Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase

Toxicological Sciences

Volumn 43, Issue 2, 1998, Pages 121-128

  Allon, Nahum ^a   Raveh, Lily ^a   Gilat, Eran ^a   Cohen, Ephraim ^a,b   Grunwald, Jacob ^a   Ashani, Yacov ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; BENACTYZINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; NEUROTOXIN; ORGANOPHOSPHORUS COMPOUND; PYRIDOSTIGMINE; SOMAN;

ANIMAL MODEL; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; GUINEA PIG; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LD 50; MALE; NEUROTOXICITY; NONHUMAN; TOXICOKINETICS;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0031879541     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2463     Document Type: Article

References (36)

1. Ashani, Y., Shapira, S., Levy, D., Wolfe, A. D., Doctor, B. P., and Raven, L. (1991). Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice. Biochem. Pharmacol. 41, 37-41.
2. Benschop, H.P., and de Jong, L.P.A. (1991). Toxicokinetics of soman: Species variation and stereospecificity in elimination pathways. Neurosci. Biobehav. Rev. 15, 73-77.
3. Benschop, H.P., de Jong, L.P.A., and Langenberg, J.P. (1995). Inhalation toxicokinetics of C(±)P(±)-soman and (±)-sarin in the guinea-pigs. In Enzymes of the Cholinesterase Family (D.M. Quin, A.S. Balasubramanian, B.P. Doctor, and P. Taylor, Eds.), pp. 361-368. Plenum, New York.
4. 2. Am. Ind. Hyg. Assoc. J. 39, 129-138.
5. Brandeis, R., Raveh, L., Grunwald, J., Cohen, E., and Ashani, Y. (1993). Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats. Pharmacol. Biochem. Behav. 46, 889-896.
6. Broomfield, C.A., Maxwell, D.M., Solana, R.P., Castro, C.A., Finger, A.V., and Lenz, D.E. (1991). Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates. J. Pharmacol. Exp. Ther. 259(2), 633-638.
7. Cascio, C., Comite, C., Ghiara, M., Lanza, G., and Popnchione, A. (1988). The use of serum cholinesterase in severe phosphorus poisoning. Minerva Anestesiol. 54, 337-338.
8. Dirnhuber, P., French, M.C., Green, D.M., Leadbeater, L., and Startton, J.A. (1979). The protection of primates against soman poisoning by pretreatment with pyridostigmine. J. Pharm. Pharmacol. 31, 295-299.
9. Doctor, B.P., Raveh, L., Wolfe, A.D., Maxwell, D.M., and Ashani, Y. (1991). Enzymes as pretreatment drugs for organophosphate poisoning. Neuorosci. Biobehav. Rev. 15, 123-128.
10. Due, H.A., Trap, H.C., Van Der Wiel, H.J., and Benschop, H.P. (1993). Effect of pretreatment with CBDP on the toxicokinetics of soman stereoisomers in rats and guinea pigs. Arch. Toxicol. 67, 706-711.
11. Due, A.H., Trap, H.C., Langenberg, P.J., and Benschop, H.P. (1994). Toxicokinetics of soman stereoisomers after subcutaneous administration to atropinized guinea-pigs. Arch. Toxicol. 68, 60-63.
12. Dunn, M.A., and Sidell, F.R. (1989). Progress in medical defense against nerve agents. J. Am. Med. Assoc. 262, 649-652.
13. Ellman, G.L., Courtney, K.D., Andres, V., Jr., and Featherstone, R.M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88-95.
14. Finney, D.J. (1964). The Spearman-Karber method. In Statistical Methods in Biological Assay (D.J. Finney, Ed.), pp. 524-530. Charles Griffin, London.
15. Franz, D.R., and Hilaski, R. (1990). Sequence of cardiorespitatory effects of soman altered by roue of administration. Toxicol. Lett. 51, 221-225.
16. Grunwald, J., Marcus, D., Papier, Y., Raveh, L., Pittel, Z., and Ashani, Y. (1997). Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drug. J. Biochem. Biophys. Methods 34, 123-135.
17. Guyton, A.C. (1947). Measurement of respiratory volume of laboratory animals. Ann. J. Physiol. 150, 70-87.
18. Jenkins, T., Balinski, D., and Patient, D.W. (1967). Cholinesterase in plasma: First reported absence in the Bantu - Half-life determination. Science 156, 1748-1750.
19. Keijer, H.J., and Wolring, G.Z. (1969). Stereospecific aging of phosphonylated cholinesterases. Biochim. Biophys. Acta 185, 465-468.
20. Langenberg, J.P., de Jong, L.P.A., and Benschop, H.P. (1996). Protection of guinea pigs against soman poisoning by pretreatment with p-nitropheny phosphoramidate. Toxicol. Appl. Pharmacol. 140, 444-450.
21. Laub, P.B., and Gallo, J.M. (1996). N-COMP - A Windows-based program for noncompartmental analysis of pharmacokinetic data. J. Pharmacol. Sci. 85, 393-395.
22. Maxwell, D.M., Brecht, K.M., and O'Neill, B.L. (1987). The effect of carboxylesterase inhibitio on interspecies differences in soman toxicity. Toxicol. Lett. 39, 35-42.
23. Maxwell, D.M., Brecht, K.M., Lenz, D.E., and O'neill, B. (1988). Effect of carboxylesterase inhibition on carbamate protection against soman toxicity. J. Pharmacol. Exp. Ther. 246, 986-991.
24. Maxwell, D.M., and Brecht, K.M. (1991). The role of carboxylesterase in species variation of oxime protection against soman. Neuorosci. Biobehav. Rev. 15, 135-139.
25. Maxwell, D.M., Castro, C.A., De La Hoz, D.M., Gentry, M.K., Gold, M.B., Solana, R.P., Wolfe, A.D., and Doctor, B.P. (1992). Protection of rehsus monkeys against soman and prevention of performance decrement by pretreatment with acetylcholinesterase. Toxicol. Appl. Pharmacol. 115, 44-49.
26. Maxwell, D.M., Brecht, K.M., Doctor, B.P., and Wolfe, A.D. (1993). Comparison of antidote protection against soman by pyridostigmine, HI6, and acetylcholinesterase. J. Pharmacol. Exp. Ther. 264, 1085-1089.
27. Ostergaard, D., Viby-Mogensen, J., Hanel, H.K., and Skovgaard, L.T. (1988) Half-life of plasma cholinesterase. Acta. Anaesth. Scand. 32, 266-269.
28. Raveh, L., Ashani, Y., Levy, D., De La Hoz, D., Wolfe, A.D., and Doctor, B.P. (1989). Acetylcholinesterase prophylaxis against organophosphorus poisoning: Quantitative correlation between protection and blood-enzyme level in mice. Biochem. Pharmacol. 38, 529-534.
29. Raveh, L., Grunwald, J., Marcus, D., Papier, Y., Cohen, E., and Ashani, Y. (1993). Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity: In vitro and in vivo quantitative characterization. Biochem. Pharamacol. 45, 2465-2474.
30. Raveh, L., Grauer, E., Grunwald, J., Cohen, E., and Ashani, Y. (1997). The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase. Toxicol. Appl. Pharmacol. 145, 43-53.
31. Saxena, A., Ashani, Y., Raveh, L., Stevenson, D., Patel, T., and Doctor, B.P. (1998). The role of oligosaccharide in the pharmacokinetics of tissue-derived and genetically engineered cholinestersaes. Mol. Pharmacol. 59, 112-122.
32. Sterri, S.H., Kloster, O., and Valdal, G. (1982). Reduction of blood cholinesterase activities following administration of soman by different routes in guinea-pigs. Acta Pharmacol. Toxicol. 50, 326-331.
33. Sterri, S.H., and Fonnum, F. (1989). Carboxylesterase - the soman scavenger in rodents: Heterogeneity and hormonal influence. In Enzymes Hydrolysing Organophosphorus Compounds (E. Reiner, W.N. Aldridge, and F.C.G. Hoskin, Eds.), pp. 155-164. Ellis Horwood, Chichester.
34. Shih, T-M., Koviak, T.A., and Capacio, B.R. (1991). Anticonvulsants for poisoning by the organophosphorus compound soman: Pharmacological mechanism Neurosci. Biobehav. Rev. 15, 349-362.
35. Walday, P., Aas, P., Haider, T., and Fonnum, F. (1993). Effect of pyridostigmine pretreatment, HI6 and toxogonin treatment on rat tracheal smooth muscle response to cholinergic stimulation after organophosphorus inhalation exposure. Arch. Toxicol. 67, 212-210.
36. Wolfe, A.D., Rush, R.S., Doctor, B.P., and Jones, D. (1987). Acetylcholinesterase prophylaxis against organophosphate: Toxicity. Fundam. Appl. Toxicol. 9, 266-270.