Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: A Mechanism for Mitochondrial Dysfunction and Neurotoxicity

Journal of Neuroscience

Volumn 35, Issue 6, 2015, Pages 2516-2529

  Jin, Lee Way ^a,b   Horiuchi, Makoto ^a   Wulff, Heike ^c   Liu, Xiao Bo ^a   Cortopassi, Gino A ^c   Erickson, Jeffrey D ^d   Maezawa, Izumi ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Glutamate; Glutamine; Microglia; Mitochondria; Rett; Transporter

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; ARALKYLAMINE ACETYLTRANSFERASE; CATALASE; CD11B ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; GLUTAMIC ACID; GLUTAMINE; METHYL CPG BINDING PROTEIN 2; REACTIVE OXYGEN METABOLITE; SNAT1 PROTEIN; SZETO SCHILLER 31; UNCLASSIFIED DRUG; AMINO ACID TRANSPORTER; GLYCINE; MECP2 PROTEIN, MOUSE; SLC38A1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CELL ISOLATION; CELL PROLIFERATION; CELL VIABILITY; COLORIMETRY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENT MITOCHONDRIAL ASSAY; FLUOROMETRY; GENE; GENETIC MANIPULATION; IMMUNOFLUORESCENCE TEST; MICROGLIA; MOUSE; MTT ASSAY; NEUROTOXICITY; NONHUMAN; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; RETT SYNDROME; SLC38A1 GENE; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PRIMARY CELL CULTURE; TOXICITY AND INTOXICATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID TRANSPORT SYSTEM A; ANIMALS; GLUTAMIC ACID; GLYCINE; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MITOCHONDRIAL DISEASES; NEUROTOXICITY SYNDROMES; OXYGEN CONSUMPTION; PRIMARY CELL CULTURE; RETT SYNDROME;

EID: 84922513388     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2778-14.2015     Document Type: Article

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