-
1
-
-
76349103272
-
Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype
-
Ameri K., Luong R., Zhang H., Powell A.A., Montgomery K.D., Espinosa I., Bouley D.M., Harris A.L., Jeffrey S.S. Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype. Br. J. Cancer 2010, 102:561-569.
-
(2010)
Br. J. Cancer
, vol.102
, pp. 561-569
-
-
Ameri, K.1
Luong, R.2
Zhang, H.3
Powell, A.A.4
Montgomery, K.D.5
Espinosa, I.6
Bouley, D.M.7
Harris, A.L.8
Jeffrey, S.S.9
-
2
-
-
84877001869
-
Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress
-
Ameri K., Rajah A.M., Nguyen V., Sanders T.A., Jahangiri A., Delay M., Donne M., Choi H.J., Tormos K.V., Yeghiazarians Y., et al. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS ONE 2013, 8:e62758.
-
(2013)
PLoS ONE
, vol.8
-
-
Ameri, K.1
Rajah, A.M.2
Nguyen, V.3
Sanders, T.A.4
Jahangiri, A.5
Delay, M.6
Donne, M.7
Choi, H.J.8
Tormos, K.V.9
Yeghiazarians, Y.10
-
3
-
-
84884672726
-
Investigation of tumor suppressor genes apart from VHL on 3p by deletion mapping in sporadic clear cell renal cell carcinoma (cRCC)
-
Bhat Singh R., Amare Kadam P.S. Investigation of tumor suppressor genes apart from VHL on 3p by deletion mapping in sporadic clear cell renal cell carcinoma (cRCC). Urol. Oncol. 2013, 31:1333-1342.
-
(2013)
Urol. Oncol.
, vol.31
, pp. 1333-1342
-
-
Bhat Singh, R.1
Amare Kadam, P.S.2
-
4
-
-
84860595935
-
Microenvironments dictating tumor cell dormancy
-
Bragado P., Sosa M.S., Keely P., Condeelis J., Aguirre-Ghiso J.A. Microenvironments dictating tumor cell dormancy. Recent Results Cancer Res. 2012, 195:25-39.
-
(2012)
Recent Results Cancer Res.
, vol.195
, pp. 25-39
-
-
Bragado, P.1
Sosa, M.S.2
Keely, P.3
Condeelis, J.4
Aguirre-Ghiso, J.A.5
-
5
-
-
0028241636
-
Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development
-
Buchhagen D.L., Qiu L., Etkind P. Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3-3p21.3 in sporadic breast-cancer development. Int. J. Cancer 1994, 57:473-479.
-
(1994)
Int. J. Cancer
, vol.57
, pp. 473-479
-
-
Buchhagen, D.L.1
Qiu, L.2
Etkind, P.3
-
7
-
-
9444296528
-
Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function
-
Catrina S.B., Okamoto K., Pereira T., Brismar K., Poellinger L. Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes 2004, 53:3226-3232.
-
(2004)
Diabetes
, vol.53
, pp. 3226-3232
-
-
Catrina, S.B.1
Okamoto, K.2
Pereira, T.3
Brismar, K.4
Poellinger, L.5
-
8
-
-
41549114264
-
A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer
-
Chanrion M., Negre V., Fontaine H., Salvetat N., Bibeau F., Mac Grogan G., Mauriac L., Katsaros D., Molina F., Theillet C., Darbon J.M. A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer. Clin. Cancer Res. 2008, 14:1744-1752.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 1744-1752
-
-
Chanrion, M.1
Negre, V.2
Fontaine, H.3
Salvetat, N.4
Bibeau, F.5
Mac Grogan, G.6
Mauriac, L.7
Katsaros, D.8
Molina, F.9
Theillet, C.10
Darbon, J.M.11
-
9
-
-
38949203787
-
Is mitochondrial generation of reactive oxygen species a trigger for autophagy?
-
Chen Y., Gibson S.B. Is mitochondrial generation of reactive oxygen species a trigger for autophagy?. Autophagy 2008, 4:246-248.
-
(2008)
Autophagy
, vol.4
, pp. 246-248
-
-
Chen, Y.1
Gibson, S.B.2
-
10
-
-
84863229229
-
Identification of a protein mediating respiratory supercomplex stability
-
Chen Y.C., Taylor E.B., Dephoure N., Heo J.M., Tonhato A., Papandreou I., Nath N., Denko N.C., Gygi S.P., Rutter J. Identification of a protein mediating respiratory supercomplex stability. Cell Metab. 2012, 15:348-360.
-
(2012)
Cell Metab.
, vol.15
, pp. 348-360
-
-
Chen, Y.C.1
Taylor, E.B.2
Dephoure, N.3
Heo, J.M.4
Tonhato, A.5
Papandreou, I.6
Nath, N.7
Denko, N.C.8
Gygi, S.P.9
Rutter, J.10
-
11
-
-
0029561919
-
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC
-
Davies S.P., Helps N.R., Cohen P.T., Hardie D.G. 5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC. FEBS Lett. 1995, 377:421-425.
-
(1995)
FEBS Lett.
, vol.377
, pp. 421-425
-
-
Davies, S.P.1
Helps, N.R.2
Cohen, P.T.3
Hardie, D.G.4
-
12
-
-
84902578831
-
Dormancy of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia
-
Endo H., Okuyama H., Ohue M., Inoue M. Dormancy of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia. PLoS ONE 2014, 9:e98858.
-
(2014)
PLoS ONE
, vol.9
, pp. e98858
-
-
Endo, H.1
Okuyama, H.2
Ohue, M.3
Inoue, M.4
-
13
-
-
84872159532
-
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth invivo
-
Faubert B., Boily G., Izreig S., Griss T., Samborska B., Dong Z., Dupuy F., Chambers C., Fuerth B.J., Viollet B., et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth invivo. Cell Metab. 2013, 17:113-124.
-
(2013)
Cell Metab.
, vol.17
, pp. 113-124
-
-
Faubert, B.1
Boily, G.2
Izreig, S.3
Griss, T.4
Samborska, B.5
Dong, Z.6
Dupuy, F.7
Chambers, C.8
Fuerth, B.J.9
Viollet, B.10
-
14
-
-
84865110875
-
Endoplasmic reticulum stress induced by oxidative stress in decidual cells: a possible mechanism of early pregnancy loss
-
Gao H.J., Zhu Y.M., He W.H., Liu A.X., Dong M.Y., Jin M., Sheng J.Z., Huang H.F. Endoplasmic reticulum stress induced by oxidative stress in decidual cells: a possible mechanism of early pregnancy loss. Mol. Biol. Rep. 2012, 39:9179-9186.
-
(2012)
Mol. Biol. Rep.
, vol.39
, pp. 9179-9186
-
-
Gao, H.J.1
Zhu, Y.M.2
He, W.H.3
Liu, A.X.4
Dong, M.Y.5
Jin, M.6
Sheng, J.Z.7
Huang, H.F.8
-
15
-
-
84887981252
-
Mechanisms governing metastatic dormancy and reactivation
-
Giancotti F.G. Mechanisms governing metastatic dormancy and reactivation. Cell 2013, 155:750-764.
-
(2013)
Cell
, vol.155
, pp. 750-764
-
-
Giancotti, F.G.1
-
16
-
-
84863337299
-
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death
-
Graham N.A., Tahmasian M., Kohli B., Komisopoulou E., Zhu M., Vivanco I., Teitell M.A., Wu H., Ribas A., Lo R.S., et al. Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Mol. Syst. Biol. 2012, 8:589.
-
(2012)
Mol. Syst. Biol.
, vol.8
, pp. 589
-
-
Graham, N.A.1
Tahmasian, M.2
Kohli, B.3
Komisopoulou, E.4
Zhu, M.5
Vivanco, I.6
Teitell, M.A.7
Wu, H.8
Ribas, A.9
Lo, R.S.10
-
17
-
-
78149479438
-
Redox regulation of the AMP-activated protein kinase
-
Han Y., Wang Q., Song P., Zhu Y., Zou M.H. Redox regulation of the AMP-activated protein kinase. PLoS ONE 2010, 5:e15420.
-
(2010)
PLoS ONE
, vol.5
, pp. e15420
-
-
Han, Y.1
Wang, Q.2
Song, P.3
Zhu, Y.4
Zou, M.H.5
-
18
-
-
84860294684
-
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
-
Harada H., Inoue M., Itasaka S., Hirota K., Morinibu A., Shinomiya K., Zeng L., Ou G., Zhu Y., Yoshimura M., et al. Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat. Commun. 2012, 3:783.
-
(2012)
Nat. Commun.
, vol.3
, pp. 783
-
-
Harada, H.1
Inoue, M.2
Itasaka, S.3
Hirota, K.4
Morinibu, A.5
Shinomiya, K.6
Zeng, L.7
Ou, G.8
Zhu, Y.9
Yoshimura, M.10
-
19
-
-
84876320551
-
LKB1 and AMPK and the cancer-metabolism link - ten years after
-
Hardie D.G., Alessi D.R. LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC Biol. 2013, 11:36.
-
(2013)
BMC Biol.
, vol.11
, pp. 36
-
-
Hardie, D.G.1
Alessi, D.R.2
-
20
-
-
84858782079
-
AMPK: a nutrient and energy sensor that maintains energy homeostasis
-
Hardie D.G., Ross F.A., Hawley S.A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 2012, 13:251-262.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
21
-
-
84855644497
-
Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
-
Hofstetter C.P., Burkhardt J.K., Shin B.J., Gürsel D.B., Mubita L., Gorrepati R., Brennan C., Holland E.C., Boockvar J.A. Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. PLoS ONE 2012, 7:e30059.
-
(2012)
PLoS ONE
, vol.7
-
-
Hofstetter, C.P.1
Burkhardt, J.K.2
Shin, B.J.3
Gürsel, D.B.4
Mubita, L.5
Gorrepati, R.6
Brennan, C.7
Holland, E.C.8
Boockvar, J.A.9
-
22
-
-
84859385707
-
Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
-
Hu Y.L., DeLay M., Jahangiri A., Molinaro A.M., Rose S.D., Carbonell W.S., Aghi M.K. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 2012, 72:1773-1783.
-
(2012)
Cancer Res.
, vol.72
, pp. 1773-1783
-
-
Hu, Y.L.1
DeLay, M.2
Jahangiri, A.3
Molinaro, A.M.4
Rose, S.D.5
Carbonell, W.S.6
Aghi, M.K.7
-
23
-
-
84875808625
-
Insights into the regulation of tumor dormancy by angiogenesis in experimental tumors
-
Indraccolo S. Insights into the regulation of tumor dormancy by angiogenesis in experimental tumors. Adv. Exp. Med. Biol. 2013, 734:37-52.
-
(2013)
Adv. Exp. Med. Biol.
, vol.734
, pp. 37-52
-
-
Indraccolo, S.1
-
24
-
-
0020641117
-
The protein phosphatases involved in cellular regulation. 6. Measurement of type-1 and type-2 protein phosphatases in extracts of mammalian tissues; an assessment of their physiological roles
-
Ingebritsen T.S., Stewart A.A., Cohen P. The protein phosphatases involved in cellular regulation. 6. Measurement of type-1 and type-2 protein phosphatases in extracts of mammalian tissues; an assessment of their physiological roles. Eur. J. Biochem. 1983, 132:297-307.
-
(1983)
Eur. J. Biochem.
, vol.132
, pp. 297-307
-
-
Ingebritsen, T.S.1
Stewart, A.A.2
Cohen, P.3
-
25
-
-
15444342958
-
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
-
Iyer N.V., Kotch L.E., Agani F., Leung S.W., Laughner E., Wenger R.H., Gassmann M., Gearhart J.D., Lawler A.M., Yu A.Y., Semenza G.L. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998, 12:149-162.
-
(1998)
Genes Dev.
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
26
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
Jeon S.M., Chandel N.S., Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012, 485:661-665.
-
(2012)
Nature
, vol.485
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
27
-
-
0035895888
-
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties
-
Kelso G.F., Porteous C.M., Coulter C.V., Hughes G., Porteous W.K., Ledgerwood E.C., Smith R.A., Murphy M.P. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J.Biol. Chem. 2001, 276:4588-4596.
-
(2001)
J.Biol. Chem.
, vol.276
, pp. 4588-4596
-
-
Kelso, G.F.1
Porteous, C.M.2
Coulter, C.V.3
Hughes, G.4
Porteous, W.K.5
Ledgerwood, E.C.6
Smith, R.A.7
Murphy, M.P.8
-
28
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
-
Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3:177-185.
-
(2006)
Cell Metab.
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
29
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J., Kundu M., Viollet B., Guan K.L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 2011, 13:132-141.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
30
-
-
84861709686
-
A two-dimensional screen for AMPK substrates identifies tumor suppressor fumarate hydratase as a preferential AMPKα2 substrate
-
Klaus A., Polge C., Zorman S., Auchli Y., Brunisholz R., Schlattner U. A two-dimensional screen for AMPK substrates identifies tumor suppressor fumarate hydratase as a preferential AMPKα2 substrate. J.Proteomics 2012, 75:3304-3313.
-
(2012)
J.Proteomics
, vol.75
, pp. 3304-3313
-
-
Klaus, A.1
Polge, C.2
Zorman, S.3
Auchli, Y.4
Brunisholz, R.5
Schlattner, U.6
-
31
-
-
84871813739
-
AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity
-
Kwan H.T., Chan D.W., Cai P.C., Mak C.S., Yung M.M., Leung T.H., Wong O.G., Cheung A.N., Ngan H.Y. AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity. PLoS ONE 2013, 8:e53597.
-
(2013)
PLoS ONE
, vol.8
-
-
Kwan, H.T.1
Chan, D.W.2
Cai, P.C.3
Mak, C.S.4
Yung, M.M.5
Leung, T.H.6
Wong, O.G.7
Cheung, A.N.8
Ngan, H.Y.9
-
32
-
-
84875143073
-
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells
-
Lagadinou E.D., Sach A., Callahan K., Rossi R.M., Neering S.J., Minhajuddin M., Ashton J.M., Pei S., Grose V., O'Dwyer K.M., et al. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell 2013, 12:329-341.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 329-341
-
-
Lagadinou, E.D.1
Sach, A.2
Callahan, K.3
Rossi, R.M.4
Neering, S.J.5
Minhajuddin, M.6
Ashton, J.M.7
Pei, S.8
Grose, V.9
O'Dwyer, K.M.10
-
33
-
-
1642359043
-
Microenvironmental regulation of proliferation in multicellular spheroids is mediated through differential expression of cyclin-dependent kinase inhibitors
-
LaRue K.E., Khalil M., Freyer J.P. Microenvironmental regulation of proliferation in multicellular spheroids is mediated through differential expression of cyclin-dependent kinase inhibitors. Cancer Res. 2004, 64:1621-1631.
-
(2004)
Cancer Res.
, vol.64
, pp. 1621-1631
-
-
LaRue, K.E.1
Khalil, M.2
Freyer, J.P.3
-
34
-
-
84861078292
-
Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes
-
Lenin R., Maria M.S., Agrawal M., Balasubramanyam J., Mohan V., Balasubramanyam M. Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes. Exp. Diabetes Res. 2012, 2012:356487.
-
(2012)
Exp. Diabetes Res.
, vol.2012
, pp. 356487
-
-
Lenin, R.1
Maria, M.S.2
Agrawal, M.3
Balasubramanyam, J.4
Mohan, V.5
Balasubramanyam, M.6
-
35
-
-
84867884641
-
Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent
-
Lin H.Y., Kuo Y.C., Weng Y.I., Lai I.L., Huang T.H., Lin S.P., Niu D.M., Chen C.S. Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent. Prostate 2012, 72:1767-1778.
-
(2012)
Prostate
, vol.72
, pp. 1767-1778
-
-
Lin, H.Y.1
Kuo, Y.C.2
Weng, Y.I.3
Lai, I.L.4
Huang, T.H.5
Lin, S.P.6
Niu, D.M.7
Chen, C.S.8
-
36
-
-
84897468362
-
Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits
-
Lindert S., Maslennikov I., Chiu E.J., Pierce L.C., McCammon J.A., Choe S. Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits. Biochem. Biophys. Res. Commun. 2014, 445:724-733.
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.445
, pp. 724-733
-
-
Lindert, S.1
Maslennikov, I.2
Chiu, E.J.3
Pierce, L.C.4
McCammon, J.A.5
Choe, S.6
-
37
-
-
77958114507
-
Oxygen consumption and ROS production are increased at the time of fertilization and cell cleavage in bovine zygotes
-
Lopes A.S., Lane M., Thompson J.G. Oxygen consumption and ROS production are increased at the time of fertilization and cell cleavage in bovine zygotes. Hum. Reprod. 2010, 25:2762-2773.
-
(2010)
Hum. Reprod.
, vol.25
, pp. 2762-2773
-
-
Lopes, A.S.1
Lane, M.2
Thompson, J.G.3
-
38
-
-
84872241559
-
Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes
-
Mackenzie R.M., Salt I.P., Miller W.H., Logan A., Ibrahim H.A., Degasperi A., Dymott J.A., Hamilton C.A., Murphy M.P., Delles C., Dominiczak A.F. Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clin. Sci. 2013, 124:403-411.
-
(2013)
Clin. Sci.
, vol.124
, pp. 403-411
-
-
Mackenzie, R.M.1
Salt, I.P.2
Miller, W.H.3
Logan, A.4
Ibrahim, H.A.5
Degasperi, A.6
Dymott, J.A.7
Hamilton, C.A.8
Murphy, M.P.9
Delles, C.10
Dominiczak, A.F.11
-
39
-
-
57449092891
-
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
-
Malhotra J.D., Miao H., Zhang K., Wolfson A., Pennathur S., Pipe S.W., Kaufman R.J. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc. Natl. Acad. Sci. USA 2008, 105:18525-18530.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18525-18530
-
-
Malhotra, J.D.1
Miao, H.2
Zhang, K.3
Wolfson, A.4
Pennathur, S.5
Pipe, S.W.6
Kaufman, R.J.7
-
40
-
-
0030943461
-
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
-
Maltepe E., Schmidt J.V., Baunoch D., Bradfield C.A., Simon M.C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997, 386:403-407.
-
(1997)
Nature
, vol.386
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.A.4
Simon, M.C.5
-
41
-
-
58249093939
-
How mitochondria produce reactive oxygen species
-
Murphy M.P. How mitochondria produce reactive oxygen species. Biochem. J. 2009, 417:1-13.
-
(2009)
Biochem. J.
, vol.417
, pp. 1-13
-
-
Murphy, M.P.1
-
42
-
-
84899893679
-
Recurrent epimutations activate gene body promoters in primary glioblastoma
-
Nagarajan R.P., Zhang B., Bell R.J., Johnson B.E., Olshen A.B., Sundaram V., Li D., Graham A.E., Diaz A., Fouse S.D., et al. Recurrent epimutations activate gene body promoters in primary glioblastoma. Genome Res. 2014, 24:761-774.
-
(2014)
Genome Res.
, vol.24
, pp. 761-774
-
-
Nagarajan, R.P.1
Zhang, B.2
Bell, R.J.3
Johnson, B.E.4
Olshen, A.B.5
Sundaram, V.6
Li, D.7
Graham, A.E.8
Diaz, A.9
Fouse, S.D.10
-
43
-
-
79958866010
-
Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization
-
Nardo G., Favaro E., Curtarello M., Moserle L., Zulato E., Persano L., Rossi E., Esposito G., Crescenzi M., Casanovas O., et al. Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization. Cancer Res. 2011, 71:4214-4225.
-
(2011)
Cancer Res.
, vol.71
, pp. 4214-4225
-
-
Nardo, G.1
Favaro, E.2
Curtarello, M.3
Moserle, L.4
Zulato, E.5
Persano, L.6
Rossi, E.7
Esposito, G.8
Crescenzi, M.9
Casanovas, O.10
-
44
-
-
82355191512
-
Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice
-
Ochiai D., Goda N., Hishiki T., Kanai M., Senoo-Matsuda N., Soga T., Johnson R.S., Yoshimura Y., Suematsu M. Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice. Biochem. Biophys. Res. Commun. 2011, 415:445-449.
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.415
, pp. 445-449
-
-
Ochiai, D.1
Goda, N.2
Hishiki, T.3
Kanai, M.4
Senoo-Matsuda, N.5
Soga, T.6
Johnson, R.S.7
Yoshimura, Y.8
Suematsu, M.9
-
45
-
-
77954177298
-
Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization
-
Osada-Oka M., Hashiba Y., Akiba S., Imaoka S., Sato T. Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization. FEBS Lett. 2010, 584:3073-3079.
-
(2010)
FEBS Lett.
, vol.584
, pp. 3073-3079
-
-
Osada-Oka, M.1
Hashiba, Y.2
Akiba, S.3
Imaoka, S.4
Sato, T.5
-
46
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I., Cairns R.A., Fontana L., Lim A.L., Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006, 3:187-197.
-
(2006)
Cell Metab.
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
47
-
-
77955412723
-
Upregulation of Na+/H+ exchanger by the AMP-activated protein kinase
-
Rotte A., Pasham V., Eichenmüller M., Bhandaru M., Föller M., Lang F. Upregulation of Na+/H+ exchanger by the AMP-activated protein kinase. Biochem. Biophys. Res. Commun. 2010, 398:677-682.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.398
, pp. 677-682
-
-
Rotte, A.1
Pasham, V.2
Eichenmüller, M.3
Bhandaru, M.4
Föller, M.5
Lang, F.6
-
48
-
-
0032100732
-
HIF-1 alpha is required for solid tumor formation and embryonic vascularization
-
Ryan H.E., Lo J., Johnson R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 1998, 17:3005-3015.
-
(1998)
EMBO J.
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
49
-
-
0033870727
-
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
-
Ryan H.E., Poloni M., McNulty W., Elson D., Gassmann M., Arbeit J.M., Johnson R.S. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 2000, 60:4010-4015.
-
(2000)
Cancer Res.
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
50
-
-
84897019542
-
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology
-
Semenza G.L. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu. Rev. Pathol. 2014, 9:47-71.
-
(2014)
Annu. Rev. Pathol.
, vol.9
, pp. 47-71
-
-
Semenza, G.L.1
-
51
-
-
84868007565
-
Physiological roles of mitochondrial reactive oxygen species
-
Sena L.A., Chandel N.S. Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 2012, 48:158-167.
-
(2012)
Mol. Cell
, vol.48
, pp. 158-167
-
-
Sena, L.A.1
Chandel, N.S.2
-
52
-
-
38449086370
-
Induction of DNA hypomethylation by tumor hypoxia
-
Shahrzad S., Bertrand K., Minhas K., Coomber B.L. Induction of DNA hypomethylation by tumor hypoxia. Epigenetics 2007, 2:119-125.
-
(2007)
Epigenetics
, vol.2
, pp. 119-125
-
-
Shahrzad, S.1
Bertrand, K.2
Minhas, K.3
Coomber, B.L.4
-
53
-
-
77957336892
-
Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells
-
Skowronski K., Dubey S., Rodenhiser D., Coomber B. Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells. Epigenetics 2010, 5:547-556.
-
(2010)
Epigenetics
, vol.5
, pp. 547-556
-
-
Skowronski, K.1
Dubey, S.2
Rodenhiser, D.3
Coomber, B.4
-
54
-
-
23844485492
-
Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors
-
Sobhanifar S., Aquino-Parsons C., Stanbridge E.J., Olive P. Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. Cancer Res. 2005, 65:7259-7266.
-
(2005)
Cancer Res.
, vol.65
, pp. 7259-7266
-
-
Sobhanifar, S.1
Aquino-Parsons, C.2
Stanbridge, E.J.3
Olive, P.4
-
55
-
-
84875804581
-
Regulation of tumor cell dormancy by tissue microenvironments and autophagy
-
Sosa M.S., Bragado P., Debnath J., Aguirre-Ghiso J.A. Regulation of tumor cell dormancy by tissue microenvironments and autophagy. Adv. Exp. Med. Biol. 2013, 734:73-89.
-
(2013)
Adv. Exp. Med. Biol.
, vol.734
, pp. 73-89
-
-
Sosa, M.S.1
Bragado, P.2
Debnath, J.3
Aguirre-Ghiso, J.A.4
-
56
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter H.M., Ratcliffe P.J., Watson P., Greenberg A.H., Harris A.L. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 2001, 61:6669-6673.
-
(2001)
Cancer Res.
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
57
-
-
84861320506
-
Rcf1 and Rcf2, members of the hypoxia-induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex
-
Strogolova V., Furness A., Robb-McGrath M., Garlich J., Stuart R.A. Rcf1 and Rcf2, members of the hypoxia-induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex. Mol. Cell. Biol. 2012, 32:1363-1373.
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 1363-1373
-
-
Strogolova, V.1
Furness, A.2
Robb-McGrath, M.3
Garlich, J.4
Stuart, R.A.5
-
58
-
-
0024281372
-
Cell and environment interactions in tumor microregions: the multicell spheroid model
-
Sutherland R.M. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 1988, 240:177-184.
-
(1988)
Science
, vol.240
, pp. 177-184
-
-
Sutherland, R.M.1
-
59
-
-
69949124669
-
Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response
-
van den Beucken T., Koritzinsky M., Niessen H., Dubois L., Savelkouls K., Mujcic H., Jutten B., Kopacek J., Pastorekova S., van der Kogel A.J., et al. Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response. J.Biol. Chem. 2009, 284:24204-24212.
-
(2009)
J.Biol. Chem.
, vol.284
, pp. 24204-24212
-
-
van den Beucken, T.1
Koritzinsky, M.2
Niessen, H.3
Dubois, L.4
Savelkouls, K.5
Mujcic, H.6
Jutten, B.7
Kopacek, J.8
Pastorekova, S.9
van der Kogel, A.J.10
-
60
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
61
-
-
33746078851
-
Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival
-
Wang J., Cao Y., Chen Y., Chen Y., Gardner P., Steiner D.F. Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proc. Natl. Acad. Sci. USA 2006, 103:10636-10641.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 10636-10641
-
-
Wang, J.1
Cao, Y.2
Chen, Y.3
Chen, Y.4
Gardner, P.5
Steiner, D.F.6
-
62
-
-
83255189409
-
AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases
-
Wu S.B., Wei Y.H. AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases. Biochim. Biophys. Acta 2012, 1822:233-247.
-
(2012)
Biochim. Biophys. Acta
, vol.1822
, pp. 233-247
-
-
Wu, S.B.1
Wei, Y.H.2
-
63
-
-
84899487410
-
Si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma
-
Xiang J., Luo F., Chen Y., Zhu F., Wang J. si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma. Clin Res Hepatol Gastroenterol 2014, 38:181-189.
-
(2014)
Clin Res Hepatol Gastroenterol
, vol.38
, pp. 181-189
-
-
Xiang, J.1
Luo, F.2
Chen, Y.3
Zhu, F.4
Wang, J.5
-
64
-
-
84920928879
-
A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells
-
Yao J., Zhou B., Zhang J., Geng P., Liu K., Zhu Y., Zhu W. A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells. Tumour Biol. 2014, 35:7935-7944.
-
(2014)
Tumour Biol.
, vol.35
, pp. 7935-7944
-
-
Yao, J.1
Zhou, B.2
Zhang, J.3
Geng, P.4
Liu, K.5
Zhu, Y.6
Zhu, W.7
-
65
-
-
84894542141
-
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
-
Zhang X., Fryknäs M., Hernlund E., Fayad W., De Milito A., Olofsson M.H., Gogvadze V., Dang L., Påhlman S., Schughart L.A., et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat. Commun. 2014, 5:3295.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3295
-
-
Zhang, X.1
Fryknäs, M.2
Hernlund, E.3
Fayad, W.4
De Milito, A.5
Olofsson, M.H.6
Gogvadze, V.7
Dang, L.8
Påhlman, S.9
Schughart, L.A.10
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