Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice

Journal of Molecular Neuroscience

Volumn 53, Issue 3, 2014, Pages 409-416

  Murthy, Vishakantha ^a   Gao, Yang ^a   Geng, Liyi ^a   LeBrasseur, Nathan ^a   White, Thomas ^a   Brimijoin, Stephen ^a  

^a MAYO CLINIC   (United States)

Author keywords

Addiction; Adeno associated viral vector; Butyrylcholinesterase; Cocaine; Gene therapy; Helper dependent adenoviral vector

Indexed keywords

CHOLINESTERASE; COCAINE HYDROLASE; LUCIFERASE; PARVOVIRUS VECTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG; COCAINE;

ANIMAL EXPERIMENT; ARTICLE; BODY EQUILIBRIUM; COGNITION; CONTROLLED STUDY; COORDINATION; ENDURANCE; GENE EXPRESSION; GENE TRANSFER; GRIP STRENGTH; HELPER DEPENDENT ADENOVIRUS; LOCOMOTION; MALE; MEMORY; MOTOR PERFORMANCE; MOUSE; MUSCLE STRENGTH; NEUROMUSCULAR FUNCTION; NONHUMAN; ROTAROD TEST; TRANSGENE; TREADMILL TEST; VIRAL GENE THERAPY; ANIMAL; BAGG ALBINO MOUSE; COCAINE-RELATED DISORDERS; DEPENDOPARVOVIRUS; GENE THERAPY; GENETICS; HAND STRENGTH; HUMAN; MAZE TEST; METABOLISM; PSYCHOMOTOR PERFORMANCE;

ANIMALS; BUTYRYLCHOLINESTERASE; COCAINE; COCAINE-RELATED DISORDERS; DEPENDOVIRUS; GENETIC THERAPY; HAND STRENGTH; HUMANS; MALE; MAZE LEARNING; MICE; MICE, INBRED BALB C; PSYCHOMOTOR PERFORMANCE;

EID: 84900806845     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0130-5     Document Type: Article

References (29)

1. Anglister L, Eichler J, Szabo M, Haesaert B, Salpeter MM (1998) 125I-labeled fasciculin 2: a new tool for quantitation of acetylcholinesterase densities at synaptic sites by EM-autoradiography. J Neurosci Methods 81:63-71 (Pubitemid 28293720)
2. Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D (2012) Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 481:81-84
3. Ben Assayag E, Shenhar-Tsarfaty S, Ofek K, Soreq L, Bova I, Shopin L, Berg RMG, Berliner S, Shapira I, Bornstein NM, Soreq H (2010) Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Mol Med 16:276-286
4. Brimijoin S, Shen ML, Sun H (2002) Radiometric solvent-partitioning assay for screening cocaine hydrolases andmeasuring cocaine levels in milligram tissue samples. Anal Biochem 309:200-205 (Pubitemid 35387310)
5. Brimijoin S, Orson F, Kosten TR, Kinsey B, Shen XY, White SJ, Gao Y (2013) Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. Chem-Biol Interact 203:212-216
6. Duysen EG, Li B, Darvesh S, Lockridge O (2007) Sensitivity of butyrylcholinesterase knockout mice to (-)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. Toxicology 233:60-69
7. Gao Y, Geng L, Orson F, Kinsey B, Kosten TR, Shen X, Brimijoin S (2013) Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. Chem-Biol Interact 203:208-211
8. Geng L, Gao Y, Chen X, Hou S, Zhan CG, Radic Z, Parks RJ, Russell SJ, Pham L, Brimijoin S (2013) Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity. PLoS One 8:e67446
9. Hikosaka O, Nakamura K, Sakai K, Nakahara H (2002) Central mechanisms of motor skill learning. Curr Opin Neurobiol 12:217-222 (Pubitemid 34518343)
10. Johnson CD, Russell RL (1975) A rapid simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal Biochem 64:229-238
11. Jueptner M, Frith CD, Brooks DJ, Frackowiak RS, Passingham RE (1997) Anatomy of motor learning. II. Subcortical structures and learning by trial and error. J Neurophysiol 77:1325-1337 (Pubitemid 27137028)
12. Kim IH, Jozkowicz A, Piedra PA, Oka K, Chan L (2001) Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci U S A 98:13282-13287 (Pubitemid 33051354)
13. Lenz DE, Maxwell DM, Koplovitz I, Clark CR, Capacio BR, Cerasoli DM, Federko JM, Luo C, Saxena A, Doctor BP, Olson C (2005) Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys. Chem-Biol Interact 157-158:205-210 (Pubitemid 41757652)
14. Li B, Stribley JA, Ticu A, Xie W, Schopfer LM, Hammond P, Brimijoin S, Hinrichs SH, Lockridge O (2000) Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J Neurochem 75:1320-1331 (Pubitemid 30660523)
15. Li B, Duysen EG, Carlson M, Lockridge O (2008) The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency. J Pharmacol Exp Ther 324:1146-1154 (Pubitemid 351397863)
16. Manoharan I, Wieseler S, Layer PG, Lockridge O, Boopathy R (2006) Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India. Pharmacogenet Genomics 16:461-468 (Pubitemid 43922343)
17. Manoharan I, Boopathy R, Darvesh S, Lockridge O (2007) A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India. Clin Chim Acta 378:128-135
18. Massaquoi SG, Hallett M (1998) Ataxia and other cerebellar syndromes. Parkinson's disease and movement disorders. Williams & Wilkins, Baltimore, pp 623-86
19. Miyagi N, Rao VP, Ricci D, Du Z, Byrne GW, Bailey KR, Nakai H, Russell SJ, McGregor CG (2008) Efficient and durable gene transfer to transplanted heart using adeno-associated virus 9 vector. J Heart Lung Transplant 27:554-560, The Official Publication of the International Society for Heart Transplantation (Pubitemid 351602177)
20. Parks RJ, Chen L, Anton M, Sankar U, Rudnicki MA, Graham FL (1996) A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A 93:13565-13570 (Pubitemid 26424159)
21. Pistell PJ, Ingram DK (2010) Development of a water-escape motivated version of the Stone T-maze for mice. Neuroscience 166:61-72
22. Saxena A, Sun W, Luo C, Doctor BP (2005) Human serum butyrylcholinesterase: in vitro and in vivo stability, pharmacokinetics, and safety in mice. Chem-Biol Interact 157-158:199-203 (Pubitemid 41757651)
23. Saxena A, Sun W, Fedorko JM, Koplovitz I, Doctor BP (2011) Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX. Biochem Pharmacol 81:164-169
24. Schirmer JM, Miyagi N, Rao VP, Ricci D, Federspiel MJ, Kotin RM, Russell SJ, McGregor CG (2007) Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart. Transplant International 20:550-557, Official Journal of the European Society for Organ Transplantation (Pubitemid 46701083)
25. Silver A (1974) The biology of cholinesterases. Elsevier-North Holland, Amsterdam, pp 67-98
26. Waehler R, Russell SJ, Curiel DT (2007) Engineering targeted viral vectors for gene therapy. Nat Rev Genet 8:573-587 (Pubitemid 47077278)
27. Weber A, Butterweck H, Mais-Paul U, Teschner W, Lei L, Muchitsch EM, Kolarich D, Altmann F, Ehrlich HJ, Schwarz HP (2011) Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use. Vox Sanguinis 100:285-297
28. Yang W, Xue L, Fang L, Chen X, Zhan CG (2010) Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine. Chem-Biol Interact 187:148-152
29. Zheng F, Yang W, Ko MC, Liu J, Cho H, Gao D, Tong M, Tai HH, Woods JH, Zhan CG (2008) Most efficient cocaine hydrolase designed by virtual screening of transition states. J Am Chem Soc 130:12148-12155