Toxicity of β-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-d-aspartate receptor subunits

Neurochemistry International

Volumn 50, Issue 6, 2007, Pages 872-880

  Domingues, A ^a,b   Almeida, S ^a   da Cruz e Silva, E F ^b   Oliveira, C R ^a   Rego, A C ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

Alzheimer's disease; Calcium influx; Cell death; Excitotoxicity; NMDA receptors

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN[1-40]; CALCIUM; CALPAIN; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; DIZOCILPINE; DNA FRAGMENT; GLYCINE; LACTATE DEHYDROGENASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; TRYPAN BLUE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL ENERGY; CELL MEMBRANE; CELL STRAIN HEK293; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; EXCITOTOXICITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; AMYLOID BETA-PROTEIN; BLOTTING, WESTERN; CALCIUM; CASPASES; CELL LINE; CELL SURVIVAL; DIZOCILPINE MALEATE; DNA FRAGMENTATION; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; IMMUNOHISTOCHEMISTRY; L-LACTATE DEHYDROGENASE; RECEPTORS, N-METHYL-D-ASPARTATE; STIMULATION, CHEMICAL; TRANSFECTION;

EID: 34248172476     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2007.03.001     Document Type: Article

References (58)

1. Adamec E., Mohan P., Vonsattel J.P., and Nixon R.A. Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta Neuropathol. 104 (2002) 92-104
2. Almeida S., Domingues A., Rodrigues L., Oliveira C.R., and Rego A.C. FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures. Neurobiol. Dis. 17 (2004) 435-444
3. Alvarez A., Toro R., Caceres A., and Maccioni R.B. Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death. FEBS Lett. 459 (1999) 421-426
4. Anegawa N.J., Guttmann R.P., Grant E.R., Anand R., Lindstrom J., and Lynch D.R. N-Methyl-d-aspartate receptor mediated toxicity in nonneuronal cell lines: characterization using fluorescent measures of cell viability and reactive oxygen species production. Brain Res. Mol. Brain Res. 77 (2000) 163-175
5. Anegawa N.J., Lynch D.R., Verdoorn T.A., and Pritchett D.B. Transfection of N-methyl-d-aspartate receptors in a nonneuronal cell line leads to cell death. J. Neurochem. 64 (1995) 2004-2012
6. Arundine M., and Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 34 (2003) 325-337
7. Behl C., Davis J.B., Klier F.G., and Schubert D. Amyloid beta peptide induces necrosis rather than apoptosis. Brain Res. 645 (1994) 253-264
8. Blevins T., Mirshahi T., and Woodward J.J. Increased agonist and antagonist sensitivity of N-methyl-d-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure. Neurosci. Lett. 200 (1995) 214-218
9. Boeckman F.A., and Aizenman E. Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-d-aspartate receptor subunits. J. Pharmacol. Exp. Ther. 279 (1996) 515-523
10. Brorson J.R., Marcuccilli C.J., and Miller R.J. Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Stroke 26 (1995) 1259-1266
11. Budd S.L., Tenneti L., Lishnak T., and Lipton S.A. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proceedings of the National Academy of Sciences of the United States of America, 97 (2000) 6161-6166
12. Citron M., Diehl T.S., Gordon G., Biere A.L., Seubert P., and Selkoe D.J. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proceedings of the National Academy of Sciences of the United States of America, 93 (1996) 13170-13175
13. Cohen G.M. Caspases: the executioners of apoptosis. Biochem. J. 326 (1997) 1-16
14. Cowburn R.F., Messamore E., Li M.L., Winblad B., and Sundstrom E. Beta-amyloid related peptides exert differential effects on [3H]MK-801 binding to rat cortical membranes. Neuroreport 5 (1994) 405-408
15. Cowburn R.F., Wiehager B., Trief E., Li-Li M., and Sundstrom E. Effects of beta-amyloid-(25-35) peptides on radioligand binding to excitatory amino acid receptors and voltage-dependent calcium channels: evidence for a selective affinity for the glutamate and glycine recognition sites of the NMDA receptor. Neurochem. Res. 22 (1997) 1437-1442
16. Dong Y.N., Wu H.Y., Hsu F.C., Coulter D.A., and Lynch D.R. Developmental and cell-selective variations in N-methyl-d-aspartate receptor degradation by calpain. J. Neurochem. 99 (2006) 206-217
17. Goto Y., Niidome T., Akaike A., Kihara T., and Sugimoto H. Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor. Biochem. Biophys. Res. Commun. 351 (2006) 259-265
18. Guo Q., Fu W., Sopher B.L., Miller M.W., Ware C.B., Martin G.M., and Mattson M.P. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat. Med. 5 (1999) 101-106
19. Guttmann R.P., Sokol S., Baker D.L., Simpkins K.L., Dong Y., and Lynch D.R. Proteolysis of the N-methyl-d-aspartate receptor by calpain in situ. J. Pharmacol. Exp. Ther. 302 (2002) 1023-1030
20. Harada J., and Sugimoto M. Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons. Brain Res. 842 (1999) 311-323
21. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20 (1997) 154-159
22. Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
23. Harkany T., Abraham I., Timmerman W., Laskay G., Toth B., Sasvari M., Konya C., Sebens J.B., Korf J., Nyakas C., Zarandi M., Soos K., Penke B., and Luiten P.G. Beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Eur. J. Neurosci. 12 (2000) 2735-2745
24. Harkany T., Mulder J., Sasvari M., Abraham I., Konya C., Zarandi M., Penke B., Luiten P.G., and Nyakas C. N-Methyl-d-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neurons against beta-amyloid neurotoxicity. Neurobiol. Dis. 6 (1999) 109-121
25. Hynd M.R., Scott H.L., and Dodd P.R. Differential expression of N-methyl-d-aspartate receptor NR2 isoforms in Alzheimer's disease. J. Neurochem. 90 (2004) 913-919
26. Hynd M.R., Scott H.L., and Dodd P.R. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem. Int. 45 (2004) 583-595
27. Kelly B.L., and Ferreira A. Beta-amyloid-induced dynamin 1 degradation is mediated by N-methyl-d-aspartate receptors in hippocampal neurons. J. Biol. Chem. 281 (2006) 28079-28089
28. Kemp J.A., and McKernan R.M. NMDA receptor pathways as drug targets. Nat. Neurosci. Suppl. 5 (2002) 1039-1042
29. Lassus P., Opitz-Araya X., and Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 297 (2002) 1352-1354
30. Li B.S., Sun M.K., Zhang L., Takahashi S., Ma W., Vinade L., Kulkarni A.B., Brady R.O., and Pant H.C. Regulation of NMDA receptors by cyclin-dependent kinase-5. Proceedings of the National Academy of Sciences of the United States of America, 98 (2001) 12742-12747
31. Lipton S.A., and Chen H.S. Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine. Cell Death Differ. 11 (2004) 18-20
32. Lynch D.R., and Guttmann R.P. NMDA receptor pharmacology: perspectives from molecular biology. Curr. Drug Targets 2 (2001) 215-231
33. Lynch D.R., and Guttmann R.P. Excitotoxicity: perspectives based on N-methyl-d-aspartate receptor subtypes. J. Pharmacol. Exp. Ther. 300 (2002) 717-723
34. Mattson M.P., Cheng B., Davis D., Bryant K., Lieberburg I., and Rydel R.E. Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12 (1992) 376-389
35. Mattson M.P., Partin J., and Begley J.G. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites. Brain Res. 807 (1998) 167-176
36. Michaelis E.K. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog. Neurobiol. 54 (1998) 369-415
37. Mishizen-Eberz A.J., Rissman R.A., Carter T.L., Ikonomovic M.D., Wolfe B.B., and Armstrong D.M. Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology. Neurobiol. Dis. 15 (2004) 80-92
38. Monaghan D.T., and Larsen H. NR1 and NR2 subunit contributions to N-methyl-d-aspartate receptor channel blocker pharmacology. J. Pharmacol. Exp. Ther. 280 (1997) 614-620
39. Monyer H., Burnashev N., Laurie D.J., Sakmann B., and Seeburg P.H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12 (1994) 529-540
40. Morikawa E., Mori H., Kiyama Y., Mishina M., Asano T., and Kirino T. Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor. J. Neurosci. 18 (1998) 9727-9732
41. Nicotera P., and Melino G. Regulation of the apoptosis-necrosis switch. Oncogene 23 (2004) 2757-2765
42. Nixon R.A., Saito K.I., Grynspan F., Griffin W.R., Katayama S., Honda T., Mohan P.S., Shea T.B., and Beermann M. Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Ann. N. Y. Acad. Sci. 747 (1994) 77-91
43. Pereira C., Moreira P., Seica R., Santos M.S., and Oliveira C.R. Susceptibility to beta-amyloid-induced toxicity is decreased in goto-kakizaki diabetic rats: involvement of oxidative stress. Exp. Neurol. 161 (2000) 383-391
44. Rego A.C., and Oliveira C.R. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochem. Res. 28 (2003) 1563-1574
45. Rego A.C., Santos M.S., and Oliveira C.R. Adenosine triphosphate degradation products after oxidative stress and metabolic dysfunction in cultured retinal cells. J. Neurochem. 69 (1997) 1228-1235
46. Reisberg B., Doody R., Stoffler A., Schmitt F., Ferris S., and Mobius H.J. Memantine in moderate-to-severe Alzheimer's disease. New Engl. J. Med. 348 (2003) 1333-1341
47. Santos M.J., Quintanilla R.A., Toro A., Grandy R., Dinamarca M.C., Godoy J.A., and Inestrosa N.C. Peroxisomal proliferation protects from beta-amyloid neurodegeneration. J. Biol. Chem. 280 (2005) 41057-41068
48. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
49. Shimohama S., Suenaga T., Araki W., Yamaoaka Y., Shimizu K., and Kimura J. Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. Brain Res. 558 (1991) 105-108
50. Simpkins K.L., Guttmann R.P., Dong Y., Chen Z., Sokol S., Neumar R.W., and Lynch D.R. Selective activation induced cleavage of the NR2B subunit by calpain. J. Neurosci. 23 (2003) 11322-11331
51. Snyder E.M., Nong Y., Almeida C.G., Paul S., Moran T., Choi E.Y., Nairn A.C., Salter M.W., Lombroso P.J., Gouras G.K., and Greengard P. Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 8 (2005) 1051-1058
52. Sze C., Bi H., Kleinschmidt-DeMasters B.K., Filley C.M., and Martin L.J. N-Methyl-d-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease. J. Neurol. Sci. 182 (2001) 151-159
53. Velez-Pardo C., Arroyave S.T., Lopera F., Castano A.D., and Jimenez Del R.M. Ultrastructure evidence of necrotic neural cell death in familial Alzheimer's disease brains bearing presenilin-1 E280A mutation. J. Alzheimer's Dis. 3 (2001) 409-415
54. Wang J., Liu S., Fu Y., Wang J.H., and Lu Y. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat. Neurosci. 6 (2003) 1039-1047
55. Wang K.K. Calpain and caspase: can you tell the difference?. Trends Neurosci. 23 (2000) 20-26
56. Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16 (1996) 921-932
57. Zeron M.M., Hansson O., Chen N., Wellington C.L., Leavitt B.R., Brundin P., Hayden M.R., and Raymond L.A. Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron 33 (2002) 849-860
58. Zhou M., and Baudry M. Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. J. Neurosci. 26 (2006) 2956-2963