Unanticipated repression function linked to erythroid Krüppel-like factor

Molecular and Cellular Biology

Volumn 21, Issue 9, 2001, Pages 3118-3125

  Chen, X ^a   Bieker, J J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; DNA BINDING PROTEIN; ERYTHROID KRUPPEL LIKE FACTOR; HISTONE DEACETYLASE; PROTEIN P300; TRANSCRIPTION FACTOR; TRICHOSTATIN A; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ERYTHROID CELL; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION;

3T3 CELLS; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; HISTONE DEACETYLASES; HUMANS; K562 CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; ZINC FINGERS;

ANIMALIA;

EID: 0035048250     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.9.3118-3125.2001     Document Type: Article

References (42)

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2. Activation of beta-globin promoter by erythroid Kruppel-like factor
3. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
4. The erythroid Kruppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter
5. Erythroid Kruppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions
6. Chromatin structure and transcriptional control elements of the erythroid Kruppel-like factor (EKLF) gene
7. Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo
8. Myc target genes
9. Expression of a human beta-globin transgene in mice with the CACC motif and upstream sequences deleted from the promoter still depends on erythroid Kruppel-like factor
10. Erythroid Kruppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression
11. Histone deacetylase activity is required for full transcriptional repression by mSin3A
12. Positive and negative transcriptional control by the TAL1 helix-loop-helix protein
13. Histone deacetylases specifically down-regulate p53-dependent gene activation
14. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
15. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
16. The beta-globin promoter is important for recruitment of erythroid Kruppel-like factor to the locus control region in erythroid cells
17. Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor
18. A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains
19. Deacetylation of p53 modulates its effect on cell growth and apoptosis
20. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF
21. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins
22. pEF-BOS, a powerful mammalian expression vector
23. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
24. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
25. Erythroid Kruppel like factor: From fishing expedition to gourmet meal
26. Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF
27. Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos
28. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
29. GATA1 and YY1 are developmental repressors of the human epsilon-globin gene
30. DNA binding of the glucocorticoid receptor is not essential for survival
31. An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3
32. A simple phase-extraction assay for chloramphenicol acyltransferase activity
33. Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization
34. Erythroid Kruppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny
35. Hemoglobin switching
36. Histone acetylation and transcriptional regulatory mechanisms
37. Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5′HS3 of the beta-globin locus control region
38. The role of EKLF in human beta-globin gene competition
39. A Smad transcriptional corepressor
40. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC
41. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
42. Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases