A global role for EKLF in definitive and primitive erythropoiesis

Blood

Volumn 107, Issue 8, 2006, Pages 3359-3370

  Hodge, Denise ^b   Coghill, Elise ^b   Keys, Janelle ^b   Maguire, Tina ^b   Hartmann, Belinda ^b   McDowall, Alasdair ^b   Weiss, Mitchell ^b   Grimmond, Sean ^b   Perkins, Andrew ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HEMOGLOBIN STABILIZING PROTEIN.; BLOOD GROUP ANTIGEN; CYTOSKELETON PROTEIN; ENZYME; ERYTHROCYTE BAND 4.9 PROTEIN; ERYTHROID KRUPPEL LIKE FACTOR; ESTROGEN RECEPTOR; HEME; HEMOGLOBIN A; HEMOGLOBIN DERIVATIVE; HEMOPROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANEMIA; ARTICLE; CELL LINE; CONSENSUS SEQUENCE; CYTOSKELETON; DNA RESPONSIVE ELEMENT; DOWN REGULATION; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; ERYTHROID CELL; ERYTHROPOIESIS; FEMALE; FETUS CELL; FETUS LIVER; GENE CONSTRUCT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TARGETING; GENETIC TRANSCRIPTION; HEME SYNTHESIS; HUMAN; LETHAL GENE; MOLECULAR PHYLOGENY; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; REPORTER GENE; UNINDEXED SEQUENCE; UPREGULATION; YOLK SAC;

EID: 33645743530     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-07-2888     Document Type: Article

References (71)

1. Myers RM, Tilly K, Maniatis T. Fine structure genetic analysis of a beta-globin promoter. Science. 1986;232:613-618.
2. Myers RM, Cowie A, Stuve L, Hartzog G, Gaensler K. Genetic and biochemical analysis of the mouse beta-major globin promoter. Prog Clin Biol Res. 1989;316A:117-127.
3. Charnay P, Mellon P, Maniatis T. Linker scanning mutagenesis of the 5′-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Mol Cell Biol. 1985;5:1498-1511.
4. Cowie A, Myers RM. DNA sequences involved in transcriptional regulation of the mouse beta-globin promoter in murine erythroleukemia cells. Mol Cell Biol. 1988;8:3122-3128.
5. Gordon CT, Fox VJ, Najdovska S, Perkins AC. C/EBPdelta and C/EBPgamma bind the CCAAT-box in the human beta-globin promoter and modulate the activity of the CACC-box binding protein, EKLF. Biochim Biophys Acta. 2005;1729:74-80.
6. Orkin SH, Antonarakis SE, Kazazian HH Jr. Base substitution at position -88 in a beta-thalassemic globin gene: further evidence for the role of distal promoter element ACACCC. J Biol Chem. 1984;259:8679-8681.
7. Rahuel C, Vignal A, London J, et al. Structure of the 5′ flanking region of the gene encoding human glycophorin A and analysis of its multiple transcripts. Gene. 1989;85:471-477.
8. Gregory RC, Taxman DJ, Seshasayee D, Kensinger MH, Bieker JJ, Wojchowski DM. Functional interaction of GATA1 with erythroid Kruppel-like factor and Sp1 at defined erythroid promoters. Blood. 1996;87:1793-1801.
9. Tsai SF, Strauss E, Orkin SH. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 1991;5:919-931.
10. Raich N, Romeo PH. Erythroid regulatory elements. Stem Cells (Dayt). 1993;11:95-104.
11. Youssoufian H, Zon LI, Orkin SH, D'Andrea AD, Lodish HF. Structure and transcription of the mouse erythropoietin receptor gene. Mol Cell Biol. 1990;10:3675-3682.
12. Surinya KH, Cox TC, May BK. Transcriptional regulation of the human erythroid 5-aminolevulinate synthase gene: identification of promoter elements and role of regulatory proteins. J Biol Chem. 1997;272:26585-26594.
13. Hartzog GA, Myers RM. Discrimination among potential activators of the beta-globin CACCC element by correlation of binding and transcriptional properties. Mol Cell Biol. 1993;13:44-56.
14. Miller IJ, Bieker JJ. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol. 1993;13:2776-2786.
15. Philipsen S, Suske G. A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999;27:2991-3000.
16. Turner J, Crossley M. Mammalian Kruppel-like transcription factors: more than just a pretty finger. Trends Biochem Sci. 1999;24:236-240.
17. van Ree JH, Roskrow MA, Becher AM, et al. The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13. Genomics. 1997;39:393-395.
18. Benzeno S, Narla G, Allina J, et al. Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. Cancer Res. 2004;64:3885-3891.
19. Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature. 1995;375:316-318.
20. Perkins AC, Sharpe AH, Orkin SH. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995;375:318-322.
21. Perkins AC, Gaensler KM, Orkin SH. Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proc Natl Acad Sci U S A. 1996;93:12267-12271.
22. Wijgerde M, Gribnau J, Trimborn T, et al. The role of EKLF in human beta-globin gene competition. Genes Dev. 1996;10:2894-2902.
23. Yang B, Kirby S, Lewis J, Detloff PJ, Maeda N, Smithies O. A mouse model for beta 0-thalassemia. Proc Natl Acad Sci U S A. 1995;92:11608-11612.
24. Perkins AC, Peterson KR, Stamatoyannopoulos G, Witkowska HE, Orkin SH. Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. Blood. 2000;95:1827-1833.
25. Spadaccini A, Tilbrook PA, Sarna MK, Crossley M, Bieker JJ, Klinken SP. Transcription factor erythroid Kruppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation. J Biol Chem. 1998;273:23793-23798.
26. Coghill E, Eccleston S, Fox V, et al. Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice. Blood. 2001;97:1861-1868.
27. Kihm AJ, Kong Y, Hong W, et al. An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature. 2002;417:758-763.
28. Frank BS, Vardar D, Chishti AH, McKnight CJ. The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site. J Biol Chem. 2004;279:7909-7916.
29. Gallagher PG, Pilon AM, Nilson DG, Wong E, Bodine DM. Multiple defects in erythroid gene expression in erythroid Kruppel-like factor (EKLF) target genes in EKLF-deficient mice [abstract]. Blood Cells Mol Dis. 2005;34:71-134.
30. European Bioinformatics Institute. MIAME: minimum information about a microarray experiment. http://www.mged.org/Workgroups/MIAME/miame. html. Accessed January 2005.
31. Ovcharenko I, Nobrega MA, Loots GG, Stubbs L. ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Nucleic Acids Res. 2004;32:W280-W286.
32. Ovcharenko I, Loots GG, Giardine BM, et al. Mulan: multiple-sequence local alignment and visualization for studying function and evolution. Genome Res. 2005;15:184-194.
33. Feng WC, Southwood CM, Bieker JJ. Analyses of beta-thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an erythroid cell-specific transcription factor. J Biol Chem. 1994;269:1493-1500.
34. Merika M, Orkin SH. DNA-binding specificity of GATA family transcription factors. Mol Cell Biol. 1993;13:3999-4010.
35. Loots GG, Ovcharenko I. rVISTA 2.0: evolutionary analysis of transcription factor binding sites. Nucleic Acids Res. 2004;32:W217-W221.
36. Im H, Grass JA, Christensen HM, Perkins A, Bresnick EH. Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. Biochemistry. 2002;41:15152-15160.
37. Letting DL, Rakowski C, Weiss MJ, Blobel GA. Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1. Mol Cell Biol. 2003;23:1334-1340.
38. Azim AC, Kim AC, Lutchman M, Andrabi S, Peters LL, Chishti AH. cDNA sequence, genomic structure, and expression of the mouse dematin gene (Epb4.9). Mamm Genome. 1999;10:1026-1029.
39. Manalo DJ, Rowan A, Lavoie T, et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood. 2005;105:659-669.
40. Signet. http://spring.imb.uq.edu.au. Accessed 2005.
41. Khanna R, Chang SH, Andrabi S, et al. Head-piece domain of dematin is required for the stability of the erythrocyte membrane. Proc Natl Acad Sci U S A. 2002;99:6637-6642.
42. Kong Y, Zhou S, Kihm AJ, et al. Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia. J Clin Invest. 2004;114:1457-1466.
43. Papathanasiou P, Perkins AC, Cobb BS, et al. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity. 2003;19:131-144.
44. Dorsky RI, Raible DW, Moon RT. Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway. Genes Dev. 2000;14:158-162.
45. Southwood CM, Downs KM, Bieker JJ. Erythroid Kruppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev Dyn. 1996;206:248-259.
46. Guy LG, Mei Q, Perkins AC, Orkin SH, Wall L. Erythroid Kruppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression. Blood. 1998;91:2259-2263.
47. Tewari R, Gillemans N, Wijgerde M, et al. Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5′HS3 of the beta-globin locus control region. EMBO J. 1998;17:2334-2341.
48. University of California at Santa Cruz. UCSC genome browser. http://genome.ucsc.edu. Accessed March 2005.
49. Merika M, Orkin SH. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF. Mol Cell Biol. 1995;15:2437-2447.
50. Donze D, Townes TM, Bieker JJ. Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching. J Biol Chem. 1995;270:1955-1959.
51. Chen X, Bieker JJ. Erythroid Kruppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions. EMBO J. 1996;15:5888-5896.
52. Welch JJ, Watts JA, Vakoc CR, et al. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood. 2004;104:3136-3147.
53. Drissen R, von Lindern M, Kolbus A, et al. The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol. 2005;25:5205-5214.
54. Basu P, Morris PE, Haar JL, et al. KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic {beta}-like globin genes in vivo. Blood. 2005;106:2566-2571.
55. Edgar AJ, Vidyatilake HM, Wickramasinghe SN. X-linked sideroblastic anaemia due to a mutation in the erythroid 5-aminolaevulinate synthase gene leading to an arginine 170 to leucine substitution. Eur J Haematol. 1998;61:55-58.
56. Nakajima O, Takahashi S, Harigae H, et al. Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload. EMBO J. 1999;18:6282-6289.
57. Brownlie A, Donovan A, Pratt SJ, et al. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia [see comments]. Nat Genet. 1998;20:244-250.
58. Kramer MF, Gunaratne P, Ferreira GC. Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene. Gene. 2000;247:153-166.
59. Surinya KH, Cox TC, May BK. Identification and characterization of a conserved erythroid-specific enhancer located in intron 8 of the human 5-aminolevulinate synthase 2 gene. J Biol Chem. 1998;273:16798-16809.
60. Mignotte V, Eleouet JF, Raich N, Romeo PH. Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene. Proc Natl Acad Sci U S A. 1989;86:6548-6552.
61. Porcher C, Pitiot G, Plumb M, Lowe S, de Verneuil H, Grandchamp B. Characterization of hypersensitive sites, protein-binding motifs, and regulatory elements in both promoters of the mouse porphobilinogen deaminase gene. J Biol Chem. 1991;266:10562-10569.
62. Rebeiz N, Arkins S, Kelley KW, Rebeiz CA. Enhancement of coproporphyrinogen III transport into isolated transformed leukocyte mitochondria by ATP. Arch Biochem Biophys. 1996;333:475-481.
63. Ye TZ, Gordon CT, Lai YH, et al. Ermap, a gene coding for a novel erythroid specific adhesion/ receptor membrane protein. Gene. 2000;242:337-345.
64. Wagner FF, Poole J, Flegel WA. Scianna antigens including Rd are expressed by ERMAP. Blood. 2003;101:752-757.
65. Bailly P, Tontti E, Hermand P, Cartron JP, Gahmberg CG. The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins. Eur J Immunol. 1995;25:3316-3320.
66. Furusawa T, Yanai N, Hara T, Miyajima A, Obinata M. Integrin-associated protein (IAP, also termed CD47) is involved in stroma-supported erythropoiesis. J Biochem (Tokyo). 1998;123:101-106.
67. Van Kim CL, Colin Y, Cartron JP. Rh proteins: key structural and functional components of the red cell membrane. Blood Rev. 2005. Epub ahead of print.
68. Petranka JG, Fleenor DE, Sykes K, Kaufman RE, Rosse WF. Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. Proc Natl Acad Sci U S A. 1992;89:7876-7879.
69. Yang LV, Nicholson RH, Kaplan J, Galy A, Li L. Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms. Mech Dev. 2001;104:105-111.
70. Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995;92:8690-8694.
71. Crossley M, Whitelaw E, Perkins A, Williams G, Fujiwara Y, Orkin SH. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol Cell Biol. 1996;16:1695-1705.