Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro

Archives of Toxicology

Volumn 88, Issue 6, 2014, Pages 1257-1266

  Worek, Franz ^a   Seeger, Thomas ^a   Goldsmith, Moshe ^b   Ashani, Yacov ^b   Leader, Haim ^b   Sussman, Joel S ^b   Tawfik, Dan ^b   Thiermann, Horst ^a   Wille, Timo ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Bioscavenger; Detoxification; Mutant; Nerve agents; Paraoxonase; Protection

Indexed keywords

ACETYLCHOLINESTERASE; ARYLDIALKYLPHOSPHATASE 1; CYCLOSARIN; HYDROLASE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; MUTANT PROTEIN; ORGANOPHOSPHORUS COMPOUND; SOMAN; TABUN; ANTIDOTE; ARYLDIALKYLPHOSPHATASE; CHEMICAL WARFARE AGENT; CHOLINESTERASE INHIBITOR; ORGANOPHOSPHATE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CATALYSIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DEGRADATION KINETICS; DETOXIFICATION; DRUG EXPOSURE; DRUG INTOXICATION; ENZYME ACTIVITY; ERYTHROCYTE; GUINEA PIG MODEL; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; ISOMER; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; STEREOCHEMISTRY; TOXICITY TESTING; ANIMAL; BRAIN; DOSE RESPONSE; DRUG EFFECTS; GENETICS; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; TOXICITY; VALIDATION STUDY;

CAVIA;

ACETYLCHOLINESTERASE; ANIMALS; ANTIDOTES; ARYLDIALKYLPHOSPHATASE; BRAIN; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; GUINEA PIGS; INJECTIONS, INTRAVENOUS; MALE; ORGANOPHOSPHATES; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS;

EID: 84903455973     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1204-z     Document Type: Article

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