Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months

Biological Psychiatry

Volumn 71, Issue 8, 2012, Pages 700-705

  Anker, Justin J ^a   Brimijoin, Stephen ^b   Gao, Yang ^b   Geng, Liyi ^b   Zlebnik, Natalie E ^a   Parks, Robin J ^c   Carroll, Marilyn E ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Addiction; butyrylcholinesterase; cocaine; cocaine hydrolase; gene therapy; prevention; relapse

Indexed keywords

CHOLINESTERASE; COCAINE HYDROLASE VECTOR; DEXAMPHETAMINE; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG SEEKING BEHAVIOR; ENZYME ACTIVITY; FEMALE; GENE TRANSFER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT DURATION;

ANIMALS; BUTYRYLCHOLINESTERASE; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; COCAINE-RELATED DISORDERS; DEXTROAMPHETAMINE; DRUG-SEEKING BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MALE; RATS; RECURRENCE; REINFORCEMENT (PSYCHOLOGY); TRANSGENES;

EID: 84856813588     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.11.014     Document Type: Article

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