메뉴 건너뛰기




Volumn 37, Issue 11, 2014, Pages 1031-1040

A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome

Author keywords

Cardiovascular disease; Diabetes; Dyslipidemia; Hypertension; Metabolic syndrome; Nigella sativa; Obesity; Thymoquinone

Indexed keywords

ANTIDIABETIC AGENT; BENZOQUINONE DERIVATIVE; PLANT EXTRACT; THYMOQUINONE;

EID: 84922404807     PISSN: 10429670     EISSN: 15457230     Source Type: Journal    
DOI: 10.1007/s40618-014-0150-1     Document Type: Review
Times cited : (103)

References (83)
  • 1
    • 33748776056 scopus 로고    scopus 로고
    • Metabolic syndrome and risk of cardiovascular disease: A meta-analysis
    • 17000207 10.1016/j.amjmed.2006.02.031 1:CAS:528:DC%2BD28XpvFemtrk%3D
    • Galassi A (2006) Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med 119:812-819
    • (2006) Am J Med , vol.119 , pp. 812-819
    • Galassi, A.1
  • 2
    • 84869022134 scopus 로고    scopus 로고
    • A decision tree-based approach for identifying urban-rural differences in metabolic syndrome risk factors in the adult Korean population
    • 22293132 1:STN:280:DC%2BC38vhs1CktQ%3D%3D
    • Kim TN, Kim JM, Won JC, Park MS, Lee SK, Yoon SH et al (2012) A decision tree-based approach for identifying urban-rural differences in metabolic syndrome risk factors in the adult Korean population. J Endocrinol Invest 35:847-852
    • (2012) J Endocrinol Invest , vol.35 , pp. 847-852
    • Kim, T.N.1    Kim, J.M.2    Won, J.C.3    Park, M.S.4    Lee, S.K.5    Yoon, S.H.6
  • 3
    • 0037021505 scopus 로고    scopus 로고
    • The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    • 12460094 10.1001/jama.288.21.2709
    • Lakka H, Laaksonen D, Lakka T, Niskanen L, Kumpusalo E, Tuomilehto J et al (2002) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288:2709-2716
    • (2002) JAMA , vol.288 , pp. 2709-2716
    • Lakka, H.1    Laaksonen, D.2    Lakka, T.3    Niskanen, L.4    Kumpusalo, E.5    Tuomilehto, J.6
  • 4
    • 84899871835 scopus 로고    scopus 로고
    • A randomised controlled trial on hypolipidemic effects of Nigella sativa seeds powder in menopausal women
    • Ibrahim RM, Hamdan NS, Mahmud R, Imam MU, Saini SM, Rashid SNA et al (2014) A randomised controlled trial on hypolipidemic effects of Nigella sativa seeds powder in menopausal women. J Translat Med 12:82
    • (2014) J Translat Med , vol.12 , pp. 82
    • Ibrahim, R.M.1    Hamdan, N.S.2    Mahmud, R.3    Imam, M.U.4    Saini, S.M.5    Rashid, S.N.A.6
  • 6
    • 16844377925 scopus 로고    scopus 로고
    • A review of medicinal uses and pharmacological activities of Nigella sativa
    • Gilani A, Jabeen Q, Ullah khan M (2004) A review of medicinal uses and pharmacological activities of Nigella sativa. Pak J Biol Sci 7:441-451
    • (2004) Pak J Biol Sci , vol.7 , pp. 441-451
    • Gilani, A.1    Jabeen, Q.2    Ullah Khan, M.3
  • 7
    • 84893025828 scopus 로고    scopus 로고
    • Pharmacognosy and pharmacology of Nigella sativa- A review
    • Rajsekhar S, Kuldeep B (2011) Pharmacognosy and pharmacology of Nigella sativa- A review. Int Res J Pharm 2:36-39
    • (2011) Int Res J Pharm , vol.2 , pp. 36-39
    • Rajsekhar, S.1    Kuldeep, B.2
  • 8
    • 84867199955 scopus 로고    scopus 로고
    • Review of pharmacological and toxicological effects of Nigella sativa and its active constituents
    • Ziaee T, Moharreri N, Hosseinzadeh H (2012) Review of pharmacological and toxicological effects of Nigella sativa and its active constituents. J Med Plants 11:16-42
    • (2012) J Med Plants , vol.11 , pp. 16-42
    • Ziaee, T.1    Moharreri, N.2    Hosseinzadeh, H.3
  • 9
    • 34547395342 scopus 로고    scopus 로고
    • Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus
    • 17291733 10.1016/j.phymed.2006.12.005 1:CAS:528:DC%2BD2sXhtFemsrzF
    • Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T (2007) Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine 14:621-627
    • (2007) Phytomedicine , vol.14 , pp. 621-627
    • Hosseinzadeh, H.1    Parvardeh, S.2    Asl, M.N.3    Sadeghnia, H.R.4    Ziaee, T.5
  • 11
    • 34548661065 scopus 로고    scopus 로고
    • Antibacterial activity of total extracts and essential oil of Nigella sativa L. Seeds in mice
    • Hosseinzadeh H, Fazly Bazzaz BS, Haghi MM (2007) Antibacterial activity of total extracts and essential oil of Nigella sativa L. seeds in mice. Pharmacologyonline 429-35
    • (2007) Pharmacologyonline , pp. 429-435
    • Hosseinzadeh, H.1    Fazly Bazzaz, B.S.2    Haghi, M.M.3
  • 12
  • 13
    • 84910658455 scopus 로고    scopus 로고
    • Effect of Nigella sativa on the kidney function in rats
    • Aziz Dollah M, Parhizkar S, Izwan M (2013) Effect of Nigella sativa on the kidney function in rats. Avicenna J Phytomed 3:152-158
    • (2013) Avicenna J Phytomed , vol.3 , pp. 152-158
    • Aziz Dollah, M.1    Parhizkar, S.2    Izwan, M.3
  • 14
    • 84910629472 scopus 로고    scopus 로고
    • In vitro and in vivo study of the antibacterial effects of Nigella sativa methanol extract in dairy cow mastitis
    • Rakhshandeh H, Vahdati-Mashhadian N, Khajekaramadini M (2011) In vitro and in vivo study of the antibacterial effects of Nigella sativa methanol extract in dairy cow mastitis. Avicenna J Phytomed 1:29-35
    • (2011) Avicenna J Phytomed , vol.1 , pp. 29-35
    • Rakhshandeh, H.1    Vahdati-Mashhadian, N.2    Khajekaramadini, M.3
  • 15
    • 2642534478 scopus 로고    scopus 로고
    • Possible mechanism(s) for relaxant effect of aqueous and macerate extracts from Nigella sativa on tracheal chains of guinea pig
    • 15070429 10.1186/1471-2210-4-3 385228
    • Boskabady MH, Shirmohammadi B, Jandaghi P, Kiani S (2004) Possible mechanism(s) for relaxant effect of aqueous and macerate extracts from Nigella sativa on tracheal chains of guinea pig. BMC Pharmacol 4:3
    • (2004) BMC Pharmacol , vol.4 , pp. 3
    • Boskabady, M.H.1    Shirmohammadi, B.2    Jandaghi, P.3    Kiani, S.4
  • 17
    • 57349164816 scopus 로고    scopus 로고
    • The possible prophylactic effect of Nigella sativa seed extract on respiratory symptoms, pulmonary function tests on chemical war victims
    • Boskabady MH, Farhadi F (2008) The possible prophylactic effect of Nigella sativa seed extract on respiratory symptoms, pulmonary function tests on chemical war victims. J Alt Comple Med 14(9):1137-1144
    • (2008) J Alt Comple Med , vol.14 , Issue.9 , pp. 1137-1144
    • Boskabady, M.H.1    Farhadi, F.2
  • 19
    • 79953044972 scopus 로고    scopus 로고
    • Physicochemical characteristics of nigella seed (Nigella sativa L.) oil as affected by different extraction methods
    • 1:CAS:528:DC%2BC3MXjt1Slsbc%3D
    • Khoddami A, Ghazali H, Yassoralipour A, Ramakrishnan Y, Ganjloo A (2011) Physicochemical characteristics of nigella seed (Nigella sativa L.) oil as affected by different extraction methods. J Am Oil Chem Soc 88:533-540
    • (2011) J Am Oil Chem Soc , vol.88 , pp. 533-540
    • Khoddami, A.1    Ghazali, H.2    Yassoralipour, A.3    Ramakrishnan, Y.4    Ganjloo, A.5
  • 20
    • 0027323712 scopus 로고
    • Chemical composition of Nigella sativa L. Seeds
    • 1:CAS:528:DyaK3sXmt1Cks7o%3D
    • Nergiz C, Otles S (1993) Chemical composition of Nigella sativa L. seeds. Food Chem 48:259-261
    • (1993) Food Chem , vol.48 , pp. 259-261
    • Nergiz, C.1    Otles, S.2
  • 21
    • 0033120349 scopus 로고    scopus 로고
    • High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.)
    • 10698539 10.1016/S0731-7085(98)00300-8 1:CAS:528:DyaK1MXisVChs78%3D
    • Ghosheh OA, Houdi AA, Crooks PA (1999) High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). J Pharm Biomed Anal 19:757-762
    • (1999) J Pharm Biomed Anal , vol.19 , pp. 757-762
    • Ghosheh, O.A.1    Houdi, A.A.2    Crooks, P.A.3
  • 22
  • 23
    • 84862863403 scopus 로고    scopus 로고
    • Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle
    • 22271000 10.1007/s00210-012-0726-2 1:CAS:528:DC%2BC38XkvV2qtb8%3D
    • Hosseinzadeh H, Taiari S, Nassiri-Asl M (2012) Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol 385:503-508
    • (2012) Naunyn Schmiedebergs Arch Pharmacol , vol.385 , pp. 503-508
    • Hosseinzadeh, H.1    Taiari, S.2    Nassiri-Asl, M.3
  • 24
    • 2342626583 scopus 로고    scopus 로고
    • Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug
    • 15103664 10.1002/ptr.1390 1:CAS:528:DC%2BD2cXks1KgsLk%3D
    • Hajhashemi V, Ghannadi A, Jafarabadi H (2004) Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res 18:195-199
    • (2004) Phytother Res , vol.18 , pp. 195-199
    • Hajhashemi, V.1    Ghannadi, A.2    Jafarabadi, H.3
  • 25
    • 53249097538 scopus 로고    scopus 로고
    • Antitussive effect of thymoquinone, a constituent of Nigella Sativa seeds, in Guinea pigs nephroprotective
    • Hosseinzadeh H, Eskandari M, Ziaee T (2008) Antitussive effect of thymoquinone, a constituent of Nigella Sativa seeds, in Guinea pigs nephroprotective. Pharmacologyonline 2:480-484
    • (2008) Pharmacologyonline , vol.2 , pp. 480-484
    • Hosseinzadeh, H.1    Eskandari, M.2    Ziaee, T.3
  • 26
    • 34248370219 scopus 로고    scopus 로고
    • Protective effect of Nigella sativa L. Extracts and thymoquinone, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats
    • Hosseinzadeh H, Montahaei R (2007) Protective effect of Nigella sativa L. extracts and thymoquinone, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. Pharmacologyonline 1:176-189
    • (2007) Pharmacologyonline , vol.1 , pp. 176-189
    • Hosseinzadeh, H.1    Montahaei, R.2
  • 27
    • 23644444586 scopus 로고    scopus 로고
    • Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. Seeds, through intracerebroventricular injection
    • Parvardeh S, Nassiri-Asl M, Mansouri MT, Hosseinzadeh H (2005) Study on the anticonvulsant activity of thymoquinone, the major constituent of Nigella sativa L. seeds, through intracerebroventricular injection. J Med Plants 4:45-52
    • (2005) J Med Plants , vol.4 , pp. 45-52
    • Parvardeh, S.1    Nassiri-Asl, M.2    Mansouri, M.T.3    Hosseinzadeh, H.4
  • 28
    • 38949116268 scopus 로고    scopus 로고
    • Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats
    • 17929168 10.1007/s11064-007-9481-z 1:CAS:528:DC%2BD1cXhs1aiu74%3D
    • Kanter M (2008) Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats. Neurochem Res 33:579-588
    • (2008) Neurochem Res , vol.33 , pp. 579-588
    • Kanter, M.1
  • 29
    • 1042303460 scopus 로고    scopus 로고
    • Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice
    • 14971722 10.1078/0944-7113-00376 1:CAS:528:DC%2BD2cXjtFaqu7s%3D
    • Hosseinzadeh H, Parvardeh S (2004) Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine 11:56-64
    • (2004) Phytomedicine , vol.11 , pp. 56-64
    • Hosseinzadeh, H.1    Parvardeh, S.2
  • 30
    • 17444422880 scopus 로고    scopus 로고
    • Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats
    • Hosseinzadeh H, Parvardeh S, Nassiri-Asl M, Mansouri MT (2005) Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med Sci Monitor 11:BR106-BR110
    • (2005) Med Sci Monitor , vol.11 , pp. BR106-BR110
    • Hosseinzadeh, H.1    Parvardeh, S.2    Nassiri-Asl, M.3    Mansouri, M.T.4
  • 31
    • 84910669666 scopus 로고    scopus 로고
    • Effects of combinations of curcumin, linalool, rutin, safranal, and thymoquinone on glucose/serum deprivation-induced cell death
    • 25050289 4075728
    • Alinejad B, Ghorbani A, Sadeghnia HR (2013) Effects of combinations of curcumin, linalool, rutin, safranal, and thymoquinone on glucose/serum deprivation-induced cell death. Avicenna J Phytomed 3:321-328
    • (2013) Avicenna J Phytomed , vol.3 , pp. 321-328
    • Alinejad, B.1    Ghorbani, A.2    Sadeghnia, H.R.3
  • 32
    • 84874993896 scopus 로고    scopus 로고
    • Protective effect of Nigella sativa and thymoquinone on serum/glucose deprivation-induced DNA damage in PC12 cells
    • 25050241 1:CAS:528:DC%2BC2cXht1WhurnE 4075672
    • Babazadeh B, Sadeghnia HR, Safarpour EK, Parsaee H, Nasri S, Tayarani-Najaran Z (2012) Protective effect of Nigella sativa and thymoquinone on serum/glucose deprivation-induced DNA damage in PC12 cells. Avicenna J Phytomed 2:125-132
    • (2012) Avicenna J Phytomed , vol.2 , pp. 125-132
    • Babazadeh, B.1    Sadeghnia, H.R.2    Safarpour, E.K.3    Parsaee, H.4    Nasri, S.5    Tayarani-Najaran, Z.6
  • 33
    • 0033836675 scopus 로고    scopus 로고
    • Protective effect of thymoquinone against doxorubicin- induced cardiotoxicity in rats: A possible mechanism of protection
    • 10675279 10.1006/phrs.1999.0585 1:CAS:528:DC%2BD3cXhtFWjs78%3D
    • Nagi M, Mansurou M (2000) Protective effect of thymoquinone against doxorubicin- induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res 41:283-289
    • (2000) Pharmacol Res , vol.41 , pp. 283-289
    • Nagi, M.1    Mansurou, M.2
  • 34
    • 77953178795 scopus 로고    scopus 로고
    • Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: Role of reactive oxygen species
    • 1:CAS:528:DC%2BC3cXpsVOjtr8%3D
    • Koka P, Mondal D, Schultz M, Abdel-Mageed A, Agrawal K (2010) Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. Exper Biol Med 235:751-760
    • (2010) Exper Biol Med , vol.235 , pp. 751-760
    • Koka, P.1    Mondal, D.2    Schultz, M.3    Abdel-Mageed, A.4    Agrawal, K.5
  • 35
    • 84878818756 scopus 로고    scopus 로고
    • Elucidation of mechanisms of actions of thymoquinone-enriched methanolic and volatile oil extracts from Nigella sativa against cardiovascular risk parameters in experimental hyperlipidemia
    • 23758650 10.1186/1476-511X-12-86 3693939
    • Ahmad S, Beg Z (2013) Elucidation of mechanisms of actions of thymoquinone-enriched methanolic and volatile oil extracts from Nigella sativa against cardiovascular risk parameters in experimental hyperlipidemia. Lipids Health Dis 12:86
    • (2013) Lipids Health Dis , vol.12 , pp. 86
    • Ahmad, S.1    Beg, Z.2
  • 36
    • 70349503806 scopus 로고    scopus 로고
    • The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats
    • 19618002
    • Kocyigit Y, Atamer Y, Uysal E (2009) The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats. Saudi Med J 30:893-896
    • (2009) Saudi Med J , vol.30 , pp. 893-896
    • Kocyigit, Y.1    Atamer, Y.2    Uysal, E.3
  • 37
    • 65649111745 scopus 로고    scopus 로고
    • Regulation of apolipoprotein A-1 and apolipoprotein B100 genes by thymoquinone rich fraction and thymoquinone in HEPG2 cells
    • 1:CAS:528:DC%2BD1MXptVaqsLk%3D
    • Al-Naqeeb G, Ismail M (2009) Regulation of apolipoprotein A-1 and apolipoprotein B100 genes by thymoquinone rich fraction and thymoquinone in HEPG2 cells. J Food Lipids 16:245-258
    • (2009) J Food Lipids , vol.16 , pp. 245-258
    • Al-Naqeeb, G.1    Ismail, M.2
  • 38
    • 84873717734 scopus 로고    scopus 로고
    • Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats
    • 23411222 10.1016/j.foodchem.2012.11.109 1:CAS:528:DC%2BC3sXitlart7k%3D
    • Ahmad S, Beg ZH (2013) Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats. Food Chem 138:1116-1124
    • (2013) Food Chem , vol.138 , pp. 1116-1124
    • Ahmad, S.1    Beg, Z.H.2
  • 39
    • 0033800305 scopus 로고    scopus 로고
    • Nigella sativa L. Oil protects against induced hepatotoxicity and improves serum lipid profile in rats
    • 1:STN:280:DC%2BD3crgtlWqsA%3D%3D
    • El-Dakhakhny M, Mady N, Halim M (2000) Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneim-Forsch 50:832-836
    • (2000) Arzneim-Forsch , vol.50 , pp. 832-836
    • El-Dakhakhny, M.1    Mady, N.2    Halim, M.3
  • 40
    • 80052752544 scopus 로고    scopus 로고
    • Antiatherogenic potential of Nigella sativa seeds and oil in diet induced hypercholesterolemia in rabbits
    • Al-Naqeep G, Al-Zubairi AS, Ismail M et al (2011) Antiatherogenic potential of Nigella sativa seeds and oil in diet induced hypercholesterolemia in rabbits. Evid Based Complement Alter Med. doi: 10.1093/ecam/neq071
    • (2011) Evid Based Complement Alter Med
    • Al-Naqeep, G.1    Al-Zubairi, A.S.2    Ismail, M.3
  • 41
    • 77954527277 scopus 로고    scopus 로고
    • Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits
    • 20422375 10.1007/s12272-010-0420-1 1:CAS:528:DC%2BC3cXlt1amsrc%3D
    • Nader MA, El-Agamy DS, Suddek GM (2010) Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharm Res 33:637-643
    • (2010) Arch Pharm Res , vol.33 , pp. 637-643
    • Nader, M.A.1    El-Agamy, D.S.2    Suddek, G.M.3
  • 42
    • 77955013372 scopus 로고    scopus 로고
    • Effect of prophetic medicine kalonji [Nigella sativa l.] on lipid profile of human beings. An invivo approach
    • 1:CAS:528:DC%2BD1MXhsVemtrbL
    • Bhatti IU, Ur Rehman F, Khan MA, Marwat SK (2009) Effect of prophetic medicine kalonji [Nigella sativa l.] on lipid profile of human beings. An invivo approach. World Appl Sci J 6:1053-1057
    • (2009) World Appl Sci J , vol.6 , pp. 1053-1057
    • Bhatti, I.U.1    Ur Rehman, F.2    Khan, M.A.3    Marwat, S.K.4
  • 43
    • 84896730185 scopus 로고    scopus 로고
    • Effect of nigella sativa and allium sativum coadminstered with simvastatin in dyslipidemia patients: A prospective, randomized, double-blind trial
    • 1:CAS:528:DC%2BC2cXisFOlu7o%3D
    • Alobaidi AHA (2014) Effect of nigella sativa and allium sativum coadminstered with simvastatin in dyslipidemia patients: A prospective, randomized, double-blind trial. Anti Inflam Anti Allergy Agents Med Chem 13:68-74
    • (2014) Anti Inflam Anti Allergy Agents Med Chem , vol.13 , pp. 68-74
    • Alobaidi, A.H.A.1
  • 44
    • 79953319474 scopus 로고    scopus 로고
    • Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male
    • 1:STN:280:DC%2BC3cjmt1CnsQ%3D%3D
    • Datau E, Wardhana EE, Surachmanto K, Pandelaki JA, Langi F (2010) Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Med Indones-Indones J Intern Med 42:130-134
    • (2010) Acta Med Indones-Indones J Intern Med , vol.42 , pp. 130-134
    • Datau, E.1    Wardhana, E.E.2    Surachmanto, K.3    Pandelaki, J.A.4    Langi, F.5
  • 45
    • 84861678038 scopus 로고    scopus 로고
    • Mitigation of Obesity-Promoted Diseases by Nigella sativa and Thymoquinone
    • 22477645 10.1007/s11130-012-0279-z 1:CAS:528:DC%2BC38XnvFOns7s%3D
    • Vanamala J, Kester AC, Heuberger AL, Reddivari L (2012) Mitigation of Obesity-Promoted Diseases by Nigella sativa and Thymoquinone. Plant Foods Hum Nutr 67:111-119
    • (2012) Plant Foods Hum Nutr , vol.67 , pp. 111-119
    • Vanamala, J.1    Kester, A.C.2    Heuberger, A.L.3    Reddivari, L.4
  • 47
  • 48
    • 29244439017 scopus 로고    scopus 로고
    • Effects of aqueous and macerated extracts from Nigella sativa on guinea pig isolated heart activity
    • 16398273 1:CAS:528:DC%2BD2MXhtleksrrF
    • Boskabady M, Shafei M, Parsaee H (2005) Effects of aqueous and macerated extracts from Nigella sativa on guinea pig isolated heart activity. Pharmazie 60:943-948
    • (2005) Pharmazie , vol.60 , pp. 943-948
    • Boskabady, M.1    Shafei, M.2    Parsaee, H.3
  • 49
    • 0034186616 scopus 로고    scopus 로고
    • Diuretic and hypotensive effects of Nigella sativa on the spontaneously hypertensive rat
    • 10967716 1:STN:280:DC%2BD3cvmtVyiuw%3D%3D
    • Zaoui A, Cherrah Y, Lacaille-Dubois MA, Settaf A, Amarouch H, Hassar M (2000) Diuretic and hypotensive effects of Nigella sativa on the spontaneously hypertensive rat. Therapie 55:379-382
    • (2000) Therapie , vol.55 , pp. 379-382
    • Zaoui, A.1    Cherrah, Y.2    Lacaille-Dubois, M.A.3    Settaf, A.4    Amarouch, H.5    Hassar, M.6
  • 50
    • 0027264732 scopus 로고
    • The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: Elucidation of the mechanism of action
    • 8270171 10.1016/0306-3623(93)90359-6 1:CAS:528:DyaK3sXms1ahs7s%3D
    • El-Tahir KEH, Ashour MM, AlHarbi MM (1993) The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 24:1123-1131
    • (1993) Gen Pharmacol , vol.24 , pp. 1123-1131
    • El-Tahir, K.E.H.1    Ashour, M.M.2    Alharbi, M.M.3
  • 51
    • 0001361119 scopus 로고
    • Effect of volatile oilof Nigella sativa on the arterial blood pressure and heart rate of the guineapig
    • 1:CAS:528:DyaK2MXjs1Sjs7g%3D
    • El-Tahir KEH, Ageel AM (1994) Effect of volatile oilof Nigella sativa on the arterial blood pressure and heart rate of the guineapig. Saudi Pharm J 2:163-168
    • (1994) Saudi Pharm J , vol.2 , pp. 163-168
    • El-Tahir, K.E.H.1    Ageel, A.M.2
  • 52
    • 0043131868 scopus 로고    scopus 로고
    • Some cardiovascular effects of the dethymoquinonated Nigella sativa volatile oil and its major components
    • El-Tahir KEH, Al-Ajmi MF, Al-Bekairi AM (2003) Some cardiovascular effects of the dethymoquinonated Nigella sativa volatile oil and its major components. Saudi Pharm J 11:104-110
    • (2003) Saudi Pharm J , vol.11 , pp. 104-110
    • El-Tahir, K.E.H.1    Al-Ajmi, M.F.2    Al-Bekairi, A.M.3
  • 53
    • 84875454044 scopus 로고    scopus 로고
    • Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats
    • Tasar N, Sehirli O, Yigner O et al (2012) Protective effects of Nigella sativa against hypertension-induced oxidative stress and cardiovascular dysfunction in rats. Marmara Pharm J 16:141-149
    • (2012) Marmara Pharm J , vol.16 , pp. 141-149
    • Tasar, N.1    Sehirli, O.2    Yigner, O.3
  • 54
    • 79960655137 scopus 로고    scopus 로고
    • Oleic and linoleic acids are active principles in Nigella sativa and stabilize an e 2P conformation of the Na, K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump
    • Mahmmouda YM, Christensen S (2011) Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E 2P conformation of the Na, K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. Biochim Biophys Acta 1808:2413-2420
    • (2011) Biochim Biophys Acta , vol.1808 , pp. 2413-2420
    • Mahmmouda, Y.M.1    Christensen, S.2
  • 55
    • 34248165186 scopus 로고    scopus 로고
    • Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats
    • 17236176 10.1002/ptr.2083 1:CAS:528:DC%2BD2sXmtVyrtro%3D
    • Khattab MM, Nagi MN (2007) Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytother Res 21:410-414
    • (2007) Phytother Res , vol.21 , pp. 410-414
    • Khattab, M.M.1    Nagi, M.N.2
  • 56
    • 0033509416 scopus 로고    scopus 로고
    • Pharmacological studies on sesame and Nigella sativa fixed oils: Effects on the sensitivities of the adrenoceptors, baroreceptors, platelets and the uterus of the rat
    • 1:CAS:528:DC%2BD3cXisFSjtbY%3D
    • ElTahir KEH, Al-Tahir AY, Ageel AM (1999) Pharmacological studies on sesame and Nigella sativa fixed oils: Effects on the sensitivities of the adrenoceptors, baroreceptors, platelets and the uterus of the rat. Saudi Pharm J 7:205-215
    • (1999) Saudi Pharm J , vol.7 , pp. 205-215
    • Eltahir, K.E.H.1    Al-Tahir, A.Y.2    Ageel, A.M.3
  • 57
    • 55949121968 scopus 로고    scopus 로고
    • Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension
    • 18705755 10.1111/j.1472-8206.2008.00607.x 1:CAS:528:DC%2BD1cXptlalt70%3D
    • Dehkordi F, Kamkhah A (2008) Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 22:447-452
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 447-452
    • Dehkordi, F.1    Kamkhah, A.2
  • 58
    • 84890553602 scopus 로고    scopus 로고
    • Blood pressure lowering effect of Nigella sativa l. Seed oil in healthy Volunteers: A randomized, double-blind, placebo-controlled clinical trial
    • 23436437 10.1002/ptr.4944 1:STN:280:DC%2BC3svgvVegsg%3D%3D
    • Fallah Huseini H, Amini M, Mohtashami R, Ghamarchehre ME, Sadeqhi Z, Kianbakht S et al (2013) Blood pressure lowering effect of Nigella sativa l. seed oil in healthy Volunteers: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res 27:1849-1853
    • (2013) Phytother Res , vol.27 , pp. 1849-1853
    • Fallah Huseini, H.1    Amini, M.2    Mohtashami, R.3    Ghamarchehre, M.E.4    Sadeqhi, Z.5    Kianbakht, S.6
  • 59
    • 84896710798 scopus 로고    scopus 로고
    • Effect of dietary supplementation of black seed (N. Sativa L.) on lipid profile of patients suffering from diabetes
    • 1:CAS:528:DC%2BC2cXisFOqtLo%3D
    • Qidwai W, Ashfaq T (2014) Effect of dietary supplementation of black seed (N. Sativa L.) on lipid profile of patients suffering from diabetes. Anti Inflam Anti Allergy Agents Med Chem 13:3-8
    • (2014) Anti Inflam Anti Allergy Agents Med Chem , vol.13 , pp. 3-8
    • Qidwai, W.1    Ashfaq, T.2
  • 60
    • 84887147624 scopus 로고    scopus 로고
    • Best herbs for managing diabetes: A review of clinical studies
    • 1:CAS:528:DC%2BC2cXmt1KgtQ%3D%3D
    • Ghorbani A (2013) Best herbs for managing diabetes: A review of clinical studies. Braz J Pharm Sci 49:413-422
    • (2013) Braz J Pharm Sci , vol.49 , pp. 413-422
    • Ghorbani, A.1
  • 61
    • 0035752777 scopus 로고    scopus 로고
    • Effect of Nigella sativa on glucose concentration, lipid peroxidation, antioxidant defence system and liver damage in experimentally induced diabetic rabbits
    • 1:STN:280:DC%2BD387hsFGrtw%3D%3D
    • Meral I, Yener Z, Kahraman T, Mert N (2001) Effect of Nigella sativa on glucose concentration, lipid peroxidation, antioxidant defence system and liver damage in experimentally induced diabetic rabbits. J Vet Med Ser 48:593-599
    • (2001) J Vet Med ser , vol.48 , pp. 593-599
    • Meral, I.1    Yener, Z.2    Kahraman, T.3    Mert, N.4
  • 62
    • 0036273437 scopus 로고    scopus 로고
    • The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions
    • El-Dakhakhny M, Mady N, Lembert N, Ammon HPT (2002) The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med 48:465-466
    • (2002) Planta Med , vol.48 , pp. 465-466
    • El-Dakhakhny, M.1    Mady, N.2    Lembert, N.3    Ammon, H.P.T.4
  • 63
    • 84892366399 scopus 로고    scopus 로고
    • Therapeutic effect of Nigella sativa oil on different clinical and biochemical parameters in metabolic syndrome
    • Najmi A, Haque S, Khan RA, Nasiruddin M (2008) Therapeutic effect Of Nigella sativa oil on different clinical and biochemical parameters in metabolic syndrome. Inter J Pharmacol 5:8
    • (2008) Inter J Pharmacol , vol.5 , pp. 8
    • Najmi, A.1    Haque, S.2    Khan, R.A.3    Nasiruddin, M.4
  • 64
    • 84881402430 scopus 로고    scopus 로고
    • Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: An experimental study with histopathological evaluation
    • 23947821 10.1186/1746-1596-8-137 3849825
    • Alimohammadi S, Hobbenaghi R, Javanbakht J, Kheradmand D, Mortezaee R, Tavakoli M et al (2013) Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: An experimental study with histopathological evaluation. Diagn Pathol 8:137
    • (2013) Diagn Pathol , vol.8 , pp. 137
    • Alimohammadi, S.1    Hobbenaghi, R.2    Javanbakht, J.3    Kheradmand, D.4    Mortezaee, R.5    Tavakoli, M.6
  • 65
    • 1842525226 scopus 로고    scopus 로고
    • Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbits
    • 1:CAS:528:DC%2BD2cXjt1eru7Y%3D
    • Meral I, Donmez N, Baydas B, Belge F, Kanter M (2004) Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbits. Scandinavian J Lab Animal Sci 31:49-53
    • (2004) Scandinavian J Lab Animal Sci , vol.31 , pp. 49-53
    • Meral, I.1    Donmez, N.2    Baydas, B.3    Belge, F.4    Kanter, M.5
  • 66
    • 33745726077 scopus 로고    scopus 로고
    • Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic beta-cell damage in cadmium-treated rats
    • 1:CAS:528:DC%2BD28XlvVCjsrs%3D
    • Demir H, Kanter M, Coskun O et al (2006) Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic beta-cell damage in cadmium-treated rats. Trace Elem Res 110:151-162
    • (2006) Trace Elem Res , vol.110 , pp. 151-162
    • Demir, H.1    Kanter, M.2    Coskun, O.3
  • 67
    • 77951023404 scopus 로고    scopus 로고
    • Protective effects of the volatile oil of Nigella sativa seeds on beta-cell damage in streptozotocin-induced diabetic rats: A light and electron microscopic study
    • 20049514 10.1007/s10735-009-9251-0 1:CAS:528:DC%2BC3cXivFGgsrw%3D
    • Kanter M, Akpolat M, Aktas C (2009) Protective effects of the volatile oil of Nigella sativa seeds on beta-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study. J Mol Histol 40:379-385
    • (2009) J Mol Histol , vol.40 , pp. 379-385
    • Kanter, M.1    Akpolat, M.2    Aktas, C.3
  • 68
    • 78649673581 scopus 로고    scopus 로고
    • Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic b-cells of streptozotocin-induced diabetic rats
    • 20923501 10.1111/j.1753-0407.2010.00091.x 1:CAS:528:DC%2BC3cXhsFygtrbF
    • Abdelmeguid N, Fakhoury R, Kamal S, Al Wafai R (2010) Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic b-cells of streptozotocin-induced diabetic rats. J Diabetes 2:256-266
    • (2010) J Diabetes , vol.2 , pp. 256-266
    • Abdelmeguid, N.1    Fakhoury, R.2    Kamal, S.3    Al Wafai, R.4
  • 69
    • 1642544733 scopus 로고    scopus 로고
    • Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats
    • 14690013 10.1620/tjem.201.213
    • Kanter M, Meral I, Yener Z et al (2003) Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. Tohoku J Exp Med 201:213-219
    • (2003) Tohoku J Exp Med , vol.201 , pp. 213-219
    • Kanter, M.1    Meral, I.2    Yener, Z.3
  • 70
    • 68549098103 scopus 로고    scopus 로고
    • Effects of N. Sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats
    • 19684436 10.1159/000234466 1:CAS:528:DC%2BD1MXhtFOhtrbJ
    • Hamdy N, Taha R (2009) Effects of N. sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats. Pharmacology 84:127-134
    • (2009) Pharmacology , vol.84 , pp. 127-134
    • Hamdy, N.1    Taha, R.2
  • 71
    • 79959277526 scopus 로고    scopus 로고
    • The in vivo antidiabetic activity of Nigella sativa is mediated through activation of the AMPK pathway and increased muscle Glut4 content
    • Benhaddou-Andaloussi A, Martineau L, Vuong T et al (2011) The in vivo antidiabetic activity of Nigella sativa is mediated through activation of the AMPK pathway and increased muscle Glut4 content. Evid Based Complement Alter Med. doi: 10.1155/2011/538671
    • (2011) Evid Based Complement Alter Med
    • Benhaddou-Andaloussi, A.1    Martineau, L.2    Vuong, T.3
  • 72
    • 58149215637 scopus 로고    scopus 로고
    • Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats
    • Meddah B, Ducroc R, El Abbes Faouzi M, et al (2009) Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol 121:419-24
    • (2009) J Ethnopharmacol , vol.121 , pp. 419-424
    • Meddah, B.1    Ducroc, R.2    El Abbes Faouzi, M.3
  • 73
    • 4344587232 scopus 로고    scopus 로고
    • The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat
    • 15325727 10.1016/j.jep.2004.04.030
    • Le P, Benhaddou-Andaloussi A, Elimadi A et al (2004) The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol 94:251-259
    • (2004) J Ethnopharmacol , vol.94 , pp. 251-259
    • Le, P.1    Benhaddou-Andaloussi, A.2    Elimadi, A.3
  • 74
    • 79957777232 scopus 로고    scopus 로고
    • Preventive effect of nigella sativa on metabolic syndrome in menopause induced rats
    • Saadat P, Latiffa AL, Sabariah AR, Mohammad AD (2011) Preventive effect of nigella sativa on metabolic syndrome in menopause induced rats. J Med Plants Res 5:1478-1484
    • (2011) J Med Plants Res , vol.5 , pp. 1478-1484
    • Saadat, P.1    Latiffa, A.L.2    Sabariah, A.R.3    Mohammad, A.D.4
  • 75
    • 7944227115 scopus 로고    scopus 로고
    • Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets
    • 1:CAS:528:DC%2BD2cXpvVCktL8%3D
    • Rchid H, Chevassus H, Nmila R et al (2004) Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets. Fund Clin Pharmacol 18:525-529
    • (2004) Fund Clin Pharmacol , vol.18 , pp. 525-529
    • Rchid, H.1    Chevassus, H.2    Nmila, R.3
  • 76
    • 73349091554 scopus 로고    scopus 로고
    • Multiple molecular targets underlie the antidiabetic effect of N. Sativa seed extract in skeletal muscle, adipocyte and liver cells
    • Benhaddou-Andaloussi A, Martineau L, Vallerand D, et al (2010) Multiple molecular targets underlie the antidiabetic effect of N. sativa seed extract in skeletal muscle, adipocyte and liver cells. Diabetes Obes Metab 12:148-157
    • (2010) Diabetes Obes Metab , vol.12 , pp. 148-157
    • Benhaddou-Andaloussi, A.1    Martineau, L.2    Vallerand, D.3
  • 77
    • 66449135129 scopus 로고    scopus 로고
    • HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: Protection with thymoquinone
    • 1:CAS:528:DC%2BD1MXksVKmu7w%3D
    • Chandra S, Mondal D, Agrawal KC (2009) HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: Protection with thymoquinone. Exp Biol Med 234:442-452
    • (2009) Exp Biol Med , vol.234 , pp. 442-452
    • Chandra, S.1    Mondal, D.2    Agrawal, K.C.3
  • 78
    • 79956213144 scopus 로고    scopus 로고
    • Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus
    • Bamosa A (2010) Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol and Pharmacol 54:344-354
    • (2010) Indian J Physiol and Pharmacol , vol.54 , pp. 344-354
    • Bamosa, A.1
  • 79
    • 84896710798 scopus 로고    scopus 로고
    • Effect of dietary supplementation of black seed (N. Sativa L.) on lipid profile of patients suffering from diabetes
    • 1:CAS:528:DC%2BC2cXisFOqtLo%3D
    • Qidwai W, Ashfaq T (2014) Effect of dietary supplementation of black seed (N. Sativa L.) on lipid profile of patients suffering from diabetes. Antiinflam Antiallergy Agents Med Chem 13:3-8
    • (2014) Antiinflam Antiallergy Agents Med Chem , vol.13 , pp. 3-8
    • Qidwai, W.1    Ashfaq, T.2
  • 81
    • 84878725673 scopus 로고    scopus 로고
    • Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients
    • Kaatabi H, Bamosa AO, Lebdaa FM, Elq AM, Al-Sultan A (2012) Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients. J Fam Community Med 19:155-161
    • (2012) J Fam Community Med , vol.19 , pp. 155-161
    • Kaatabi, H.1    Bamosa, A.O.2    Lebdaa, F.M.3    Elq, A.M.4    Al-Sultan, A.5
  • 82
    • 79956213144 scopus 로고    scopus 로고
    • Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus
    • Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A (2010) Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 54: 344-354
    • (2010) Indian J Physiol Pharmacol , vol.54 , pp. 344-354
    • Bamosa, A.O.1    Kaatabi, H.2    Lebdaa, F.M.3    Elq, A.M.4    Al-Sultanb, A.5
  • 83
    • 84875443004 scopus 로고    scopus 로고
    • Potential antihypertensive and antioxidative effects of Nigella sativa seeds or biomass and Syzygium aromaticum extracts on L-NAME-induced hypertensive rats
    • Sayed HM, El-Latif HAA, Eid NI, Elsayed AZ, El-Kader EMA (2009) Potential antihypertensive and antioxidative effects of Nigella sativa seeds or biomass and Syzygium aromaticum extracts on L-NAME-induced hypertensive rats. Egyptian J Pharm Sci 50:127-146
    • (2009) Egyptian J Pharm Sci , vol.50 , pp. 127-146
    • Sayed, H.M.1    El-Latif, H.A.A.2    Eid, N.I.3    Elsayed, A.Z.4    El-Kader, E.M.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.