Blood pressure lowering effect of Nigella sativa l. seed oil in healthy Volunteers: A randomized, double-blind, placebo-controlled clinical trial

Phytotherapy Research

Volumn 27, Issue 12, 2013, Pages 1849-1853

  Fallah Huseini, H ^a   Amini, M ^b   Mohtashami, R ^b   Ghamarchehre, M E ^b   Sadeqhi, Z ^c   Kianbakht, S ^a   Fallah Huseini, A ^d  

^a Institute of Medicinal Plants   (Iran)

^b BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c Human Resource and Management Development Deputy   (Iran)

^d SHAHED UNIVERSITY   (Iran)

Author keywords

black seed; blood pressure; clinical trial; Nigella sativa seed oil

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATININE; MINERAL OIL; NIGELLA SATIVA EXTRACT; PLACEBO; VEGETABLE OIL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLACK CUMIN; BLOOD PRESSURE MEASUREMENT; BODY MASS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FATTY ACID ANALYSIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MIDDLE AGED; NORMAL HUMAN; PLANT SEED; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; TREATMENT RESPONSE; UREA NITROGEN BLOOD LEVEL;

NIGELLA SATIVA;

BLACK SEED; BLOOD PRESSURE; CLINICAL TRIAL; NIGELLA SATIVA SEED OIL;

ADULT; BLOOD PRESSURE; BODY MASS INDEX; DOUBLE-BLIND METHOD; FEMALE; HEALTHY VOLUNTEERS; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NIGELLA SATIVA; PHYTOTHERAPY; PLANT OILS; SEEDS;

EID: 84890553602     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4944     Document Type: Article

References (42)

1. Actis-Goretta L, Ottaviani JI, Fraga CG,. 2006. Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem 11: 229-34.
2. Alderman MH, Budner N, Cohen H, Lamport B, Ooi WL,. 1988. Prevalence of drug resistant hypertension. Hypertension 11: 1171-1175.
3. Alonso A, Ruiz-Gutierrez V, Martínez-González MA,. 2006. Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidence. Public Health Nutr 9 (2): 251-7.
4. American Heart Association. 1988. Recommendations for human blood pressure determination by sphygmomanometers. Circulation 77: 501A-514A.
5. Andriambeloson E, Magnier C, Haan-Archipoff G, et al,. 1998. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 128: 2324-2333.
6. Bamosa AO,. 1997. Effect of oral ingestion of Nigella sativa seeds in some blood parameters. Saudi Pharm J 5: 126-129.
7. Bilal A, Masud T, Uppal AM, Naveed AK,. 2009. Effects of Nigella sativa oil on some blood parameters in type 2 diabetes mellitus patients. Asian J Chem 21: 5373-5381.
8. Burits M, and, Bucar F,. 2000. Antioxidant activity of Nigella sativa essential oil. Phytother Res 14: 323-328.
9. Carr A, Frei B,. 2000. The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide. Free Rad Biol Med 28: 1806-1814.
10. Dehkordi FR, Kamkhah AF,. 2008. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 22: 447-452.
11. Diebolt M, Bucher B, Andriantsitohaina R,. 2001. Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression Hypertension 38: 159-165.
12. Dogan S, Diken ME, Dogan M,. 2010. Antioxidant, phenolic and protein contents of some medicinal plants. IJMPR 4: 2566-2573.
13. Duchateau G, V OostenHJ, Vasconcellos MA,. 1996 Analysis of cis-fatty acid and trans-fatty acid isomers in hydrogenated and refined vegetable oils by capillary gas-liquid chromatography. J Am Oil Chem Soc 73: 275-282.
14. El Ashry A, Heagerty AM, Ollerenshaw JD, Thurston H,. 1989. The effect of dietary linoleic acid on blood pressure and erythrocyte sodium transport. J Hum Hypertens 3: 9-15.
15. El Tahir KE, Ashour MM, al Harbi MM,. 1993. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 24: 1123-1131.
16. El Tahir KEH, Ageel AM,. 1994. Effect of the volatile oil of (Nigella sativa) on the arterial blood pressure and heart rate of the guinea-pig. Saudi Pharm J 2: 163-168.
17. Galleano M, Pechanova O, Fraga CG,. 2010. Hypertension, nitric oxide, oxidants, and dietary plant polyphenols. Curr Pharm Biotechnol 11: 837-48.
18. Ghosheh OA, Houdi AA, Crooks PA,. 1999. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). J Pharm Biomed Anal 19: 757-762.
19. Hajhashemi V, Ghannadi A, Jafarabadi H,. 2004. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res 18: 195-199.
20. Haji Sharifi A,. 2003. Black Cumin. In Secretes in Medicinal Plants (3rd edn) Hafez-e-Novin press: Tehran Iran; 658-661.
21. Jazayeri GhA,. 2004. Black Cumin. In Zaban-e-khorakiha, volum 3, Amir kabir press: Tehran Iran; 53-54.
22. Jun T, Ke-Yan F, Catalano M,. 1996. Increased superoxide anion production in humans: a possible mechanism for the pathogenesis of hypertension. J Human Hypertens 10: 305-9.
23. Kanter M, Coskun O, Budankamanak M,. 2005. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol 11: 6684-6688.
24. Khattab MM, Nagi MN,. Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytother Res 2007; 21 (5): 410-414.
25. Kunnumakkara AB, Koca C, Dey S, et al,. 2009. Traditional Uses of Spices: An Overview. In Molecular Targets and therapeutic Uses of Spices- Modern Uses for Ancient Medicine, Kunnumakkara AB, Aggarwal BB, (ed). World Scientific Publishing Co. Pte. Ltd. Stallion Press: Singapore; 12-13.
26. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R,. 2002. Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61prospective studies. Prospective Studies Collaboration. Lancet 360: 1903-13.
27. Liou YS, Ma T, Tien L, Chien C, Chou P, Jong GP,. 2008. Long-term effects of antihypertensive drugs on the risk of new-onset diabetes in elderly Taiwanese hypertensives. Int Heart J 49: 205-211.
28. Medina-Remõn A, Zamora-Ros R, Rotchés-Ribalta M, et al,. 2011. Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk. Nutr Metab Cardiovasc Dis 21: 323-31
29. Miura K, Stamler J, Nakagawa H, et al,. 2008. Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study. Hypertension 52: 408-14.
30. Oparil MD, Zaman MA, Calhoun DA,. 2003. Pathogenesis of hypertension. Ann Intern Med 139: 761-76.
31. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A,. 2004. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr 80: 1012-18.
32. Pearson TA, Blair SN, Daniels SR, Eckel RH,. 2002. AHA Scientific Statement. AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: Update 2002. Consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases. Circulation 106: 388-391.
33. Pierdomenico SD, Di Nicola M, Esposito AL, et al,. 2009. " Prognostic Value of Different Indices of Blood Pressure Variability in Hypertensive Patients ". Am J Hypertens 22: 842-847.
34. Rout SK, Dutta S, Sengupta M, Das S, Rout B,. 2010. Antihypertensive therapy: The concept of management with herbal and systemic agents for pulmonary hypertension. IJPSR 3: 72-79.
35. Sacks FM, Kass EH,. 1988. Low blood pressure in vegetarians: effects of specific foods and nutrients. Am J Clin Nutr 48: 795-800.
36. Salehi Surmaghi MH,. 2008. Nigella Sativa. In Herbal Medicine and Herbal Therapy, volum 2, Donyay Taghziah press: Tehran Iran; 216-219.
37. Salem ML, Hossain MS,. 2000. Protective effect of black seed oil from Nigella sativa against murine cytomegalouirus infection. Int J Immunopharmacol 22: 729-740.
38. Sanson-Fisher RW, Clover K,. 1995. Compliance in the treatment of hypertension: a need for action. Am J Hypertens 8: 82S-88S.
39. Takeuchi H, Sakurai C, Noda R, et al,. 2007. Antihypertensive effect and safety of dietary alpha-linolenic acid in subjects with high-normal blood pressure and mild hypertension. J Oleo Sci 56: 347-60.
40. Terés S, Barcelõ-Coblijn G, Benet M, et al,. 2008. Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. PNAS 105: 13811-16.
41. Tsimidou M, Papadopoulos G, Boskou B,. 1992. Determination of phenolic compounds in virgin olive oil by reversed-phase HPLC with emphasis on UV detection. Food Chem 44: 53-60.
42. Zaoui A, Cherrah Y, Lacaille-Dubois MA, Settat A, Amarouch H, Hassar M,. 2000. Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Therapie 55: 379-382.