Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase

Chemico-Biological Interactions

Volumn 157-158, Issue , 2005, Pages 115-121

  Chilukuri, N ^a   Parikh, K ^a   Sun, W ^a   Naik, R ^a   Tipparaju, P ^a   Doctor, B P ^a   Saxena, A ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Adenoviral vectors; Butyrylcholinesterase; Gene therapy; Organophosphorus compounds; Polyethylene glycosylation

Indexed keywords

ADENOVIRUS VECTOR; AMMONIUM SULFATE; ANTIDOTE; CHOLINESTERASE; COBALT; MACROGOL; POLYETHYLENE; PROCAINAMIDE; PROLINE; RECOMBINANT ENZYME; SEPHAROSE; TETRAMER;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; CELL STRAIN HEK293; CHEMICAL MODIFICATION; COLUMN CHROMATOGRAPHY; CONFERENCE PAPER; CULTURE MEDIUM; DRUG EFFICACY; DRUG SCREENING; DRUG STABILITY; ENZYME PURIFICATION; ENZYME STABILITY; FEMALE; FRACTIONATION; GLYCOSYLATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANIMALS; BUTYRYLCHOLINESTERASE; CELL LINE; FEMALE; GENE EXPRESSION; GLYCOSYLATION; HUMANS; KINETICS; MALE; MICE; MICE, INBRED BALB C; PEPTIDE HYDROLASES; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; TIME FACTORS;

ADENOVIRIDAE; ANIMALIA; PRIMATES; RODENTIA;

EID: 28744447265     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.10.013     Document Type: Conference Paper

References (21)

1. D.M. Maxwell, A.D. Wolfe, Y. Ashani, B.P. Doctor, Cholinesterase and carboxyesterase as scavengers for organophosphorous agents, in: Massoulie et al. (Eds.) Proceedings of the Third International Meeting on Cholinesterase, ACS Book, Washington, DC (1991) 206-209.
2. O. Lockridge, H.W. Eckerson, and B.N. La Du Inter-chain disulfide bonds and subunit organization in human serum cholinesterase J. Biol. Chem. 25 1979 8324 8333
3. C.A. Broomfield, D.M. Maxwell, R.P. Solana, C.A. Castro, A.V. Finger, and D.E. Lenz Protection of butyrylcholinesterase against organophosphorous poisoning in nonhuman primates J. Pharmacol. Exp. Ther. 259 1991 633 638
4. A.D. Wolfe, D.W. Blick, M.R. Murphy, S.A. Miller, M.K. Gentry, S.L. Hartgraves, and B.P. Doctor Use of cholinesterases as pretreatment drugs for the protection of rhesus monkeys against soman toxicity Toxicol. Appl. Pharmacol. 117 1992 189 193
5. L. Raveh, E. Grauer, J. Grunwald, E. Cohen, and Y. Ashani The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase Toxicol. Appl. Pharmacol. 145 1997 43 53
6. N. Allon, L. Raveh, E. Gilat, E. Cohen, J. Grunwald, and Y. Ashani Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase Toxicol. Sci. 43 1998 121 128
7. Y. Ashani, D. Grauer, and J. Grunwald Current capabilities in extrapolating from animal to human the capacity of human BChE to detoxify organophosphates B.P. Doctor D.M. Quinn R.L. Rotunda P. Taylor Structure and Function of Cholinesterases and Related Proteins 1998 Plenum Press New York 255 260
8. G.L. Ellman, A.D. Courtney, V. Andres Jr., and R.M. Featherstone A new and rapid colorimetric determination of acetycholinesterase activity Biochem. Pharmacol. 7 1961 88 95
9. P.B. Laub, and J.M. Gallo NCOM-a windows-based computer program for noncompartmental analysis of pharmacokinetic data J. Pharma Sci. 85 1996 393 395
10. U.K. Laemmli Cleavage of structural proteins during the assembly of head of bacteriophage T4 Nature 227 1970 680 685
11. Z. Radic, N.A. Pickering, D.C. Vellom, S. Camp, and P. Taylor Three distinct domains in the cholinesterase molecule confer sensitivity for acetyl- and butyrylcholinesterase inhibitors Biochemistry 32 1993 12074 12084
12. S. Bon, and J. Massoulie Quatenary associations of actylcholinesterase; I. Oligomeric associations of T subunits with and without the amino-terminal domain of the collage tail J. Biol. Chem. 272 1997 3007 3015
13. S. Bon, F. Coussen, and J. Massoulie Quatenary associations of actylcholinesterase; II. The polyproline attachment domain of the collagen tail J. Biol. Chem. 272 1997 3016 3021
14. Y. Tsutsumi, T. Kihira, S. Tsunoda, K. Kubo, S. Nakagawa, M. Miyake, Y. Horisawa, T. Kanamori, H. Ikegami, and T. Mayumi Chemical modification of natural human tumor necrosis factor alpha with polyethylene glycol increases its anti-tumor potency Jpn. J. Cancer Res. 85 1994 9 12
15. A. Kozlowski, and J.M. Harris Improvements in protein PEGylation: pegylated interferons for the treatment of hepatitis C J. Control. Release 72 2001 217 224
16. E.G. Duysen, C.F. Bartles, and O. Lockridge Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in chinese hamster ovary cells have a 16-h half-life in the circulation and protect mice from cocaine toxicity J. Pharmacol. Exp. Ther. 302 2002 751 758
17. H. Sun, M.L. Shen, Y.P. Pang, O. Lockridge, and S. Brimijoin Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase J. Pharmacol. Exp. Ther. 302 2002 710 716
18. S.A. Charles, J.M. Harris, S. Pedder, and S. Kumar Improving hepatitis C therapy; attaching polyethylene glycol "tail" to interferon for better clinical properties Mod. Drug Discov. 5 2000 59 65
19. O. Cohen, C. Kronman, T. Chitlauru, A. Ordentlich, B. Velan, and A. Shafferman Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity Biochem. J. 357 2001 795 802
20. O. Cohen, C. Kronman, B. Velan, and A. Shafferman Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus monkeys (Macaca mulatta) Biochem. J. 378 2004 117 128
21. M.J. McConnel, and M.J. Imperiale Biology of adenovirus and its use as a vector for gene therapy Hum. Gene Ther. 15 2004 1022 1033