Experimental treatments for cocaine toxicity: A difficult transition to the bedside

Journal of Pharmacology and Experimental Therapeutics

Volumn 347, Issue 2, 2013, Pages 251-257

  Connors, Nicholas J ^a   Hoffman, Robert S ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ADENOVIRUS VECTOR; ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBOXYLESTERASE; CHLORPROMAZINE; CHOLINESTERASE; COCAINE; COCAINE HYDROLASE; DIAZEPAM; DRUG METABOLIZING ENZYME; ECGONINE METHYL ESTER; GLYCERYL TRINITRATE; HALOPERIDOL; LIPID EMULSION; LOCAL ANESTHETIC AGENT; MIDAZOLAM; NEUROLEPTIC AGENT; NEUROMUSCULAR BLOCKING AGENT; NEUROTRANSMITTER RECEPTOR; NORADRENALIN; OLANZAPINE; PHENTOLAMINE; PIMOZIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; ZIPRASIDONE;

ANTICHOLINERGIC EFFECT; ANTICONVULSANT ACTIVITY; COCAINE DEPENDENCE; CONVULSION; DELIRIUM; DRUG ABSORPTION; DRUG FATALITY; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG TRANSPORT; EXPERIMENTAL THERAPY; HEART ARRHYTHMIA; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HUMAN; HYPERTHERMIA; INDUCED HYPOTHERMIA; LIVER TOXICITY; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEIZURE THRESHOLD; THORAX PAIN; TRANQUILIZING ACTIVITY; VIRAL GENE DELIVERY SYSTEM;

ADRENERGIC ANTAGONISTS; ANIMALS; ANTIDOTES; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CLINICAL TRIALS AS TOPIC; COCAINE; COCAINE-RELATED DISORDERS; HUMANS; HYPOTHERMIA, INDUCED; VACCINATION;

EID: 84886080606     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.206383     Document Type: Review

References (65)

1. Amin M, Gabelman G, Karpel J., and Buttrick P (1990) Acute myocardial infarction and chest pain syndromes after cocaine use. Am J Cardiol 66:1434-1437.
2. Armstrong LE, Crago AE, Adams R, Roberts W.O., and Maresh CM (1996) Whole-body cooling of hyperthermic runners: comparison of two field therapies. Am J Emerg Med 14:355-358.
3. Arora NP, Berk WA, Aaron C.K., and Williams KA (2013) Usefulness of intravenous lipid emulsion for cardiac toxicity from cocaine overdose. Am J Cardiol 111: 445-447.
4. Baumann BM, Perrone J, Hornig S.E., Shofer FS, and Hollander JE (2000) Randomized, double-blind, placebo-controlled trial of diazepam, nitroglycerin, or both for treatment of patients with potential cocaine-associated acute coronary syndromes. Acad Emerg Med 7:878-885.
5. Brimijoin S, Gao Y, Anker J.J., Gliddon LA, Lafleur D, Shah R, Zhao Q., Singh M, and Carroll ME (2008) A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology 33:2715-2725.
6. Brimijoin S, Orson F, Kosten T.R., Kinsey B., Shen XY, White SJ, and Gao Y (2013) Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. Chem Biol Interact 203:212-216.
7. Carmona GN, Jufer RA, Goldberg S.R., Gorelick DA, Greig NH, Yu QS, Cone E.J., and Schindler CW (2000) Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans. Drug Metab Dispos 28:367-371.
8. Carmona GN, Schindler CW, Greig N.H., Holloway HW, Jufer RA, Cone EJ, and Gorelick DA (2005) Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in rats. Eur J Pharmacol 517: 186-190.
9. Carroll ME, Zlebnik NE, Anker J.J., Kosten TR, Orson FM, Shen X, Kinsey B., Parks RJ, Gao Y, and Brimijoin S (2012) Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. PLoS ONE 7:e43536 10.1371/journal.pone.0043536.
10. Catravas JD and Waters IW (1981) Acute cocaine intoxication in the conscious dog: studies on the mechanism of lethality. J Pharmacol Exp Ther 217:350-356.
11. Chow MJ, Ambre JJ, Ruo T.I., Atkinson AJ, Jr, Bowsher DJ, and Fischman MW (1985) Kinetics of cocaine distribution, elimination, and chronotropic effects. Clin Pharmacol Ther 38:318-324.
12. Cleveland NJ, Dewitt CD, and Heard K (2005) Ziprasidone pretreatment attenuates the lethal effects of cocaine in a mouse model. Acad Emerg Med 12:385-388.
13. Cleveland NR, Krier S, and Heard K (2007) Ziprasidone, diazepam, or the combination for prevention of cocaine toxicity in a mouse model. Acad Emerg Med 14: 691-694.
14. Collins GT, Brim RL, Noon K.R., Narasimhan D., Lukacs NW, Sunahara RK, Woods JH, and Ko MC (2012) Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. J Pharmacol Exp Ther 342:205-213.
15. Collins GT, Carey KA, Narasimhan D, Nichols J., Berlin AA, Lukacs NW, Sunahara RK, Woods J.H., and Ko MC (2011) Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology 36:1047-1059.
16. Cooper ZD, Narasimhan D, Sunahara R.K., Mierzejewski P., Jutkiewicz EM, Larsen NA, Wilson IA, Landry D.W., and Woods JH (2006) Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol 70:1885-1891.
17. Crandall CG, Vongpatanasin W, and Victor RG (2002) Mechanism of cocaine-induced hyperthermia in humans. Ann Intern Med 136:785-791.
18. Daras M, Kakkouras L, Tuchman A.J., and Koppel BS (1995) Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome? Acta Neurol Scand 92:161-165.
19. Dean RA, Christian CD, Sample R.H., and Bosron WF (1991) Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J 5:2735-2739.
20. Fareed FN, Chan G, and Hoffman RS (2007) Death temporally related to the use of a Beta adrenergic receptor antagonist in cocaine associated myocardial infarction. J Med Toxicol 3:169-172.
21. Fox BS, Kantak KM, Edwards M.A., Black KM, Bollinger BK, Botka AJ, French T.L., Thompson TL, Schad VC, and Greenstein JL, et al. (1996) Efficacy of a therapeutic cocaine vaccine in rodent models. Nat Med 2:1129-1132.
22. French D, Smollin C, Ruan W., Wong A, Drasner K, and Wu AH (2011) Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol (Phila) 49:801-809.
23. Gao Y and Brimijoin S (2004) An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats. J Pharmacol Exp Ther 310:1046-1052.
24. Gao Y, Geng L, Orson F., Kinsey B, Kosten TR, Shen X, and Brimijoin S (2013) Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. Chem Biol Interact 203:208-211.
25. Gitter MJ, Goldsmith SR, Dunbar D.N., and Sharkey SW (1991) Cocaine and chest pain: clinical features and outcome of patients hospitalized to rule out myocardial infarction. Ann Intern Med 115:277-282.
26. Guinn MM, Bedford JA, and Wilson MC (1980) Antagonism of intravenous cocaine lethality in nonhuman primates. Clin Toxicol 16:499-508.
27. Heard KJ, Cleveland NR, and Krier S (2009) The effect of olanzapine pretreatment on acute cocaine toxicity in mice. Clin Toxicol (Phila) 47:542-544.
28. Heard K, Cleveland NR, and Krier S (2011) Benzodiazepines and antipsychotic medications for treatment of acute cocaine toxicity in animal models - a systematic review and meta-analysis. Hum Exp Toxicol 30:1849-1854.
29. Hoffman RS, Henry GC, Howland M.A., Weisman RS, Weil L, and Goldfrank LR (1992) Association between life-threatening cocaine toxicity and plasma cholinesterase activity. Ann Emerg Med 21:247-253.
30. Hollander JE, Carter WA, and Hoffman RS (1992) Use of phentolamine for cocaine-induced myocardial ischemia. N Engl J Med 327:361.
31. Honderick T, Williams D, Seaberg D., and Wears R (2003) A prospective, randomized, controlled trial of benzodiazepines and nitroglycerine or nitroglycerine alone in the treatment of cocaine-associated acute coronary syndromes. Am J Emerg Med 21: 39-42.
32. Jakkala-Saibaba R., Morgan PG, and Morton GL (2011) Treatment of cocaine overdose with lipid emulsion. Anaesthesia 66:1168-1170.
33. Jamaty C, Bailey B, Larocque A., Notebaert E, Sanogo K, and Chauny JM (2010) Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies. Clin Toxicol (Phila) 48:1-27.
34. Kasanetz F, Lafourcade M, Deroche-Gamonet V, Revest J.M., Berson N., Balado E, Fiancette JF, Renault P, Piazza P.V., and Manzoni OJ (2013) Prefrontal synaptic markers of cocaine addiction-like behavior in rats. Mol Psychiatry 18:729-737.
35. Kiyatkin EA (2013) The hidden side of drug action: brain temperature changes induced by neuroactive drugs. Psychopharmacology (Berl) 225:765-780.
36. Ko MC, Narasimhan D, Berlin A.A., Lukacs NW, Sunahara RK, and Woods JH (2009) Effects of cocaine esterase following its repeated administration with cocaine in mice. Drug Alcohol Depend 101:202-209.
37. Lange RA, Cigarroa RG, Flores E.D., McBride W., Kim AS, Wells PJ, Bedotto JB, Danziger R.S., and Hillis LD (1990) Potentiation of cocaine-induced coronary vasoconstriction by beta-adrenergic blockade. Ann Intern Med 112:897-903.
38. Lange RA, Cigarroa RG, Yancy C.W., Jr, Willard JE, Popma JJ, Sills MN, McBride W, Kim AS, and Hillis LD (1989) Cocaine-induced coronary-artery vasoconstriction. N Engl J Med 321:1557-1562.
39. Leducq N, Bono F, Sulpice T., Vin V, Janiak P, Fur G.L., O'Connor SE, and Herbert JM (2003) Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion. J Pharmacol Exp Ther 306:828-837.
40. Lynch TJ, Mattes CE, Singh A, Bradley R.M., Brady RO, and Dretchen KL (1997) Cocaine detoxification by human plasma butyrylcholinesterase. Toxicol Appl Pharmacol 145:363-371.
41. Madden JA and Powers RH (1990) Effect of cocaine and cocaine metabolites on cerebral arteries in vitro. Life Sci 47:1109-1114.
42. Martell BA, Orson FM, Poling J, Mitchell E., Rossen RD, Gardner T, and Kosten TR (2009) Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. Arch Gen Psychiatry 66:1116-1123.
43. Marzuk PM, Tardiff K, Leon A.C., Hirsch CS, Portera L, Iqbal MI, Nock M.K., and Hartwell N (1998) Ambient temperature and mortality from unintentional cocaine overdose. JAMA 279:1795-1800.
44. Mattes CE, Lynch TJ, Singh A, Bradley R.M., Kellaris PA, Brady RO, and Dretchen KL (1997) Therapeutic use of butyrylcholinesterase for cocaine intoxication. Toxicol Appl Pharmacol 145:372-380.
45. Menaker J, Farcy DA, Boswell S.A., Stein DM, Dutton RP, Hess JR, and Scalea TM (2011) Cocaine-induced agitated delirium with associated hyperthermia: a case report. J Emerg Med 41:e49-e53.
46. Misra AL, Nayak PK, Bloch R, and Mulé SJ (1975) Estimation and disposition of [3H] benzoylecgonine and pharmacological activity of some cocaine metabolites. J Pharm Pharmacol 27:784-786.
47. Negus BH, Willard JE, Hillis L.D., Glamann DB, Landau C, Snyder RW, and Lange RA (1994) Alleviation of cocaine-induced coronary vasoconstriction with intravenous verapamil. Am J Cardiol 73:510-513.
48. Obame FN, Zini R, Souktani R., Berdeaux A, and Morin D (2007) Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization. J Pharmacol Exp Ther 323:336-345.
49. Roberts JR, Quattrocchi E, and Howland MA (1984) Severe hyperthermia secondary to intravenous drug abuse. Am J Emerg Med 2:373.
50. Rosenberg J, Pentel P, Pond S., Benowitz N, and Olson K (1986) Hyperthermia associated with drug intoxication. Crit Care Med 14:964-969.
51. Rosenblatt MA, Abel M, Fischer G.W., Itzkovich CJ, and Eisenkraft JB (2006) Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 105:217-218.
52. Samuels TL, Papadopoulou A, Willers J.W., and Uncles DR (2012) Logging the delivery of intravenous lipid emulsion for cocaine and other lipophilic drug overdoses. Anaesthesia 67:437-438.
53. Seubert CN, Morey TE, Martynyuk A.E., Cucchiara RF, and Dennis DM (2000) Midazolam selectively potentiates the A(2A) - but not A1-receptor - mediated effects of adenosine: role of nucleoside transport inhibition and clinical implications. Anesthesiology 92:567-577.
54. Smith JA, Mo Q, Guo H., Kunko PM, and Robinson SE (1995) Cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens. Brain Res 683:264-269.
55. Substance Abuse and Mental Health Services Administration (2011) Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-41, HHS Publication No. (SMA) 11-4658, Substance Abuse and Mental Health Services Administration, Rockville, MD.
56. Sun H, Pang YP, Lockridge O, and Brimijoin S (2002a) Re-engineering butyr-ylcholinesterase as a cocaine hydrolase. Mol Pharmacol 62:220-224.
57. Sun H, Shen ML, Pang Y.P., Lockridge O., and Brimijoin S (2002b) Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase. J Pharmacol Exp Ther 302:710-716.
58. Weinberg GL, VadeBoncouer T, Ramaraju G.A., Garcia-Amaro MF, and Cwik MJ (1998) Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 88:1071-1075.
59. Williams J and Lacey M (1988) Actions of cocaine on central monoamine neurons: intracellular recordings in vitro. NIDA Res Monogr 90:234-242.
60. Wilson CO and Gisvold O, Block JH, and Beale JM, editors (2004) Appendix: Calculated Log P, Log D, and pKa, in Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry, pp 948-57, Lippincott Williams & Wilkins, Philadelphia.
61. Witkin JM, Goldberg SR, and Katz JL (1989) Lethal effects of cocaine are reduced by the dopamine-1 receptor antagonist SCH 23390 but not by haloperidol. Life Sci 44: 1285-1291.
62. Wu S, Pearl-Davis MS, Manini A.F., and Hoffman RS (2008) Use of antipsychotics to treat cocaine toxicity? Acad Emerg Med 15:105-, author reply 106.
63. Young MJ, Sisti DA, Rimon-Greenspan H, Schwartz J.L., and Caplan AL (2012) Immune to addiction: the ethical dimensions of vaccines against substance abuse. Nat Immunol 13:521-524.
64. Yuksel A, Erdur B, Kortunay S., and Ergin A (2013) Assessment of propofol, mid-azolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model. Environ Toxicol Pharmacol 35:61-66.
65. Zheng F, Yang W, Ko M.C., Liu J., Cho H, Gao D, Tong M., Tai HH, Woods JH, and Zhan CG (2008) Most efficient cocaine hydrolase designed by virtual screening of transition states. J Am Chem Soc 130:12148-12155.