Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation

Genomics

Volumn 105, Issue 2, 2015, Pages 116-122

  Sorolla, Anabel ^a   Tallack, Michael R ^b   Oey, Harald ^c   Harten, Sarah K ^a   Daxinger, Lucia Clemens ^d   Magor, Graham W ^b   Combes, Alex N ^a   Ilsley, Melissa ^b   Whitelaw, Emma ^a,c   Perkins, Andrew C ^b,e  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c LA TROBE UNIVERSITY   (Australia)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

EKLF; ENU mutagenesis; Epigenetics; Erythropoiesis; KLF1; Position effect variegation; Transcriptional regulation; Zinc finger transcription factor; Globin

Indexed keywords

ALPHA GLOBULIN; ERYTHROID KRUPPEL LIKE FACTOR; ZINC FINGER PROTEIN; ERYTHROID KRUPPEL-LIKE FACTOR; HEMOGLOBIN ALPHA CHAIN; KRUPPEL LIKE FACTOR;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CODON; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; GENETIC LINKAGE; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; KLF1 GENE; LOSS OF FUNCTION MUTATION; MICROCYTIC ANEMIA; MOLECULAR CLONING; MOUSE; NONHUMAN; NULL ALLELE; POINT MUTATION; TRANSGENE; ANEMIA; ANIMAL; EMBRYOLOGY; GENETICS; MUTATION; POSITION EFFECT VARIEGATION; PROCEDURES; SPLENOMEGALY; TRANSGENIC MOUSE;

MURINAE; MUS;

ALPHA-GLOBINS; ANEMIA; ANIMALS; CHROMOSOMAL POSITION EFFECTS; GENETIC TESTING; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, TRANSGENIC; MUTATION; SPLENOMEGALY; ZINC FINGERS;

EID: 84922753486     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2014.09.013     Document Type: Article

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