Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

Nature Communications

Volumn 6, Issue , 2015, Pages

  Yang, Chul Su ^a,b   Kim, Jwa Jin ^a,c   Kim, Tae Sung ^a   Lee, Phil Young ^d   Kim, Soo Yeon ^a   Lee, Hye Mi ^a   Shin, Dong Min ^a   Nguyen, Loi T ^d   Lee, Moo Seung ^d   Jin, Hyo Sun ^a   Kim, Kwang Kyu ^e   Lee, Chul Ho ^d   Kim, Myung Hee ^d   Park, Sung Goo ^d   Kim, Jin Man ^a   Choi, Hueng Sik ^f   Jo, Eun Kyeong ^a  

^a Chungnam National University   (South Korea)

^b Hanyang University   (South Korea)

^c Konyang University   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^e Daejeon University   (South Korea)

^f Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CRYOPYRIN; HETERODIMER; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; ORPHAN NUCLEAR RECEPTOR; SMALL HETERODIMER PARTNER; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CARRIER PROTEIN; CELL RECEPTOR; INTERLEUKIN 1BETA; NLRP3 PROTEIN, HUMAN; NLRP3 PROTEIN, MOUSE; NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2; PROTEIN BINDING; PYCARD PROTEIN, MOUSE;

APOPTOSIS; GENE EXPRESSION; GROWTH REGULATOR; HOMEOSTASIS; INHIBITION; MITOCHONDRION; PROTEIN; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL DIFFERENTIATION; CELL FRACTIONATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; IMMUNOFLUORESCENCE; KIDNEY TUBULE NECROSIS; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN HOMEOSTASIS; PROTEIN PROTEIN INTERACTION; ANIMAL; C57BL MOUSE; DEFICIENCY; HEK293 CELL LINE; HOMEOSTASIS; HUMAN; METABOLISM; PROTEIN TRANSPORT;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 1; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HEK293 CELLS; HOMEOSTASIS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MICE, INBRED C57BL; MITOCHONDRIA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84923102584     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7115     Document Type: Article

References (43)

1. Latz, E. et al. Activation and regulation of the inflammasomes. Nat. Rev. Immunol. 13, 397-411 (2013).
2. Zhang, Y. et al. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol. Cell. Biol. 30, 1341-1356 (2010).
3. Garruti, G. et al. A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways. J. Lipids 2012, 304292 (2012).
4. Chanda, D. et al. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J. Biol. Chem. 284, 28510-28521 (2009).
5. Yuk, J. M. et al. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat. Immunol. 12, 742-751 (2011).
6. Yang, C. S. et al. Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2. PLoS ONE 8, e63435 (2013).
7. Sutterwala, F. S. et al. The inflammasome in pathogen recognition and inflammation. J. Leukoc. Biol. 82, 259-264 (2007).
8. Srinivasula, S. M. et al. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J. Biol. Chem. 277, 21119-21122 (2002).
9. Vajjhala, P. R. et al. Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein. J. Biol. Chem. 287, 41732-41743 (2012).
10. Fernandes-Alnemri, T. et al. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ. 14, 1590-1604 (2007).
11. Proell, M. et al. The CARD plays a critical role in ASC foci formation and inflammasome signalling. Biochem. J. 449, 613-621 (2013).
12. Miao, J. et al. Bile acid signaling pathways increase stability of small heterodimer partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes Dev. 23, 986-996 (2009).
13. Zambon, A. & Cusi, K. The role of fenofibrate in clinical practice. Diab. Vasc. Dis. Res. 4 (Suppl 3) S15-S20 (2007).
14. Bochner, B. R. & Ames, B. N. ZTP (5-amino 4-imidazole carboxamide riboside 50-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency. Cell 29, 929-937 (1982).
15. Subramanian, N. et al. The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 153, 348-361 (2013).
16. Bauernfeind, F. & Hornung, V. Of inflammasomes and pathogenssensing of microbes by the inflammasome. EMBO Mol. Med. 5, 814-826 (2013).
17. Bauernfeind, F. G. et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787-791 (2009).
18. Martin, W. J. et al. Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout. Arthritis Rheum. 63, 1322-1332 (2011).
19. Zhou, R. et al. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011).
20. Misawa, T. et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat. Immunol. 14, 454-460 (2013).
21. Zhang, Y. et al. Characterization of the mitochondrial localization of the nuclear receptor SHP and regulation of its subcellular distribution by interaction with Bcl2 and HNF4a. PLoS ONE 8, e68491 (2013).
22. Nakahira, K. et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222-230 (2011).
23. Chen, S. et al. Negative regulation of NLRP3 inflammasome signaling. Protein Cell 4, 251-258 (2013).
24. Vande, W. L. et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature 512, 69-73 (2014).
25. Zhang, Y., Hagedorn, C. H. & Wang, L. Role of nuclear receptor SHP in metabolism and cancer. Biochim. Biophys. Acta 1812, 893-908 (2011).
26. Lamkanfi, M. et al. Inflammasomes and their roles in health and disease. Annu. Rev. Cell Dev. Biol. 28, 137-161 (2012).
27. Tschopp, J. et al. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat. Rev. Immunol. 10, 210-215 (2010).
28. Lawlor, K. E. et al. Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria? Biochim. Biophys. Acta 1840, 1433-1440 (2014).
29. Shimada, K. et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36, 401-414 (2012).
30. Jabaut, J. et al. Mitochondria-targeted drugs enhance Nlrp3 inflammasomedependent IL-1b secretion in association with alterations in cellular redox and energy status. Free Radic. Biol. Med. 60, 233-245 (2013).
31. Lerner, A. G. et al. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 16, 250-264 (2012).
32. Menu, P. et al. ER stress activates the NLRP3 inflammasome via an UPRindependent pathway. Cell Death Dis. 3, e261 (2012).
33. Oslowski, C. M. et al. Thioredoxin-interacting protein mediates ER stressinduced b cell death through initiation of the inflammasome. Cell Metab. 16, 265-273 (2012).
34. Raturi, A. et al. Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM). Biochim. Biophys. Acta 1833, 213-224 (2013).
35. Wang, L. et al. Redundant pathways for negative feedback regulation of bile acid production. Dev. Cell 2, 721-731 (2002).
36. Kim, J. J. et al. Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. Cell Host Microbe 11, 457-468 (2012).
37. Kim, Y. D. et al. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 57, 306-314 (2008).
38. Gross, O. Measuring the inflammasome. Methods Mol. Biol. 844, 199-222 (2012).
39. Guarda, G. et al. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34, 213-223 (2011).
40. Wieckowski, M. R. et al. Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat. Protoc. 4, 1582-1590 (2009).
41. Bozidis, P. et al. Isolation of endoplasmic reticulum, mitochondria, and mitochondria-associated membrane fractions from transfected cells and from human cytomegalovirus-infected primary fibroblasts. Curr. Protoc. Cell Biol.. Chapter 3 Unit 3.27 (2007).
42. Clatworthy, M. R. et al. Magnetic resonance imaging with hyperpolarized [1,4 (13)C2] fumarate allows detection of early renal acute tubular necrosis. Proc. Natl Acad. Sci. USA 109, 13374-13379 (2012).
43. Gross, O. et al. Inflammasome activators induce interleukin-1a secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36, 388-400 (2012).