Drug screening strategy for human membrane proteins: From NMR protein backbone structure to in silica- and NMR-screened hits

Biochemical and Biophysical Research Communications

Volumn 445, Issue 4, 2014, Pages 724-733

  Lindert, Steffen ^a   Maslennikov, Innokentiy ^b,c   Chiu, Ellis J C ^b   Pierce, Levi C ^a,e   McCammon, J Andrew ^a   Choe, Senyon ^b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c Songdo Global University Campus   (South Korea)

^d Drug Discovery Collaboratory   (United States)

^e SCHRÖDINGER INC   (United States)

Author keywords

Computational docking; Human membrane proteins; Molecular dynamics; NMR screening

Indexed keywords

MEMBRANE PROTEIN;

ARTICLE; CELL FREE SYSTEM; COMPUTER SIMULATION; DRUG SCREENING; GENE; GENETIC SCREENING; HIGD 1A GENE; HIGD 1B GENE; HUMAN; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

COMPUTATIONAL DOCKING; HUMAN MEMBRANE PROTEINS; MOLECULAR DYNAMICS; NMR SCREENING;

BINDING SITES; DRUG DESIGN; HUMANS; LIGANDS; MEMBRANE PROTEINS; MOLECULAR DOCKING SIMULATION; NEOPLASM PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION;

EID: 84897468362     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.01.179     Document Type: Article

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