Preventive effect of nigella sativa on metabolic syndrome in menopause induced rats

Journal of Medicinal Plants Research

Volumn 5, Issue 8, 2011, Pages 1478-1484

  Parhizkar, Saadat ^a,b   Latiff, Latiffa A ^a   Rahman, Sabariah A ^a   Dollah, Mohammad A ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b YASUJ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Menopause; Metabolic syndrome; Nigella sativa; Ovariectomized rats

Indexed keywords

CONJUGATED ESTROGEN; GLUCOSE; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLACK CUMIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HORMONE DETERMINATION; LOW DRUG DOSE; MENOPAUSE; METABOLIC SYNDROME X; NONHUMAN; PLANT SEED; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMALIA; EQUIDAE; NIGELLA SATIVA; RATTUS;

EID: 79957777232     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Al AFM, Fatania H, Shamte U (1991). The effect of a plant mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats. Diabetes Res., 18: 163-168.
2. Al HA, Aqel M, Hasan Z (1993). Hypoglycemiceffect of volatile oil of Nigella Sativa seeds. Int. J. Pharmacog., 31:96-100.
3. Amin KA, Nagy MA (2009). Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Diabetol. Metab. Syndr., 16(1): 1-17.
4. Aqel M (1992). The relaxing effect of the volatile oil of Nigella sativa seeds on vascular smooth muscle. Dirasat Series B, Pure Appl. Sci.,19: 91-100.
5. Araujo LBF, Soares JM, Simoes RS, Ricardo SS, Calió PL, Ricardo OFM, Simões MJ, Haidar MA, Baracat EC (2006). Effect of conjugated equine estrogens and tamoxifen administration on thyroid gland histomorphology of the rat, Clin., 61: 321-326.
6. Arjmandi BH, Birnbaum R, Goyal NV, Getlinger MJ, Juma S, Alekel L, Hasler CM, Drum ML, Hollis BW, Kukreja SC (1998). Bone-sparingeffect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content. Am. J. Clin. Nutr., 68: 1364S-1368S.
7. Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Luben R, Kastelein JJP, Khaw KT, Boekholdt SM (2007).Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPICNorfolk prospective population study. Eur. Heart J., 28(22): 2770-2777.
8. Babiker F, Leon J (2002). Estrogenic hormone action in the heart: regulatory network and function. Cardiovasc. Res., 53: 709-719.
9. Bamosa AO, Ali BA, Sawayan SA (1997). Effect of oral ingestion of Nigella Sativa seed on some blood parameters. J. Saudi Pharm., 5: 126-129.
10. Buriro MA and Tayyab M (2007). Effect of Nigella sativa on Lipid Profile in Albino Rats. Gomal J. Med. Sci. (GJMS)., 5(1): 28-31.
11. El DM, Mady NL, Halim MA (2000). Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneim. Forsch., 50(9): 832-836.
12. El NARM, El DAEM (1992). A study of some biological activities of Nigella sativa (black seeds) "Habbat El-Barka". J. Egypt Soc. Pharmacol. Exp. Ther., 11(2): 781-800.
13. El SOA, Nada SA (1996). Biological evaluation of Multi component tea used as hypoglycemic in rats. Fitoterapia, 15(2):99-102.
14. Enazzani AR, Stomati M, Bernardi F, Luisi S, Casarosa E, Puccetti S, Genazzani AD, Palumbo M, Luisi M (2004). Conjugated equine estrogens reverse the effects of aging on central and peripheral allopregnanolone and beta-endorphin levels in female rats. Fertil Steril., 81(1): 757-766.
15. Eskander H, Emad F, Won JA, Ibrahim K, Abelal WE (1995). Hypoglycemic effect of a herbal formulation in alloxan-induced diabetic rats. Egypt. J. Pharm. Sci., 36: 253-270.
16. Fait T, Malkova J, Zivny J (2002). Effect of hormone replacement therapy on the cardiovascular system. Ceska. Gynekol., 67(5): 285-293.
17. Fararh KM, Atoji Y, Shimizu Y, Takewaki T (2002). Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster. Res. Vet. Sci., 73(3): 279-282.
18. Fried M, Hainer V, Basdevant A, Buchwald H, Dietel M, Finer N, Greve JW, Horber F, Mathus VE, Scopinaro N, Steffen R, Tsigos C, Weiner R, Widhalm K (2008). Interdisciplinary European guidelines on surgery for severe obesity. Rozhl Chir., 87:468-476.
19. Haddad PS, Martineau L, Lyoussi B, Le PM (2006) Middle Eastern and African medicine. In: A. Soumyanath, Editor, In Traditional Herbal Medicines for Modern Times: Antidiabetic Plants, CRC Press, Boca Raton, FL, pp. 221-241.
20. Hafanizam MBH, Dollah MA, Latiff AL, Rahman SA (2008). Toxicity effects of Nigella sativa supplementation on the liver function of rats. Universiti Putra Malaysia, Unpublished Thesis.
21. Hajdu A, Chappel CI, Rona G (1965). The influence of estrogens on scorbutic bone lesions in guinea-pigs. CMLS., 21(8): 466-467.
22. Hawsawi ZA, Ali BA, Bamosa AO (2001). Effect of Nigella sativa (Black seed) and thymoquinone on blood glucose in Albino rats. Ann. Saudi Med., 21(3/4): 242-244.
23. Hedaya SA (1995). Effect of Nigella sativa seeds (black seeds) extract on some heamatologica and biochemical parameters in rats. Alexandria J. Vet. Sci., 11(2): 95-99.
24. Hioki C, Yoshimoto K, Yoshida T (2004). Efficacy of Bofu-tsusho-san, an oriental herbal medicine, in obese Japanese women with impaired glucose tolerance. Clin. Exp. Pharmacol. Physiol., 31: 614-619.
25. Houcher Z, Boudiaf Kh, Benboubetra M, Houcher B (2007). Effects of Methanolic Extract and Commercial Oil of Nigella sativa L. on Blood Glucose and Antioxidant Capacity in Alloxan-Induced Diabetic Rats. Pteridines, 18: 8-18.
26. Izwan MEM, Dollah MA, Latiff AL, Rahman SA (2008). Toxicity effects of Nigella sativa supplementation on the kidney function of rats. Universiti Putra Malaysia, Unpublished Thesis.
27. Kopelman PG (2000). Obesity as a medical problem. Natare, 404: 635-643.
28. Labhal A, Settaf A, Bennani KN, Cherrah Y, Slaoui A, Hassar M (1997). Action anti-obésité, hypocholestérolémiante et hypotriglycéridémiante de Nigella sativa chez le Psammomys obesus. Caducée, 27: 26-28.
29. Labhal A, Settaf A, Zalagh F, Cherrah Y, Hassar M, Slaoui A (1999). Propriétés anti-diabétiques des graines de Nigella sativa chez leMeriones shawi obese et diabétique. Espérance Médicale, 47: 72-74.
30. Lavie CJ, Artham SM, Milani RV, Ventura HO (2008). The obesity paradox: impact of obesity on the prevalence prognosis of cardiovascular diseases. Postgrad.Med., 120: 34-41.
31. Le PM, Benhaddou AA, Settaf A, Cherrah Y, Haddad PS (2004). The petroleum ether extract of Nigella sativa exerts lipid lowering action in the rats. J. Ethanopharmacol., 94(2/3): 251-259.
32. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y (2006). Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin resistant states. Diabetes, 55: 2256-2264.
33. Liu M, Xu X, Rang W, Li Y, Song Y (2004). Influence of ovariectomy and 17 β-estradiol treatment on insulin sensitivity, lipid metabolism and post-ischemic cardiac function. Int. J. Cardiol.,97(3): 485-493.
34. Mai LP, Benhaddou AA, Elimadi A, Settaf A, Cherrah Y, Haddad PS (2004). The petroleum ether extract of Nigella sativa exerts lipidlowering and insulin-sensitizing actions in the rat. J. Ethnopharmacol., 94(2/3): 251-259.
35. Meddah B, Ducroc R, El Abbes Faouzi M (2009). Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J. Ethnopharmacol., 121: 419-424.
36. Meral I, Yener Z, Kahraman T, Mert N (2001).Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defense system and liver damage in experimentally-induced diabetic rabbits. J. Vet. Med. A., 48: 593-599.
37. Najmi A, Haque ShF, Khan RA, Nasiruddin M (2008). Therapeutic Effect of Nigella Sativa Oil on Different Clinical and Biochemical Parameters in Metabolic Syndrome. Int J. Diabetes Metabol.,16: 85-87.
38. Oropeza MV, Orozco S, Ponce H, Campos MG (2005). Tofupill lacks peripheral estrogen-like actions in the rat reproductive tract. Reprod. Toxicol.,20: 261-266.
39. Pagotto U, Vanuzzo D, Vicennati V, Pasquali RG (2008). Pharmacological therapy of obesity. G. Ital. Cardiol., (Rome), 9(4 Suppl 1):83S-93S.
40. Parhizkar S, Latiff L, Rahman S, Dollah MA (2011). Assessing estrogenic activity of Nigella sativa in ovariectomized rats using vaginal cornification assay. Afr. J. Pharm. Pharmacol., (AJPP). [In Press].
41. Pourghassem GB, Ebrahimzadeh AV, Rafraf M, Gorbani A (2009). Effect of dietary supplementation with Nigella sativa L. on serum lipid profile, lipid peroxidation and antioxidant defense system in hyperlipidemic rabbits. J. Med. Plant. Res., 3(10): 815-821.
42. Qidwai W, Hamza HB, Qureshi R, Gilani A (2009). Effectiveness, Safety, and Tolerability of Powdered Nigella sativa (Kalonji) Seed in Capsules on Serum Lipid Levels, Blood Sugar, Blood Pressure, and Body Weight in Adults: Results of a Randomized, Double-Blind Controlled Trial. J. Altern. Complement. Med., 15(6): 639-644.
43. Roghani DF, Kamkhah AF (2008). Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam. Clin. Pharm., 22(4): 447-453.
44. Sarkaki A, Amani R, Badavi M, Safahani M, Aligholi H (2008). Effect of Ovariectomy on Reference Memory Version of Morris Water Maze in Young Adult Rats. Iranian Biomed. J. (IBJ)., 12 (2): 123-128.
45. Schneider JG, Tompkins C, Blumenthal RS, Mora S (2006). The metabolic syndrome in women. Cardiol. Rev., 14: 286-291.
46. shida H, Uesugi T, Hirai K, Toda T, Nukaya H, Yokotsuka K, Tsuji K (1998). Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet. Biol. Pharm. Bull., 21: 62-66.
47. Spiegelman BM, Flier JS (2001). Obesity and the regulation of energy balance. Cell. 104: 531-543.
48. Tansey G, Hughes CLJ, Cline JM, Krummer A, Walmer DK, Schmoltzer S (1998). Effects of dietary soybean estrogens on the reproductive tract in female rats. Proc. Soc. Exp. Biol. Med., 217: 340-344.
49. Tollba AAH, Shabaan SAM, Abdel MMAA (2010). Effects of using aromatic herbal extract and blended with organic acids on productive and physiological performance of poultry 2 - the growth during cold winter stress. Egypt. Poult. Sci., 30(I): 229-248.
50. Turner RT, Vandersteenhoven JJ, Bell NH (1987). The effects of ovariectomy and 12-beta-estradiol on cortical bone histomorphometry in growing rats. J. Bone Miner. Res., 2: 115-122.
51. Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M (2002). Acute and chronic toxicity of Nigella sativa fixed oil. Phytomed., 9: 69-74.