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Volumn 36, Issue 2, 2015, Pages 680-692

Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Author keywords

Alzheimer's disease; Amyloid oligomers; Calcium; GluN2B subunit; Mitochondria; N methyl d aspartate receptor

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; BECLOMETASONE; CALCIUM; IFENPRODIL; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; NR2B NMDA RECEPTOR; PIPERIDINE DERIVATIVE; ROTENONE;

EID: 84922927392     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.09.006     Document Type: Article
Times cited : (74)

References (52)
  • 1
    • 0037363599 scopus 로고    scopus 로고
    • Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides
    • Agostinho P., Oliveira C.R. Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides. Eur. J. Neurosci. 2003, 17:1189-1196.
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 1189-1196
    • Agostinho, P.1    Oliveira, C.R.2
  • 5
    • 0027490362 scopus 로고
    • Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein [AβP-(1-40)] in bilayer membranes
    • Arispe N., Pollard H.B., Rojas E. Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein [AβP-(1-40)] in bilayer membranes. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:10573-10577.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 10573-10577
    • Arispe, N.1    Pollard, H.B.2    Rojas, E.3
  • 6
    • 0037135272 scopus 로고    scopus 로고
    • Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists
    • Bi X., Gall C.M., Zhou J., Lynch G. Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists. Neuroscience 2002, 112:827-840.
    • (2002) Neuroscience , vol.112 , pp. 827-840
    • Bi, X.1    Gall, C.M.2    Zhou, J.3    Lynch, G.4
  • 7
    • 84874303866 scopus 로고    scopus 로고
    • Impaired transcription in Alzheimer's disease: key role in mitochondrial dysfunction and oxidative stress
    • Caldeira G.L., Ferreira I.L., Rego A.C. Impaired transcription in Alzheimer's disease: key role in mitochondrial dysfunction and oxidative stress. J.Alzheimers Dis. 2013, 34:115-131.
    • (2013) J.Alzheimers Dis. , vol.34 , pp. 115-131
    • Caldeira, G.L.1    Ferreira, I.L.2    Rego, A.C.3
  • 8
    • 79955665348 scopus 로고    scopus 로고
    • Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease
    • Camandola S., Mattson M.P. Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease. Biochim. Biophys. Acta 2011, 1813:965-973.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 965-973
    • Camandola, S.1    Mattson, M.P.2
  • 10
    • 84866452758 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers
    • Costa R.O., Lacor P.N., Ferreira I.L., Resende R., Auberson Y.P., Klein W.L., Oliveira C.R., Rego A.C., Pereira C.M. Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers. Aging Cell 2012, 11:823-833.
    • (2012) Aging Cell , vol.11 , pp. 823-833
    • Costa, R.O.1    Lacor, P.N.2    Ferreira, I.L.3    Resende, R.4    Auberson, Y.P.5    Klein, W.L.6    Oliveira, C.R.7    Rego, A.C.8    Pereira, C.M.9
  • 11
    • 34249672242 scopus 로고    scopus 로고
    • Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
    • De Felice F.G., Velasco P.T., Lambert M.P., Viola K., Fernandez S.J., Ferreira S.T., Klein W.L. Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J.Biol. Chem. 2007, 282:11590-11601.
    • (2007) J.Biol. Chem. , vol.282 , pp. 11590-11601
    • De Felice, F.G.1    Velasco, P.T.2    Lambert, M.P.3    Viola, K.4    Fernandez, S.J.5    Ferreira, S.T.6    Klein, W.L.7
  • 12
    • 65249093004 scopus 로고    scopus 로고
    • Arole for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses
    • Deshpande A., Kawai H., Metherate R., Glabe C.G., Busciglio J. Arole for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J.Neurosci. 2009, 29:4004-4015.
    • (2009) J.Neurosci. , vol.29 , pp. 4004-4015
    • Deshpande, A.1    Kawai, H.2    Metherate, R.3    Glabe, C.G.4    Busciglio, J.5
  • 13
    • 34248172476 scopus 로고    scopus 로고
    • Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits
    • Domingues A., Almeida S., da Cruz e Silva E.F., Oliveira C.R., Rego A.C. Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits. Neurochem. Int. 2007, 50:872-880.
    • (2007) Neurochem. Int. , vol.50 , pp. 872-880
    • Domingues, A.1    Almeida, S.2    da Cruze Silva, E.F.3    Oliveira, C.R.4    Rego, A.C.5
  • 14
    • 77956197971 scopus 로고    scopus 로고
    • Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice
    • Dragicevic N., Mamcarz M., Zhu Y., Buzzeo R., Tan J., Arendash G.W., Bradshaw P.C. Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice. J.Alzheimers Dis. 2010, 20(Suppl 2):S535-S550.
    • (2010) J.Alzheimers Dis. , vol.20 , pp. S535-S550
    • Dragicevic, N.1    Mamcarz, M.2    Zhu, Y.3    Buzzeo, R.4    Tan, J.5    Arendash, G.W.6    Bradshaw, P.C.7
  • 16
    • 84860176236 scopus 로고    scopus 로고
    • Synaptic mitochondrial pathology in Alzheimer's disease
    • Du H., Guo L., Yan S.S. Synaptic mitochondrial pathology in Alzheimer's disease. Antioxid. Redox Signal. 2012, 16:1467-1475.
    • (2012) Antioxid. Redox Signal. , vol.16 , pp. 1467-1475
    • Du, H.1    Guo, L.2    Yan, S.S.3
  • 18
    • 84856958510 scopus 로고    scopus 로고
    • Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-D-aspartate receptors in cortical cultures
    • Ferreira I.L., Bajouco L.M., Mota S.I., Auberson Y.P., Oliveira C.R., Rego A.C. Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-D-aspartate receptors in cortical cultures. Cell Calcium 2012, 51:95-106.
    • (2012) Cell Calcium , vol.51 , pp. 95-106
    • Ferreira, I.L.1    Bajouco, L.M.2    Mota, S.I.3    Auberson, Y.P.4    Oliveira, C.R.5    Rego, A.C.6
  • 20
    • 84863688106 scopus 로고    scopus 로고
    • Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers
    • Ferreiro E., Baldeiras I., Ferreira I.L., Costa R.O., Rego A.C., Pereira C.F., Oliveira C.R. Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int. J. Cell Biol. 2012, 2012:735206.
    • (2012) Int. J. Cell Biol. , vol.2012 , pp. 735206
    • Ferreiro, E.1    Baldeiras, I.2    Ferreira, I.L.3    Costa, R.O.4    Rego, A.C.5    Pereira, C.F.6    Oliveira, C.R.7
  • 21
    • 2642541799 scopus 로고    scopus 로고
    • 2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide
    • 2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide. J.Neurosci. Res. 2004, 76:872-880.
    • (2004) J.Neurosci. Res. , vol.76 , pp. 872-880
    • Ferreiro, E.1    Oliveira, C.R.2    Pereira, C.3
  • 22
    • 43649083316 scopus 로고    scopus 로고
    • The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway
    • Ferreiro E., Oliveira C.R., Pereira C.M. The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol. Dis. 2008, 30:331-342.
    • (2008) Neurobiol. Dis. , vol.30 , pp. 331-342
    • Ferreiro, E.1    Oliveira, C.R.2    Pereira, C.M.3
  • 23
    • 33747195017 scopus 로고    scopus 로고
    • An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity
    • Ferreiro E., Resende R., Costa R., Oliveira C.R., Pereira C.M. An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. Neurobiol. Dis. 2006, 23:669-678.
    • (2006) Neurobiol. Dis. , vol.23 , pp. 669-678
    • Ferreiro, E.1    Resende, R.2    Costa, R.3    Oliveira, C.R.4    Pereira, C.M.5
  • 24
    • 0023201733 scopus 로고
    • Calcium and the aging nervous system
    • Gibson G.E., Peterson C. Calcium and the aging nervous system. Neurobiol. Aging 1987, 8:329-343.
    • (1987) Neurobiol. Aging , vol.8 , pp. 329-343
    • Gibson, G.E.1    Peterson, C.2
  • 26
    • 84873130522 scopus 로고    scopus 로고
    • Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons
    • Guo L., Du H., Yan S., Wu X., McKhann G.M., Chen J.X., Yan S.S. Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. PLoS One 2013, 8:e54914.
    • (2013) PLoS One , vol.8 , pp. e54914
    • Guo, L.1    Du, H.2    Yan, S.3    Wu, X.4    McKhann, G.M.5    Chen, J.X.6    Yan, S.S.7
  • 27
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 2007, 8:101-112.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 30
    • 0034527137 scopus 로고    scopus 로고
    • Calcium sequestering ability of mitochondria modulates influx of calcium through glutamate receptor channel
    • Kannurpatti S.S., Joshi P.G., Joshi N.B. Calcium sequestering ability of mitochondria modulates influx of calcium through glutamate receptor channel. Neurochem. Res. 2000, 25:1527-1536.
    • (2000) Neurochem. Res. , vol.25 , pp. 1527-1536
    • Kannurpatti, S.S.1    Joshi, P.G.2    Joshi, N.B.3
  • 31
    • 33144484368 scopus 로고    scopus 로고
    • Synaptic targeting by Abeta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease
    • Klein W.L. Synaptic targeting by Abeta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease. Alzheimers Dement. 2006, 2:43-55.
    • (2006) Alzheimers Dement. , vol.2 , pp. 43-55
    • Klein, W.L.1
  • 33
    • 0037111837 scopus 로고    scopus 로고
    • Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice
    • Lazarov O., Lee M., Peterson D.A., Sisodia S.S. Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J.Neurosci. 2002, 22:9785-9793.
    • (2002) J.Neurosci. , vol.22 , pp. 9785-9793
    • Lazarov, O.1    Lee, M.2    Peterson, D.A.3    Sisodia, S.S.4
  • 34
    • 84863459157 scopus 로고    scopus 로고
    • New developments on the role of NMDA receptors in Alzheimer's disease
    • Malinow R. New developments on the role of NMDA receptors in Alzheimer's disease. Curr. Opin. Neurobiol. 2012, 22:559-563.
    • (2012) Curr. Opin. Neurobiol. , vol.22 , pp. 559-563
    • Malinow, R.1
  • 35
    • 53949085542 scopus 로고    scopus 로고
    • Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades
    • Matos M., Augusto E., Oliveira C.R., Agostinho P. Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades. Neuroscience 2008, 156:898-910.
    • (2008) Neuroscience , vol.156 , pp. 898-910
    • Matos, M.1    Augusto, E.2    Oliveira, C.R.3    Agostinho, P.4
  • 36
    • 0032487648 scopus 로고    scopus 로고
    • Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites
    • Mattson M.P., Partin J., Begley J.G. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites. Brain Res. 1998, 807:167-176.
    • (1998) Brain Res. , vol.807 , pp. 167-176
    • Mattson, M.P.1    Partin, J.2    Begley, J.G.3
  • 37
    • 0035780141 scopus 로고    scopus 로고
    • Amyloid β-peptide promotes permeability transition pore in brain mitochondria
    • Moreira P.I., Santos M.S., Moreno A., Oliveira C. Amyloid β-peptide promotes permeability transition pore in brain mitochondria. Biosci. Rep. 2001, 2:789-800.
    • (2001) Biosci. Rep. , vol.2 , pp. 789-800
    • Moreira, P.I.1    Santos, M.S.2    Moreno, A.3    Oliveira, C.4
  • 38
    • 84866468436 scopus 로고    scopus 로고
    • Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures
    • Mota S.I., Ferreira I.L., Pereira C., Oliveira C.R., Rego A.C. Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures. Curr. Alzheimer Res. 2012, 9:844-856.
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 844-856
    • Mota, S.I.1    Ferreira, I.L.2    Pereira, C.3    Oliveira, C.R.4    Rego, A.C.5
  • 39
    • 84886641553 scopus 로고    scopus 로고
    • Dysfunctional synapse in Alzheimer's disease - a focus on NMDA receptors
    • Mota S.I., Ferreira I.L., Rego A.C. Dysfunctional synapse in Alzheimer's disease - a focus on NMDA receptors. Neuropharmacology 2014, 76(Pt A):16-26.
    • (2014) Neuropharmacology , vol.76 , pp. 16-26
    • Mota, S.I.1    Ferreira, I.L.2    Rego, A.C.3
  • 40
    • 68649104009 scopus 로고    scopus 로고
    • Mitochondrial calcium function and dysfunction in the central nervous system
    • Nicholls D.G. Mitochondrial calcium function and dysfunction in the central nervous system. Biochim. Biophys. Acta 2009, 1787:1416-1424.
    • (2009) Biochim. Biophys. Acta , vol.1787 , pp. 1416-1424
    • Nicholls, D.G.1
  • 42
    • 79955454688 scopus 로고    scopus 로고
    • Amyloid-Beta interaction with mitochondria
    • Pagani L., Eckert A. Amyloid-Beta interaction with mitochondria. Int. J. Alzheimers Dis. 2011, 2011:925050.
    • (2011) Int. J. Alzheimers Dis. , vol.2011 , pp. 925050
    • Pagani, L.1    Eckert, A.2
  • 44
  • 45
    • 0035869336 scopus 로고    scopus 로고
    • Mitochondria control ampa/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells
    • Rego A.C., Ward M.W., Nicholls D.G. Mitochondria control ampa/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells. J.Neurosci. 2001, 21:1893-1901.
    • (2001) J.Neurosci. , vol.21 , pp. 1893-1901
    • Rego, A.C.1    Ward, M.W.2    Nicholls, D.G.3
  • 46
    • 49249118742 scopus 로고    scopus 로고
    • Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death
    • Resende R., Ferreiro E., Pereira C., Oliveira C.R. Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death. Neuroscience 2008, 155:725-737.
    • (2008) Neuroscience , vol.155 , pp. 725-737
    • Resende, R.1    Ferreiro, E.2    Pereira, C.3    Oliveira, C.R.4
  • 48
    • 84860669170 scopus 로고    scopus 로고
    • Comparative impact of voltage-gated calcium channels and NMDA receptors on mitochondria-mediated neuronal injury
    • Stanika R.I., Villanueva I., Kazanina G., Andrews S.B., Pivovarova N.B. Comparative impact of voltage-gated calcium channels and NMDA receptors on mitochondria-mediated neuronal injury. J.Neurosci. 2012, 32:6642-6650.
    • (2012) J.Neurosci. , vol.32 , pp. 6642-6650
    • Stanika, R.I.1    Villanueva, I.2    Kazanina, G.3    Andrews, S.B.4    Pivovarova, N.B.5
  • 49
    • 77549084517 scopus 로고    scopus 로고
    • The dysregulation of intracellular calcium in Alzheimer disease
    • Supnet C., Bezprozvanny I. The dysregulation of intracellular calcium in Alzheimer disease. Cell Calcium 2010, 47:183-189.
    • (2010) Cell Calcium , vol.47 , pp. 183-189
    • Supnet, C.1    Bezprozvanny, I.2
  • 51
    • 0033966834 scopus 로고    scopus 로고
    • Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit
    • Tovar K.R., Sprouffske K., Westbrook G.L. Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit. J.Neurophysiol. 2000, 83:616-620.
    • (2000) J.Neurophysiol. , vol.83 , pp. 616-620
    • Tovar, K.R.1    Sprouffske, K.2    Westbrook, G.L.3
  • 52
    • 0034307759 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells
    • Ward M.W., Rego A.C., Frenguelli B.G., Nicholls D.G. Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J.Neurosci. 2000, 20:7208-7219.
    • (2000) J.Neurosci. , vol.20 , pp. 7208-7219
    • Ward, M.W.1    Rego, A.C.2    Frenguelli, B.G.3    Nicholls, D.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.