugs against soman poisoning Neurotoxicology 20 1999 551 559 (Pubitemid 29420356)
43. P.J. Podrid, and P.R. Kowey Cardiac arrhythmia: mechanisms, diagnosis and management 2001 Lippincott Williams & Wilkins
44. T.M. Shih, and J.H. McDonough Jr. Neurochemical mechanisms in soman-induced seizures J Appl Toxicol 17 1997 255 264 (Pubitemid 27344907)
45. S.O. Jacobsson, A. Sellstrom, S.A. Persson, and G.E. Cassel Correlation between cortical EEG and striatal microdialysis in soman-intoxicated rats Neurosci Lett 231 1997 155 158 (Pubitemid 27381937)
46. K.H. Schuleri, A.J. Boyle, M. Centola, L.C. Amado, R. Evers, and J.M. Zimmet The adult Gottingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies Comp Med 58 2008 568 579
47. K. Nahas, P. Baneux, and D. Detweiler Electrocardiographic monitoring in the Gottingen minipig Comp Med 52 2002 258 264
48. A. Eckenfels, and S. Schuler The normal electrocardiogram of miniature swine Arzneimittelforschung 38 1988 253 259
49. T.W. Dukes, and M. Szabuniewicz The electrocardiogram of conventional and miniature swine (Sus scrofa) Can J Comp Med 33 1969 118 127