Protein disulfide isomerase regulates endoplasmic reticulum stress and the apoptotic process during prion infection and PrP mutant-induced cytotoxicity

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Wang, Shao Bin ^a   Shi, Qi ^a   Xu, Yin ^a   Xie, Wu Ling ^a   Zhang, Jin ^a   Tian, Chan ^a   Guo, Yan ^a   Wang, Ke ^a   Zhang, Bao Yun ^a   Chen, Cao ^a   Gao, Chen ^a   Dong, Xiao Ping ^a,b  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; GLUCOSE REGULATED PROTEIN 78; MUTANT PROTEIN; PRION PROTEIN; PROTEIN DISULFIDE ISOMERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN TISSUE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME MODIFICATION; HAMSTER; MEMBRANE POTENTIAL; MITOCHONDRION; NITROSYLATION; NONHUMAN; PATHOGENESIS; PRION DISEASE; PROTEIN EXPRESSION; PROTEIN MISFOLDING; PROTEIN STRUCTURE; RODENT; SCRAPIE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN; CELL SURVIVAL; CRICETINAE; CRICETULUS; ENDOPLASMIC RETICULUM STRESS; HEAT-SHOCK PROTEINS; HEK293 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MOLECULAR CHAPERONES; MUTATION; NITRIC OXIDE; PRIONS; PROTEIN DISULFIDE-ISOMERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA INTERFERENCE; SCRAPIE;

EID: 84862001706     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038221     Document Type: Article

References (33)

1. Prusiner SB, (1998) The prion diseases. Brain Pathol 8: 499-513.
2. Hetz C, Glimcher LH, (2009) Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell 35: 551-561.
3. Torres M, Castillo K, Armisen R, Stutzin A, Soto C, et al. (2010) Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress. PLoS One 5: e15658.
4. Kim BH, Lee HG, Choi JK, Kim JI, Choi EK, et al. (2004) The cellular prion protein (PrPC) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation. Brain Res Mol Brain Res 124: 40-50.
5. Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, et al. (2008) UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell 15: 829-840.
6. Hampton RY, (2000) ER stress response: getting the UPR hand on misfolded proteins. Curr Biol 10: R518-521.
7. Turano C, Coppari S, Altieri F, Ferraro A, (2002) Proteins of the PDI family: unpredicted non-ER locations and functions. J Cell Physiol 193: 154-163.
8. Tanaka S, Uehara T, Nomura Y, (2000) Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death. J Biol Chem 275: 10388-10393.
9. Hetz CA, (2007) ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. Antioxid Redox Signal 9: 2345-2355.
10. Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, et al. (2010) Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. Nat Chem Biol 6: 900-906.
11. Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, et al. (2006) S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 441: 513-517.
12. Wang X, Shi Q, Xu K, Gao C, Chen C, et al. (2011) Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells. PLoS One 6: e14602.
13. Guo YJ, Wang XF, Han J, Zhang BY, Zhao WQ, et al. (2008) A patient with Creutzfeldt-Jakob disease with an insertion of 7 octa-repeats in the PRNP gene: molecular characteristics and clinical features. Am J Med Sci 336: 519-523.
14. Han L, Wan YZ, Han J, Chen L, Sun L, et al. (2007) Preliminary analyses for influence of mutant PrPs with different number of octapeptide. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 21: 208-210.
15. Xu K, Wang X, Shi Q, Chen C, Tian C, et al. (2011) Human prion protein mutants with deleted and inserted octarepeats undergo different pathways to trigger cell apoptosis. J Mol Neurosci 43: 225-234.
16. Ashok A, Hegde RS, (2009) Selective processing and metabolism of disease-causing mutant prion proteins. PLoS Pathog 5: e1000479.
17. Castilla J, Gutierrez-Adan A, Brun A, Pintado B, Salguero FJ, et al. (2005) Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection. FEBS Lett 579: 6237-6246.
18. An R, Dong C, Lei Y, Han L, Li P, et al. (2008) PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress. Sci China C Life Sci 51: 630-639.
19. Martin SF, Herva ME, Espinosa JC, Parra B, Castilla J, et al. (2006) Cell expression of a four extra octarepeat mutated PrPC modifies cell structure and cell cycle regulation. FEBS Lett 580: 4097-4104.
20. Boyce M, Yuan J, (2006) Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 13: 363-373.
21. Ferri KF, Kroemer G, (2001) Organelle-specific initiation of cell death pathways. Nat Cell Biol 3: E255-263.
22. Chiesa R, Piccardo P, Biasini E, Ghetti B, Harris DA, (2008) Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities. J Neurosci 28: 13258-13267.
23. Liberski PP, Brown DR, Sikorska B, Caughey B, Brown P, (2008) Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies). Folia Neuropathol 46: 1-25.
24. Kristiansen M, Messenger MJ, Klohn PC, Brandner S, Wadsworth JD, et al. (2005) Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis. J Biol Chem 280: 38851-38861.
25. Nunziante M, Ackermann K, Dietrich K, Wolf H, Gadtke L, et al. (2011) Proteasomal dysfunction and ER stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of PrPSc. J Biol Chem.
26. Yoo BC, Krapfenbauer K, Cairns N, Belay G, Bajo M, et al. (2002) Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease. Neurosci Lett 334: 196-200.
27. Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C, (2003) Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J 22: 5435-5445.
28. Hetz C, Russelakis-Carneiro M, Walchli S, Carboni S, Vial-Knecht E, et al. (2005) The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity. J Neurosci 25: 2793-2802.
29. Quaglio E, Restelli E, Garofoli A, Dossena S, De Luigi A, et al. (2011) Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction. PLoS One 6: e19339.
30. Unterberger U, Hoftberger R, Gelpi E, Flicker H, Budka H, et al. (2006) Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. J Neuropathol Exp Neurol 65: 348-357.
31. Hetz C, Lee AH, Gonzalez-Romero D, Thielen P, Castilla J, et al. (2008) Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A 105: 757-762.
32. Garthwaite J, Charles SL, Chess-Williams R, (1988) Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336: 385-388.
33. Shi Q, Dong XP, (2011) (Ctm) PrP and ER stress: A neurotoxic mechanism of some special PrP mutants. Prion 5.